Ahmed Z, Cooper J, Murray TK, Garn K, McNaughton E, Clark H et al (2014) A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity. Acta Neuropathol 127:667–683. https://doi.org/10.1007/s00401-014-1254-6
Article CAS PubMed PubMed Central Google Scholar
Alafuzoff I, Arzberger T, Al-Sarraj S, Bodi I, Bogdanovic N, Braak H et al (2008) Staging of neurofibrillary pathology in Alzheimer’s disease: a study for the BrainNet Europe Consortium. Brain Pathol 18:484–496. https://doi.org/10.1111/j.1750-3639.2008.00147.x
Article PubMed PubMed Central Google Scholar
Arendt T (2000) Alzheimer’s disease as a loss of differentiation control in a subset of neurons that retain immature features in the adult brain. Neurobiol Aging 21:783–796. https://doi.org/10.1016/s0197-4580(00)00216-5
Article CAS PubMed Google Scholar
Arendt T, Stieler J, Ueberham U (2017) Is sporadic Alzheimer’s disease a developmental disorder? J Neurochem 143:396–408. https://doi.org/10.1111/jnc.14036
Article CAS PubMed Google Scholar
Arnsten A, Datta D, Del Tredici K, Braak H (2021) Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer’s disease. Alzheimer’s Dement 17:115–124. https://doi.org/10.1002/alz.12192
Augustinack JC, Helmer K, Huber KE, Kakunoori S, Zöllei L, Fischl B (2010) Direct visualization of the perforant pathway in the human brain with ex vivo diffusion tensor imaging. Front Hum Neurosci 28(4):42. https://doi.org/10.3389/fnhum.2010.00042
Belloy ME, Napolioni V, Greicius MD (2019) A quarter century of APOE and Alzheimer’s disease: progress to date and the path forward. Neuron 101:820–838. https://doi.org/10.1016/j.neuron.2019.01.056
Article CAS PubMed PubMed Central Google Scholar
Betts MJ, Kirilina E, Otaduy MCG, Ivanov D, Acosta-Cabronero J, Callaghan MF et al (2019) Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases. Brain 142:2558–2571. https://doi.org/10.1093/brain/awz193
Article PubMed PubMed Central Google Scholar
Blazquez-Llorca L, Garcia-Marin V, Merino-Serrais P, Avila J, DeFelipe J (2011) Abnormal tau phosphorylation in the thorny excrescences of CA3 hippocampal neurons in patients with Alzheimer’s disease. J Alzheimer Dis 23:1–16. https://doi.org/10.3233/JAD-2011-110659
Braak E, Braak H (1997) Alzheimer’s disease: transiently developing dendritic changes in pyramidal cells of sector CA1 of the Ammon’s horn. Acta Neuropathol 93:323–325. https://doi.org/10.1007/s004010050622
Article CAS PubMed Google Scholar
Braak E, Braak H, Mandelkow EM (1994) A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol 87:554–567. https://doi.org/10.1007/BF00293315
Article CAS PubMed Google Scholar
Braak H (1980) Architectonics of the human telencephalic cortex. Springer, Berlin
Braak H, Braak E (1985) On areas of transition between entorhinal allocortex and temporal isocortex in the human brain. Normal morphology and lamina-specific pathology in Alzheimer’s disease. Acta Neuropathol 68:325–332. https://doi.org/10.1007/BF00690836
Article CAS PubMed Google Scholar
Braak H, Braak E, Grundke-Iqbal I, Iqbal K (1986) Occurrence of neuropil threads in the senile human brain and in Alzheimer’s disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neurosci Lett 65:351–351
Article CAS PubMed Google Scholar
Braak H, Braak E (1988) Neuropil threads occur in dendrites of tangle-bearing nerve cells. Neuropathol Appl Neurobiol 14:39–44. https://doi.org/10.1111/j.1365-2990.1988.tb00864.x
Article CAS PubMed Google Scholar
Braak H, Braak E (1987) Argyrophilic grains: characteristic pathology of cerebral cortex in cases of adult onset dementia without Alzheimer changes. Neurosci Lett 76:124–127. https://doi.org/10.1016/0304-3940(87)90204-7
Article CAS PubMed Google Scholar
Braak H, Braak E (1989) Cortical and subcortical argyrophilic grains characterize a disease associated with adult onset dementia. Neuropathol Appl Neurobiol 15:13–26. https://doi.org/10.1111/j.1365-2990.1989.tb01146.x
Article CAS PubMed Google Scholar
Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239–259. https://doi.org/10.1007/BF00308809
Article CAS PubMed Google Scholar
Braak H, Braak E (1991) Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections. Brain Pathol 1:213–216. https://doi.org/10.1111/j.1750-3639.1991.tb00661.x
Article CAS PubMed Google Scholar
Braak H, Braak E (1992) The human entorhinal cortex: normal morphology and lamina-specific pathology in various diseases. Neurosci Res 15:6–31. https://doi.org/10.1016/0168-0102(92)90014-4
Article CAS PubMed Google Scholar
Braak H, Del Tredici K (2011) The pathological process underlying Alzheimer’s disease in individuals under thirty. Acta Neuropathol 121:171–181. https://doi.org/10.1007/s00401-010-0789-4
Braak H, Del Tredici K (2014) Are cases with tau pathology occurring in the absence of Aβ deposits part of the AD-related pathological process? Acta Neuropathol 128:767–772. https://doi.org/10.1007/s00401-014-1356-1
Braak H, Del Tredici K (2015) Neuroanatomy and pathology of sporadic Alzheimer’s disease. Adv Anat Embryol Cell Biol 215:1–162
Braak H, Del Tredici K (2018) Spreading of tau pathology in sporadic Alzheimer’s disease along cortico-cortical top-down connections. Cereb Cortex 28:3372–3384. https://doi.org/10.1093/cercor/bhy152
Article PubMed PubMed Central Google Scholar
Braak H, Del Tredici K (2020) From the entorhinal region via the prosubiculum to the dentate fascia: Alzheimer disease-related neurofibrillary changes in the temporal allocortex. J Neuropathol Exp Neurol 79:163–175. https://doi.org/10.1093/jnen/nlz123
Article CAS PubMed PubMed Central Google Scholar
Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K (2006) Staging of Alzheimer’s disease-associated neurofibrillary pathology using paraffin sections and immunohistochemistry. Acta Neuropathol 112:389–404. https://doi.org/10.1007/s00401-006-0127-z
Article PubMed PubMed Central Google Scholar
Braak H, Thal DR, Ghebremedhin E, Del Tredici K (2011) Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol 70:960–969. https://doi.org/10.1097/NEN.0b013e318232a379
Article CAS PubMed Google Scholar
Braak H, Feldengut S, Kassubek J, Yilmazer-Hanke D, Del Tredici K (2018) Two histological methods for recognition and study of cortical microinfarctions in thick sections. Eur J Histochem 62:2989. https://doi.org/10.4081/ejh.2018.2989
Article CAS PubMed PubMed Central Google Scholar
Branco T, Häusser M (2011) Synaptic integration gradients in single cortical pyramidal cell dendrites. Neuron 69:885–892. https://doi.org/10.1016/j.neuron.2011.02.006
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