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Functional omics of ORP7 in primary endothelial cells
Functional omics of ORP7 in primary endothelial cells
Many members of the oxysterol-binding protein-related protein (ORP) family have been characterized in detail over the past...
The 24-kDa subunit of mitochondrial complex I regulates growth, microsclerotia development, stress tolerance, and virulence in Verticillium dahliae
The 24-kDa subunit of mitochondrial complex I regulates growth, microsclerotia development, stress tolerance, and virulence in Verticillium dahliae
The complete mitochondrial respiratory chain is a precondition for maintaining cellular energy supply, development, and me...
Accurate RNA velocity estimation based on multibatch network reveals complex lineage in batch scRNA-seq data
Accurate RNA velocity estimation based on multibatch network reveals complex lineage in batch scRNA-seq data
RNA velocity, as an extension of trajectory inference, is an effective method for understanding cell development using sin...
Pheromone relay networks in the honeybee: messenger workers distribute the queen’s fertility signal throughout the hive
Pheromone relay networks in the honeybee: messenger workers distribute the queen’s fertility signal throughout the hive
The harmonious operation of many insect societies depends upon colony-wide dissemination of a non-volatile pheromone produ...
The human Dicer helicase domain is capable of ATP hydrolysis and single-stranded nucleic acid binding
The human Dicer helicase domain is capable of ATP hydrolysis and single-stranded nucleic acid binding
Vertebrates have one Dicer ortholog that generates both microRNAs (miRNAs) and small interfering RNAs (siRNAs), in contras...
Expanded gene and taxon sampling of diplomonads shows multiple switches to parasitic and free-living lifestyle
Expanded gene and taxon sampling of diplomonads shows multiple switches to parasitic and free-living lifestyle
Diplomonads are anaerobic flagellates classified within Metamonada. They contain both host-associated commensals and paras...
Resolving biology’s dark matter: species richness, spatiotemporal distribution, and community composition of a dark taxon
Resolving biology’s dark matter: species richness, spatiotemporal distribution, and community composition of a dark taxon
Zoology’s dark matter comprises hyperdiverse, poorly known taxa that are numerically dominant but largely unstudied,...
Drug-target interaction prediction with collaborative contrastive learning and adaptive self-paced sampling strategy
Drug-target interaction prediction with collaborative contrastive learning and adaptive self-paced sampling strategy
Drug-target interaction (DTI) prediction plays a pivotal role in drug discovery and drug repositioning, enabling the ident...
CRISPR-mediated megabase-scale transgene de-duplication to generate a functional single-copy full-length humanized DMD mouse model
CRISPR-mediated megabase-scale transgene de-duplication to generate a functional single-copy full-length humanized DMD mouse model
The development of sequence-specific precision treatments like CRISPR gene editing therapies for Duchenne muscular dystrop...
Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes
Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes
Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type ...
Asymmetry between the dorsal and ventral digging valves of the female locust: function and mechanics
Asymmetry between the dorsal and ventral digging valves of the female locust: function and mechanics
The female locust is equipped with unique digging tools, namely two pairs of valves—a dorsal and a ventral—uti...
3D exploration of gene expression in chicken embryos through combined RNA fluorescence in situ hybridization, immunofluorescence, and clearing
3D exploration of gene expression in chicken embryos through combined RNA fluorescence in situ hybridization, immunofluorescence, and clearing
Fine characterization of gene expression patterns is crucial to understand many aspects of embryonic development. The chic...
A hybrid TIM complex mediates protein import into hydrogenosomes of Trichomonas vaginalis
A hybrid TIM complex mediates protein import into hydrogenosomes of Trichomonas vaginalis
Hydrogenosomes are a specific type of mitochondria that have adapted for life under anaerobiosis. Limited availability of ...
ARID1A loss promotes RNA editing of CDK13 in an ADAR1-dependent manner
ARID1A loss promotes RNA editing of CDK13 in an ADAR1-dependent manner
ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is thought to play a significant role both in tumor suppres...
How much do we know about the function of mammalian genes?
How much do we know about the function of mammalian genes?
The last two decades have seen impressive advances in functional genomics, but we are still a long way from understanding ...
Single-sample network modeling on omics data
Single-sample network modeling on omics data
Modeling networks for single samples can facilitate discoveries in biology that go beyond those found when analyzing an &#...
A muscle exercise research revolution powered by -omics at single cell and nucleus resolution
A muscle exercise research revolution powered by -omics at single cell and nucleus resolution
In the last few years, single cell and single nucleus RNA-sequencing technologies have been leveraged in exercised adult s...
Lessons in immune adaptations to hypoxia revealed by comparative and evolutionary physiology
Lessons in immune adaptations to hypoxia revealed by comparative and evolutionary physiology
Recent findings from comparative and evolutionary physiologists reveal novel insights into the regulation of inflammation ...
Evolution beyond DNA: epigenetic drivers for evolutionary change?
Evolution beyond DNA: epigenetic drivers for evolutionary change?
Epigenetics has been a buzzword in science for many years, but 20 years ago, the idea that epigenetic gene regula...
DNA polymerases in precise and predictable CRISPR/Cas9-mediated chromosomal rearrangements
DNA polymerases in precise and predictable CRISPR/Cas9-mediated chromosomal rearrangements
Recent studies have shown that, owning to its cohesive cleavage, Cas9-mediated CRISPR gene editing outcomes at junctions o...
Imputation strategies for genomic prediction using nanopore sequencing
Imputation strategies for genomic prediction using nanopore sequencing
Genomic prediction describes the use of SNP genotypes to predict complex traits and has been widely applied in humans and ...
Geroprotector drugs and exercise: friends or foes on healthy longevity?
Geroprotector drugs and exercise: friends or foes on healthy longevity?
Physical activity and several pharmacological approaches individually combat age-associated conditions and extend healthy ...
Follicular fluid C3a-peptide promotes oocyte maturation through F-actin aggregation
Follicular fluid C3a-peptide promotes oocyte maturation through F-actin aggregation
Immature cumulus-oocyte complexes are retrieved to obtain mature oocytes by in vitro maturation (IVM), a laboratory tool i...
New chromosome-scale genomes provide insights into marine adaptations of sea snakes (Hydrophis: Elapidae)
New chromosome-scale genomes provide insights into marine adaptations of sea snakes (Hydrophis: Elapidae)
Sea snakes underwent a complete transition from land to sea within the last ~ 15 million years, yet they remai...
Diversity across organisational scale emerges through dispersal ability and speciation dynamics in tropical fish
Diversity across organisational scale emerges through dispersal ability and speciation dynamics in tropical fish
Biodiversity exists at different levels of organisation: e.g. genetic, individual, population, species, and community. The...
Identification of FtfL as a novel target of berberine in intestinal bacteria
Identification of FtfL as a novel target of berberine in intestinal bacteria
Berberine (BBR) is a commonly used anti-intestinal inflammation drug, and its anti-cancer activity has been found recently...
FGF-independent MEK1/2 signalling in the developing foetal testis is essential for male germline differentiation in mice
FGF-independent MEK1/2 signalling in the developing foetal testis is essential for male germline differentiation in mice
Disrupted germline differentiation or compromised testis development can lead to subfertility or infertility and are stron...
Plasmodium yoelii iron transporter PyDMT1 interacts with host ferritin and is required in full activity for malarial pathogenesis
Plasmodium yoelii iron transporter PyDMT1 interacts with host ferritin and is required in full activity for malarial pathogenesis
The rapid reproduction of malaria parasites requires proper iron uptake. However, the process of iron absorption by parasi...
Fruit bats adjust their decision-making process according to environmental dynamics
Fruit bats adjust their decision-making process according to environmental dynamics
One of the main functions of behavioral plasticity lies in the ability to contend with dynamic environments. Indeed, while...
Cisplatin exposure alters tRNA-derived small RNAs but does not affect epimutations in C. elegans
Cisplatin exposure alters tRNA-derived small RNAs but does not affect epimutations in C. elegans
The individual lifestyle and environment of an organism can influence its phenotype and potentially the phenotype of its o...
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