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Oral submucous fibrosis: pathogenesis and therapeutic approaches
Oral submucous fibrosis: pathogenesis and therapeutic approaches
Oral submucous fibrosis (OSF), characterized by excessive deposition of extracellular matrix (ECM) that causes oral mucosa...
Expert consensus on orthodontic treatment of protrusive facial deformities
Expert consensus on orthodontic treatment of protrusive facial deformities
Protrusive facial deformities, characterized by the forward displacement of the teeth and/or jaws beyond the normal range,...
Emerging roles of extracellular vesicles in oral and maxillofacial areas
Emerging roles of extracellular vesicles in oral and maxillofacial areas
The oral and maxillofacial region is a highly complex area composed of multiple tissue types and bears various critical fu...
Circadian disruption by simulated shift work aggravates periodontitis via orchestrating BMAL1 and GSDMD-mediated pyroptosis
Circadian disruption by simulated shift work aggravates periodontitis via orchestrating BMAL1 and GSDMD-mediated pyroptosis
Approximately 20% to 30% of the global workforce is engaged in shift work. As a significant cause of circadian disruption,...
Porphyromonas gingivalis potentiates stem-like properties of oral squamous cell carcinoma by modulating SCD1-dependent lipid synthesis via NOD1/KLF5 axis
Porphyromonas gingivalis potentiates stem-like properties of oral squamous cell carcinoma by modulating SCD1-dependent lipid synthesis via NOD1/KLF5 axis
Cancer stem cells (CSCs) are widely acknowledged as primary mediators to the initiation and progression of tumors. The ass...
Expert consensus on the prevention and treatment of enamel demineralization in orthodontic treatment
Expert consensus on the prevention and treatment of enamel demineralization in orthodontic treatment
Enamel demineralization, the formation of white spot lesions, is a common issue in clinical orthodontic treatment. The app...
Expert consensus on intentional tooth replantation
Expert consensus on intentional tooth replantation
Intentional tooth replantation (ITR) is an advanced treatment modality and the procedure of last resort for preserving tee...
Evolution of temporomandibular joint reconstruction: from autologous tissue transplantation to alloplastic joint replacement
Evolution of temporomandibular joint reconstruction: from autologous tissue transplantation to alloplastic joint replacement
The reconstruction of the temporomandibular joint presents a multifaceted clinical challenge in the realm of head and neck...
Gingipain from Porphyromonas gingivalis causes insulin resistance by degrading insulin receptors through direct proteolytic effects
Gingipain from Porphyromonas gingivalis causes insulin resistance by degrading insulin receptors through direct proteolytic effects
Periodontitis is a critical risk factor for the occurrence and development of diabetes. Porphyromonas gingivalis may parti...
Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A. actinomycetemcomitans exacerbates arthritis
Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A. actinomycetemcomitans exacerbates arthritis
Clinical studies have shown that Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is associated with aggre...
Expert consensus on the diagnosis and therapy of endo-periodontal lesions
Expert consensus on the diagnosis and therapy of endo-periodontal lesions
Endo-periodontal lesions (EPLs) involve both the periodontium and pulp tissue and have complicated etiologies and pathogen...
The circadian clock in enamel development
The circadian clock in enamel development
Circadian rhythms are self-sustaining oscillations within biological systems that play key roles in a diverse multitude of...
Experts consensus on management of tooth luxation and avulsion
Experts consensus on management of tooth luxation and avulsion
Traumatic dental injuries (TDIs) of teeth occur frequently in children and adolescents. TDIs that impact the periodontal t...
CREB3L1 deficiency impairs odontoblastic differentiation and molar dentin deposition partially through the TMEM30B
CREB3L1 deficiency impairs odontoblastic differentiation and molar dentin deposition partially through the TMEM30B
Odontoblasts are primarily responsible for synthesizing and secreting extracellular matrix proteins, which are crucial for...
Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches
Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches
Periodontitis is a chronic inflammatory disease initiated by biofilm microorganisms and mediated by host immune imbalance....
An unexpected role of neurite outgrowth inhibitor A as regulator of tooth enamel formation
An unexpected role of neurite outgrowth inhibitor A as regulator of tooth enamel formation
Neurite outgrowth inhibitor A (Nogo-A) is a major player in neural development and regeneration and the target of clinical...
Expert consensus on endodontic therapy for patients with systemic conditions
The overall health condition of patients significantly affects the diagnosis, treatment, and prognosis of endodontic disea...
Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC
Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC
Metabolic heterogeneity plays a central role in sustaining uncontrolled cancer cell proliferation and shaping the tumor mi...
Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma
Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) associated pain commonly predicts adverse events among patients. This clinical feature...
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis
Oral submucous fibrosis (OSF) is a chronic and inflammatory mucosal disease caused by betel quid chewing, which belongs to...
Stabilization of EREG via STT3B-mediated N-glycosylation is critical for PDL1 upregulation and immune evasion in head and neck squamous cell carcinoma
Stabilization of EREG via STT3B-mediated N-glycosylation is critical for PDL1 upregulation and immune evasion in head and neck squamous cell carcinoma
Dysregulated Epiregulin (EREG) can activate epidermal growth factor receptor (EGFR) and promote tumor progression in head ...
Author Correction: FUT8-mediated aberrant N-glycosylation of SEMA7A promotes head and neck squamous cell carcinoma progression
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Synthetic high-density lipoprotein (sHDL): a bioinspired nanotherapeutics for managing periapical bone inflammation
Synthetic high-density lipoprotein (sHDL): a bioinspired nanotherapeutics for managing periapical bone inflammation
Apical periodontitis (AP) is a dental-driven condition caused by pathogens and their toxins infecting the inner portion of...
Evaluation of a newly developed oral and maxillofacial surgical robotic platform (KD-SR-01) in head and neck surgery: a preclinical trial in porcine models
Evaluation of a newly developed oral and maxillofacial surgical robotic platform (KD-SR-01) in head and neck surgery: a preclinical trial in porcine models
Traditional open head and neck surgery often leaves permanent scars, significantly affecting appearance. The emergence of ...
The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis
The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis
The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectio...
Tim4 deficiency reduces CD301b+ macrophage and aggravates periodontitis bone loss
Tim4 deficiency reduces CD301b+ macrophage and aggravates periodontitis bone loss
Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately res...
The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats
The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats
The utilization of optimal orthodontic force is crucial to prevent undesirable side effects and ensure efficient tooth mov...
Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma
Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma
Ameloblastoma is a benign tumor characterized by locally invasive phenotypes, leading to facial bone destruction and a hig...
Expert consensus on difficulty assessment of endodontic therapy
Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the r...
Expert consensus on irrigation and intracanal medication in root canal therapy
Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant ...
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