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Low-dose SAHA enhances CD8+ T cell-mediated antitumor immunity by boosting MHC I expression in non-small cell lung cancer
Low-dose SAHA enhances CD8+ T cell-mediated antitumor immunity by boosting MHC I expression in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is a highly aggressive type of lung cancer with poor responses to traditional therapies...
Pre-existing cell subpopulations in primary prostate cancer tumors display surface fingerprints of docetaxel-resistant cells
Pre-existing cell subpopulations in primary prostate cancer tumors display surface fingerprints of docetaxel-resistant cells
Docetaxel resistance is a significant obstacle in the treatment of prostate cancer (PCa), resulting in unfavorable patient...
Fasting in combination with the cocktail Sorafenib:Metformin blunts cellular plasticity and promotes liver cancer cell death via poly-metabolic exhaustion
Fasting in combination with the cocktail Sorafenib:Metformin blunts cellular plasticity and promotes liver cancer cell death via poly-metabolic exhaustion
Dual-Interventions targeting glucose and oxidative metabolism are receiving increasing attention in cancer therapy. Sorafe...
BHLHE41, a transcriptional repressor involved in physiological processes and tumor development
BHLHE41, a transcriptional repressor involved in physiological processes and tumor development
BHLHE41 is a nuclear transcriptional repressor that belongs to the basic helix-loop-helix protein superfamily. BHLHE41 exp...
LPA released from dying cancer cells after chemotherapy inactivates Hippo signaling and promotes pancreatic cancer cell repopulation
LPA released from dying cancer cells after chemotherapy inactivates Hippo signaling and promotes pancreatic cancer cell repopulation
The Hippo pathway in the tumorigenesis and progression of PDAC, with lysophosphatidic acid (LPA) regulating the Hippo path...
Predicting the early therapeutic response to hepatic artery infusion chemotherapy in patients with unresectable HCC using a contrast-enhanced computed tomography-based habitat radiomics model: a multi-center retrospective study
Predicting the early therapeutic response to hepatic artery infusion chemotherapy in patients with unresectable HCC using a contrast-enhanced computed tomography-based habitat radiomics model: a multi-center retrospective study
Predicting the therapeutic response before initiation of hepatic artery infusion chemotherapy (HAIC) with fluorouracil, le...
Pathways and outputs orchestrated in tumor microenvironment cells by hypoxia-induced tumor-derived exosomes in pan-cancer
Pathways and outputs orchestrated in tumor microenvironment cells by hypoxia-induced tumor-derived exosomes in pan-cancer
Hypoxia is a critical microenvironmental condition that plays a major role in driving tumorigenesis and cancer progression...
Meningeal leukaemic aggregates as foci of cell expansion and chemoresistance in acute lymphoblastic leukaemia metastasis
Meningeal leukaemic aggregates as foci of cell expansion and chemoresistance in acute lymphoblastic leukaemia metastasis
Central nervous system (CNS) involvement and/or relapse remains one of the most important causes of morbidity/mortality in...
Evaluating the prognostic significance of tumor deposits in gastric cancer and strategies for their integration into the TNM staging system: a single-center retrospective study
Evaluating the prognostic significance of tumor deposits in gastric cancer and strategies for their integration into the TNM staging system: a single-center retrospective study
To propose a new optimal strategy for incorporating tumor deposit (TD) into TNM staging. Totally, 2730 consecutive gastric...
Tumor-infiltrating myeloid cells; mechanisms, functional significance, and targeting in cancer therapy
Tumor-infiltrating myeloid cells; mechanisms, functional significance, and targeting in cancer therapy
Tumor-infiltrating myeloid cells (TIMs), which encompass tumor-associated macrophages (TAMs), tumor-associated neutrophils...
The MEK5/ERK5 pathway promotes the activation of the Hedgehog/GLI signaling in melanoma cells
The MEK5/ERK5 pathway promotes the activation of the Hedgehog/GLI signaling in melanoma cells
Malignant melanoma is the deadliest skin cancer, with a poor prognosis in advanced stages. We reported that both Hedgehog-...
Thymidine kinase 1 indicates resistance to immune checkpoint plus tyrosine kinase inhibition in renal cell carcinoma
Thymidine kinase 1 indicates resistance to immune checkpoint plus tyrosine kinase inhibition in renal cell carcinoma
Immune checkpoint plus tyrosine kinase inhibition (IO + TKI) has emerged as the first-line therapy in metastat...
Spatial distribution of tertiary lymphoid structures in the molecular and clinical context of non-small cell lung cancer
Spatial distribution of tertiary lymphoid structures in the molecular and clinical context of non-small cell lung cancer
Tertiary lymphoid structures (TLS) are lymphocyte aggregates resembling secondary lymphoid organs and are pivotal in cance...
Allelic expression imbalance of CDKN2A variants in childhood acute lymphoblastic leukemia
Allelic expression imbalance of CDKN2A variants in childhood acute lymphoblastic leukemia
Germline CDKN2A variant predisposes to childhood acute lymphoblastic leukemia (ALL) through allelic expression imbalance (...
Targeting tumor associated macrophages (TAMs) reprograms tumor immune microenvironment to promote solid tumor immunotherapy
Targeting tumor associated macrophages (TAMs) reprograms tumor immune microenvironment to promote solid tumor immunotherapy
A.V.R. Kornepati, R.K. Vadlamudi, T.J. Curiel, Programmed death ligand 1 signals in cancer cells. Nat. Rev. Cancer. 22, 17...
Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma
Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is notorious for its resistance to various treatment modalities. The genetic heter...
Unveiling therapeutic avenues targeting xCT in head and neck cancer
Unveiling therapeutic avenues targeting xCT in head and neck cancer
Head and neck cancer (HNC) remains a major global health burden, prompting the need for innovative therapeutic strategies....
Inhibition of EREG/ErbB/ERK by Astragaloside IV reversed taxol-resistance of non-small cell lung cancer through attenuation of stemness via TGFβ and Hedgehog signal pathway
Inhibition of EREG/ErbB/ERK by Astragaloside IV reversed taxol-resistance of non-small cell lung cancer through attenuation of stemness via TGFβ and Hedgehog signal pathway
Taxol is the first-line chemo-drug for advanced non-small cell lung cancer (NSCLC), but it frequently causes acquired resi...
Mitochondria in tumor immune surveillance and tumor therapies targeting mitochondria
Mitochondria in tumor immune surveillance and tumor therapies targeting mitochondria
Mitochondria play a central role in cellular energy production and metabolic regulation, and their function has been ident...
Tumour cell-released autophagosomes promote lung metastasis by upregulating PD-L1 expression in pulmonary vascular endothelial cells in breast cancer
Tumour cell-released autophagosomes promote lung metastasis by upregulating PD-L1 expression in pulmonary vascular endothelial cells in breast cancer
Establishing an immunosuppressive premetastatic niche (PMN) in distant organs is crucial for breast cancer metastasis. Vas...
ALKBH4 functions as a hypoxia-responsive tumor suppressor and inhibits metastasis and tumorigenesis
ALKBH4 functions as a hypoxia-responsive tumor suppressor and inhibits metastasis and tumorigenesis
The human AlkB homolog (ALKBH) dioxygenase superfamily plays a crucial role in gene regulation and is implicated in cancer...
Targeting the Notch-Furin axis with 2-hydroxyoleic acid: a key mechanism in glioblastoma therapy
Targeting the Notch-Furin axis with 2-hydroxyoleic acid: a key mechanism in glioblastoma therapy
Glioblastomas (GBMs) are highly treatment-resistant and aggressive brain tumors. 2OHOA, which is currently running a phase...
BCAT1 contributes to the development of TKI-resistant CML
BCAT1 contributes to the development of TKI-resistant CML
Although most of chronic myeloid leukemia (CML) patients can be effectively treated by the tyrosine kinase inhibitors (TKI...
ATF3-induced activation of NF-κB pathway results in acquired PARP inhibitor resistance in pancreatic adenocarcinoma
ATF3-induced activation of NF-κB pathway results in acquired PARP inhibitor resistance in pancreatic adenocarcinoma
Olaparib, an inhibitor of poly-(adenosine diphosphate-ribose) polymerase (PARP), has been shown to have anticancer benefit...
DNA repair in tumor radioresistance: insights from fruit flies genetics
DNA repair in tumor radioresistance: insights from fruit flies genetics
Radiation therapy (RT) is a key anti-cancer treatment that involves using ionizing radiation to kill tumor cells. However,...
NK cells as powerful therapeutic tool in cancer immunotherapy
NK cells as powerful therapeutic tool in cancer immunotherapy
Natural killer (NK) cells have gained considerable attention and hold great potential for their application in tumor immun...
Asymmetric post-translational modifications regulate the nuclear translocation of STAT3 homodimers in response to leukemia inhibitory factor
Asymmetric post-translational modifications regulate the nuclear translocation of STAT3 homodimers in response to leukemia inhibitory factor
STAT3 is a pleiotropic transcription factor overactivated in 70% of solid tumours. We have recently reported that inactiva...
The PPP2R1A cancer hotspot mutant p.R183W increases clofarabine resistance in uterine serous carcinoma cells by a gain-of-function mechanism
The PPP2R1A cancer hotspot mutant p.R183W increases clofarabine resistance in uterine serous carcinoma cells by a gain-of-function mechanism
Uterine serous carcinoma (USC) is generally associated with poor prognosis due to a high recurrence rate and frequent trea...
IRE1α inhibitor enhances paclitaxel sensitivity of triple-negative breast cancer cells
IRE1α inhibitor enhances paclitaxel sensitivity of triple-negative breast cancer cells
Breast cancer is the most commonly diagnosed cancer in women, and triple-negative breast cancer (TNBC) accounts for approx...
Deciphering the molecular landscape: evolutionary progression from gynecomastia to aggressive male breast cancer
Deciphering the molecular landscape: evolutionary progression from gynecomastia to aggressive male breast cancer
Gynecomastia denotes the benign proliferation of glandular breast tissue and stands as a recognized risk factor for male b...
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