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Tectal glioma: clinical, radiological, and pathological features, and the importance of molecular analysis
Tectal glioma: clinical, radiological, and pathological features, and the importance of molecular analysis
Tectal glioma (TG) is a rare lower grade glioma (LrGG) that occurs in the tectum, mainly affecting children. TG shares pat...
Primary papillary epithelial tumor of the sella: a case report of an emerging tumor type
Primary papillary epithelial tumor of the sella: a case report of an emerging tumor type
Primary papillary epithelial tumor of the sella (PPETS) is a newly described tumor entity with prototypical location in th...
Development of a rapid and comprehensive genomic profiling test supporting diagnosis and research for gliomas
Development of a rapid and comprehensive genomic profiling test supporting diagnosis and research for gliomas
A prompt and reliable molecular diagnosis for brain tumors has become crucial in precision medicine. While Comprehensive G...
Rise of oligodendroglioma hypermutator phenotype from a subclone harboring TP53 mutation after TMZ treatment
Rise of oligodendroglioma hypermutator phenotype from a subclone harboring TP53 mutation after TMZ treatment
Oligodendrogliomas characterized and defined by 1p/19q co-deletion are slowly growing tumors showing better prognosis than...
Intratumoral heterogeneity of CDKN2A deletions in IDH-mutant astrocytoma
Intratumoral heterogeneity of CDKN2A deletions in IDH-mutant astrocytoma
Broggi G, Barresi V (2023) Assessment of CDKN2A/B homozygous deletion in gliomas: to FISH or not to FISH? J Neuropathol Ex...
Oligodendroglioma, IDH-mutant and 1p/19q-codeleted-prognostic factors, standard of care and chemotherapy, and future perspectives with neoadjuvant strategy
Oligodendroglioma, IDH-mutant and 1p/19q-codeleted-prognostic factors, standard of care and chemotherapy, and future perspectives with neoadjuvant strategy
Oligodendroglioma, IDH-mutant and 1p/19q-codeleted is known for their relative chemosensitivity and indolent clinical cour...
Comprehensive genomic analysis reveals clonal origin and subtype-specific evolution in a case of sporadic multiple meningiomas
Comprehensive genomic analysis reveals clonal origin and subtype-specific evolution in a case of sporadic multiple meningiomas
Meningioma is the most common primary intracranial tumor in adults, with up to 10% manifesting as multiple tumors. Data on...
MAPK pathway alterations in polymorphous low-grade neuroepithelial tumor of the young: diagnostic considerations
MAPK pathway alterations in polymorphous low-grade neuroepithelial tumor of the young: diagnostic considerations
Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a recently recognised tumor type with indolent behavi...
Comparative analyses of immune cells and alpha-smooth muscle actin-positive cells under the immunological microenvironment between with and without dense fibrosis in primary central nervous system lymphoma
Comparative analyses of immune cells and alpha-smooth muscle actin-positive cells under the immunological microenvironment between with and without dense fibrosis in primary central nervous system lymphoma
Histopathologic examinations of primary central nervous system lymphoma (PCNSL) reveal concentric accumulation of lymphocy...
Double-hit primary central nervous system lymphoma with histogenetically proven bone marrow infiltration: a case report and a review of the literature
Double-hit primary central nervous system lymphoma with histogenetically proven bone marrow infiltration: a case report and a review of the literature
Double-hit lymphoma (DHL) formerly referred to high-grade B-cell lymphoma with concurrent MYC and BCL2 or BCL6 rearrangeme...
Novel case of ependymoma-like tumor with mesenchymal differentiation harboring ZFTA::RELA fusion in an adult
Novel case of ependymoma-like tumor with mesenchymal differentiation harboring ZFTA::RELA fusion in an adult
High-grade supratentorial tumors harboring ZFTA::NCOA1/2 fusion in infants presenting with mixed histology of embryonal-ap...
Astroblastoma with MN1::BEND2 in an elderly patient: A case report and review of the literature
Astroblastoma with MN1::BEND2 in an elderly patient: A case report and review of the literature
Louis DN, Perry A, Wesseling P et al (2021) The 2021 WHO classification of tumors of the central nervous system: a summary...
Combination treatment with histone deacetylase and carbonic anhydrase 9 inhibitors shows therapeutic potential in experimental diffuse intrinsic pontine glioma
Combination treatment with histone deacetylase and carbonic anhydrase 9 inhibitors shows therapeutic potential in experimental diffuse intrinsic pontine glioma
Diffuse intrinsic pontine glioma (DIPG) remains a significant therapeutic challenge due to the lack of effective and safe ...
Clinical and radiological features of intracranial ancient schwannomas: a single-institution, retrospective analysis
Clinical and radiological features of intracranial ancient schwannomas: a single-institution, retrospective analysis
Ancient schwannoma (AS) is a subtype of schwannoma characterized by slow progression despite degenerative changes in patho...
Recent advances in liquid biopsy of central nervous system lymphomas: case presentations and review of the literature
Recent advances in liquid biopsy of central nervous system lymphomas: case presentations and review of the literature
Surgical biopsy is the gold standard for diagnosing central nervous system (CNS) lymphomas. However, reliable liquid biops...
Status of alternative angiogenic pathways in glioblastoma resected under and after bevacizumab treatment
Status of alternative angiogenic pathways in glioblastoma resected under and after bevacizumab treatment
Glioblastoma multiforme (GBM) acquires resistance to bevacizumab (Bev) treatment. Bev affects angiogenic factors other tha...
Pediatric diffuse glioma with EP300::BCOR fusion manifesting as low-grade epilepsy-associated neuroepithelial tumor: a case presentation
Pediatric diffuse glioma with EP300::BCOR fusion manifesting as low-grade epilepsy-associated neuroepithelial tumor: a case presentation
Wu Z, Rajan S, Chung HJ et al (2022) Molecular and clinicopathologic characteristics of gliomas with EP300::BCOR fusions. ...
FISH analysis reveals CDKN2A and IFNA14 co-deletion is heterogeneous and is a prominent feature of glioblastoma
FISH analysis reveals CDKN2A and IFNA14 co-deletion is heterogeneous and is a prominent feature of glioblastoma
Deletion of CDKN2A occurs in 50% of glioblastomas (GBM), and IFNA locus deletion in 25%. These genes reside closely on chr...
A rare case of primary central nervous system histiocytic sarcoma harboring a novel ARHGAP45::BRAF fusion: a case report and literature review
A rare case of primary central nervous system histiocytic sarcoma harboring a novel ARHGAP45::BRAF fusion: a case report and literature review
Patients with histiocytic sarcoma occurring in the central nervous system (CNS) are rare and have a very poor prognosis. T...
Touch imprint cytology is useful for the intraoperative pathological diagnosis of PitNETs’ surgical margins
Touch imprint cytology is useful for the intraoperative pathological diagnosis of PitNETs’ surgical margins
Touch imprint cytology (TIC) and frozen section (FS) procedures are essential for intraoperative pathological diagnosis (I...
Intraventricular central neurocytoma molecularly defined as extraventricular neurocytoma: a case representing the discrepancy between clinicopathological and molecular classifications
Intraventricular central neurocytoma molecularly defined as extraventricular neurocytoma: a case representing the discrepancy between clinicopathological and molecular classifications
Central neurocytoma (CN) is classically defined by its intraventricular location, neuronal/neurocytic differentiation, and...
Integrated analysis of multiple methods reveals characteristics of the immune microenvironment in medulloblastoma
Integrated analysis of multiple methods reveals characteristics of the immune microenvironment in medulloblastoma
To explore the characteristics of the immune microenvironment (IME) of medulloblastoma (MB) by four methods: flow cytometr...
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype: case series of a new entity
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype: case series of a new entity
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype (pHGG) is a rare and aggressive brain tumor charac...
Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis—a case report
Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis—a case report
Malignant peripheral nerve sheath tumors (MPNSTs) arising from the trigeminal nerves are extremely rare (only 45 cases, in...
A clinicopathological analysis of supratentorial ependymoma, ZFTA fusion-positive: utility of immunohistochemical detection of CDKN2A alterations and characteristics of the immune microenvironment
A clinicopathological analysis of supratentorial ependymoma, ZFTA fusion-positive: utility of immunohistochemical detection of CDKN2A alterations and characteristics of the immune microenvironment
EPN-ZFTA is a rare brain tumor where prognostic factors remain unclear and no effective immunotherapy or chemotherapy is c...
α-SMA positive vascular mural cells suppress cyst formation in hemangioblastoma
α-SMA positive vascular mural cells suppress cyst formation in hemangioblastoma
Approximately 60% of hemangioblastomas (HBs) have peritumoral cysts adjacent to the tumor, which can cause neurological de...
IDH wild-type lower-grade gliomas with glioblastoma molecular features: a systematic review and meta-analysis
IDH wild-type lower-grade gliomas with glioblastoma molecular features: a systematic review and meta-analysis
The WHO 2021 classification defines IDH wild type (IDHw) histologically lower-grade glioma (hLGG) as molecular glioblastom...
Lynch syndrome-associated chordoma with high tumor mutational burden and significant response to immune checkpoint inhibitors
Lynch syndrome-associated chordoma with high tumor mutational burden and significant response to immune checkpoint inhibitors
Chordoma is a rare malignant bone tumor arising from notochordal tissue. Conventional treatments, such as radical resectio...
Immunohistochemical and ultrastructural review of six cases previously diagnosed as null cell PitNETs
Immunohistochemical and ultrastructural review of six cases previously diagnosed as null cell PitNETs
Pituitary neuroendocrine tumors (PitNETs) lacking lineage affiliation are termed “null cell” PitNETs (NCTs). N...
Spatial metabolic heterogeneity of oligodendrogliomas at single-cell resolution
Spatial metabolic heterogeneity of oligodendrogliomas at single-cell resolution
Oligodendrogliomas are a type of rare and incurable gliomas whose metabolic profiles have yet to be fully examined. The pr...
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