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The impact of ionizing radiation compared to drug-induced immunological changes
The impact of ionizing radiation compared to drug-induced immunological changes
Ionizing radiation (IR) activates several signaling pathways. This study shows the impact of acute low-dose IR on crucial ...
Effects of a high-fat low-carbohydrate diet under different energy conditions on glucose homeostasis and fatty liver development in rats and on gluconeogenesis in the isolated perfused liver
Effects of a high-fat low-carbohydrate diet under different energy conditions on glucose homeostasis and fatty liver development in rats and on gluconeogenesis in the isolated perfused liver
The beneficial effects of high-fat low-carbohydrate (HFLC) diets on glucose metabolism have been questioned and their effe...
Alleviation of adipose–hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF-κB/NLRP3 repression
Alleviation of adipose–hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF-κB/NLRP3 repression
This study hypothesized that acetate breaks the vicious cycle driving adipose–hepatic metabolic dysregulation in a rat mod...
Caloric restriction improves inflammation in different tissues of the Wistar rats with obesity and 2K1C renovascular hypertension
Caloric restriction improves inflammation in different tissues of the Wistar rats with obesity and 2K1C renovascular hypertension
Renovascular hypertension (RHV) is the cause of high blood pressure due to left renal ischemia, and obesity and hypertensi...
Thyroid hormone induces restrictive cardiomyopathy in β1-adrenoceptor knockout mice
Thyroid hormone induces restrictive cardiomyopathy in β1-adrenoceptor knockout mice
The purpose of this study was to characterize the role of β1-AR signaling and its cross-talk between cardiac renin–angiote...
MiR-122 knockdown regulates vascular smooth muscle cells phenotypic switching through enhanced FOXO3 expression
MiR-122 knockdown regulates vascular smooth muscle cells phenotypic switching through enhanced FOXO3 expression
Vascular smooth muscle cells (VSMCs) phenotypic switching is identified as enhanced dedifferentiation, proliferation, and ...
Tumour adaptation to immune factors: old and new ideas for cancer immunotherapy
Tumour adaptation to immune factors: old and new ideas for cancer immunotherapy
The tumour is fully functional in the zone of action of immune mediators. Moreover, the tumour needs immune system mediato...
Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients
Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients
Platelet hyperactivity is one of the key factors implicated in the development and progression of diabetic vascular compli...
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery
Cardiac surgery-associated acute kidney injury is a common post-operative complication, mostly due to increasing oxidative...
Long-term potentiation and its neurotrophin-dependent modulation in the superior cervical ganglion of the rat are influenced by KCNQ channel function
Long-term potentiation and its neurotrophin-dependent modulation in the superior cervical ganglion of the rat are influenced by KCNQ channel function
Ganglionic long-term potentiation (gLTP) in the rat superior cervical ganglion (SCG) is differentially modulated by neurot...
Sleep deprivation disturbs uterine contractility and structure in pregnant rats: role of matrix metalloproteinase 9 and transforming growth factor-β
Sleep deprivation disturbs uterine contractility and structure in pregnant rats: role of matrix metalloproteinase 9 and transforming growth factor-β
Sleep deprivation (SD) during pregnancy can impact the delivery procedure, with prolongation of the labor duration. Matrix...
NLG-919 combined with cisplatin to enhance inhibitory effect on cell migration and invasion via IDO1–Kyn–AhR pathway in human nasopharyngeal carcinoma cell
NLG-919 combined with cisplatin to enhance inhibitory effect on cell migration and invasion via IDO1–Kyn–AhR pathway in human nasopharyngeal carcinoma cell
As a common aggressive head and neck cancer, nasopharyngeal carcinoma (NPC) received cisplatin treatment as a first-line c...
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma
Cuproptosis is the latest cell death type caused by enhanced mitochondrial-dependent energy metabolism. This study plans t...
Novel mediators regulating angiogenesis in diabetic foot ulcer healing
Novel mediators regulating angiogenesis in diabetic foot ulcer healing
A non-healing diabetic foot ulcer (DFU) is a debilitating clinical problem amounting to socioeconomic and psychosocial bur...
Neonatal administration of fenofibrate had no developmental programming effect on the lipid profile and relative leucocyte telomere lengths of adolescent rats fed a high-fructose diet postnatally
Neonatal administration of fenofibrate had no developmental programming effect on the lipid profile and relative leucocyte telomere lengths of adolescent rats fed a high-fructose diet postnatally
Telomere length, a marker of ageing, is susceptible to developmental programming that may cause its accelerated attrition....
Simultaneous intervention against oxidative stress and inflammation by targeting Nrf2/ARE and NLRP3 inflammasome pathway mitigates thioacetamide-induced liver fibrosis in rat
Simultaneous intervention against oxidative stress and inflammation by targeting Nrf2/ARE and NLRP3 inflammasome pathway mitigates thioacetamide-induced liver fibrosis in rat
Liver fibrosis is a typical pathological state/stage involved in most chronic liver diseases and its persistence results i...
Mechanical activation of vagal afferents involves opposing cation and TREK1 currents and NO regulation
Mechanical activation of vagal afferents involves opposing cation and TREK1 currents and NO regulation
Vagal afferents convey signals of mechanical stimulation in the gut to the brain, which is essential for the regulation of...
Sex hormone dose escalation for treating abnormal sleep in ovariectomized rats: in vitro GABA synthesis in sleep-related brain areas
Sex hormone dose escalation for treating abnormal sleep in ovariectomized rats: in vitro GABA synthesis in sleep-related brain areas
No data in the literature have evaluated sex hormone dose escalation for treating abnormal sleep of ovariectomized rats—no...
Copaiba oil improves pulmonary nitric oxide bioavailability in monocrotaline-treated rats
Copaiba oil improves pulmonary nitric oxide bioavailability in monocrotaline-treated rats
Oxidative stress is involved in increased pulmonary vascular resistance (PVR) and right ventricular (RV) hypertrophy, char...
Detection of joining points for genomic DNA circularization in cell culture
Detection of joining points for genomic DNA circularization in cell culture
We previously reported on extrachromosomal circular DNA extracted from mouse brain. We attempted to reconfirm the formatio...
Opioid prescriptions and patients’ health services utilization and cost before and during the COVID-19 pandemic: an exploratory population-based administrative data analysis
Opioid prescriptions and patients’ health services utilization and cost before and during the COVID-19 pandemic: an exploratory population-based administrative data analysis
The objective was to explore percentages of the population treated with prescribed opioids and costs of opioid-related hos...
High salt-induced morphological and glycocalyx remodeling of human vascular smooth muscle cells is reversible but induces a high sodium salt-like sensitive memory
High salt-induced morphological and glycocalyx remodeling of human vascular smooth muscle cells is reversible but induces a high sodium salt-like sensitive memory
Our recent work showed that short-term treatment (1–2 days) with high sodium salt had no effect on the morphology of human...
Therapeutic effect of ouabagenin, a novel liver X receptor agonist, on atherosclerosis in nonalcoholic steatohepatitis in SHRSP5/Dmcr rat model
Therapeutic effect of ouabagenin, a novel liver X receptor agonist, on atherosclerosis in nonalcoholic steatohepatitis in SHRSP5/Dmcr rat model
The liver X receptor (LXR) can enhance cholesterol transporters, which could remove excess cholesterol from foam cells in ...
Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice
Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice
This study aimed to determine the effect of administration of oral vitamins A and E at different doses on plasma and brain...
Sex- and enantiospecific differences in the formation rate of hydroxyeicosatetraenoic acids in rat organs
Sex- and enantiospecific differences in the formation rate of hydroxyeicosatetraenoic acids in rat organs
Hydroxyeicosatetraenoic acids (HETEs) are hydroxylated arachidonic acid (AA) metabolites that are classified into midchain...
Protective effects of diclofenac on liver graft preservation
Protective effects of diclofenac on liver graft preservation
This study aims to evaluate the effect of diclofenac addition to the preservation solution Celsior on liver graft preserva...
URB597 attenuates stress-induced ventricular structural remodeling by modulating cytokines, NF-κB, and JAK2/STAT3 pathways in female and male rats
URB597 attenuates stress-induced ventricular structural remodeling by modulating cytokines, NF-κB, and JAK2/STAT3 pathways in female and male rats
Endocannabinoids act as a stress response system; simultaneously, the modulation of this system has emerged a novel approa...
Porphyromonas gingivalis induces cardiovascular dysfunction
Porphyromonas gingivalis induces cardiovascular dysfunction
Porphyromonas gingivalis (P. gingivalis) is one of the most responsible periodontopathogenic bacteria in the development o...
CD38 deficiency promotes skeletal muscle and brown adipose tissue energy expenditure through activating NAD+-Sirt1-PGC1α signaling pathway
CD38 deficiency promotes skeletal muscle and brown adipose tissue energy expenditure through activating NAD+-Sirt1-PGC1α signaling pathway
Obesity is a metabolic syndrome characterized by abnormal lipid deposition and energy imbalance. CD38 is a single-chain tr...
Anticancer activity of sinapic acid by inducing apoptosis in HT-29 human colon cancer cell line
Anticancer activity of sinapic acid by inducing apoptosis in HT-29 human colon cancer cell line
Colorectal cancer is the third most lethal and fourth most commonly diagnosed cancer worldwide. Sinapic acid, a derivative...
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