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Treating AAV by targeting T cell responses
Treating AAV by targeting T cell responses
Glucocorticoids are currently used to induce remission in patients with antineutrophil cytoplasmic antibody glomerulonephr...
Bacteria caught in neutrophil and UMOD traps in urine
Bacteria caught in neutrophil and UMOD traps in urine
Several mechanisms prevent the ascent of uropathogenic bacteria from the bladder to the kidney, which can lead to pyelonep...
International expert consensus statement on the diagnosis and management of congenital nephrogenic diabetes insipidus (arginine vasopressin resistance)
International expert consensus statement on the diagnosis and management of congenital nephrogenic diabetes insipidus (arginine vasopressin resistance)
Congenital nephrogenic diabetes insipidus (NDI; also known as arginine vasopressin resistance) is a rare inherited disorde...
A guide to gene–disease relationships in nephrology
A guide to gene–disease relationships in nephrology
The use of next-generation sequencing technologies such as exome and genome sequencing in research and clinical care has t...
ECM remodelling by ADAMTS12 in fibrosis
Fibrosis results from the continuous deposition of extracellular matrix (ECM) by fibroblasts in response to injurious stim...
Kidney disease and reproductive health
Kidney disease and reproductive health
Understanding the relationship between reproductive health and kidney function is important to provide holistic care for p...
Collagen formation, function and role in kidney disease
Collagen formation, function and role in kidney disease
Highly abundant in mammals, collagens define the organization of tissues and participate in cell signalling. Most...
Advancing gender equity to improve kidney care for women: a patient perspective
Women living with kidney disease are exposed to several sex and gender gaps in the clinical practice of standard hemodialy...
Anti-nephrin autoantibodies: a paradigm shift in podocytopathies
Anti-nephrin autoantibodies: a paradigm shift in podocytopathies
A new study demonstrates that anti-nephrin autoantibodies are not merely markers but also actively contribute to the patho...
Drug repurposing for glomerular diseases: an underutilized resource
Drug repurposing for glomerular diseases: an underutilized resource
Drug repurposing in glomerular disease can deliver opportunities for steroid-free regimens, enable personalized multi-targ...
Making advance care planning easier for adults with kidney disease and their clinicians
Advance care planning (ACP) has evolved from a narrow focus on end-of-life preference, such as resuscitation, to a continu...
Lymphocytes and innate immune cells in acute kidney injury and repair
Lymphocytes and innate immune cells in acute kidney injury and repair
Acute kidney injury (AKI) is a common and serious disease entity that affects native kidneys and allografts but for which ...
From improbable to possible: pregnancy with advanced chronic kidney disease
From improbable to possible: pregnancy with advanced chronic kidney disease
Reproductive health is an acknowledged right, yet women with chronic kidney disease (CKD) not only face reduced fertility ...
A focus on kidney ageing
Population ageing will exacerbate the burden of ageing-related diseases, including chronic kidney disease. Mitigating the ...
The global landscape of kidney registries: immense challenges and unique opportunities
The global landscape of kidney registries: immense challenges and unique opportunities
Kidney registries are essential to understanding the burden of kidney disease and facilitating the development of sustaina...
Kidney disease: a global health priority
Kidney disease: a global health priority
The prevalence of kidney disease and its associated morbidity and mortality continue to rise. This crisis cannot be tackle...
Combination therapy for kidney disease in people with diabetes mellitus
Combination therapy for kidney disease in people with diabetes mellitus
Diabetic kidney disease (DKD), defined as co-existing diabetes and chronic kidney disease in the absence of other clear ca...
Chronic kidney disease and the global public health agenda: an international consensus
Chronic kidney disease and the global public health agenda: an international consensus
Early detection is a key strategy to prevent kidney disease, its progression and related complications, but numerous studi...
A new era in the science and care of kidney diseases
A new era in the science and care of kidney diseases
Notable progress in basic, translational and clinical nephrology research has been made over the past five decades. Noneth...
Thiazides in kidney transplant recipients: skin in the game
Thiazides in kidney transplant recipients: skin in the game
Clinical trial data suggest that thiazides and thiazide-like drugs could be beneficial for blood-pressure lowering in pati...
Epithelial cell states associated with kidney and allograft injury
Epithelial cell states associated with kidney and allograft injury
The kidney epithelium, with its intricate arrangement of highly specialized cell types, constitutes the functional core of...
Calcium signalling and transport in the kidney
Calcium signalling and transport in the kidney
The kidney plays a pivotal role in regulating calcium levels within the body. Approximately 98% of the filtered calcium is...
Progress towards improving blood pressure control
Progress towards improving blood pressure control
Despite the availability of effective therapies, the majority of patients with hypertension have poor blood pressure contr...
Consideration of sex differences is necessary to achieve health equity
Improved understanding of the impact of sex and gender-related factors on human health and disease and the inclusion of pe...
Targeted identification of risk and treatment of diabetic kidney disease
Basic discovery and clinical trials in diabetic kidney disease (DKD) have continued to be reported in 2023 despite the dis...
Differences in the epidemiology, management and outcomes of kidney disease in men and women
Differences in the epidemiology, management and outcomes of kidney disease in men and women
Improved understanding of differences in kidney disease epidemiology, management and outcomes in men and women could help ...
Mechanisms and consequences of sex differences in immune responses
Mechanisms and consequences of sex differences in immune responses
Biological sex differences refer to differences between males and females caused by the sex chromosome complement (that is...
Author Correction: The immunoregulatory roles of non-haematopoietic cells in the kidney
Authors and AffiliationsDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USAGeorge C. Tsokos, Afr...
Renoprotective effects of sparsentan: clinical trial evidence in IgA nephropathy and FSGS
Renoprotective effects of sparsentan: clinical trial evidence in IgA nephropathy and FSGS
In early 2023, the dual endothelin–angiotensin receptor antagonist sparsentan became the first non-immunosuppressive thera...
Targeting APRIL to slow progression of IgA nephropathy
Targeting APRIL to slow progression of IgA nephropathy
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