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Endocrine-disrupting chemicals as prostate carcinogens
Endocrine-disrupting chemicals as prostate carcinogens
Endocrine-disrupting chemicals (EDCs) are natural or synthetic compounds that are ubiquitous in the environment and in dai...
Testosterone affects the vaginal microbiome in transgender men
Gender-affirming hormone therapy for transgender men can affect their vaginal microbiome, potentially adversely influencin...
Perspectives on chemsex
Chemsex is a practice that sits at the intersection of substance use and sexuality, which is predominantly reported by men...
Pronouns in English: a user’s guide
Pronouns are small but mighty words. However, the conscious use of gender-neutral pronouns has recently led to heated disc...
Synergistic targeting strategies for prostate cancer
Synergistic targeting strategies for prostate cancer
Prostate cancer is the second most commonly diagnosed cancer and the fifth leading cause of death among men worldwide. And...
Pride, not prejudice
In June 2020, at the height of the COVID-19 lockdown, Nature Reviews Urology published its first Pride special issue. At t...
Telesurgery in urology — advances, challenges and future directions
Telesurgery, also known as remote surgery, has emerged as a revolutionary paradigm in urology. The use of telesurgery and ...
Effects of degradation-associated polypropylene particles in the surrounding tissue after surgical mesh implantation
Effects of degradation-associated polypropylene particles in the surrounding tissue after surgical mesh implantation
Evidence of polypropylene mesh degradation has revealed particle accumulation in surrounding tissues, raising concerns abo...
177Lu-PSMA-617 extends progression-free survival in taxane-naive mCRPC
A new phase III, randomized, controlled trial was carried out to assess the efficacy of 177Lu-PSMA-617 in patients with ta...
Tivozanib monotherapy outperforms combination therapy in post-ICI RCC
The multicentre, randomized, phase III trial TiNivo-2 was conducted to assess the efficacy of the vascular endothelial gro...
Metabolism, mitochondria and metastasis in kidney cancer
A study published in Nature investigating tumour metabolism in kidney cancers provides insight into the influence of mitoc...
Disruption of circadian rhythm as a potential pathogenesis of nocturia
Disruption of circadian rhythm as a potential pathogenesis of nocturia
Increasing evidence suggested the multifactorial nature of nocturia, but the true pathogenesis of this condition still rem...
Molecular imaging of renal cell carcinomas: ready for prime time
Molecular imaging of renal cell carcinomas: ready for prime time
The clinical diagnosis of renal cell carcinoma (RCC) is constantly evolving. Diagnostic imaging of RCC relying on enhanced...
HSD3B1, prostate cancer mortality and modifiable outcomes
HSD3B1, prostate cancer mortality and modifiable outcomes
Androgen receptor stimulation by testosterone and dihydrotestosterone is crucial for prostate cancer progression. Despite ...
Tomorrow’s patient management: LLMs empowered by external tools
Tomorrow’s patient management: LLMs empowered by external tools
Large language models are gaining increasing interest in the medical community; however, an important but overlooked aspec...
Metastasis development in non-muscle-invasive bladder cancer
Metastasis development in non-muscle-invasive bladder cancer
Non-muscle-invasive bladder cancer (NMIBC) is the most common type of bladder cancer presentation and is characterized by ...
Neoadjuvant lutetium PSMA, the TIME and immune response in high-risk localized prostate cancer
Neoadjuvant lutetium PSMA, the TIME and immune response in high-risk localized prostate cancer
High-risk localized prostate cancer remains a lethal disease with high rates of recurrence, metastases and death, despite ...
AI for drug discovery
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Urology’s carbon footprint
A cradle-to-grave life-cycle assessment has been undertaken of the greenhouse gas emissions from the transurethral resecti...
Field effect and forerunner genes drive bladder cancer initiation
The idea that common epithelial cancers evolve from dysplasia or carcinoma in situ has been challenged by the discovery of...
A CAF subpopulation promotes LVI in early-stage bladder cancer
In a new article published in Cancer Cell, a subset of cancer-associated fibroblasts (CAFs) was shown to have a crucial ro...
Patient-reported toxic effects of hypofractionated versus conventional RT
Post-prostatectomy radiotherapy (RT) is a common second-line treatment for patients with prostate cancer. In the phase III...
Safe delivery of ICI therapy through sub-urothelial injection
Systemic treatment with the human monoclonal anti-PDL1 antibody durvalumab showed benefit in several cancers. In a phase I...
HRQoL in patients receiving EV versus chemotherapy
In the phase III EV-301 trial, enfortumab vedotin (EV) has been shown to increase overall survival compared with chemother...
Unlocking ferroptosis in prostate cancer — the road to novel therapies and imaging markers
Unlocking ferroptosis in prostate cancer — the road to novel therapies and imaging markers
Ferroptosis is a distinct form of regulated cell death that is predominantly driven by the build-up of intracellular iron ...
EAU à la mode
Urologists from around the world congregated at the 39th Annual Congress of the European Association of Urology (EAU), whi...
The evolving landscape of monogenic nephrolithiasis and therapeutic innovations
Monogenic causes account for up to 20% of nephrolithiasis instances and are crucial for developing targeted treatments. Wh...
Bladder cancer variants — one disease with many faces
Bladder cancer progression to microscopically distinct variants such as sarcomatoid, small cell, micropapillary and plasma...
Human-relevant urothelial model provides insight into infection strategies and host response
Use of a 3D urine-tolerant human urothelial model (3D-UHU), which recapitulates the crucial features of human urothelium, ...
Management and cost of stent encrustation in pregnancy
Ureteral stents are useful devices for urological management in pregnancy. However, stent encrustation occurs in up to 13%...
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