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Parkinson disease therapy: current strategies and future research priorities
Parkinson disease therapy: current strategies and future research priorities
Parkinson disease (PD) is the fastest growing neurological disorder globally and poses substantial management cha...
Glymphatic dysfunction in PD clinical progression
Risk of clinical milestones in Parkinson disease (PD) is associated with reduced glymphatic drainage, according to new res...
Dementia risk scores in diverse populations
A recent analysis of dementia risk scores across diverse populations found that the validity of scores can differ between ...
High prevalence of hepatitis B in NMOSD
A new study of a Taiwanese cohort found a high prevalence of resolved hepatitis B virus (HBV) infection in people with neu...
Immune responses influence sex differences in Alzheimer disease
Sex differences in Alzheimer disease could be influenced by differences in immune responses, new research suggests.
Oligodendrocyte progenitor cell transplant for MS
Transplantation of genetically modified oligodendrocyte progenitor cells (OPCs) into a mouse model of MS improves remyelin...
Intracerebral haemorrhage — mechanisms, diagnosis and prospects for treatment and prevention
Intracerebral haemorrhage — mechanisms, diagnosis and prospects for treatment and prevention
Intracerebral haemorrhage (ICH) is a devastating condition associated with high mortality and substantial residual disabil...
Diets to promote healthy brain ageing
Diets to promote healthy brain ageing
Diet is a modifiable lifestyle factor with a proven role in cardiovascular disease risk reduction that might also play an ...
Single-cell atlas of Alzheimer disease vulnerability
A single-cell transcriptomic atlas of six anatomical regions in the aged human brain with and without Alzheimer disease (A...
Shared glial pathology in HD and schizophrenia
A new study suggests that glial cells in both Huntington disease (HD) and schizophrenia share abnormal gene transcription ...
Identifying and reducing risks of neurological complications associated with vaccination
Identifying and reducing risks of neurological complications associated with vaccination
Vaccines protect against many infectious diseases, including some that can directly or indirectly cause nervous system dam...
Disentangling clinical and biological trajectories of neurodegenerative diseases
Disentangling clinical and biological trajectories of neurodegenerative diseases
In recent years, we have seen a shift towards defining sporadic neurodegenerative diseases as a biological continuum. Here...
Peripheral nervous system immune-related adverse events due to checkpoint inhibition
Peripheral nervous system immune-related adverse events due to checkpoint inhibition
Immune checkpoint inhibitors have revolutionized cancer therapy and are increasingly used to treat a wide range of oncolog...
Antisense oligonucleotide shows potential in Charcot–Marie–Tooth disease
Antisense oligonucleotide shows potential in Charcot–Marie–Tooth disease
Antisense oligonucleotide treatment has therapeutic potential in a severe form of Charcot–Marie–Tooth disease,...
Insights from 25 years of onabotulinumtoxinA in migraine — mechanisms and management
Insights from 25 years of onabotulinumtoxinA in migraine — mechanisms and management
OnabotulinumtoxinA (BTX-A) was first linked to beneficial effects in migraine 25 years ago and was approved by the F...
Author Correction: Neurological care for LGBT+ people
Authors and AffiliationsCollege of Medicine, SUNY Downstate Health Sciences University, New York City, NY, USASalvatore Gi...
Diversity, equity and inclusion in neurology
In this issue of Nature Reviews Neurology, we launch a Series to highlight the importance of diversity, equity and inclusi...
Addressing disparities in neurology by building the workforce in LMICs
Addressing disparities in neurology by building the workforce in LMICs
Nature Reviews Neurology is interviewing individuals who are driving efforts to address disparities in neurology through a...
Support for network theories of schizophrenia
Support for network theories of schizophrenia
A computational neuroimaging study has shed new light on the relationship between morphological changes in the brain in sc...
BTK inhibitor falters in multiple sclerosis trials
Findings of phase III trials of the Bruton’s tyrosine kinase inhibitor evobrutinib in patients with relapsing multip...
EBV-specific T cells in multiple sclerosis
New data recently reported at the ACTRIMS Forum add to growing evidence of an aetiological role for Epstein–Barr vir...
Addressing disparities in neurology by identifying gaps in hospital care
Addressing disparities in neurology by identifying gaps in hospital care
Nature Reviews Neurology is interviewing individuals who are driving efforts to address disparities in neurology through a...
Neurofilaments as biomarkers in neurological disorders — towards clinical application
Neurofilaments as biomarkers in neurological disorders — towards clinical application
Neurofilament proteins have been validated as specific body fluid biomarkers of neuro-axonal injury. The advent of highly ...
Neuronal activity drives glymphatic waste clearance
Two new studies show that clearance of waste, including pathogenic amyloid, through the glymphatic system is driven by syn...
Improved quality of life with MS treatment
Cladribine tablets can improve quality of life in people with highly active relapsing multiple sclerosis (MS), according t...
IGFBP2 levels associated with Alzheimer disease
A study published in Brain has found correlations between serum and cerebrospinal fluid levels of insulin-like growth fact...
A multiple hits hypothesis for memory dysfunction in Parkinson disease
A multiple hits hypothesis for memory dysfunction in Parkinson disease
Cognitive disorders are increasingly recognized in Parkinson disease (PD), even in early disease stages, and memory is one...
Restoring synaptic plasticity after stroke
Gamma oscillations induced by optogenetic stimulation restore functional synaptic plasticity in a mouse model of stroke, a...
CD11c+ macrophages mediate brain-to-gut α-synuclein trafficking
CD11c+ macrophages mediate brain-to-gut α-synuclein trafficking
New research indicates that in a mouse model of Parkinson disease, α-synuclein is trafficked from the brain to the gu...
ALS pathogenesis linked to actin barrier collapse
Repulsive guidance molecule A (RGMa) regulates actin dynamics via neogenin 1 signalling. A new study found that the cerebr...
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