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Scutellaria barbata D.Don and Hedyotis diffusa Willd herb pair combined with cisplatin synergistically inhibits ovarian cancer progression through modulating oxidative stress via NRF2-FTH1 autophagic degradation pathway
Scutellaria barbata D.Don and Hedyotis diffusa Willd herb pair combined with cisplatin synergistically inhibits ovarian cancer progression through modulating oxidative stress via NRF2-FTH1 autophagic degradation pathway
Cisplatin (DDP) is one of the most effective anticancer drugs, commonly used to treat advanced ovarian cancer (OC). Howeve...
TIGIT+ CD4+ regulatory T cells enhance PD-1 expression on CD8+ T cells and promote tumor growth in a murine ovarian cancer model
TIGIT+ CD4+ regulatory T cells enhance PD-1 expression on CD8+ T cells and promote tumor growth in a murine ovarian cancer model
Immune checkpoint-based immunotherapy has shown limited efficacy in the treatment of ovarian cancer. In recent years, the ...
Extracellular vesicles-derived MicroRNA-145-5p is upregulated in the uterine fluid of women with endometriosis and impedes mouse and human blastocyst development
Extracellular vesicles-derived MicroRNA-145-5p is upregulated in the uterine fluid of women with endometriosis and impedes mouse and human blastocyst development
Previous work indicated that the implantation and pregnancy rates of women with endometriosis are lower than those of heal...
Protective effect of afamin protein against oxidative stress related injury in human ovarian granulosa cells
Protective effect of afamin protein against oxidative stress related injury in human ovarian granulosa cells
Ovarian granulosa cells (GCs) play crucial roles in follicular growth and development. Their normal function is influenced...
Effect of body mass index on ovarian reserve and ART outcomes in infertile women: a large retrospective study
Effect of body mass index on ovarian reserve and ART outcomes in infertile women: a large retrospective study
Obesity poses a significant global health challenge, with profound implications for women’s reproductive health. The...
In vitro drug testing using patient-derived ovarian cancer organoids
In vitro drug testing using patient-derived ovarian cancer organoids
Ovarian cancer is the most lethal gynecological cancer. As the primary treatment, chemotherapy has a response rate of only...
Identifying therapeutic targets for primary ovarian insufficiency through integrated genomic analyses
Identifying therapeutic targets for primary ovarian insufficiency through integrated genomic analyses
Primary ovarian insufficiency (POI) is a disorder characterized by the premature decline in ovarian function, leading to s...
ADC: a deadly killer of platinum resistant ovarian cancer
ADC: a deadly killer of platinum resistant ovarian cancer
Platinum is a key component of ovarian cancer systemic therapy. However, most patients will eventually face a recurrence, ...
In vitro matured oocytes have a higher developmental potential than in vivo matured oocytes after hormonal ovarian stimulation in Callithrix jacchus
In vitro matured oocytes have a higher developmental potential than in vivo matured oocytes after hormonal ovarian stimulation in Callithrix jacchus
The common marmoset, Callithrix jacchus, is an invaluable model in biomedical research. Its use includes genetic engineeri...
Enhancing angiogenesis and inhibiting apoptosis: evaluating the therapeutic efficacy of bone marrow mesenchymal stem cell-derived exosomes in a DHEA-induced PCOS mouse model
Enhancing angiogenesis and inhibiting apoptosis: evaluating the therapeutic efficacy of bone marrow mesenchymal stem cell-derived exosomes in a DHEA-induced PCOS mouse model
Polycystic Ovary Syndrome (PCOS) is a widespread endocrine disorder among women, characterized by symptoms like ovarian cy...
DNA methylation profiles of ovarian cysts resemble ovarian tissues but not endometrial tissues
DNA methylation profiles of ovarian cysts resemble ovarian tissues but not endometrial tissues
Endometriosis is a heritable, complex chronic inflammatory disease, for which much of the causal pathogenic mechanism rema...
HOXB2 promotes cisplatin resistance by upregulating lncRNA DANCR in ovarian cancer
HOXB2 promotes cisplatin resistance by upregulating lncRNA DANCR in ovarian cancer
Ovarian cancer (OV) is a highly fatal malignant disease that commonly manifests at an advanced stage. Drug resistance, par...
Correction: Alteration of the N6‑methyladenosine methylation landscape in a mouse model of polycystic ovary syndrome
Correction: Alteration of the N6‑methyladenosine methylation landscape in a mouse model of polycystic ovary syndrome
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Retraction Note: H3K27ac-induced lncRNA PAXIP1-AS1 promotes cell proliferation, migration, EMT and apoptosis in ovarian cancer by targeting miR-6744-5p/PCBP2 axis
Retraction Note: H3K27ac-induced lncRNA PAXIP1-AS1 promotes cell proliferation, migration, EMT and apoptosis in ovarian cancer by targeting miR-6744-5p/PCBP2 axis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
MiR-134-3p targets HMOX1 to inhibit ferroptosis in granulosa cells of sheep follicles
MiR-134-3p targets HMOX1 to inhibit ferroptosis in granulosa cells of sheep follicles
The intricate interplay of gene expression within ovarian granulosa cells (GCs) is not fully understood. This study aimed ...
In-vitro generation of follicle-like structures from human germ cell-like cells derived from theca stem cell combined with ovarian somatic cells
In-vitro generation of follicle-like structures from human germ cell-like cells derived from theca stem cell combined with ovarian somatic cells
The objective of this study was to induce the differentiation of human theca stem cells (hTSCs) into germ cell-like cells ...
Do we overlook predictive factors in Poseidon 1 patients? A retrospective analysis co-evaluating antral follicle counts & diameters
Do we overlook predictive factors in Poseidon 1 patients? A retrospective analysis co-evaluating antral follicle counts & diameters
An unexpected impaired ovarian response pertains to an insufficient reaction to controlled ovarian hyperstimulation. This ...
Exosomal biomarkers in the differential diagnosis of ovarian tumors: the emerging roles of CA125, HE4, and C5a
Exosomal biomarkers in the differential diagnosis of ovarian tumors: the emerging roles of CA125, HE4, and C5a
Investigating the utility of serum exosomal markers CA125, HE4, and C5a, both individually and in combination, for disting...
The pregnancy and oncology outcome of fertility-sparing management for synchronous primary neoplasm of endometrium and ovary
The pregnancy and oncology outcome of fertility-sparing management for synchronous primary neoplasm of endometrium and ovary
To investigate the efficacy of fertility-preserving treatment for young women with synchronous primary neoplasm of endomet...
Characterization of MicroRNA expression profiles in the ovarian tissue of goats during the sexual maturity period
Characterization of MicroRNA expression profiles in the ovarian tissue of goats during the sexual maturity period
The ovary is an important reproductive organ in mammals, and its development directly affects the sexual maturity and repr...
Proteomic analysis of exosomes secreted during the epithelial-mesenchymal transition and potential biomarkers of mesenchymal high-grade serous ovarian carcinoma
Proteomic analysis of exosomes secreted during the epithelial-mesenchymal transition and potential biomarkers of mesenchymal high-grade serous ovarian carcinoma
The epithelial-mesenchymal transition (EMT) promotes cell signaling and morphology alterations, contributing to cancer pro...
Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells
Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells
Chromobox protein homolog 7 (CBX7), a member of the Polycomb repressor complex, is a potent epigenetic regulator and gene ...
BRCA1 and BRCA2 deficient tumour models generate distinct ovarian tumour microenvironments and differential responses to therapy
BRCA1 and BRCA2 deficient tumour models generate distinct ovarian tumour microenvironments and differential responses to therapy
Clinical trials are currently exploring combinations of PARP inhibitors and immunotherapies for the treatment of ovarian c...
The prolactin receptor gene (PRLR) is linked and associated with the risk of polycystic ovarian syndrome
The prolactin receptor gene (PRLR) is linked and associated with the risk of polycystic ovarian syndrome
The prolactin receptor gene (PRLR) may contribute to polycystic ovarian syndrome (PCOS) since it plays important roles in ...
Dose inhibin B or anti-Müllerian hormone relate to precocious puberty in girls? result of a systematic review and meta-analysis
Dose inhibin B or anti-Müllerian hormone relate to precocious puberty in girls? result of a systematic review and meta-analysis
Existing studies have investigated the relationship between the levels of serum inhibin B (INHB), anti-müllerian horm...
Progress of the application clinical prediction model in polycystic ovary syndrome
Progress of the application clinical prediction model in polycystic ovary syndrome
Clinical prediction models play an important role in the field of medicine. These can help predict the probability of an i...
Novel variants in TUBB8 gene cause multiple phenotypic abnormalities in human oocytes and early embryos
Novel variants in TUBB8 gene cause multiple phenotypic abnormalities in human oocytes and early embryos
The genotype-phenotype relationships between TUBB8 variants and female infertility are difficult to clearly define due to ...
IFN-γ in ovarian tumor microenvironment upregulates HLA-E expression and predicts a poor prognosis
IFN-γ in ovarian tumor microenvironment upregulates HLA-E expression and predicts a poor prognosis
Inflammation and immunity are two main characteristics of tumor microenvironment (TME). Interferon-gamma (IFN-γ) is g...
The effect of calorie-restriction along with thylakoid membranes of spinach on the gut-brain Axis Pathway and oxidative stress biomarkers in obese women with polycystic ovary syndrome: a Randomized, Double-blind, placebo-controlled clinical trial
The effect of calorie-restriction along with thylakoid membranes of spinach on the gut-brain Axis Pathway and oxidative stress biomarkers in obese women with polycystic ovary syndrome: a Randomized, Double-blind, placebo-controlled clinical trial
Women with polycystic ovary syndrome (PCOS) have higher intestinal mucosal permeability, leading to the lipopolysaccharide...
The long non-coding RNA NEAT1 promotes the progression of human ovarian cancer through targeting miR-214-3p and regulating angiogenesis
The long non-coding RNA NEAT1 promotes the progression of human ovarian cancer through targeting miR-214-3p and regulating angiogenesis
Angiogenesis and metastasis contributes substantially to the poor outcome of patients with ovarian cancer. We aimed to exp...
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