RalB promotes lymph node metastasis in tongue squamous cell carcinoma

Cemeli T, Guasch-Vallés M, Ribes-Santolaria M, Ibars E, Navaridas R, Dolcet X, Pedraza N, Colomina N, Torres-Rosell J, Ferrezuelo F et al (2022) Antitumor effects of Ral-GTPases downregulation in glioblastoma. Int J Mol Sci 23(15):8199

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dhillon S (2020) Tirabrutinib: first approval. Drugs 80:835–840

Article  PubMed  CAS  Google Scholar 

Estupiñán HY, Berglöf A, Zain R, Smith CIE (2021) Comparative analysis of BTK inhibitors and mechanisms underlying adverse effects. Front Cell Dev Biol 9:630942

Article  PubMed  PubMed Central  Google Scholar 

Gao P, Liu S, Yoshida R, Shi CY, Yoshimachi S, Sakata N, Goto K, Kimura T, Shirakawa R, Nakayama H et al (2019) Ral GTPase activation by downregulation of RalGAP enhances oral squamous cell carcinoma progression. J Dent Res 98:1011–1019

Article  PubMed  CAS  Google Scholar 

Gao Y, Gong Y, Liu Y, Xue Y, Zheng K, Guo Y, Hao L, Peng Q, Shi X (2023) Integrated analysis of transcriptomics and metabolomics in human hepatocellular carcinoma HepG2215 cells after YAP1 knockdown. Acta Histochem 125:151987

Article  PubMed  CAS  Google Scholar 

George B, Seals S, Aban I (2014) Survival analysis and regression models. J Nucl Cardiol 21:686–694

Article  PubMed  PubMed Central  Google Scholar 

Ghoroghi S, Mary B, Larnicol A, Asokan N, Klein A, Osmani N, Busnelli I, Delalande F, Paul N, Halary S, et al. (2021) Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes. Elife 10

Huang G, Xu X, Ju C, Zhong N, He J, Tang XX (2022) Identification and validation of autophagy-related gene expression for predicting prognosis in patients with idiopathic pulmonary fibrosis. Front Immunol 13:997138

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kozaki R, Vogler M, Walter HS, Jayne S, Dinsdale D, Siebert R, Dyer MJS, Yoshizawa T (2018) Responses to the selective Bruton’s Tyrosine Kinase (BTK) inhibitor tirabrutinib (ONO/GS-4059) in diffuse large B-cell lymphoma cell lines. Cancers (Basel) 10(4):127

Article  PubMed  Google Scholar 

Mantovani A, Balkwill F (2006) RalB signaling: a bridge between inflammation and cancer. Cell 127:42–44

Article  PubMed  CAS  Google Scholar 

Martin TD, Chen XW, Kaplan RE, Saltiel AR, Walker CL, Reiner DJ, Der CJ (2014) Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol Cell 53:209–220

Article  PubMed  PubMed Central  CAS  Google Scholar 

Muller S, Tilakaratne WM (2022) Update from the 5th edition of the World Health Organization classification of head and neck tumors Tumours of the oral cavity and mobile tongue. Head Neck Pathol 16:54–62

Article  PubMed  PubMed Central  Google Scholar 

Munakata W, Tobinai K (2021) Tirabrutinib hydrochloride for B-cell lymphomas. Drugs Today (Barc) 57:277–289

Article  PubMed  CAS  Google Scholar 

Richardson DS, Spehar JM, Han DT, Chakravarthy PA, Sizemore ST (2022) The RAL enigma: distinct roles of RALA and RALB in cancer. Cells 11(10):1645

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rybko VA, Knizhnik AV, Komelkov AV, Aushev VN, Trukhanova LS, Tchevkina EM (2011) Different metastasis promotive potency of small G-proteins RalA and RalB in in vivo hamster tumor model. Cancer Cell Int 11:22

Article  PubMed  PubMed Central  CAS  Google Scholar 

Schneider R, Reinau D, Stoffel S, Jick SS, Meier CR, Spoendlin J (2021) Risk of skin cancer in new users of thiazides and thiazide-like diuretics: a cohort study using an active comparator group. Br J Dermatol 185:343–352

Article  PubMed  CAS  Google Scholar 

Seashore-Ludlow B, Rees MG, Cheah JH, Cokol M, Price EV, Coletti ME, Jones V, Bodycombe NE, Soule CK, Gould J et al (2015) Harnessing connectivity in a large-scale small-molecule sensitivity dataset. Cancer Discov 5:1210–1223

Article  PubMed  PubMed Central  CAS  Google Scholar 

Shi X, Li S, Wang L, Li H, Li Z, Wang W, Bai J, Sun Y, Li J, Li X (2020) RalB degradation by dihydroartemisinin induces autophagy and IFI16/caspase-1 inflammasome depression in the human laryngeal squamous cell carcinoma. Chin Med 15:64

Article  PubMed  PubMed Central  CAS  Google Scholar 

Siegel RL, Miller KD, Fuchs HE, Jemal A (2022) Cancer statistics, 2022. CA Cancer J Clin 72:7–33

Article  PubMed  Google Scholar 

Song X, Hua L, Xu Y, Fang Z, Wang Y, Gao J, Shi Q, Zhou X, Yu R (2015) Involvement of RalB in the effect of geranylgeranyltransferase I on glioma cell migration and invasion. Clin Transl Oncol 17:477–485

Article  PubMed  CAS  Google Scholar 

Tang Z, Kang B, Li C, Chen T, Zhang Z (2019) GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res 47:W556-w560

Article  PubMed  PubMed Central  CAS  Google Scholar 

Thies KA, Cole MW, Schafer RE, Spehar JM, Richardson DS, Steck SA, Das M, Lian AW, Ray A, Shakya R et al (2021) The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer. Breast Cancer Res 23:65

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tian L, Zhao L, Sze KM, Kam CS, Ming VS, Wang X, Zhang VX, Ho DW, Cheung TT, Chan LK et al (2022) Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma. Hepatology 76:48–65

Article  PubMed  CAS  Google Scholar 

Wang H, Owens C, Chandra N, Conaway MR, Brautigan DL, Theodorescu D (2010) Phosphorylation of RalB is important for bladder cancer cell growth and metastasis. Cancer Res 70:8760–8769

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang Y, Zheng Y, Chen Q, Dai Y, Li T (2021) MicroRNA-139 inhibits pancreatic-cancer carcinogenesis by suppressing RalB via the Ral/RAC/PI3K pathway. Arch Biochem Biophys 704:108719

Article  PubMed  CAS  Google Scholar 

Zago G, Biondini M, Camonis J, Parrini MC (2019) A family affair: a Ral-exocyst-centered network links Ras, Rac, Rho signaling to control cell migration. Small GTPases 10:323–330

Article  PubMed  CAS  Google Scholar 

Zago G, Veith I, Singh MK, Fuhrmann L, De Beco S, Remorino A, Takaoka S, Palmeri M, Berger F, Brandon N, et al. (2018) RalB directly triggers invasion downstream Ras by mobilizing the Wave complex. Elife 7

Zhang Q, Li L, Lai Y, Zhao T (2020) Silencing of SPP1 suppresses progression of tongue cancer by mediating the PI3K/Akt signaling pathway. Technol Cancer Res Treat 19:1533033820971306

Article  PubMed  PubMed Central  CAS  Google Scholar 

Comments (0)

No login
gif