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Effectiveness and feasibility of a theory-informed intervention to improve Mediterranean diet adherence, physical activity and cognition in older adults at risk of dementia: the MedEx-UK randomised controlled trial
Effectiveness and feasibility of a theory-informed intervention to improve Mediterranean diet adherence, physical activity and cognition in older adults at risk of dementia: the MedEx-UK randomised controlled trial
Despite an urgent need for multi-domain lifestyle interventions to reduce dementia risk, there is a lack of interventions ...
Global prevalence of Helicobacter pylori antibiotic resistance among children in the world health organization regions between 2000 and 2023: a systematic review and meta-analysis
Global prevalence of Helicobacter pylori antibiotic resistance among children in the world health organization regions between 2000 and 2023: a systematic review and meta-analysis
Helicobacter pylori infection causes gastritis, peptic ulcers, and gastric cancer. The infection is typically acquired in ...
The potential impact of inflammation on the lipid paradox in patients with acute myocardial infarction: a multicenter study
The potential impact of inflammation on the lipid paradox in patients with acute myocardial infarction: a multicenter study
Low-density lipoprotein cholesterol (LDL-C) is a well-recognized risk factor for cardiovascular diseases. However, several...
Risk of mortality between warfarin and direct oral anticoagulants: population-based cohort studies
Risk of mortality between warfarin and direct oral anticoagulants: population-based cohort studies
Direct oral anticoagulants (DOACs) have been reported to be associated with a higher risk of mortality compared with an ol...
Effects of physical and psychological multimorbidity on the risk of dementia: multinational prospective cohorts and a meta-analysis
Effects of physical and psychological multimorbidity on the risk of dementia: multinational prospective cohorts and a meta-analysis
Previous studies only considered the impact of a single physical or psychological disorder on dementia. Our study investig...
Strategies to improve the implementation of preventive care in primary care: a systematic review and meta-analysis
Strategies to improve the implementation of preventive care in primary care: a systematic review and meta-analysis
Action on smoking, obesity, excess alcohol, and physical inactivity in primary care is effective and cost-effective, but i...
Associations of combined accelerated biological aging and genetic susceptibility with incident dementia: a prospective study in the UK Biobank
Associations of combined accelerated biological aging and genetic susceptibility with incident dementia: a prospective study in the UK Biobank
Accelerated biological aging has been verified to be a critical risk factor for a number of age-related diseases, but its ...
The effectiveness of reduction in alcohol consumption achieved by the provision of non-alcoholic beverages associates with Alcohol Use Disorders Identification Test scores: a secondary analysis of a randomized controlled trial
The effectiveness of reduction in alcohol consumption achieved by the provision of non-alcoholic beverages associates with Alcohol Use Disorders Identification Test scores: a secondary analysis of a randomized controlled trial
The Alcohol Use Disorders Identification Test (AUDIT) is commonly used in clinical settings to assess the severity of alco...
Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England
Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England
Immunocompromised individuals are at increased risk of severe COVID-19 outcomes, underscoring the importance of COVID-19 v...
Validation of the Health Assessment Tool (HAT) based on four aging cohorts from the Swedish National study on Aging and Care
Validation of the Health Assessment Tool (HAT) based on four aging cohorts from the Swedish National study on Aging and Care
As global aging accelerates, routinely assessing the functional status and morbidity burden of older patients becomes para...
Examining the impact of substance use on hospital length of stay in schizophrenia spectrum disorder: a retrospective analysis
Examining the impact of substance use on hospital length of stay in schizophrenia spectrum disorder: a retrospective analysis
Among patients diagnosed with schizophrenia, the presence of substance use poses an aggravating comorbidity, exerting a ne...
Association between viral infections and glioma risk: a two-sample bidirectional Mendelian randomization analysis
Association between viral infections and glioma risk: a two-sample bidirectional Mendelian randomization analysis
Glioma is one of the leading types of brain tumor, but few etiologic factors of primary glioma have been identified. Previ...
Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease
Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease
We aimed to investigate the protein pathways linking obesity and lifestyle factors to coronary artery disease (CAD). Summa...
Prognostic value of pretreatment lymphocyte-to-monocyte ratio in patients with glioma: a meta-analysis
Prognostic value of pretreatment lymphocyte-to-monocyte ratio in patients with glioma: a meta-analysis
Many studies have explored the prognostic role of the lymphocyte-to-monocyte ratio (LMR) in patients with glioma, but the ...
Performance of a safe and dignified burial intervention during an Ebola epidemic in the eastern Democratic Republic of the Congo, 2018–2019
Performance of a safe and dignified burial intervention during an Ebola epidemic in the eastern Democratic Republic of the Congo, 2018–2019
A protracted Ebola Virus Disease (EVD) epidemic in the eastern Ituri, North and South Kivu provinces of the Democratic Rep...
Cortical structural changes of morphometric similarity network in early-onset schizophrenia correlate with specific transcriptional expression patterns
Cortical structural changes of morphometric similarity network in early-onset schizophrenia correlate with specific transcriptional expression patterns
This study aimed to investigate the neuroanatomical subtypes among early-onset schizophrenia (EOS) patients by exploring t...
Dissemination of Registered COVID-19 Clinical Trials (DIRECCT): a cross-sectional study
Dissemination of Registered COVID-19 Clinical Trials (DIRECCT): a cross-sectional study
The results of clinical trials should be completely and rapidly reported during public health emergencies such as COVID-19...
Association between ethnicity and migration status with the prevalence of single and multiple long-term conditions in UK healthcare workers
Association between ethnicity and migration status with the prevalence of single and multiple long-term conditions in UK healthcare workers
Healthcare workers’ (HCW) well-being has a direct effect on patient care. However, little is known about the prevale...
Radiomics in precision oncology: hype or ludum mutante
Radiomics in precision oncology: hype or ludum mutante
Precision oncology has emerged as the next frontier of therapeutic strategies in the treatment of human cancers. The idea ...
Clinical efficacy of sodium bicarbonate in treating pediatric metabolic acidosis with varying level of acid–base balance parameters: a real-world study
Clinical efficacy of sodium bicarbonate in treating pediatric metabolic acidosis with varying level of acid–base balance parameters: a real-world study
Sodium bicarbonate (SB) infusion is commonly used to correct metabolic acidosis, but its clinical efficacy remains controv...
Representativeness in health research studies: an audit of Greater Manchester Clinical Research Network studies between 2016 and 2021
Representativeness in health research studies: an audit of Greater Manchester Clinical Research Network studies between 2016 and 2021
There are increasing concerns that participants in health research in the UK are not representative of the UK population, ...
Maternal glycemic status during pregnancy and mid-childhood plasma amino acid profiles: findings from a multi-ethnic Asian birth cohort
Maternal glycemic status during pregnancy and mid-childhood plasma amino acid profiles: findings from a multi-ethnic Asian birth cohort
Increasing maternal glycaemia across the continuum during pregnancy may predispose offspring to subsequent cardiometabolic...
A pilot study of multi-antigen stimulated cell therapy-I plus camrelizumab and apatinib in patients with advanced bone and soft-tissue sarcomas
A pilot study of multi-antigen stimulated cell therapy-I plus camrelizumab and apatinib in patients with advanced bone and soft-tissue sarcomas
Cell-based  immunotherapy shows the therapeutic potential in sarcomas, in addition to angiogenesis-targeted tyros...
Prognostic value of circulating tumor DNA in operable non-small cell lung cancer: a systematic review and reconstructed individual patient-data based meta-analysis
Prognostic value of circulating tumor DNA in operable non-small cell lung cancer: a systematic review and reconstructed individual patient-data based meta-analysis
This reconstructed individual patient data (IPD)-based meta-analysis is aimed to summarize the current findings and compre...
Gene expression profiles separate endometriosis lesion subtypes and indicate a sensitivity of endometrioma to estrogen suppressive treatments through elevated ESR2 expression
Gene expression profiles separate endometriosis lesion subtypes and indicate a sensitivity of endometrioma to estrogen suppressive treatments through elevated ESR2 expression
Endometriosis is a common, gynaecological disease characterised by the presence of endometrial-like cells growing outside ...
Male- and female-specific reproductive risk factors across the lifespan for dementia or cognitive decline: a systematic review and meta-analysis
Male- and female-specific reproductive risk factors across the lifespan for dementia or cognitive decline: a systematic review and meta-analysis
Sex difference exists in the prevalence of dementia and cognitive decline. The impacts of sex-specific reproductive risk f...
The impact of the new acute respiratory distress syndrome (ARDS) criteria on Berlin criteria ARDS patients: a multicenter cohort study
The impact of the new acute respiratory distress syndrome (ARDS) criteria on Berlin criteria ARDS patients: a multicenter cohort study
The European Society of Intensive Care Medicine (ESICM) recently recommended changes to the criteria of acute respiratory ...
Are breast cancer patients with suboptimal adherence to cardiovascular treatment more likely to discontinue adjuvant endocrine therapy? Competing risk survival analysis in a nationwide cohort of postmenopausal women
Are breast cancer patients with suboptimal adherence to cardiovascular treatment more likely to discontinue adjuvant endocrine therapy? Competing risk survival analysis in a nationwide cohort of postmenopausal women
High rates of discontinuation undermine the effectiveness of adjuvant endocrine therapy (AET) among hormone-receptive brea...
Why diversity among participants in clinical studies is not always preferable: the case for small, exploratory studies
Why diversity among participants in clinical studies is not always preferable: the case for small, exploratory studies
While we welcome the increasing number of initiatives to diminish unbalanced diversity in clinical trials, we would like t...
Mood, Activity Participation, and Leisure Engagement Satisfaction (MAPLES): results from a randomised controlled pilot feasibility trial for low mood in acquired brain injury
Mood, Activity Participation, and Leisure Engagement Satisfaction (MAPLES): results from a randomised controlled pilot feasibility trial for low mood in acquired brain injury
Acquired brain injury (ABI) is linked to increased depression risk. Existing therapies for depression in ABI (e.g., cognit...
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