Risk of mortality between warfarin and direct oral anticoagulants: population-based cohort studies

National Institute for Health and Care Excellence. Atrial fibrillation: diagnosis and management 2021 [Available from: https://www.nice.org.uk/guidance/ng196.

National Institute for Health and Care Excellence. Venous thromboembolism in over 16s: reducing the risk of hospital-acquired deep vein thrombosis or pulmonary embolism 2019 [Available from: https://www.nice.org.uk/guidance/ng89.

Afzal S, Zaidi STR, Merchant HA, Babar Z-U-D, Hasan SS. Prescribing trends of oral anticoagulants in England over the last decade: a focus on new and old drugs and adverse events reporting. Journal of Thrombosis and Thrombolysis. 2021;52(2):646–53.

Wheelock KM, Ross JS, Murugiah K, Lin Z, Krumholz HM, Khera R. Clinician Trends in Prescribing Direct Oral Anticoagulants for US Medicare Beneficiaries. JAMA Network Open. 2021;4(12):e2137288-e.

Yu Z, Yu L, Shan C. Trends of ambulatory oral anticoagulant prescription in five major cities of China, 2012–2017. BMC Health Serv Res. 2020;20(1):1–6.

Article  Google Scholar 

Laetitia H, Cyril F, Christel R, Amélie B, Sophie L, Léa B, et al. Trends in initiation of direct oral anticoagulant therapies for atrial fibrillation in a national population-based cross-sectional study in the French health insurance databases. BMJ Open. 2018;8(3): e018180.

Article  Google Scholar 

Li X, Pathadka S, Man KK, Ng VW, Siu CW, Wong IC, et al. Comparative outcomes between direct oral anticoagulants, warfarin, and antiplatelet monotherapy among Chinese patients with atrial fibrillation: a population-based cohort study. Drug Saf. 2020;43:1023–33.

Article  CAS  PubMed  Google Scholar 

Carnicelli AP, Hong H, Connolly SJ, Eikelboom J, Giugliano RP, Morrow DA, et al. Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials With Interaction Testing by Age and Sex. Circulation. 2022;145(4):242–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nakao YM, Nakao K, Wu J, Nadarajah R, Camm AJ, Gale CP. Risks and benefits of oral anticoagulants for stroke prophylaxis in atrial fibrillation according to body mass index: Nationwide cohort study of primary care records in England. EClinicalMedicine. 2022;54:101709.

Stolk LM, de Vries F, Ebbelaar C, de Boer A, Schalekamp T, Souverein P, et al. Risk of myocardial infarction in patients with atrial fibrillation using vitamin K antagonists, aspirin or direct acting oral anticoagulants. Br J Clin Pharmacol. 2017;83(8):1835–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee CJ-Y, Gerds TA, Carlson N, Bonde AN, Gislason GH, Lamberts M, et al. Risk of Myocardial Infarction in Anticoagulated Patients With Atrial Fibrillation. Journal of the American College of Cardiology. 2018;72(1):17–26.

Vinogradova Y, Coupland C, Hill T, Hippisley-Cox J. Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care. BMJ. 2018;362: k2505.

Article  PubMed  PubMed Central  Google Scholar 

Nielsen PB, Skjøth F, Søgaard M, Kjældgaard JN, Lip GYH, Larsen TB. Effectiveness and safety of reduced dose non-vitamin K antagonist oral anticoagulants and warfarin in patients with atrial fibrillation: propensity weighted nationwide cohort study. BMJ. 2017;356: j510.

Article  PubMed  PubMed Central  Google Scholar 

Rahme E, Godin R, Nedjar H, Dasgupta K, Tagalakis V. Dose specific effectiveness and safety of DOACs in patients with non-valvular atrial fibrillation: A Canadian retrospective cohort study. Thromb Res. 2021;203:121–30.

Article  CAS  PubMed  Google Scholar 

Ikeda S, Hiasa K-i, Inoue H, Yamashita T, Akao M, Atarashi H, et al. Clinical outcomes and anticoagulation therapy in elderly non-valvular atrial fibrillation and heart failure patients. ESC Heart Failure. 2024;11(2):902–13.

Durand M, Schnitzer ME, Pang M, Carney G, Eltonsy S, Filion KB, et al. Comparative effectiveness and safety of direct oral anticoagulants versus vitamin K antagonists in nonvalvular atrial fibrillation: a Canadian multicentre observational cohort study. Canadian Medical Association Open Access Journal. 2020;8(4):E877–86.

Google Scholar 

Yamashita T, Akao M, Atarashi H, Ikeda T, Koretsune Y, Okumura K, et al. Causes of Death in Elderly Patients With Non-Valvular Atrial Fibrillation-Results From the ANAFIE Registry-. Circ J. 2023;87(7):957–63.

Article  PubMed  Google Scholar 

Gómez-Outes A, Terleira-Fernández AI, Calvo-Rojas G, Suárez-Gea ML, Vargas-Castrillón E. Dabigatran, rivaroxaban, or apixaban versus warfarin in patients with nonvalvular atrial fibrillation: a systematic review and meta-analysis of subgroups. Thrombosis. 2013;2013(1):640723.

Clinical Practice Research Datalink. Data, Primary care and linked data to address public health research 2022 [Available from: https://cprd.com/data.

Clinical Practice Research Datalink. CPRD Aurum May 2022 data set 2022 [Available from: https://doi.org/10.48329/t89s-kf12.

Clinical Practice Research Datalink. Defining your study population 2023 [Available from: https://cprd.com/defining-your-study-population.

Clinical Practice Research Datalink. CPRD linked data 2023 [Available from: https://cprd.com/cprd-linked-data#HES%20Admitted%20Patient%20Care%20data.

Chan VKY, Cheung ECL, Chan SSM, Knapp M, Hayes JF, Fan M, et al. Mortality-causing mechanisms and healthcare resource utilisation of treatment-resistant depression: A six-year population-based cohort study. The Lancet Regional Health - Western Pacific. 2022;22: 100426.

Article  PubMed  PubMed Central  Google Scholar 

Lau WCY, Chan EW, Cheung C-L, Sing CW, Man KKC, Lip GYH, et al. Association Between Dabigatran vs Warfarin and Risk of Osteoporotic Fractures Among Patients With Nonvalvular Atrial Fibrillation. JAMA. 2017;317(11):1151–8.

Article  CAS  PubMed  Google Scholar 

Cadogan SL, Powell E, Wing K, Wong AY, Smeeth L, Warren-Gash C. Anticoagulant prescribing for atrial fibrillation and risk of incident dementia. Heart. 2021;107(23):1898–904.

Article  PubMed  Google Scholar 

Silverwood RJ, Mansfield KE, Mulick A, Wong AYS, Schmidt SAJ, Roberts A, et al. Atopic eczema in adulthood and mortality: UK population-based cohort study, 1998–2016. J Allergy Clin Immunol. 2021;147(5):1753–63.

Article  PubMed  PubMed Central  Google Scholar 

Hong Kong Census and Statistics Department. Hong Kong Annual Digest of Statistics 2022. 2021. [cited 06 Dec 2024]. Available from: https://www.censtatd.gov.hk/en/EIndexbySubject.html?pcode=B1010003&scode=410#section1.

Lane DA, Lip GYH. Use of the CHA2DS2-VASc and HAS-BLED Scores to Aid Decision Making for Thromboprophylaxis in Nonvalvular Atrial Fibrillation. Circulation. 2012;126(7):860–5.

Article  PubMed  Google Scholar 

Inoue K, Hirao K, Aonuma K, Kumagai K, Kimura M, Miyauchi Y, et al. HAS-BLED score as a predictor of bleeding complications from catheter ablation of atrial fibrillation: A subanalysis of the Japanese Anti-Coagulation Regimen Exploration in AF Catheter Ablation Registries. J Cardiol. 2020;75(1):82–9.

Article  PubMed  Google Scholar 

Levey AS, Stevens LA, Schmid CH, Zhang Y, Castro AF III, Feldman HI, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604–12.

Article  PubMed  PubMed Central  Google Scholar 

Bidulka P, Vestergaard SV, Hlupeni A, Kjærsgaard A, Wong AYS, Langan SM, et al. Adverse outcomes after partner bereavement in people with reduced kidney function: Parallel cohort studies in England and Denmark. PLoS ONE. 2021;16(9): e0257255.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rosenbaum PR, Rubin DB. The central role of the propensity score in observational studies for causal effects. Biometrika. 1983;70(1):41–55.

Article  Google Scholar 

Chesnaye NC, Stel VS, Tripepi G, Dekker FW, Fu EL, Zoccali C, et al. An introduction to inverse probability of treatment weighting in observational research. Clin Kidney J. 2022;15(1):14–20.

Article  PubMed  Google Scholar 

Elze MC, Gregson J, Baber U, Williamson E, Sartori S, Mehran R, et al. Comparison of Propensity Score Methods and Covariate Adjustment: Evaluation in 4 Cardiovascular Studies. J Am Coll Cardiol. 2017;69(3):345–57.

Article  PubMed  Google Scholar 

National Institute for Health and Care Excellence. Scenario: Warfarin 2024 [updated April 2024. Available from: https://cks.nice.org.uk/topics/anticoagulation-oral/management/warfarin/.

Powell EM, Douglas IJ, Gungabissoon U, Smeeth L, Wing K. Real-world effects of medications for stroke prevention in atrial fibrillation: protocol for a UK population-based non-interventional cohort study with validation against randomised trial results. BMJ Open. 2021;11(4): e042947.

Article  PubMed  PubMed Central  Google Scholar 

Rosendaal F, Cannegieter S, Van der Meer F, Briet E. A method to determine the optimal intensity of oral anticoagulant therapy. Thromb Haemost. 1993;69(03):236–9.

Article  CAS  PubMed  Google Scholar 

Haas S, ten Cate H, Accetta G, Angchaisuksiri P, Bassand J-P, Camm AJ, et al. Quality of Vitamin K Antagonist Control and 1-Year Outcomes in Patients with Atrial Fibrillation: A Global Perspective from the GARFIELD-AF Registry. PLoS ONE. 2016;11(10): e0164076.

Article  PubMed  PubMed Central  Google Scholar 

Hern´an MA, Robins JM. Causal Inference: What If. Boca Raton: Chapman & Hall/CRC; 2020. Avaliable from: https://www.hsph.harvard.edu/miguelhernan/causal-inference-book/.

Rizk DV, Warnock DG. Warfarin-related nephropathy: another newly recognized complication of an old drug. Kidney Int. 2011;80(2):131–3.

Article  CAS  PubMed  Google Scholar 

King CS, Freiheit E, Brown AW, Shlobin OA, Aryal S, Ahmad K, et al. Association Between Anticoagulation and Survival in Interstitial Lung Disease: An Analysis of the Pulmonary Fibrosis Foundation Patient Registry. Chest. 2021;159(4):1507–16.

Article  CAS  PubMed  Google Scholar 

Naqvi SF, Sohail AH, Lakhani DA, Maurer J, Sofka S, Hadi YB. Warfarin Use Is Associated with Increased Mortality at One Year in Patients with Idiopathic Pulmonary Fibrosis. Pulm Med. 2021;2021:3432362.

Article  PubMed  PubMed Central  Google Scholar 

Fang MC, Go AS, Chang Y, Hylek EM, Henault LE, Jensvold NG, et al. Death and disability from warfarin-associated intracranial and extracranial hemorrhages. Am J Med. 2007;120(8):700–5.

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