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Dysregulated Treg repair responses lead to chronic rejection after heart transplantation
Research ArticleImmunologyTransplantation Open Access | 10.1172/JCI173593 Jordan J.P. Warunek...
YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production
Research ArticleImmunologyOncology Open Access | 10.1172/JCI181612 Chuangyu Wen,1,2 Liang...
Reduced thymic IL-4 impairs negative T cell selection in nonobese diabetic mice
NOD HR+ETP fate decision is biased toward the T cell lineage. Recently a new subset of ETPs was discovered whose potentia...
Sex, cells, and metabolism: Androgens temper Th17-mediated immunity
The study by Chowdhury and colleagues provides compelling evidence that AR activity plays a critical role in regulating T...
Combined HDAC8 and checkpoint kinase inhibition induces tumor-selective synthetic lethality in preclinical models
Research ArticleCell biologyTherapeutics Open Access | 10.1172/JCI165448 Ting-Yu Chang,1 ...
FoxO1/Rictor axis induces a nongenetic adaptation to ibrutinib via Akt activation in chronic lymphocytic leukemia
Research ArticleHematologyOncology Open Access | 10.1172/JCI173770 Laura Ondrisova,1,2 Va...
EMC3 regulates trafficking and pulmonary toxicity of the SFTPCI73T mutation associated with interstitial lung disease
Research ArticleCell biologyPulmonology Open Access | 10.1172/JCI173861 Xiaofang Tang,1,2 ...
The Nr4a family regulates intrahepatic Treg proliferation and liver fibrosis in MASLD models
Expression of the Nr4a family is upregulated in hepatic T cells from MASH mice. To investigate the function of the Nr4a f...
Transcription factor KROX20 marks epithelial stem cell ancestors for hair follicle formation
Research ArticleDevelopmentStem cells Open Access | 10.1172/JCI180160 Elnaz Ghotbi,1 Edem...
Androgen signaling restricts glutaminolysis to drive sex-specific Th17 metabolism in allergic airway inflammation
Research ArticleImmunologyPulmonology Open Access | 10.1172/JCI177242 Nowrin U. Chowdhury,1,2...
Therapeutic hypoxia for mitochondrial disease via enhancement of hemoglobin affinity and inhibition of HIF-2α
Research LetterGenetics Open Access | 10.1172/JCI185569 Hong Wang,1,2,3 Maria Miranda,1,2...
HO-1 impairs the efficacy of radiotherapy by redistributing cGAS and STING in tumors
A metabolic CRISPR/Cas9 screen identifies HO-1 as a potent IFN-I production inhibitor in response to RT. Tumor metabolism...
Supportive care or exhausted neglect: the role of microglia at the end stage of prion disease
Prion diseases are invariably fatal neurodegenerative diseases associated with the accumulation of a misfolded form of th...
Taking the STING out of radiotherapy: STING checkpoints mediate radiation resistance
In this issue of the JCI, two reports (10, 11) define how distinct mechanisms, induced by RT, restrain STING signaling an...
Adipocyte lipin 1 expression associates with human metabolic health and regulates systemic metabolism in mice
Research ArticleHepatologyMetabolism Open Access | 10.1172/JCI169722 Andrew LaPoint,1 Jas...
Nonclassical action of Ku70 promotes Treg-suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma
Research ArticleImmunologyOncology Open Access | 10.1172/JCI178079 Qianru Huang,1 Na Tian...
Reactive microglia partially envelop viable neurons in prion diseases
Reactive microglia extend into the pyramidal layer of the CA1 region of the hippocampus. Among known mouse-adapted prion ...
PCDH15 dual-AAV gene therapy for deafness and blindness in Usher syndrome type 1F models
Sex as a biological variable. The study did not consider the sex of the mice and NHPs. Initial experiments showed no sex-...
Palmitoylation acts as a checkpoint for MAVS aggregation to promote antiviral innate immune responses
Sex as a biological variable. The sex of the mice used in this study was not considered as a biological variable. Mice. C...
Recruitment of CXCR4+ type 1 innate lymphoid cells distinguishes sarcoidosis from other skin granulomatous diseases
Immune cell landscape in sarcoid and non-sarcoid skin granulomas. We collected 4-mm skin biopsies (affected and unaffecte...
Body mass index and adiposity influence responses to immune checkpoint inhibition in endometrial cancer
Clinical MedicineMetabolismOncology Open Access | 10.1172/JCI180516 Nicolás Gómez-Banoy,1,2,3...
Adeno-associated virus–based gene therapy treats inflammatory kidney disease in mice
Research ArticleNephrologyTherapeutics Open Access | 10.1172/JCI174722 Guochao Wu,1,2 Shu...
Inflammation primes the murine kidney for recovery by activating AZIN1 adenosine-to-inosine editing
Research ArticleNephrology Open Access | 10.1172/JCI180117 Segewkal Hawaze Heruye,1 Jered...
Somatic RAP1B gain-of-function variant underlies isolated thrombocytopenia and immunodeficiency
Research ArticleHematologyImmunology Open Access | 10.1172/JCI169994 Marta Benavides-Nieto,1,...
The cancer-associated secretory phenotype: a new frontier in targeted therapeutics
Viewpoint Open Access | 10.1172/JCI182652 Xiaochao Tan,1 Guan-Yu Xiao,2 Priyam Banerj...
Type 1 innate lymphoid cells: a biomarker and therapeutic candidate in sarcoidosis
Granulomas increase the local concentration and activity of immune cells and, therefore, the likelihood of a self-directe...
Unhealthy visceral fat is associated with improved efficacy of immunotherapy in endometrial cancer
The advent of immune checkpoint inhibitors as a therapeutic strategy to augment the endogenous anticancer immune response...
Disease-specific T cell receptors maintain pathogenic T helper cell responses in postinfectious Lyme arthritis
Clinical MedicineAutoimmunityInfectious disease Open Access | 10.1172/JCI179391 Johannes Dirk...
Revisiting sex as a biological variable in hypertension research
Review Series Open Access | 10.1172/JCI180078 Michael J. Ryan,1,2 John S. Clemmer,3 R...
Cancer therapy–related salivary dysfunction
Gene therapy. Many groups are investigating the utility of gene therapy in the treatment of RIX. These studies focus on i...
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