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Corrigendum to STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice
Published in Volume 135, Issue 14 on July 15, 2025 J Clin Invest. 2025;135(14):e195974. https://doi.org/10.1172/JCI195...
Chemokine gradients spare graft endothelium from CD8+ T cell–mediated injury during allograft rejection
Trafficking signals — specifically, a chemokine gradient within the tissue epithelial compartment — could be responsible ...
HIF-1 promotes murine breast cancer brain metastasis by increasing production of integrin β3–containing extracellular vesicles
Identification of HIF target genes in brain-metastatic BC cells by RNA-Seq and ChIP-Seq. MDA-MB-231-BrM2 (hereafter desig...
FGFR3-induced Y158 PARP1 phosphorylation promotes PARP inhibitor resistance via BRG1/MRE11-mediated DNA repair in breast cancer models
Research ArticleOncology Open Access | 10.1172/JCI173757 Mei-Kuang Chen,1,2 Hirohito Yama...
Cancer-associated SPOP mutations enlarge nuclear size and facilitate nuclear envelope rupture upon farnesyltransferase inhibitor treatment
Research ArticleCell biology Open Access | 10.1172/JCI189048 Zixi Wang,1 Lei Li,1 Qi ...
Aldehyde metabolism governs resilience of mucociliary clearance to air pollution exposure
Sex as a biological variable. Our study examined both male and female mice, with similar findings observed in both sexes....
Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis–induced cytokine transcriptional responses
Research ArticleGeneticsInfectious disease Open Access | 10.1172/JCI179822 Joshua J. Ivie,1 ...
Evolving concepts in adjuvant/neoadjuvant therapy for resectable pancreas cancer
Given the high rate of distant relapse after surgical resection of PDAC, systemic therapy is essential for curative treat...
The NUDIX hydrolase NUDT5 influences purine nucleotide metabolism and thiopurine pharmacology
Cells need a constant supply of purine nucleotides (PNs), as PNs play a crucial role in cell signaling, energy transport,...
The NUDIX hydrolase NUDT5 regulates thiopurine metabolism and cytotoxicity
Research ArticleGeneticsOncology Open Access | 10.1172/JCI190443 Maud Maillard,1 Rina Nis...
Disruption of the KLHL37–N-Myc complex restores N-Myc degradation and arrests neuroblastoma growth in mouse models
Research ArticleOncology Open Access | 10.1172/JCI176655 Senfeng Xiang,1,2 Pengfei Chen,1...
Metastatic heterogeneity in pancreatic cancer: mechanisms and opportunities for targeted intervention
To colonize distant organs, tumor cells must extravasate from the vasculature, a process often facilitated by the mechani...
Sending science down yonder
Icahn School of Medicine at Mount Sinai, New York, New York, USA. Find articles by Bright, A. in: P...
School-based health centers and inspiring the next generation of biomedical leaders
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Find articles by Cai, C. in: ...
An approach to targeting Nav1.7 for pain sensations
Alternative approaches, such as targeting intrinsic modulators of Nav1.7 currents in nociceptive neurons, have recently b...
Are you listening?
Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA. Find articles by Pinski, ...
Biomedical education in the era of large language models: a paradigm shift
Department of Otorhinolaryngology–Head & Neck Surgery, School of Medical Sciences, Health Campus, Universiti Sains ...
Pathogenic SIV infection is associated with acceleration of epigenetic age in rhesus macaques
To test the hypothesis that host age at the time of infection is critical to the course of SIV disease, the pace of host ...
Sensory neuron–expressed FGF13 controls nociceptive signaling in diabetic neuropathy models
Research ArticleNeurosciencePublic Health Open Access | 10.1172/JCI183749 Aditya K. Singh,1 ...
Trapα deficiency impairs the early events of insulin biosynthesis and glucose homeostasis
Research ArticleEndocrinologyMetabolism Open Access | 10.1172/JCI179845 Xin Li,1 Jingxin ...
Dysregulated Treg repair responses lead to chronic rejection after heart transplantation
Research ArticleImmunologyTransplantation Open Access | 10.1172/JCI173593 Jordan J.P. Warunek...
YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production
Research ArticleImmunologyOncology Open Access | 10.1172/JCI181612 Chuangyu Wen,1,2 Liang...
Reduced thymic IL-4 impairs negative T cell selection in nonobese diabetic mice
NOD HR+ETP fate decision is biased toward the T cell lineage. Recently a new subset of ETPs was discovered whose potentia...
Sex, cells, and metabolism: Androgens temper Th17-mediated immunity
The study by Chowdhury and colleagues provides compelling evidence that AR activity plays a critical role in regulating T...
Combined HDAC8 and checkpoint kinase inhibition induces tumor-selective synthetic lethality in preclinical models
Research ArticleCell biologyTherapeutics Open Access | 10.1172/JCI165448 Ting-Yu Chang,1 ...
FoxO1/Rictor axis induces a nongenetic adaptation to ibrutinib via Akt activation in chronic lymphocytic leukemia
Research ArticleHematologyOncology Open Access | 10.1172/JCI173770 Laura Ondrisova,1,2 Va...
EMC3 regulates trafficking and pulmonary toxicity of the SFTPCI73T mutation associated with interstitial lung disease
Research ArticleCell biologyPulmonology Open Access | 10.1172/JCI173861 Xiaofang Tang,1,2 ...
The Nr4a family regulates intrahepatic Treg proliferation and liver fibrosis in MASLD models
Expression of the Nr4a family is upregulated in hepatic T cells from MASH mice. To investigate the function of the Nr4a f...
Transcription factor KROX20 marks epithelial stem cell ancestors for hair follicle formation
Research ArticleDevelopmentStem cells Open Access | 10.1172/JCI180160 Elnaz Ghotbi,1 Edem...
Androgen signaling restricts glutaminolysis to drive sex-specific Th17 metabolism in allergic airway inflammation
Research ArticleImmunologyPulmonology Open Access | 10.1172/JCI177242 Nowrin U. Chowdhury,1,2...
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