Research ArticleImmunologyOncology Open Access | 10.1172/JCI178079

Qianru Huang,1 Na Tian,1,2 Jianfeng Zhang,3,4 Shiyang Song,1 Hao Cheng,1,5 Xinnan Liu,1 Wenle Zhang,1 Youqiong Ye,1 Yanhua Du,1 Xueyu Dai,1 Rui Liang,1 Dan Li,1 Sheng-Ming Dai,2 Chuan Wang,6 Zhi Chen,7,8 Qianjun Zhou,3 and Bin Li1,9,10,11

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

4Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China.

6Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

7Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.

8Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

9Department of Integrated TCM & Western Medicine, Shanghai Skin Disease Hospital; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

10Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

11Department of Oncology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Address correspondence to: Bin Li, 280 South Chongqing Road, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.6384.6590.776783; Email: binli@shsmu.edu.cn. Or to: Qianjun Zhou, 241 Huaihai Road, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.189.30927005; Email: zhouqj@sjtu.edu.cn. Or to: Chen Zhi, Pentti Kaiteran Katu 1, University of Oulu, Oulu, Finland. Phone: 358.442.523.628; Email: zhi.chen@oulu.fi. Or to: Chuan Wang, 160 Pujian Road, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.68383000, Email: denniswa2@163.com.

Authorship note: QH, NT, JZ, and SS are co–first authors.

Find articles by Huang, Q. in: JCI | PubMed | Google Scholar

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

4Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China.

6Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

7Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.

8Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

9Department of Integrated TCM & Western Medicine, Shanghai Skin Disease Hospital; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

10Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

11Department of Oncology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Address correspondence to: Bin Li, 280 South Chongqing Road, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.6384.6590.776783; Email: binli@shsmu.edu.cn. Or to: Qianjun Zhou, 241 Huaihai Road, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.189.30927005; Email: zhouqj@sjtu.edu.cn. Or to: Chen Zhi, Pentti Kaiteran Katu 1, University of Oulu, Oulu, Finland. Phone: 358.442.523.628; Email: zhi.chen@oulu.fi. Or to: Chuan Wang, 160 Pujian Road, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.68383000, Email: denniswa2@163.com.

Authorship note: QH, NT, JZ, and SS are co–first authors.

Find articles by Tian, N. in: JCI | PubMed | Google Scholar

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

4Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China.

6Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

7Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.

8Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

9Department of Integrated TCM & Western Medicine, Shanghai Skin Disease Hospital; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

10Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

11Department of Oncology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Address correspondence to: Bin Li, 280 South Chongqing Road, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.6384.6590.776783; Email: binli@shsmu.edu.cn. Or to: Qianjun Zhou, 241 Huaihai Road, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.189.30927005; Email: zhouqj@sjtu.edu.cn. Or to: Chen Zhi, Pentti Kaiteran Katu 1, University of Oulu, Oulu, Finland. Phone: 358.442.523.628; Email: zhi.chen@oulu.fi. Or to: Chuan Wang, 160 Pujian Road, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.68383000, Email: denniswa2@163.com.

Authorship note: QH, NT, JZ, and SS are co–first authors.

Find articles by Zhang, J. in: JCI | PubMed | Google Scholar

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

4Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China.

6Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

7Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.

8Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

9Department of Integrated TCM & Western Medicine, Shanghai Skin Disease Hospital; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

10Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

11Department of Oncology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Address correspondence to: Bin Li, 280 South Chongqing Road, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.6384.6590.776783; Email: binli@shsmu.edu.cn. Or to: Qianjun Zhou, 241 Huaihai Road, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.189.30927005; Email: zhouqj@sjtu.edu.cn. Or to: Chen Zhi, Pentti Kaiteran Katu 1, University of Oulu, Oulu, Finland. Phone: 358.442.523.628; Email: zhi.chen@oulu.fi. Or to: Chuan Wang, 160 Pujian Road, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.68383000, Email: denniswa2@163.com.

Authorship note: QH, NT, JZ, and SS are co–first authors.

Find articles by Song, S. in: JCI | PubMed | Google Scholar

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

4Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China.

6Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

7Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.

8Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

9Department of Integrated TCM & Western Medicine, Shanghai Skin Disease Hospital; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

10Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

11Department of Oncology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Address correspondence to: Bin Li, 280 South Chongqing Road, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.6384.6590.776783; Email: binli@shsmu.edu.cn. Or to: Qianjun Zhou, 241 Huaihai Road, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.189.30927005; Email: zhouqj@sjtu.edu.cn. Or to: Chen Zhi, Pentti Kaiteran Katu 1, University of Oulu, Oulu, Finland. Phone: 358.442.523.628; Email: zhi.chen@oulu.fi. Or to: Chuan Wang, 160 Pujian Road, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.68383000, Email: denniswa2@163.com.

Authorship note: QH, NT, JZ, and SS are co–first authors.

Find articles by Cheng, H. in: JCI | PubMed | Google Scholar

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

4Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China.

6Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

7Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.

8Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

9Department of Integrated TCM & Western Medicine, Shanghai Skin Disease Hospital; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

10Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

11Department of Oncology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Address correspondence to: Bin Li, 280 South Chongqing Road, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.6384.6590.776783; Email: binli@shsmu.edu.cn. Or to: Qianjun Zhou, 241 Huaihai Road, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.189.30927005; Email: zhouqj@sjtu.edu.cn. Or to: Chen Zhi, Pentti Kaiteran Katu 1, University of Oulu, Oulu, Finland. Phone: 358.442.523.628; Email: zhi.chen@oulu.fi. Or to: Chuan Wang, 160 Pujian Road, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.68383000, Email: denniswa2@163.com.

Authorship note: QH, NT, JZ, and SS are co–first authors.

Find articles by Liu, X. in: JCI | PubMed | Google Scholar

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

4Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China.

6Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

7Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.

8Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

9Department of Integrated TCM & Western Medicine, Shanghai Skin Disease Hospital; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

10Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

11Department of Oncology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Address correspondence to: Bin Li, 280 South Chongqing Road, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.6384.6590.776783; Email: binli@shsmu.edu.cn. Or to: Qianjun Zhou, 241 Huaihai Road, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.189.30927005; Email: zhouqj@sjtu.edu.cn. Or to: Chen Zhi, Pentti Kaiteran Katu 1, University of Oulu, Oulu, Finland. Phone: 358.442.523.628; Email: zhi.chen@oulu.fi. Or to: Chuan Wang, 160 Pujian Road, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.68383000, Email: denniswa2@163.com.

Authorship note: QH, NT, JZ, and SS are co–first authors.

Find articles by Zhang, W. in: JCI | PubMed | Google Scholar

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

4Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China.

6Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

7Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.

8Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

9Department of Integrated TCM & Western Medicine, Shanghai Skin Disease Hospital; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

10Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

11Department of Oncology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Address correspondence to: Bin Li, 280 South Chongqing Road, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.6384.6590.776783; Email: binli@shsmu.edu.cn. Or to: Qianjun Zhou, 241 Huaihai Road, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.189.30927005; Email: zhouqj@sjtu.edu.cn. Or to: Chen Zhi, Pentti Kaiteran Katu 1, University of Oulu, Oulu, Finland. Phone: 358.442.523.628; Email: zhi.chen@oulu.fi. Or to: Chuan Wang, 160 Pujian Road, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.68383000, Email: denniswa2@163.com.

Authorship note: QH, NT, JZ, and SS are co–first authors.

Find articles by Ye, Y. in: JCI | PubMed | Google Scholar |

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

4Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China.

6Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

7Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.

8Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

9Department of Integrated TCM & Western Medicine, Shanghai Skin Disease Hospital; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

10Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

11Department of Oncology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Address correspondence to: Bin Li, 280 South Chongqing Road, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.6384.6590.776783; Email: binli@shsmu.edu.cn. Or to: Qianjun Zhou, 241 Huaihai Road, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.189.30927005; Email: zhouqj@sjtu.edu.cn. Or to: Chen Zhi, Pentti Kaiteran Katu 1, University of Oulu, Oulu, Finland. Phone: 358.442.523.628; Email: zhi.chen@oulu.fi. Or to: Chuan Wang, 160 Pujian Road, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.68383000, Email: denniswa2@163.com.

Authorship note: QH, NT, JZ, and SS are co–first authors.

Find articles by Du, Y. in: JCI | PubMed | Google Scholar

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

4Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China.

6Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

7Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.

8Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

9Department of Integrated TCM & Western Medicine, Shanghai Skin Disease Hospital; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

10Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

11Department of Oncology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Address correspondence to: Bin Li, 280 South Chongqing Road, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.6384.6590.776783; Email: binli@shsmu.edu.cn. Or to: Qianjun Zhou, 241 Huaihai Road, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.189.30927005; Email: zhouqj@sjtu.edu.cn. Or to: Chen Zhi, Pentti Kaiteran Katu 1, University of Oulu, Oulu, Finland. Phone: 358.442.523.628; Email: zhi.chen@oulu.fi. Or to: Chuan Wang, 160 Pujian Road, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.68383000, Email: denniswa2@163.com.

Authorship note: QH, NT, JZ, and SS are co–first authors.

Find articles by Dai, X. in: JCI | PubMed | Google Scholar

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

4Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China.

6Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

7Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.

8Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

9Department of Integrated TCM & Western Medicine, Shanghai Skin Disease Hospital; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

10Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

11Department of Oncology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Address correspondence to: Bin Li, 280 South Chongqing Road, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.6384.6590.776783; Email: binli@shsmu.edu.cn. Or to: Qianjun Zhou, 241 Huaihai Road, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.189.30927005; Email: zhouqj@sjtu.edu.cn. Or to: Chen Zhi, Pentti Kaiteran Katu 1, University of Oulu, Oulu, Finland. Phone: 358.442.523.628; Email: zhi.chen@oulu.fi. Or to: Chuan Wang, 160 Pujian Road, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.68383000, Email: denniswa2@163.com.

Authorship note: QH, NT, JZ, and SS are co–first authors.

Find articles by Liang, R. in: JCI | PubMed | Google Scholar

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

4Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China.

6Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

7Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.

8Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

9Department of Integrated TCM & Western Medicine, Shanghai Skin Disease Hospital; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

10Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

11Department of Oncology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Address correspondence to: Bin Li, 280 South Chongqing Road, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.6384.6590.776783; Email: binli@shsmu.edu.cn. Or to: Qianjun Zhou, 241 Huaihai Road, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.189.30927005; Email: zhouqj@sjtu.edu.cn. Or to: Chen Zhi, Pentti Kaiteran Katu 1, University of Oulu, Oulu, Finland. Phone: 358.442.523.628; Email: zhi.chen@oulu.fi. Or to: Chuan Wang, 160 Pujian Road, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.68383000, Email: denniswa2@163.com.

Authorship note: QH, NT, JZ, and SS are co–first authors.

Find articles by Li, D. in: JCI | PubMed | Google Scholar

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

4Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China.

6Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

7Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.

8Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

9Department of Integrated TCM & Western Medicine, Shanghai Skin Disease Hospital; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

10Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

11Department of Oncology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Address correspondence to: Bin Li, 280 South Chongqing Road, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.6384.6590.776783; Email: binli@shsmu.edu.cn. Or to: Qianjun Zhou, 241 Huaihai Road, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.189.30927005; Email: zhouqj@sjtu.edu.cn. Or to: Chen Zhi, Pentti Kaiteran Katu 1, University of Oulu, Oulu, Finland. Phone: 358.442.523.628; Email: zhi.chen@oulu.fi. Or to: Chuan Wang, 160 Pujian Road, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.68383000, Email: denniswa2@163.com.

Authorship note: QH, NT, JZ, and SS are co–first authors.

Find articles by Dai, S. in: JCI | PubMed | Google Scholar

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

4Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China.

6Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

7Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.

8Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

9Department of Integrated TCM & Western Medicine, Shanghai Skin Disease Hospital; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

10Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

11Department of Oncology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Address correspondence to: Bin Li, 280 South Chongqing Road, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.6384.6590.776783; Email: binli@shsmu.edu.cn. Or to: Qianjun Zhou, 241 Huaihai Road, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.189.30927005; Email: zhouqj@sjtu.edu.cn. Or to: Chen Zhi, Pentti Kaiteran Katu 1, University of Oulu, Oulu, Finland. Phone: 358.442.523.628; Email: zhi.chen@oulu.fi. Or to: Chuan Wang, 160 Pujian Road, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.68383000, Email: denniswa2@163.com.

Authorship note: QH, NT, JZ, and SS are co–first authors.

Find articles by Wang, C. in: JCI | PubMed | Google Scholar

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

4Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China.

6Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

7Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.

8Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

9Department of Integrated TCM & Western Medicine, Shanghai Skin Disease Hospital; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

10Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

11Department of Oncology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Address correspondence to: Bin Li, 280 South Chongqing Road, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.6384.6590.776783; Email: binli@shsmu.edu.cn. Or to: Qianjun Zhou, 241 Huaihai Road, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.189.30927005; Email: zhouqj@sjtu.edu.cn. Or to: Chen Zhi, Pentti Kaiteran Katu 1, University of Oulu, Oulu, Finland. Phone: 358.442.523.628; Email: zhi.chen@oulu.fi. Or to: Chuan Wang, 160 Pujian Road, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.68383000, Email: denniswa2@163.com.

Authorship note: QH, NT, JZ, and SS are co–first authors.

Find articles by Chen, Z. in: JCI | PubMed | Google Scholar

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

4Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China.

6Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

7Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.

8Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

9Department of Integrated TCM & Western Medicine, Shanghai Skin Disease Hospital; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

10Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

11Department of Oncology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Address correspondence to: Bin Li, 280 South Chongqing Road, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.6384.6590.776783; Email: binli@shsmu.edu.cn. Or to: Qianjun Zhou, 241 Huaihai Road, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.189.30927005; Email: zhouqj@sjtu.edu.cn. Or to: Chen Zhi, Pentti Kaiteran Katu 1, University of Oulu, Oulu, Finland. Phone: 358.442.523.628; Email: zhi.chen@oulu.fi. Or to: Chuan Wang, 160 Pujian Road, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.68383000, Email: denniswa2@163.com.

Authorship note: QH, NT, JZ, and SS are co–first authors.

Find articles by Zhou, Q. in: JCI | PubMed | Google Scholar

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

4Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Guangdong, China.

6Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

7Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.

8Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

9Department of Integrated TCM & Western Medicine, Shanghai Skin Disease Hospital; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

10Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

11Department of Oncology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Address correspondence to: Bin Li, 280 South Chongqing Road, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.6384.6590.776783; Email: binli@shsmu.edu.cn. Or to: Qianjun Zhou, 241 Huaihai Road, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.189.30927005; Email: zhouqj@sjtu.edu.cn. Or to: Chen Zhi, Pentti Kaiteran Katu 1, University of Oulu, Oulu, Finland. Phone: 358.442.523.628; Email: zhi.chen@oulu.fi. Or to: Chuan Wang, 160 Pujian Road, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Phone: 86.021.68383000, Email: denniswa2@163.com.

Authorship note: QH, NT, JZ, and SS are co–first authors.

Find articles by Li, B. in: JCI | PubMed | Google Scholar |

Authorship note: QH, NT, JZ, and SS are co–first authors.

Published October 24, 2024 - More info

Published in Volume 134, Issue 23 on December 2, 2024
J Clin Invest. 2024;134(23):e178079. https://doi.org/10.1172/JCI178079.
© 2024 Huang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Published October 24, 2024 - Version history
Received: December 1, 2023; Accepted: October 11, 2024 View PDF Abstract

Ku70, a DNA repair protein, binds to the damaged DNA ends and orchestrates the recruitment of other proteins to facilitate repair of DNA double-strand breaks. Besides its essential role in DNA repair, sever