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Methylation of Coproporphyrin as a Protective Mechanism in Mycobacteria under Adverse Conditions
Methylation of Coproporphyrin as a Protective Mechanism in Mycobacteria under Adverse Conditions
The transition of active Mycolicibacterium smegmatis cells to a dormant state under acidification conditions is accompanie...
Application of MF3 Microbial Recombinant Protein in Refolding of Plant Chitinase
Application of MF3 Microbial Recombinant Protein in Refolding of Plant Chitinase
Expression of recombinant proteins is important for studying their biological functions. For the primary description of pr...
Protein Engineering of Lactate Oxidase
Protein Engineering of Lactate Oxidase
Lactate oxidase is a practically important enzyme widely used to detect L-lactate in medical diagnostics and in the food i...
High Throughput Screening in Drug Discovery: Problems and Solutions
High Throughput Screening in Drug Discovery: Problems and Solutions
World-wide introduction of high throughput screening (HTS) methods in drug discovery research did not result in the increa...
Strategies of N-Glycosidic Bond Cleavage by DNA Repair Enzymes
Strategies of N-Glycosidic Bond Cleavage by DNA Repair Enzymes
DNA glycosylases are enzymes that hydrolyze the N-glycosidic bond of damaged nucleotides, initiating the process of base e...
Computer Modeling of the Mechanisms of Enzymatic Reactions: Lessons from 20 Years of Practice
Computer Modeling of the Mechanisms of Enzymatic Reactions: Lessons from 20 Years of Practice
The combined quantum mechanics/molecular mechanics method is most often used to describe the molecular mechanisms of enzym...
Modern Methods of Aptamer Chemical Modification and Principles of Aptamer Library Selection
Modern Methods of Aptamer Chemical Modification and Principles of Aptamer Library Selection
Aptamers are promising for a wide application range in biomedicine and various diagnostic systems due to their unique prop...
Post-Translational Modifications of the Sulfhydryl Group of the Cysteine Residue of Glyceraldehyde-3-phosphate Dehydrogenase
Post-Translational Modifications of the Sulfhydryl Group of the Cysteine Residue of Glyceraldehyde-3-phosphate Dehydrogenase
The main types of oxidative post-translational modifications of the glycolytic enzyme glyceraldehyde-3-phosphate dehydroge...
Hydrodechlorination of Diclofenac in an Aqueous Solution over Pd/ZrO2 and Pd/ZrO2SiO2 Catalysts
Hydrodechlorination of Diclofenac in an Aqueous Solution over Pd/ZrO2 and Pd/ZrO2SiO2 Catalysts
Pd/ZrO2 and Pd/ZrO2SiO2 catalysts prepared by wet impregnation and reduced with H2 under mild (30°C, aqueous suspensi...
Antibacterial Activity of Amphiphiles Based on Indolyl-3-Carboxylic Acids and L-Lysine with an Ethylenediamine Linker
Antibacterial Activity of Amphiphiles Based on Indolyl-3-Carboxylic Acids and L-Lysine with an Ethylenediamine Linker
Recently, due to the growth in bacterial infections resistant to antibiotics, there is an urgent need for developing alter...
Regulation of Enzyme-Dependent Lysis of Microbial Cells: Is the Effector Target an Enzyme or Substrate?
Regulation of Enzyme-Dependent Lysis of Microbial Cells: Is the Effector Target an Enzyme or Substrate?
In this study, an attempt is made to analyze the published data regarding the effectors of bacterial lysis in the presence...
Neuraminidase Inhibitory Activities of Some Alcoholic Plant Extracts and Chemical Compounds
Neuraminidase Inhibitory Activities of Some Alcoholic Plant Extracts and Chemical Compounds
In today’s world, disease rates are increasing day after day because of environmental factors, lifestyles and techno...
Coelenterazine-Dependent Luciferases: Properties and Application in Molecular Analysis
Coelenterazine-Dependent Luciferases: Properties and Application in Molecular Analysis
This review presents the data on the structure of bioluminescent systems of marine animals that use coelenterazine-depende...
Identification of “Hot Spots” to Improve Maturation of the moxSAASoti Fluorescent Protein at 37°C
Identification of “Hot Spots” to Improve Maturation of the moxSAASoti Fluorescent Protein at 37°C
A search for amino acid residues, whose replacement could contribute to the optimal maturation of the moxSAASoti fluoresce...
Biopolymer Controlled Release Systems Based on Hydrolyzed Collagen: Cryoforming, Structure, and Properties
Biopolymer Controlled Release Systems Based on Hydrolyzed Collagen: Cryoforming, Structure, and Properties
Biopolymer materials based on natural collagen (gelatin, hydrolyzed collagen) are widely used in the food, pharmaceutical,...
Immunofluorescence Analysis of Estrogen Receptors Alpha Expression in Non-Small Cell Lung Cancer Tissue
Immunofluorescence Analysis of Estrogen Receptors Alpha Expression in Non-Small Cell Lung Cancer Tissue
A quantitative assessment of the expression of estrogen receptors alpha (ERα) is carried out in 115 samples of non-sm...
New Magnetic Colloidal Systems Based on Biomimetic Polycomplexes
New Magnetic Colloidal Systems Based on Biomimetic Polycomplexes
This paper presents new colloidal systems that have prospects for use as carriers of medicinal compounds and are polymer c...
Huntingtin, the Major Factor in Huntington’s Disease Development. Main Functions and Intracellular Proteolysis
Huntingtin, the Major Factor in Huntington’s Disease Development. Main Functions and Intracellular Proteolysis
This review is devoted to the consideration of pathological intracellular mechanisms characteristic of Huntington’s ...
Rheology of Structured Liquids: Newtonian Behavior
Rheology of Structured Liquids: Newtonian Behavior
In this paper, we analyze the behavior of low-molecular-weight non-Newtonian fluids (liquid paraffin, silicone oil, and FC...
Quantitative Immunofluorescence Evaluation of PD-L1 Expression in Non-Muscle-Invasive and Muscle-Invasive Urothelial Bladder Cancer
Quantitative Immunofluorescence Evaluation of PD-L1 Expression in Non-Muscle-Invasive and Muscle-Invasive Urothelial Bladder Cancer
The expression of PD-L1 protein is quantified in 56 samples of urothelial bladder cancer (BC). PD-L1 expression is detecte...
Influence of Adsorption Layers of Polyelectrolytes on the Wetting and Modification of the Polystyrene Surface
Influence of Adsorption Layers of Polyelectrolytes on the Wetting and Modification of the Polystyrene Surface
The adsorption of cationic and anionic polyelectrolytes (PEs) from aqueous solutions on the polystyrene surface is studied...
Changes in the Physicochemical and Biological Properties of Aqueous Solutions under the Influence of Factors Modeling the Conditions of Space Flight
Changes in the Physicochemical and Biological Properties of Aqueous Solutions under the Influence of Factors Modeling the Conditions of Space Flight
The results of studies in which the relationship of the self-organization, physicochemical properties, and bioeffects in d...
New Solutions in Decarbonization Technology
New Solutions in Decarbonization Technology
It is shown that the removal of CO2 from a gas can be implemented in a disk film absorber using water as an absorbent. The...
Comparative Analysis of the Capabilities of Molecular Spectroscopy Methods in Studying Internal Rotation
Comparative Analysis of the Capabilities of Molecular Spectroscopy Methods in Studying Internal Rotation
In this review, the methods used to study internal rotation in the ground (S0) and excited (S1) electronic states in the f...
Structural and Functional Aspects of the Interactions Between Medical Polymers and Liposomes and Bacterial Cells
Structural and Functional Aspects of the Interactions Between Medical Polymers and Liposomes and Bacterial Cells
Polymers are widely applied as drug delivery systems and implant coatings. This review studies the mechanisms of the inter...
Glycolipotripeptide (N-Lactitol-Gly)2-LysC16 and Its Fluorescently Labeled Analog for Visualizing Vector Systems for the Delivery of Biologically Active Substances to Target Cells
Glycolipotripeptide (N-Lactitol-Gly)2-LysC16 and Its Fluorescently Labeled Analog for Visualizing Vector Systems for the Delivery of Biologically Active Substances to Target Cells
This paper studies the preparation of a carbohydrate derivative of lipotripeptide (N-lactitol-Gly)2-LysC16 of an irregular...
Immunosensor Based on Screen-Printed Graphite Electrodes Modified with Gold Nanoparticles and a Synthetic Membrane-Like Substance for the Determination of Chloramphenicol
Immunosensor Based on Screen-Printed Graphite Electrodes Modified with Gold Nanoparticles and a Synthetic Membrane-Like Substance for the Determination of Chloramphenicol
An electrochemical immunosensor based on screen-printed graphite electrodes is developed for the determination of the anti...
Electrochemical Biosensors for SARS-CoV-2 Detection
Electrochemical Biosensors for SARS-CoV-2 Detection
The 2019 coronavirus disease (COVID-19) outbreak has become global. The unprecedented socioeconomic impact of the pandemic...
Influence of ku70 Gene Knockout on the Transformation Frequency of Penicillium verruculosum Mycelial Fungi
Influence of ku70 Gene Knockout on the Transformation Frequency of Penicillium verruculosum Mycelial Fungi
To increase the frequency of homologous recombination (HR) during the transformation of the industrial Penicillium verrucu...
Changes in the Amino Acid Composition of Gelatin After Treatment of Bovine Collagen with Enzyme Preparations
Changes in the Amino Acid Composition of Gelatin After Treatment of Bovine Collagen with Enzyme Preparations
Recently, increased attention has been paid to the study of the amino acid (AA) composition of gelatins, which is associat...
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