New prognostic markers for IgA nephropathy in children

Lee M, Suzuki H, Nihei Y, Matsuzaki K, Suzuki Y (2023) Ethnicity and IgA nephropathy: worldwide differences in epidemiology, timing of diagnosis, clinical manifestations, management and prognosis. Clin Kidney J 16:ii1–ii8

Article  PubMed  PubMed Central  Google Scholar 

Knoppova B, Reily C, King RG, Julian BA, Novak J, Green TJ (2021) Pathogenesis of IgA nephropathy: current understanding and implications for development of disease-specific treatment. J Clin Med 10:4501

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou N, Wang H, Wang XY, Jiang YP, Fu Q, Liang Y, Feng GS, Futang Research Center of Pediatric Development (2023) Characteristics of children with IgA nephropathy. Pediatr Res 93:715–719

Article  CAS  PubMed  Google Scholar 

Coppo R (2019) Pediatric IgA nephropathy in Europe. Kidney Dis (Basel) 5:182–188

Article  PubMed  PubMed Central  Google Scholar 

Barbour SJ, Coppo R, Zhang H, Liu ZH, Suzuki Y, Matsuzaki K, Katafuchi R, Er L, Espino-Hernandez G, Kim SJ, Reich HN, Feehally J, Cattran DC, International IgA Nephropathy Network (2019) Evaluating a new international risk-prediction tool in IgA nephropathy. JAMA Intern Med 179:942–952

Article  PubMed  PubMed Central  Google Scholar 

Barbour SJ, Coppo R, Zhang H, Liu ZH, Suzuki Y, Matsuzaki K, Er L, Reich HN, Barratt J, Cattran DC, International IgA Nephropathy Network (2022) Application of the international IgA nephropathy prediction tool one or two years post-biopsy. Kidney Int 102:160–172

Article  CAS  PubMed  Google Scholar 

Barbour SJ, Coppo R, Er L, Russo ML, Liu ZH, Ding J, Katafuchi R, Yoshikawa N, Xu H, Kagami S, Yuzawa Y, Emma F, Cambier A, Peruzzi L, Wyatt RJ, Cattran DC, International IgA Nephropathy Network (2021) Updating the international IgA nephropathy prediction tool for use in children. Kidney Int 99:1439–1450

Article  CAS  PubMed  Google Scholar 

Coppo R, D’Arrigo G, Tripepi G et al (2020) Is there long-term value of pathology scoring in immunoglobulin A nephropathy? A validation study of the Oxford classification for IgA nephropathy (VALIGA) update. Nephrol Dial Transplant 35:1002–1009

Article  CAS  PubMed  Google Scholar 

Coppo R (2021) Treatment of IgA nephropathy in children: a land without KDIGO guidance. Pediatr Nephrol 36:491–496

Article  PubMed  Google Scholar 

Cattran DC, Floege J, Coppo R (2023) Evaluating progression risk in patients with immunoglobulin A nephropathy. Kidney Int Rep 8:2515–2528

Article  PubMed  PubMed Central  Google Scholar 

Coppo R (2017) Biomarkers and targeted new therapies for IgA nephropathy. Pediatr Nephrol 32:725–731

Article  PubMed  Google Scholar 

Selvaskandan H, Shi S, Twaij S, Cheung CK, Barratt J (2020) Monitoring immune responses in IgA nephropathy: biomarkers to guide management. Front Immunol 11:572754

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kawasaki Y, Maeda R, Ohara S, Suyama K, Hosoya M (2018) Serum IgA/C3 and glomerular C3 staining predict severity of IgA nephropathy. Pediatr Int 60:162–167

Article  CAS  PubMed  Google Scholar 

Lang Y, Song S, Zhao L, Yang Y, Liu T, Shen Y, Wang W (2021) Serum IgA/C3 ratio and glomerular C3 staining predict progression of IgA nephropathy in children. Transl Pediatr 10:666–672

Article  PubMed  PubMed Central  Google Scholar 

Gong WY, Liu M, Luo D, Liu FN, Yin LH, Li YQ, Zhang J, Peng H (2019) High serum IgA/C3 ratio better predicts a diagnosis of IgA nephropathy among primary glomerular nephropathy patients with proteinuria. BMC Nephrol 20:150

Article  PubMed  PubMed Central  Google Scholar 

Nakata J, Suzuki Y, Suzuki H, Sato D, Kano T, Yanagawa H, Matsuzaki K, Horikoshi S, Novak J, Tomino Y (2014) Changes in nephritogenic serum galactose-deficient IgA1 in IgA nephropathy following tonsillectomy and steroid therapy. PLoS One 9:e89707

Article  PubMed  PubMed Central  Google Scholar 

Coppo R, Robert T (2020) IgA nephropathy in children and in adults: two separate entities or the same disease? J Nephrol 33:1219–1229

Article  PubMed  Google Scholar 

Kiryluk K, Sanchez-Rodriguez E, Zhou XJ et al (2023) Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy. Nat Genet 55:1091–1105

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen P, Yu G, Zhang X, Xie X, Wang J, Shi S, Liu L, Lv J, Zhang H (2019) Plasma galactose-deficient IgA1 and C3 and CKD progression in IgA nephropathy. Clin J Am Soc Nephrol 14:1458–1465

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berthoux F, Suzuki H, Thibaudin L, Yanagawa H, Maillard N, Mariat C, Tomino Y, Julian BA, Novak J (2012) Autoantibodies targeting galactose-deficient IgA1 associate with progression of IgA nephropathy. J Am Soc Nephrol 23:1579–1587

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yanagawa H, Suzuki H, Suzuki Y, Kiryluk K, Gharavi AG, Matsuoka K, Makita Y, Julian BA, Novak J, Tomino Y (2014) A panel of serum biomarkers differentiates IgA nephropathy from other renal diseases. PLoS One 9:e980812014

Article  Google Scholar 

Hastings MC, Moldoveanu Z, Suzuki H, Berthoux F, Julian BA, Sanders JT, Renfrow MB, Novak J, Wyatt RJ (2013) Biomarkers in IgA nephropathy: relationship to pathogenetic hits. Expert Opin Med Diagn 7:615–627

Article  CAS  PubMed  PubMed Central  Google Scholar 

Novak J, Raskova Kafkova L, Suzuki H, Tomana M, Matousovic K, Brown R, Hall S, Sanders JT, Eison TM, Moldoveanu Z, Novak L, Novak Z, Mayne R, Julian BA, Mestecky J, Wyatt RJ (2011) IgA1 immune complexes from pediatric patients with IgA nephropathy activate cultured human mesangial cells. Nephrol Dial Transplant 26:3451–3457

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cambier A, Gleeson PJ, Abbad L, Canesi F, da Silva J, Bex-Coudrat J, Deschênes G, Boyer O, Rabant M, Ulinski T, Hogan J, Peuchmaur M, Berthelot L, Monteiro RC (2022) Soluble CD89 is a critical factor for mesangial proliferation in childhood IgA nephropathy. Kidney Int 101:274–287

Article  CAS  PubMed  Google Scholar 

Vuong MT, Hahn-Zoric M, Lundberg S, Gunnarsson I, van Kooten C, Wramner L, Seddighzadeh M, Fernström A, Hanson LÅ, Do LT, Jacobson SH, Padyukov L (2010) Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy. Kidney Int 78:1281–1287

Article  CAS  PubMed  Google Scholar 

Moresco RN, Speeckaert MM, Zmonarski SC, Krajewska M, Komuda-Leszek E, Perkowska-Ptasinska A, Gesualdo L, Rocchetti MT, Delanghe SE, Vanholder R, Van Biesen W, Delanghe JR (2016) Urinary myeloid IgA Fc alpha receptor (CD89) and transglutaminase-2 as new biomarkers for active IgA nephropathy and Henoch-schonlein purpura nephritis. BBA Clin 5:79–84

Article  PubMed  PubMed Central  Google Scholar 

Wang X, Li T, Si R, Chen J, Qu Z, Jiang Y (2020) Increased frequency of PD-1(hi)CXCR5(-) T cells and B cells in patients with newly diagnosed IgA nephropathy. Sci Rep 10:492

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao W, Feng S, Wang Y, Wang C, Ren P, Zhang J, Yu L, Zhang C, Bai L, Chen Y, Zhou Q, Qu L, Chen J, Jiang H (2023) Elevated urinary IL-6 predicts the progression of IgA nephropathy. Kidney Int Rep 8:519–530

Article  PubMed  Google Scholar 

Bartucci R, Salvati A, Olinga P, Boersma YL (2019) Vanin 1: its physiological function and role in diseases. Int J Mol Sci 20:3891

Article  CAS  PubMed  PubMed Central 

Comments (0)

No login
gif