Novel standardized method for inducing medication-related osteonecrosis of the jaw in rats and precise quantitative assessment of pathological outcomes

Ahdi HS, Wichelmann TA, Pandravada S, Ehrenpreis ED. Medication-induced osteonecrosis of the jaw: a review of cases from the Food and Drug Administration Adverse Event Reporting System (FAERS). BMC Pharmacol Toxicol. 2023;24:15. https://doi.org/10.1186/s40360-023-00657-y.

Article  CAS  Google Scholar 

Nicolatou-Galitis O, Schiodt M, Mendes RA, Ripamonti C, Hope S, Drudge-Coates L, et al. Medication-related osteonecrosis of the jaw: definition and best practice for prevention, diagnosis, and treatment. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;127:117–35. https://doi.org/10.1016/j.oooo.2018.09.008.

Article  Google Scholar 

Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg. 2003;61:1115–7. https://doi.org/10.1016/s0278-2391(03)00720-1.

Article  Google Scholar 

Lee ES, Tsai MC, Lee JX, Wong C, Cheng YN, Liu AC, et al. Bisphosphonates and Their Connection to Dental Procedures: Exploring Bisphosphonate-Related Osteonecrosis of the Jaws. Cancers (Basel). 2023. https://doi.org/10.3390/cancers15225366.

Article  Google Scholar 

Seki K, Kaneko T, Kamimoto A, Wada M, Takeuchi Y, Furuchi M, et al. Medication-related osteonecrosis of the jaw after tooth extraction in patients receiving pharmaceutical treatment for osteoporosis: A retrospective cohort study. J Dent Sci. 2022;17:1619–25. https://doi.org/10.1016/j.jds.2022.03.014.

Article  Google Scholar 

Jiang A, Zhang Z, Qiu X, Guo Q. Medication-related osteonecrosis of the jaw (MRONJ): a review of pathogenesis hypothesis and therapy strategies. Arch Toxicol. 2024;98:689–708. https://doi.org/10.1007/s00204-023-03653-7.

Article  CAS  Google Scholar 

Cho J, Feldman G, Tomlinson R, Taub D, Diecidue R. Medication-related osteonecrosis of the jaw (MRONJ) systemic review: mevalonate pathway mechanisms explored. Oral Surg Oral Med Oral Pathol Oral Radiol. 2024;138:475–83. https://doi.org/10.1016/j.oooo.2024.05.014.

Article  Google Scholar 

Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D. American Association of Oral and Maxillofacial Surgeons’ Position Paper on Medication-Related Osteonecrosis of the Jaws-2022 Update. J Oral Maxillofac Surg. 2022;80:920–43. https://doi.org/10.1016/j.joms.2022.02.008.

Article  Google Scholar 

Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O’Ryan F, et al. Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res. 2015;30:3–23. https://doi.org/10.1002/jbmr.2405.

Article  Google Scholar 

Sanda K, Ayukawa Y, Yasunami N, Adachi N, Furuhashi A, Imai M, et al. Therapeutic effect of fluvastatin on medication-related osteonecrosis of the jaw. J Periodontol. 2022;93:837–46. https://doi.org/10.1002/JPER.21-0294.

Article  CAS  Google Scholar 

Matsunaka K, Imai M, Sanda K, Yasunami N, Furuhashi A, Atsuta I, et al. Therapeutic Effect of Benidipine on Medication-Related Osteonecrosis of the Jaw. Pharmaceuticals (Basel). 2022. https://doi.org/10.3390/ph15081020.

Article  Google Scholar 

Ervolino E, Olivo MB, Toro LF, Freire JOA, Ganzaroli VF, Guiati IZ, et al. Effectiveness of antimicrobial photodynamic therapy mediated by butyl toluidine blue in preventing medication-related osteonecrosis of the jaws in rats. Photodiagnosis Photodyn Ther. 2022;40:103172. https://doi.org/10.1016/j.pdpdt.2022.103172.

Article  CAS  Google Scholar 

Monteiro CGJ, Vieira EM, Emerick C, Azevedo RS, Pascoal VAB, Homsi N, et al. Ozonated oil effect for prevention of medication-related osteonecrosis of the jaw (MRONJ) in rats undergoing zoledronic acid therapy. Clin Oral Investig. 2021;25:6653–9. https://doi.org/10.1007/s00784-021-03951-3.

Article  CAS  Google Scholar 

Gao SY, Lin RB, Huang SH, Liang YJ, Li X, Zhang SE, et al. PDGF-BB exhibited therapeutic effects on rat model of bisphosphonate-related osteonecrosis of the jaw by enhancing angiogenesis and osteogenesis. Bone. 2021;144:115117. https://doi.org/10.1016/j.bone.2019.115117.

Article  CAS  Google Scholar 

Yadegari A, Aminzadeh A, Seyyedkhamesi S, Aminian M. The effect of melatonin on prevention of bisphosphonate-related osteonecrosis of the jaw: an animal study in rats. J Korean Assoc Oral Maxillofac Surg. 2020;46:266–74. https://doi.org/10.5125/jkaoms.2020.46.4.266.

Article  Google Scholar 

Doppelt O, Cohen G, Tamari T, Elimelech R, Sabbah N, Zigdon-Giladi H. Endothelial progenitors increase vascularization and improve fibroblasts function that prevent medication-related osteonecrosis of the jaw. Oral Dis. 2020;26:1523–31. https://doi.org/10.1111/odi.13412.

Article  Google Scholar 

Tamari T, Elimelech R, Cohen G, Cohen T, Doppelt O, Eskander-Hashoul L, et al. Endothelial Progenitor Cells inhibit jaw osteonecrosis in a rat model: A major adverse effect of bisphosphonate therapy. Sci Rep. 2019;9:18896. https://doi.org/10.1038/s41598-019-55383-5.

Article  CAS  Google Scholar 

Mergoni G, Vescovi P, Passerini P, Maestri R, Corradi D, Sala R, et al. Effects of zoledronic acid and dexamethasone on early phases of socket healing after tooth extraction in rats: A preliminary macroscopic and microscopic quantitative study. Med Oral Patol Oral Cir Bucal. 2019;24:e339–45. https://doi.org/10.4317/medoral.22883.

Article  CAS  Google Scholar 

Kaibuchi N, Iwata T, Yamato M, Okano T, Ando T. Multipotent mesenchymal stromal cell sheet therapy for bisphosphonate-related osteonecrosis of the jaw in a rat model. Acta Biomater. 2016;42:400–10. https://doi.org/10.1016/j.actbio.2016.06.022.

Article  CAS  Google Scholar 

Watanabe J, Sakai K, Urata Y, Toyama N, Nakamichi E, Hibi H. Extracellular Vesicles of Stem Cells to Prevent BRONJ. J Dent Res. 2020;99:552–60. https://doi.org/10.1177/0022034520906793.

Article  CAS  Google Scholar 

Rodriguez-Lozano FJ, Onate-Sanchez R, Gonzalvez-Garcia M, Valles-Bergada M, Martinez CM, Revilla-Nuin B, et al. Allogeneic Bone Marrow Mesenchymal Stem Cell Transplantation in Tooth Extractions Sites Ameliorates the Incidence of Osteonecrotic Jaw-Like Lesions in Zoledronic Acid-Treated Rats. J Clin Med. 2020. https://doi.org/10.3390/jcm9061649.

Article  Google Scholar 

Alonso-Rodriguez E, Gonzalez-Martin-Moro J, Cebrian-Carretero JL, Del Castillo JL, Pozo-Kreilinger JJ, Ruiz-Bravo E, et al. Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model. Med Oral Patol Oral Cir Bucal. 2019;24:e529–36. https://doi.org/10.4317/medoral.22959.

Article  CAS  Google Scholar 

Ogata K, Katagiri W, Osugi M, Kawai T, Sugimura Y, Hibi H, et al. Evaluation of the therapeutic effects of conditioned media from mesenchymal stem cells in a rat bisphosphonate-related osteonecrosis of the jaw-like model. Bone. 2015;74:95–105. https://doi.org/10.1016/j.bone.2015.01.011.

Article  CAS  Google Scholar 

Barba-Recreo P, Pardo Vera JL, Garcia-Arranz M, Yebenes L, Burgueno M. Zoledronic acid - related osteonecrosis of the jaws Experimental model with dental extractions in rats. J Craniomaxillofac Surg. 2014;42:744–50. https://doi.org/10.1016/j.jcms.2013.11.005.

Article  Google Scholar 

Hokugo A, Christensen R, Chung EM, Sung EC, Felsenfeld AL, Sayre JW, et al. Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats. J Bone Miner Res. 2010;25:1337–49. https://doi.org/10.1002/jbmr.23.

Article  CAS  Google Scholar 

Fondi C, Franchi A. Definition of bone necrosis by the pathologist. Clin Cases Miner Bone Metab. 2007;4:21–6.

Google Scholar 

Yan R, Jiang R, Hu L, Deng Y, Wen J, Jiang X. Establishment and assessment of rodent models of medication-related osteonecrosis of the jaw (MRONJ). Int J Oral Sci. 2022;14:41. https://doi.org/10.1038/s41368-022-00182-4.

Article  Google Scholar 

Mochizuki M, Nakahara T. Establishment of xenogeneic serum-free culture methods for handling human dental pulp stem cells using clinically oriented in-vitro and in-vivo conditions. Stem Cell Res Ther. 2018;9:25. https://doi.org/10.1186/s13287-017-0761-5.

Article  CAS  Google Scholar 

Nishimaki K, Kaibuchi N, Washio K, Yamato M. Application of mesenchymal stromal cell sheets to prevent medication-related osteonecrosis of the jaw with titanium implants in rats. Odontology. 2024;112:938–49. https://doi.org/10.1007/s10266-024-00900-w.

Article  CAS  Google Scholar 

Jung J, Shim GJ, Kim M, Yoon Y, Kim JE, Jue SS, et al. Effect and timing of parathyroid hormone analog administration for preventing medication-related osteonecrosis of the jaws in a murine model. J Craniomaxillofac Surg. 2021;49:719–25. https://doi.org/10.1016/j.jcms.2021.02.023.

Article  Google Scholar 

Toro LF, de Mello-Neto JM, Santos F, Ferreira LC, Statkievicz C, Cintra LTA, et al. Application of Autologous Platelet-Rich Plasma on Tooth Extraction Site Prevents Occurence of Medication-Related Osteonecrosis of the Jaws in Rats. Sci Rep. 2019;9:22. https://doi.org/10.1038/s41598-018-37063-y.

Article  CAS  Google Scholar 

Hikita H, Miyazawa K, Tabuchi M, Kimura M, Goto S. Bisphosphonate administration prior to tooth extraction delays initial healing of the extraction socket in rats. J Bone Miner Metab. 2009;27:663–72. https://doi.org/10.1007/s00774-009-0090-6.

Article  CAS  Google Scholar 

Sonis ST, Watkins BA, Lyng GD, Lerman MA, Anderson KC. Bony changes in the jaws of rats treated with zoledronic acid and dexamethasone before dental extractions mimic bisphosphonate-related osteonecrosis in cancer patients. Oral Oncol. 2009;45:164–72. https://doi.org/10.1016/j.oraloncology.2008.04.013.

Article  CAS  Google Scholar 

Kaibuchi N, Iwata T, Koga YK, Okamoto T. Novel Cell Therapy Using Mesenchymal Stromal Cell Sheets for Medication-Related Osteonecrosis of the Jaw. Front Bioeng Biotechnol. 2022;10:9

Comments (0)

No login
gif