Turkkan G, Willems Y, Hendriks LEL, Mostard R, Conemans L, Gietema HA, et al. Idiopathic pulmonary fibrosis: current knowledge, future perspectives and its importance in radiation oncology. Radiother Oncol. 2021;155:269–77.

Article  PubMed  Google Scholar 

Brown SW, Dobelle M, Padilla M, Agovino M, Wisnivesky JP, Hashim D, et al. Idiopathic pulmonary fibrosis and Lung Cancer. A systematic review and Meta-analysis. Ann Am Thorac Soc. 2019;16(8):1041–51.

Article  PubMed  Google Scholar 

Naccache JM, Gibiot Q, Monnet I, Antoine M, Wislez M, Chouaid C, et al. Lung cancer and interstitial lung disease: a literature review. J Thorac Dis. 2018;10(6):3829–44.

Article  PubMed  PubMed Central  Google Scholar 

Frank AJ, Dagogo-Jack I, Dobre IA, Tait S, Schumacher L, Fintelmann FJ, et al. Management of Lung Cancer in the patient with interstitial lung disease. Oncologist. 2023;28(1):12–22.

Article  PubMed  Google Scholar 

Saha A, Dickinson P, Shrimali RK, Salem A, Agarwal S. Is thoracic Radiotherapy an Absolute Contraindication for treatment of Lung Cancer patients with interstitial lung disease? A systematic review. Clin Oncol (R Coll Radiol). 2022;34(12):e493–504.

Article  CAS  PubMed  Google Scholar 

Jeong WG, Kim YH, Ahn SJ, Jeong JU, Lee BC, Cho IJ, et al. Effect of interstitial lung abnormality on concurrent chemoradiotherapy-treated stage III non-small cell Lung Cancer patients. Anticancer Res. 2023;43(4):1797–807.

Article  CAS  PubMed  Google Scholar 

Park SH, Lim JK, Kang MK, Park J, Hong CM, Kim CH, et al. Predictive factors for severe radiation-induced lung injury in patients with lung cancer and coexisting interstitial lung disease. Radiother Oncol. 2024;192:110053.

Article  CAS  PubMed  Google Scholar 

Liu X, Zeng L, Zhou Y, Zhao X, Zhu L, Zhang J, et al. P21 facilitates macrophage chemotaxis by promoting CCL7 in the lung epithelial cell lines treated with radiation and bleomycin. J Transl Med. 2023;21(1):314.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hubner RH, Gitter W, El Mokhtari NE, Mathiak M, Both M, Bolte H, et al. Standardized quantification of pulmonary fibrosis in histological samples. Biotechniques. 2008;44(4):507–11. 14– 7.

Article  PubMed  Google Scholar 

Chen T, Qiu H, Zhao MM, Chen SS, Wu Q, Zhou NY, et al. IL-17A contributes to HSV1 infection-induced acute lung injury in a mouse model of pulmonary fibrosis. J Cell Mol Med. 2019;23(2):908–19.

Article  CAS  PubMed  Google Scholar 

Trapnell C, Pachter L, Salzberg SL. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics. 2009;25(9):1105–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu T, De Los Santos FG, Phan SH. The Bleomycin Model of Pulmonary Fibrosis. Methods Mol Biol. 2017;1627:27–42.

Article  CAS  PubMed  Google Scholar 

Hyun DG, Han SJ, Ji W, Choi CM, Lee JC, Kim HC. Clinical characteristics and prognostic impact of acute exacerbations in patients with interstitial lung disease and lung cancer: a single-center, retrospective cohort study. Thorac Cancer. 2023;14(33):3323–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Makita K, Hamamoto Y, Kanzaki H, Nagasaki K, Sugawara Y, Kozuki T. Impact of palliative radiotherapy with or without lung irradiation in patients with interstitial lung disease. Radiother Oncol. 2023;183:109636.

Article  PubMed  Google Scholar 

Bargagli E, Bonti V, Bindi A, Scotti V, Pistolesi M, Voltolini L, et al. Fibrotic lung toxicity induced by cytotoxic drugs, radiation and immunotherapy in patients treated for lung cancer. Monaldi Arch Chest Dis. 2018;88(2):917.

Article  PubMed  Google Scholar 

Goodman CD, Nijman SFM, Senan S, Nossent EJ, Ryerson CJ, Dhaliwal I, et al. A primer on interstitial lung disease and thoracic Radiation. J Thorac Oncol. 2020;15(6):902–13.

Article  PubMed  Google Scholar 

Zhang L, Wang Y, Tian L, Li L, Chen Z, Ding C, et al. Thrombospondin-1-mediated crosstalk between autophagy and oxidative stress orchestrates repair of blast lung injury. Biochim Biophys Acta Mol Basis Dis. 2024;1870(3):167026.

Article  CAS  PubMed  Google Scholar 

Aribindi K, Lim M, Lakshminrusimha S, Albertson T. Investigational pharmacological agents for the treatment of ARDS. Expert Opin Investig Drugs. 2024;33(3):243–77.

Article  CAS  PubMed  Google Scholar 

Guo Y, Zhang H, Lv Z, Du Y, Li D, Fang H, et al. Up-regulated CD38 by daphnetin alleviates lipopolysaccharide-induced lung injury via inhibiting MAPK/NF-kappaB/NLRP3 pathway. Cell Commun Signal. 2023;21(1):66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Ma J, Li M, Tao J, Chen J, Yao C, et al. GYY4137 alleviates sepsis-induced acute lung injury in mice by inhibiting the PDGFRbeta/Akt/NF-kappaB/NLRP3 pathway. Life Sci. 2021;271:119192.

Article  CAS  PubMed  Google Scholar 

Soysouvanh F, Benadjaoud MA, Dos Santos M, Mondini M, Lavigne J, Bertho A, et al. Stereotactic lung irradiation in mice promotes Long-Term Senescence and Lung Injury. Int J Radiat Oncol Biol Phys. 2020;106(5):1017–27.

Article  PubMed  Google Scholar 

Liang J, Huang G, Liu X, Liu N, Taghavifar F, Dai K et al. Reciprocal interactions between alveolar progenitor dysfunction and aging promote lung fibrosis. Elife. 2023;12.

Li S, Shi J, Tang H. Animal models of drug-induced pulmonary fibrosis: an overview of molecular mechanisms and characteristics. Cell Biol Toxicol. 2022;38(5):699–723.

Article  CAS  PubMed  Google Scholar 

Zhou S, Zhu J, Zhou PK, Gu Y. Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis. Front Cell Dev Biol. 2022;10:999600.

Article  PubMed  PubMed Central  Google Scholar 

Cheng WH, Lee KY, Yu MC, Chen JY, Lin CH, Chen BC. Pref-1 induced lung fibroblast differentiation by hypoxia through integrin alpha5beta1/ERK/AP-1 cascade. Eur J Pharmacol. 2021;909:174385.

Article  CAS  PubMed  Google Scholar 

Ali G, Zhang M, Chang J, Zhao R, Jin Y, Zhang J, et al. PAI-1 regulates AT2-mediated re-alveolarization and ion permeability. Stem Cell Res Ther. 2023;14(1):185.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adnot S, Breau M, Houssaini A. PAI-1: a New Target for Controlling Lung-Cell Senescence and Fibrosis? Am J Respir Cell Mol Biol. 2020;62(3):271–2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee JW, Chun W, Lee HJ, Min JH, Kim SM, Seo JY et al. The role of macrophages in the development of Acute and Chronic Inflammatory Lung diseases. Cells. 2021;10(4).

Groves AM, Misra R, Clair G, Hernady E, Olson H, Orton D, et al. Influence of the irradiated pulmonary microenvironment on macrophage and T cell dynamics. Radiother Oncol. 2023;183:109543.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Onishi H, Marino K, Yamashita H, Terahara A, Onimaru R, Kokubo M, et al. Case Series of 23 patients who developed fatal Radiation Pneumonitis after stereotactic body Radiotherapy for Lung Cancer. Technol Cancer Res Treat. 2018;17:1533033818801323.

Article  PubMed  PubMed Central  Google Scholar 

Cords L, Engler S, Haberecker M, Ruschoff JH, Moch H, de Souza N, et al. Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer. Cancer Cell. 2024;42(3):396–412. e5.

Article  CAS