Causal relationship between rheumatoid arthritis and carpal tunnel syndrome: a bidirectional two-sample Mendelian randomization study

Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388(10055):2023–38.

Article  CAS  PubMed  Google Scholar 

Sparks JA. Rheumatoid Arthritis. Ann Intern Med. 2019;170(1):ITC1-6.

Article  PubMed  Google Scholar 

Olney RK. Carpal tunnel syndrome: complex issues with a ‘simple’ condition. Neurology. 2001;56(11):1431–2.

Article  CAS  PubMed  Google Scholar 

Padua L, Coraci D, Erra C, Pazzaglia C, Paolasso I, Loreti C, et al. Carpal tunnel syndrome: clinical features, diagnosis, and management. Lancet Neurol. 2016;15(12):1273–84.

Article  PubMed  Google Scholar 

Bland JDP. Carpal tunnel syndrome. Curr Opin Neurol. 2005;18(5):581–5.

Article  PubMed  Google Scholar 

Genova A, Dix O, Saefan A, Thakur M, Hassan A. Carpal tunnel syndrome: a review of literature. Cureus. 2020;12(3):e7333.

PubMed  PubMed Central  Google Scholar 

Tseng CH, Liao CC, Kuo CM, Sung FC, Hsieh DPH, Tsai CH. Medical and non-medical correlates of carpal tunnel syndrome in a Taiwan cohort of one million. Eur J Neurol. 2012;19(1):91–7.

Article  PubMed  Google Scholar 

van Dijk MAJ, Reitsma JB, Fischer JC, Sanders GTB. Indications for requesting laboratory tests for concurrent diseases in patients with carpal tunnel syndrome: a systematic review. Clin Chem. 2003;49(9):1437–44.

Article  PubMed  Google Scholar 

Shiri R. Arthritis as a risk factor for carpal tunnel syndrome: a meta-analysis. Scand J Rheumatol. 2016;45(5):339–46.

Article  CAS  PubMed  Google Scholar 

Karadag O, Kalyoncu U, Akdogan A, Karadag YS, Bilgen SA, Ozbakır S, et al. Sonographic assessment of carpal tunnel syndrome in rheumatoid arthritis: prevalence and correlation with disease activity. Rheumatol Int. 2012;32(8):2313–9.

Article  PubMed  Google Scholar 

Sakthiswary R, Singh R. Has the median nerve involvement in rheumatoid arthritis been overemphasized? Rev Bras Reumatol Engl Ed. 2017;57(2):122–8.

Article  PubMed  Google Scholar 

Lee KH, Lee CH, Lee BG, Park JS, Choi WS. The incidence of carpal tunnel syndrome in patients with rheumatoid arthritis. Int J Rheum Dis. 2015;18(1):52–7.

Article  CAS  PubMed  Google Scholar 

Evans DM, Davey SG. Mendelian randomization: new applications in the coming age of hypothesis-free causality. Annu Rev Genomics Hum Genet. 2015;16:327–50.

Article  CAS  PubMed  Google Scholar 

Didelez V, Sheehan N. Mendelian randomization as an instrumental variable approach to causal inference. Stat Methods Med Res. 2007;16(4):309–30.

Article  PubMed  Google Scholar 

Ha E, Bae SC, Kim K. Large-scale meta-analysis across East Asian and European populations updated genetic architecture and variant-driven biology of rheumatoid arthritis, identifying 11 novel susceptibility loci. Ann Rheum Dis. 2021;80(5):558–65.

Article  CAS  PubMed  Google Scholar 

Wiberg A, Ng M, Schmid AB, Smillie RW, Baskozos G, Holmes MV, et al. A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome. Nat Commun. 2019;10(1):1030.

Article  PubMed  PubMed Central  Google Scholar 

Davies NM, Holmes MV, Davey SG. Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ. 2018;12(362):k601.

Article  Google Scholar 

Pritchard JK, Przeworski M. Linkage disequilibrium in humans: models and data. Am J Hum Genet. 2001;69(1):1–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Palmer TM, Lawlor DA, Harbord RM, Sheehan NA, Tobias JH, Timpson NJ, et al. Using multiple genetic variants as instrumental variables for modifiable risk factors. Stat Methods Med Res. 2012;21(3):223–42.

Article  PubMed  PubMed Central  Google Scholar 

Levin MG, Judy R, Gill D, Vujkovic M, Verma SS, Bradford Y, et al. Genetics of height and risk of atrial fibrillation: a Mendelian randomization study. PLoS Med. 2020;17(10):e1003288.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bae SC, Lee YH. Vitamin D level and risk of systemic lupus erythematosus and rheumatoid arthritis: a Mendelian randomization. Clin Rheumatol. 2018;37(9):2415–21.

Article  PubMed  Google Scholar 

Bowden J, Del Greco MF, Minelli C, Davey Smith G, Sheehan N, Thompson J. A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization. Stat Med. 2017;36(11):1783–802.

Article  PubMed  PubMed Central  Google Scholar 

Burgess S, Thompson SG. Interpreting findings from Mendelian randomization using the MR-Egger method. Eur J Epidemiol. 2017;32(5):377–89.

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Davey Smith G, Haycock PC, Burgess S. Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol. 2016;40(4):304–14.

Article  PubMed  PubMed Central  Google Scholar 

Sun W, Zhang L, Liu W, Tian M, Wang X, Liang J, et al. Stroke and myocardial infarction: a bidirectional mendelian randomization study. Int J Gen Med. 2021;14:9537–45.

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Hemani G, Davey SG. Invited commentary: detecting individual and global horizontal pleiotropy in Mendelian randomization-a job for the humble heterogeneity statistic? Am J Epidemiol. 2018;187(12):2681–5.

PubMed  PubMed Central  Google Scholar 

Verbanck M, Chen CY, Neale B, Do R. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet. 2018;50(5):693–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Lu N, Peloquin C, Dubreuil M, Neogi T, Aviña-Zubieta JA, et al. Improved survival in rheumatoid arthritis: a general population-based cohort study. Ann Rheum Dis. 2017;76(2):408–13.

Article  PubMed  Google Scholar 

Carpenter L, Norton S, Nikiphorou E, Jayakumar K, McWilliams DF, Rennie KL, et al. Reductions in radiographic progression in early rheumatoid arthritis over twenty-five years: changing contribution from rheumatoid factor in two multicenter UK inception cohorts. Arthritis Care Res (Hoboken). 2017;69(12):1809–17.

Article  PubMed  Google Scholar 

Joaquim AF, Appenzeller S. Cervical spine involvement in rheumatoid arthritis–a systematic review. Autoimmun Rev. 2014;13(12):1195–202.

Article  PubMed  Google Scholar 

Jablecki CK, Andary MT, Floeter MK, Miller RG, Quartly CA, Vennix MJ, et al. Practice parameter: electrodiagnostic studies in carpal tunnel syndrome. Report of the American Association of Electrodiagnostic Medicine, American Academy of Neurology, and the American Academy of Physical Medicine and Rehabilitation. Neurology. 2002;58(11):1589–92.

Article  CAS  PubMed  Google Scholar 

McQueen FM, Ostergaard M. Established rheumatoid arthritis-new imaging modalities. Best Pract Res Clin Rheumatol. 2007;21(5):841–56.

Article  PubMed  Google Scholar 

Smerilli G, Di Matteo A, Cipolletta E, Carloni S, Incorvaia A, Di Carlo M, et al. Ultrasound assessment of carpal tunnel in rheumatoid arthritis and idiopathic carpal tunnel syndrome. Clin Rheumatol. 2021;40(3):1085–92.

Article  PubMed 

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