Modern approaches to radiotherapy in primary cutaneous lymphomas: insights and recommendations from the DEGRO dermato-oncology working group

Dobos G, Miladi M, Michel L et al (2022) Recent advances on cutaneous lymphoma epidemiology. Presse Med 51(1):104108. https://doi.org/10.1016/j.lpm.2022.104108

Article  CAS  PubMed  Google Scholar 

Willemze R, Cerroni L, Kempf W et al (2019) The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood 133(16):1703–1714. https://doi.org/10.1182/blood-2018-11-881268

Article  CAS  PubMed  PubMed Central  Google Scholar 

Agar NS, Wedgeworth E, Crichton S et al (2010) Survival outcomes and prognostic factors in mycosis fungoides/Sezary syndrome: validation of the revised International Society for Cutaneous Lymphomas/European Organisation for Research and Treatment of Cancer staging proposal. J Clin Oncol 28(31):4730–4739. https://doi.org/10.1200/JCO.2009.27.7665

Article  PubMed  Google Scholar 

Molloy K, Jonak C, Woei-A-Jin FJSH et al (2020) Characteristics associated with significantly worse quality of life in mycosis fungoides/Sézary syndrome from the Prospective Cutaneous Lymphoma International Prognostic Index (PROCLIPI) study. Br J Dermatol 182(3):770–779. https://doi.org/10.1111/bjd.18089

Article  CAS  PubMed  Google Scholar 

Lawrance N, Farquharson N, Parry E et al (2023) Quality of life in cutaneous lymphoma varies by lymphoma type. Eur J Cancer 190:113073. https://doi.org/10.1016/j.ejca.2023.113073

Article  Google Scholar 

Sampogna F, Frontani M, Baliva G et al (2009) Quality of life and psychological distress in patients with cutaneous lymphoma. Br J Dermatol 160(4):815–822. https://doi.org/10.1111/j.1365-2133.2008.08992.x

Article  CAS  PubMed  Google Scholar 

Demierre M‑F, Tien A, Miller D (2005) Health-related quality-of-life assessment in patients with cutaneous T‑cell lymphoma. Arch Dermatol 141(3):325–330. https://doi.org/10.1001/archderm.141.3.325

Article  PubMed  Google Scholar 

Nawar T, Elsayad K, Müller EC et al (2021) Quality of life in mycosis fungoides and Sézary-syndrome patients undergoing low-dose total skin electron beam therapy with or without maintenance therapy. J Am Acad Dermatol. https://doi.org/10.1016/j.jaad.2021.03.025

Article  PubMed  Google Scholar 

Heger A, Elsayad K, Kandler C et al (2024) Health-related quality of life in primary cutaneous B‑cell lymphoma following local radiotherapy. Jaad Int. https://doi.org/10.1016/j.jdin.2024.07.002

Article  PubMed  PubMed Central  Google Scholar 

Latzka J, Assaf C, Bagot M et al (2023) EORTC consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome—update 2023. Eur J Cancer. https://doi.org/10.1016/j.ejca.2023.113343

Article  PubMed  Google Scholar 

Dippel E, Assaf C, Becker JC et al (2022) S2k-Leitlinie – Kutane Lymphome (ICD 10 C82–C86): Update 2021. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology. JDDG 20(4):537–555. https://doi.org/10.1111/ddg.14706_g

Article  PubMed  Google Scholar 

Elsayad K, Guenova E, Assaf C et al (2024) Radiotherapy in cutaneous lymphomas: Recommendations from the EORTC cutaneous lymphoma tumour group. Eur J Cancer 212:115064. https://doi.org/10.1016/j.ejca.2024.115064

Article  CAS  PubMed  Google Scholar 

Elsayad K, Guenova E, Fournier B et al (2024) Real-World Pattern-of-Care Analysis of Primary Cutaneous Lymphomas Radiation Therapy Among European Organisation for Research and Treatment of Cancer Members. Int J Radiat Oncol Biol Phys. https://doi.org/10.1016/j.ijrobp.2024.11.011

Article  PubMed  Google Scholar 

Barsoumian HB, Sezen D, Menon H et al (2022) High Plus Low Dose Radiation Strategy in Combination with TIGIT and PD1 Blockade to Promote Systemic Antitumor Responses. Cancers. https://doi.org/10.3390/cancers14010221

Article  PubMed  PubMed Central  Google Scholar 

Demaria S, Ng B, Devitt ML et al (2004) Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol 58(3):862–870. https://doi.org/10.1016/j.ijrobp.2003.09.012

Article  Google Scholar 

Reits EA, Hodge JW, Herberts CA et al (2006) Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med 203(5):1259–1271. https://doi.org/10.1084/jem.20052494

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lievens Y, Borras JM, Grau C (2015) Cost calculation: a necessary step towards widespread adoption of advanced radiotherapy technology. Acta Oncol 54(9):1275–1281. https://doi.org/10.3109/0284186X.2015.1066932

Article  PubMed  Google Scholar 

Patel AM, West L, Atluri PS et al (2022) Optimizing Palliative Focal Radiation Therapy Dose in Cutaneous T‑Cell Lymphoma: How Low Can You Go? Pract Radiat Oncol. https://doi.org/10.1016/j.prro.2022.10.004

Article  PubMed  PubMed Central  Google Scholar 

Neelis KJ, Schimmel EC, Vermeer MH et al (2009) Low-dose palliative radiotherapy for cutaneous B‑ and T‑cell lymphomas. Int J Radiat Oncol Biol Phys 74(1):154–158. https://doi.org/10.1016/j.ijrobp.2008.06.1918

Article  PubMed  Google Scholar 

Juliette M., Kersten Rosanne, Ottevanger Saskia E., Rademakers Maarten H., Vermeer Koen D., Quint Karen. J., Neelis (2025) Modified Recommendations for the Radiation Dose in Patients with Mycosis Fungoides and Localized Lesional Disease Based on a Retrospective Analysis of Treatment Outcomes Practical Radiation Oncology. https://doi.org/10.1016/j.prro.2025.06.006

Article  Google Scholar 

Hoppe RT, Harrison C, Tavallaee M et al (2015) Low-dose total skin electron beam therapy as an effective modality to reduce disease burden in patients with mycosis fungoides: results of a pooled analysis from 3 phase-II clinical trials. J Am Acad Dermatol 72(2):286–292. https://doi.org/10.1016/j.jaad.2014.10.014

Article  PubMed  Google Scholar 

Kamstrup MR, Gniadecki R, Iversen L et al (2015) Low-dose (10-Gy) total skin electron beam therapy for cutaneous T‑cell lymphoma: an open clinical study and pooled data analysis. Int J Radiat Oncol Biol Phys 92(1):138–143. https://doi.org/10.1016/j.ijrobp.2015.01.047

Article  PubMed  Google Scholar 

Morris SL, Scarisbrick J, Frew JJ et al (2017) The results of Low dose Total Skin Electron Beam Radiotherapy (TSEB). In: patients with mycosis fungoides from the UK cutaneous lymphoma group. International Journal of Radiation Oncology*Biology*Physics. in https://doi.org/10.1016/j.ijrobp.2017.05.052

Chapter  Google Scholar 

Smits K, Quint KD, Vermeer MH et al (2022) Total skin electron beam therapy for cutaneous T‑cell lymphomas in the Netherlands: A retrospective analysis of treatment outcomes and selection for high or low dose schedule. Clin Transl Radiat Oncol 33:77–82. https://doi.org/10.1016/j.ctro.2021.12.001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elsayad K, Kriz J, Moustakis C et al (2015) Total Skin Electron Beam for Primary Cutaneous T‑cell Lymphoma. Int J Radiat Oncol Biol Phys 93(5):1077–1086. https://doi.org/10.1016/j.ijrobp.2015.08.041

Article  PubMed  Google Scholar 

Elsayad K, Weishaupt C, Moustakis C et al (2023) Ultra-hypofractionated low-dose total skin electron beam in advanced stage mycosis fungoides and Sézary syndrome. Int J Radiat Oncol Biol Phys. https://doi.org/10.1016/j.ijrobp.2023.02.052

Article  PubMed  Google Scholar 

Elsayad K, Stadler R, Steinbrink K et al (2020) Combined total skin radiotherapy and immune checkpoint inhibitors: A promising potential treatment for mycosis fungoides and Sezary syndrome. J Dtsch Dermatologischen Ges = J Ger Soc Dermatology : Jddg 18(3):193–197. https://doi.org/10.1111/ddg.14044

Article  Google Scholar 

Elsayad K, Rolf D, Sunderkötter C et al (2022) Low-dose total skin electron beam therapy plus oral bexarotene maintenance therapy for cutaneous T‑cell lymphoma. J Dtsch Dermatologischen Ges = J Ger Soc Dermatology : Jddg 20(3):279–285. https://doi.org/10.1111/ddg.14657

Article  Google Scholar 

Elsayad K, Falke I, Stadler R et al (2025) Low-Dose Total Skin Electron Beam Radiotherapy in Stage IB-IIB Mycosis Fungoides: Results From the Prospective S-MISR Study. JCO Oncology Advances (2) https://doi.org/10.1200/OA-25-00065

Elsayad K, Kandler C, Siats J et al (2025) Low-dose total skin electron beam therapy in erythrodermic mycosis fungoides and Sezary syndrome: Results From the Prospective S-MISR Study. J Dtsch Dermatol Ges. https://doi.org/10.1111/ddg.15851

Klein RS, Dunlop JD, Samimi SS et al (2013) Improvement in peripheral blood disease burden in patients with Sezary syndrome and leukemic mycosis fungoides after total skin electron beam therapy. J Am Acad Dermatol 68(6):972–977. https://doi.org/10.1016/j.jaad.2012.09.056

Article  PubMed  Google Scholar 

Million L, Yi EJ, Wu F et al (2016) Radiation Therapy for Primary Cutaneous Anaplastic Large Cell Lymphoma: An International Lymphoma Radiation Oncology Group Multi-institutional Experience. Int J Radiat Oncol Biol Phys 95(5):1454–1459. https://doi.org/10.1016/j.ijrobp.2016.03.023

Comments (0)

No login
gif