Chronic endometritis and its association with implantation history, BCL6, and ERA in infertility patients

Lou H, Li N, Guan Y, Zhang Y, Hao D, Cui S. Association between morphologic grading and implantation rate of euploid blastocyst. J Ovarian Res. 2021;14:18. https://doi.org/10.1186/s13048-021-00770-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pirtea P, Scott RT, De Ziegler D, Ayoubi JM. Recurrent implantation failure: how common is it? Curr Opin Obstet Gynecol. 2021;33:207–12. https://doi.org/10.1097/GCO.0000000000000698.

Article  PubMed  Google Scholar 

Ma J, Gao W, Li D. Recurrent implantation failure: a comprehensive summary from etiology to treatment. Front Endocrinol. 2023;13:1061766. https://doi.org/10.3389/fendo.2022.1061766.

Article  Google Scholar 

Cicinelli E, Matteo M, Tinelli R, Lepera A, Alfonso R, Indraccolo U, et al. Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy. Hum Reprod. 2015;30:323–30. https://doi.org/10.1093/humrep/deu292.

Article  PubMed  Google Scholar 

Kasius JC, Fatemi HM, Bourgain C, Sie-Go DMDS, Eijkemans RJC, Fauser BC, et al. The impact of chronic endometritis on reproductive outcome. Fertil Steril. 2011;96:1451–6. https://doi.org/10.1016/j.fertnstert.2011.09.039.

Article  PubMed  Google Scholar 

Li Y, Yu S, Huang C, Lian R, Chen C, Liu S, et al. Evaluation of peripheral and uterine immune status of chronic endometritis in patients with recurrent reproductive failure. Fertil Steril. 2020;113:187-196.e1. https://doi.org/10.1016/j.fertnstert.2019.09.001.

Article  CAS  PubMed  Google Scholar 

McQueen DB, Maniar KP, Hutchinson A, Confino R, Bernardi L, Pavone ME. Redefining chronic endometritis: the importance of endometrial stromal changes. Fertil Steril. 2021;116:855–61. https://doi.org/10.1016/j.fertnstert.2021.04.036.

Article  PubMed  Google Scholar 

Li J, Li X, Ding J, Zhao J, Chen J, Guan F, et al. Analysis of pregnancy outcomes in patients with recurrent implantation failure complicated with chronic endometritis. Front Cell Dev Biol. 2023;11:1088586. https://doi.org/10.3389/fcell.2023.1088586.

Article  PubMed  PubMed Central  Google Scholar 

Huang W, Liu B, He Y, Xie Y, Liang T, Bi Y, et al. Variation of diagnostic criteria in women with chronic endometritis and its effect on reproductive outcomes: a systematic review and meta-analysis. J Reprod Immunol. 2020;140: 103146. https://doi.org/10.1016/j.jri.2020.103146.

Article  PubMed  Google Scholar 

Pirtea P, Cedars MI, Devine K, Ata B, Franasiak J, Racowsky C, et al. Recurrent implantation failure: reality or a statistical mirage? Fertil Steril. 2023;120:45–59. https://doi.org/10.1016/j.fertnstert.2023.02.014.

Article  PubMed  Google Scholar 

Cicinelli E, Resta L, Nicoletti R, Tartagni M, Marinaccio M, Bulletti C, et al. Detection of chronic endometritis at fluid hysteroscopy. J Minim Invasive Gynecol. 2005;12:514–8. https://doi.org/10.1016/j.jmig.2005.07.394.

Article  PubMed  Google Scholar 

Singh N, Sethi A. Endometritis - diagnosis,treatment and its impact on fertility - a scoping review. JBRA Assist Reprod. 2022. https://doi.org/10.5935/1518-0557.20220015.

Article  PubMed  PubMed Central  Google Scholar 

Li Y, Yu S, Liu W, Chen Y, Yang X, Wu J, et al. The effect of the number of endometrial CD138+ cells on the pregnancy outcomes of infertile patients in the proliferative phase. Front Endocrinol. 2025;15:1437781. https://doi.org/10.3389/fendo.2024.1437781.

Article  Google Scholar 

Strug MR, Hartup LA, Ryan E, Lathi RB. Unveiling the silver lining: a narrative review of clinical evaluation and management of chronic endometritis and its impact on fertility. FS Rev. 2024;5: 100073. https://doi.org/10.1016/j.xfnr.2024.100073.

Article  Google Scholar 

Song D, Feng X, Zhang Q, Xia E, Xiao Y, Xie W, et al. Prevalence and confounders of chronic endometritis in premenopausal women with abnormal bleeding or reproductive failure. Reprod Biomed Online. 2018;36:78–83. https://doi.org/10.1016/j.rbmo.2017.09.008.

Article  PubMed  Google Scholar 

Ota K, Takahashi T, Mitsui J, Kuroda K, Hiraoka K, Kawai K. A case of discrepancy between three ERA tests in a woman with repeated implantation failure complicated by chronic endometritis. BMC Pregnancy Childbirth. 2022;22:891. https://doi.org/10.1186/s12884-022-05241-6.

Article  PubMed  PubMed Central  Google Scholar 

Ekemen S, Comunoglu C, Kayhan CK, Bilir E, Cavusoglu I, Etiler N, et al. Endometrial staining of CD56 (uterine natural killer), BCL-6, and CD138 (plasma cells) improve diagnosis and clinical pregnancy outcomes in unexplained infertility and recurrent IVF failures: standardization of diagnosis with digital pathology. Diagn Basel Switz 2023;13. https://doi.org/10.3390/diagnostics13091557.

Clain E, Devine K. Endometrial receptivity, to test or not to test: the evidence on contemporary assays. FS Rev. 2023;4:50–65. https://doi.org/10.1016/j.xfnr.2022.11.001.

Article  Google Scholar 

Wu D, Kimura F, Zheng L, Ishida M, Niwa Y, Hirata K, et al. Chronic endometritis modifies decidualization in human endometrial stromal cells. Reprod Biol Endocrinol. 2017;15: 16. https://doi.org/10.1186/s12958-017-0233-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Evans-Hoeker E, Lessey BA, Jeong JW, Savaris RF, Palomino WA, Yuan L, et al. Endometrial BCL6 overexpression in eutopic endometrium of women with endometriosis. Reprod Sci. 2016;23:1234–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Almquist LD, Likes CE, Stone B, Brown KR, Savaris R, Forstein DA, et al. Endometrial BCL6 testing for the prediction of in vitro fertilization outcomes: a cohort study. Fertil Steril. 2017;108:1063–9. https://doi.org/10.1016/j.fertnstert.2017.09.017.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Díaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA, Esteban FJ, Alamá P, Pellicer A, et al. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril. 2011;95:50-60.e15. https://doi.org/10.1016/j.fertnstert.2010.04.063.

Article  CAS  PubMed  Google Scholar 

Li Y, Xu Y, Yu S, Lin S, Chen W, Lian R, et al. Chronic endometritis impairs embryo implantation in patients with repeated implantation failure: a retrospective study. Taiwan J Obstet Gynecol. 2022;61:984–8. https://doi.org/10.1016/j.tjog.2021.01.034.

Article  PubMed  Google Scholar 

Liu Y, Chen X, Huang J, Wang C-C, Yu M-Y, Laird S, et al. Comparison of the prevalence of chronic endometritis as determined by means of different diagnostic methods in women with and without reproductive failure. Fertil Steril. 2018;109:832–9. https://doi.org/10.1016/j.fertnstert.2018.01.022.

Article  PubMed  Google Scholar 

Herlihy NS, Klimczak AM, Titus S, Scott C, Hanson BM, Kim JK, et al. The role of endometrial staining for CD138 as a marker of chronic endometritis in predicting live birth. J Assist Reprod Genet. 2022;39:473–9. https://doi.org/10.1007/s10815-021-02374-z.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiong Y, Chen Q, Chen C, Tan J, Wang Z, Gu F, et al. Impact of oral antibiotic treatment for chronic endometritis on pregnancy outcomes in the following frozen-thawed embryo transfer cycles of infertile women: a cohort study of 640 embryo transfer cycles. Fertil Steril. 2021;116:413–21. https://doi.org/10.1016/j.fertnstert.2021.03.036.

Article  CAS  PubMed  Google Scholar 

Takebayashi A, Kimura F, Kishi Y, Ishida M, Takahashi A, Yamanaka A, et al. The association between endometriosis and chronic endometritis. PLoS One. 2014;9: e88354. https://doi.org/10.1371/journal.pone.0088354.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cicinelli E, Trojano G, Mastromauro M, Vimercati A, Marinaccio M, Mitola PC, et al. Higher prevalence of chronic endometritis in women with endometriosis: a possible etiopathogenetic link. Fertil Steril. 2017;108:289-295.e1. https://doi.org/10.1016/j.fertnstert.2017.05.016.

Article  PubMed  Google Scholar 

Kuroda K, Horikawa T, Moriyama A, Nakao K, Juen H, Takamizawa S, et al. Impact of chronic endometritis on endometrial receptivity analysis results and pregnancy outcomes. Immunity Inflamm Dis. 2020;8:650–8. https://doi.org/10.1002/iid3.354.

Article  CAS  Google Scholar 

Doyle N, Combs JC, Jahandideh S, Wilkinson V, Devine K, O’Brien JE. Live birth after transfer of a single euploid vitrified-warmed blastocyst according to standard timing vs. timing as recommended by endometrial receptivity analysis. Fertil Steril 2022;118:314–21. https://doi.org/10.1016/j.fertnstert.2022.05.013.

Comments (0)

No login
gif