Paternot G, Wetzels AM, Thonon F, Vansteenbrugge A, Willemen D, Devroe J, et al. Intra- and interobserver analysis in the morphological assessment of early stage embryos during an IVF procedure: a multicentre study. Reprod Biol Endocrinol. 2011;9:127.
Article PubMed PubMed Central Google Scholar
Storr A, Venetis CA, Cooke S, Kilani S, Ledger W. Inter-observer and intra-observer agreement between embryologists during selection of a single day 5 embryo for transfer: a multicenter study. Hum Reprod. 2017;32:307–14.
Lewis EI, Farhadifar R, Farland LV, Needleman DJ, Missmer SA, Racowsky C. Use of imaging software for assessment of the associations among zona pellucida thickness variation, assisted hatching, and implantation of day 3 embryos. J Assist Reprod Genet. 2017;34:1261–9.
Article PubMed PubMed Central Google Scholar
Zacchini F, Arena R, Abramik A, Ptak GE. Embryo biopsy and development: the known and the unknown. Reproduction. 2017;154:R143–8.
Alteri A, Cermisoni GC, Pozzoni M, Gaeta G, Cavoretto PI, Vigano P. Obstetric, neonatal, and child health outcomes following embryo biopsy for preimplantation genetic testing. Hum Reprod Update. 2023;29:291–306.
Article CAS PubMed PubMed Central Google Scholar
Alix-Panabières C, Pantel K. Clinical applications of circulating tumor cells and circulating tumor DNA as liquid biopsy. Cancer Discov. 2016;6:479–91.
Buscail E. Circulating free DNA in the era of personalized medicine. Cancers (Basel). 2019;11:1656.
Article CAS PubMed Google Scholar
Handayani N, Aubry D, Boediono A, Wiweko B, Sirait B, Sini I, et al. The origin and possible mechanism of embryonic cell-free DNA release in spent embryo culture media: a review. J Assist Reprod Genet. 2023;40:1231–42.
Article PubMed PubMed Central Google Scholar
Vera-Rodriguez M, Diez-Juan A, Jimenez-Almazan J, Martinez S, Navarro R, Peinado V, et al. Origin and composition of cell-free DNA in spent medium from human embryo culture during preimplantation development. Hum Reprod. 2018;33:745–56.
Article CAS PubMed Google Scholar
Ardestani G, Banti M, Garcia-Pascual CM, Navarro-Sanchez L, Van Zyl E, Castellon JA, et al. Culture time to optimize embryo cell-free DNA analysis for frozen-thawed blastocysts undergoing noninvasive preimplantation genetic testing for aneuploidy. Fertil Steril. 2024;122:465–73.
Article CAS PubMed Google Scholar
Huang L, Bogale B, Tang YQ, Lu SJ, Xie XS, Racowsky C. Noninvasive preimplantation genetic testing for aneuploidy in spent medium may be more reliable than trophectoderm biopsy. Proc Natl Acad Sci U S A. 2019;116:14105–12.
Article CAS PubMed PubMed Central Google Scholar
Shitara A, Takahashi K, Goto M, Takahashi H, Iwasawa T, Onodera Y, et al. Cell-free DNA in spent culture medium effectively reflects the chromosomal status of embryos following culturing beyond implantation compared to trophectoderm biopsy. PLoS ONE. 2021;16:e0246438.
Article CAS PubMed PubMed Central Google Scholar
Chen K, Rajewsky N. The evolution of gene regulation by transcription factors and microRNAs. Nat Rev Genet. 2007;8:93–103.
Article CAS PubMed Google Scholar
Hannon GJ. RNA interference. Nature. 2002;418:244–51.
Article CAS PubMed Google Scholar
Chen XX, Zheng Y, Lei AM, Zhang HX, Niu HM, Li XL, et al. Early cleavage of preimplantation embryos is regulated by tRNA-derived small RNAs present in mature spermatozoa. J Biol Chem. 2020;295:10885–900.
Article CAS PubMed PubMed Central Google Scholar
Dehghan Z, Mohammadi-Yeganeh S, Rezaee D, Salehi M. Microrna-21 is involved in oocyte maturation, blastocyst formation, and pre-implantation embryo development. Dev Biol. 2021;480:69–77.
Article CAS PubMed Google Scholar
E.M. Rosenbluth, D.N. Shelton, A.E. Sparks, E. Devor, L. Christenson, B.J. Van Voorhis, MicroRNA expression in the human blastocyst, Fertil Steril 99 (2013) 855–861 e853.
Zhang HD, Zhang FJ, Chen QH, Li MZ, Lv XL, Xiao YL, et al. The piRNA pathway is essential for generating functional oocytes in golden hamsters. Nat Cell Biol. 2021;23:1013-#x0002B;
Article CAS PubMed Google Scholar
Rosenbluth EM, Shelton DN, Wells LM, Sparks AET, Van Voorhis BJ. Human embryos secrete microRNAs into culture media—a potential biomarker for implantation. Fertil Steril. 2014;101:1493–500.
Article CAS PubMed Google Scholar
Xiong Y, Shi L, Zhang M, Zhou C, Mao Y, Hong Z, et al. Differential expression of tsRNAs and miRNAs in embryo culture medium: potential impact on embryo implantation. J Assist Reprod Genet. 2024;41:781–93.
Article PubMed PubMed Central Google Scholar
Lambert M, Benmoussa A, Provost P. Small non-coding RNAs derived from eukaryotic ribosomal RNA. Non-coding RNA. 2019;5:16–28.
Article CAS PubMed PubMed Central Google Scholar
Chak LL, Mohammed J, Lai EC, Tucker-Kellogg G, Okamura K. A deeply conserved, noncanonical miRNA hosted by ribosomal DNA. RNA. 2015;21:375–84.
Article CAS PubMed PubMed Central Google Scholar
Chen Z, Sun Y, Yang X, Wu Z, Guo K, Niu X, et al. Two featured series of rRNA-derived RNA fragments (rRFs) constitute a novel class of small RNAs. PLoS ONE. 2017;12:e0176458.
Article PubMed PubMed Central Google Scholar
J. Garcia-Lopez, L. Alonso, D.B. Cardenas, H. Artaza-Alvarez, D. Hourcade Jde, S. Martinez, M.A. Brieno-Enriquez, J. Del Mazo, Diversity and functional convergence of small noncoding RNAs in male germ cell differentiation and fertilization, RNA 21 (2015) 946–962.
Bartel DP. Metazoan microRNAs. Cell. 2018;173:20–51.
Article CAS PubMed PubMed Central Google Scholar
Olena AF, Patton JG. Genomic organization of microRNAs. J Cell Physiol. 2010;222:540–5.
Article CAS PubMed PubMed Central Google Scholar
Ul Hussain M. Micro-RNAs (miRNAs): genomic organisation, biogenesis and mode of action. Cell Tissue Res. 2012;349:405–13.
Sergiev PV, Aleksashin NA, Chugunova AA, Polikanov YS, Dontsova OA. Structural and evolutionary insights into ribosomal RNA methylation. Nat Chem Biol. 2018;14:226–35.
Article CAS PubMed Google Scholar
Zhang X, Cozen AE, Liu Y, Chen Q, Lowe TM. Small RNA modifications: integral to function and disease. Trends Mol Med. 2016;22:1025–34.
Article CAS PubMed PubMed Central Google Scholar
X. Zhang, F. Trebak, L.A.C. Souza, J. Shi, T. Zhou, P.G. Kehoe, Q. Chen, Y. Feng Earley, Small RNA modifications in Alzheimer’s disease, Neurobiol Dis 145 (2020) 105058.
Shi J, Zhang Y, Tan D, Zhang X, Yan M, Zhang Y, et al. PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications. Nat Cell Biol. 2021;23:424–36.
Article CAS PubMed PubMed Central Google Scholar
Shi J, Zhang Y, Li Y, Zhang L, Zhang X, Yan M, Chen Q, Zhang Y. Optimized identification and characterization of small RNAs with PANDORA-seq. Nat Protoc. 2025 Apr 3.
Albrecht S, Andreani T, Andrade-Navarro MA, Fontaine JF. Single-cell specific and interpretable machine learning models for sparse scChIP-seq data imputation. PLoS ONE. 2022;17:e0270043.
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