Ongoing pregnancy rate is associated with trigger-day progesterone level in letrozole/clomiphene intrauterine insemination cycles

Tjon-Kon-Fat RI, Bensdorp AJ, Bossuyt PMM, et al. Is IVF-served two different ways-more cost-effective than IUI with controlled ovarian hyperstimulation? Hum Reprod. 2015;30(10):2331–9. https://doi.org/10.1093/humrep/dev193.

Article  PubMed  CAS  Google Scholar 

van Rumste MME, Custers IM, van Wely M, et al. IVF with planned single-embryo transfer versus IUI with ovarian stimulation in couples with unexplained subfertility: an economic analysis. Reprod Biomed Online. 2014;28(3):336–42. https://doi.org/10.1016/j.rbmo.2013.10.021.

Article  PubMed  Google Scholar 

Xu B, Li Z, Zhang H, et al. Serum progesterone level effects on the outcome of in vitro fertilization in patients with different ovarian response: an analysis of more than 10,000 cycles. Fertil Steril. 2012;97(6):1321-1327.e1-4. https://doi.org/10.1016/j.fertnstert.2012.03.014.

Article  PubMed  CAS  Google Scholar 

Azem F, Tal G, Lessing JB, et al. Does high serum progesterone level on the day of human chorionic gonadotropin administration affect pregnancy rate after intracytoplasmic sperm injection and embryo transfer? Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol. 2008;24(7):368–72. https://doi.org/10.1080/09513590802196353.

Article  CAS  Google Scholar 

Bosch E, Labarta E, Crespo J, et al. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod. 2010;25(8):2092–100. https://doi.org/10.1093/humrep/deq125.

Article  PubMed  CAS  Google Scholar 

Venetis CA, Kolibianakis EM, Bosdou JK, Tarlatzis BC. Progesterone elevation and probability of pregnancy after IVF: a systematic review and meta-analysis of over 60 000 cycles. Hum Reprod Update. 2013;19(5):433–57. https://doi.org/10.1093/humupd/dmt014.

Article  PubMed  CAS  Google Scholar 

Bu Z, Zhao F, Wang K, et al. Serum progesterone elevation adversely affects cumulative live birth rate in different ovarian responders during in vitro fertilization and embryo transfer: a large retrospective study. PLoS ONE. 2014;9(6):e100011. https://doi.org/10.1371/journal.pone.0100011.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Healy MW, Patounakis G, Connell MT, et al. Does a frozen embryo transfer ameliorate the effect of elevated progesterone seen in fresh transfer cycles? Fertil Steril. 2016;105(1):93-99.e1. https://doi.org/10.1016/j.fertnstert.2015.09.015.

Article  PubMed  CAS  Google Scholar 

Hill MJ, Healy MW, Richter KS, et al. Defining thresholds for abnormal premature progesterone levels during ovarian stimulation for assisted reproduction technologies. Fertil Steril. 2018;110(4):671-679.e2. https://doi.org/10.1016/j.fertnstert.2018.05.007.

Article  PubMed  CAS  Google Scholar 

Requena A, Cruz M, Pacheco A, García-Velasco JA. Ongoing pregnancy rates in intrauterine insemination are affected by late follicular-phase progesterone levels. Fertil Steril. 2015;104(4):879–83. https://doi.org/10.1016/j.fertnstert.2015.06.026.

Article  PubMed  CAS  Google Scholar 

Mutlu MF, Erdem M, Erdem A, Mutlu I, Guler I, Demirdağ E. The impact of premature progesterone rise on the outcome of intrauterine insemination cycles with controlled ovarian hyperstimulation in unexplained infertility. Eur J Obstet Gynecol Reprod Biol. 2016;203:44–8. https://doi.org/10.1016/j.ejogrb.2016.05.013.

Article  PubMed  CAS  Google Scholar 

Burks HR, Peck JD, Gavrizi S, Anderson ZS, Diamond MP, Hansen KR. Effect of prematurely elevated late follicular progesterone on pregnancy outcomes following ovarian stimulation-intrauterine insemination for unexplained infertility: secondary analysis of the AMIGOS trial. Hum Reprod. 2024;39(8):1684–91. https://doi.org/10.1093/humrep/deae113.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Franasiak JM, Forman EJ, Hong KH, et al. The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening. Fertil Steril. 2014;101(3):656-663.e1. https://doi.org/10.1016/j.fertnstert.2013.11.004.

Article  PubMed  Google Scholar 

Haviland MJ, Murphy LA, Modest AM, et al. Comparison of pregnancy outcomes following preimplantation genetic testing for aneuploidy using a matched propensity score design. Hum Reprod. 2020;35(10):2356–64. https://doi.org/10.1093/humrep/deaa161.

Article  PubMed  Google Scholar 

Simopoulou M, Sfakianoudis K, Maziotis E, et al. PGT-A: who and when? Α systematic review and network meta-analysis of RCTs. J Assist Reprod Genet. 2021;38(8):1939–57. https://doi.org/10.1007/s10815-021-02227-9.

Article  PubMed  PubMed Central  Google Scholar 

Cheng X, Zhang Y, Deng H, et al. Preimplantation genetic testing for aneuploidy with comprehensive chromosome screening in patients undergoing in vitro fertilization: a systematic review and meta-analysis. Obstet Gynecol. 2022;140(5):769–77. https://doi.org/10.1097/AOG.0000000000004962.

Article  PubMed  CAS  Google Scholar 

Pineles BL, Park E, Samet JM. Systematic review and meta-analysis of miscarriage and maternal exposure to tobacco smoke during pregnancy. Am J Epidemiol. 2014;179(7):807–23. https://doi.org/10.1093/aje/kwt334.

Article  PubMed  PubMed Central  Google Scholar 

Ng M, Freeman MK, Fleming TD, et al. Smoking prevalence and cigarette consumption in 187 countries, 1980–2012. JAMA. 2014;311(2):183–92. https://doi.org/10.1001/jama.2013.284692.

Article  PubMed  CAS  Google Scholar 

Liu L, Huang J, Li TC, et al. The effect of elevated progesterone levels before oocyte retrieval in women undergoing ovarian stimulation for IVF treatment on the genomic profile of peri-implantation endometrium. J Reprod Immunol. 2017;121:17–25. https://doi.org/10.1016/j.jri.2017.05.001.

Article  PubMed  CAS  Google Scholar 

Van Vaerenbergh I, Fatemi HM, Blockeel C, et al. Progesterone rise on HCG day in GnRH antagonist/rFSH stimulated cycles affects endometrial gene expression. Reprod Biomed Online. 2011;22(3):263–71. https://doi.org/10.1016/j.rbmo.2010.11.002.

Article  PubMed  CAS  Google Scholar 

Labarta E, Martínez-Conejero JA, Alamá P, et al. Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011;26(7):1813–25. https://doi.org/10.1093/humrep/der126.

Article  PubMed  CAS  Google Scholar 

Chen C, Zhao Y, Yu Y, Li R, Qiao J. MiR-125b regulates endometrial receptivity by targeting MMP26 in women undergoing IVF-ET with elevated progesterone on HCG priming day. Sci Rep. 2016;6:25302. https://doi.org/10.1038/srep25302.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Xiong Y, Wang J, Liu L, et al. Effects of high progesterone level on the day of human chorionic gonadotrophin administration in in vitro fertilization cycles on epigenetic modification of endometrium in the peri-implantation period. Fertil Steril. 2017;108(2):269-276.e1. https://doi.org/10.1016/j.fertnstert.2017.06.004.

Article  PubMed  CAS  Google Scholar 

Vanni VS, Somigliana E, Reschini M, et al. Top quality blastocyst formation rates in relation to progesterone levels on the day of oocyte maturation in GnRH antagonist IVF/ICSI cycles. PLoS ONE. 2017;12(5):e0176482. https://doi.org/10.1371/journal.pone.0176482.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Huang B, Ren X, Wu L, et al. Elevated progesterone levels on the day of oocyte maturation may affect top quality embryo IVF cycles. PLoS ONE. 2016;11(1):e0145895. https://doi.org/10.1371/journal.pone.0145895.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hernandez-Nieto C, Lee JA, Alkon-Meadows T, et al. Late follicular phase progesterone elevation during ovarian stimulation is not associated with decreased implantation of chromosomally screened embryos in thaw cycles. Hum Reprod. 2020;35(8):1889–99. https://doi.org/10.1093/humrep/deaa123.

Article  PubMed  Google Scholar 

Comments (0)

No login
gif