McPherson S, et al. Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management. J Hepatol. 2015;62(5):1148–55.
Geh D, Anstee QM, and Reeves HL 2021 NAFLD-associated HCC: progress and opportunities. J Hepatocell Carcinoma. 223 239.
Song Q, Zhang X. The role of gut–liver axis in gut microbiome dysbiosis associated NAFLD and NAFLD-HCC. Biomedicines. 2022;10(3):524.
Article PubMed PubMed Central Google Scholar
Ufnal M, Zadlo A, Ostaszewski R. TMAO: A small molecule of great expectations. Nutrition. 2015;31(11–12):1317–23.
Article CAS PubMed Google Scholar
He M, et al. Gut microbiota-derived trimethylamine-N-oxide: A bridge between dietary fatty acid and cardiovascular disease? Food Res Int. 2020;138:109812.
Article CAS PubMed Google Scholar
Yang G, Zhang X. TMAO promotes apoptosis and oxidative stress of pancreatic acinar cells by mediating IRE1α-XBP-1 pathway. Saudi J Gastroenterol. 2021;27(6):361.
Article PubMed PubMed Central Google Scholar
Fang Q, et al. Trimethylamine N-oxide exacerbates renal inflammation and fibrosis in rats with diabetic kidney disease. Front Physiol. 2021;12:682482.
Article PubMed PubMed Central Google Scholar
Yang G, et al. Nobiletin prevents trimethylamine oxide-induced vascular inflammation via inhibition of the NF-κB/MAPK pathways. J Agric Food Chem. 2019;67(22):6169–76.
Article CAS PubMed Google Scholar
Deng Y, et al. Effects of Shugan-Jianpi recipe on the expression of the p38 MAPK/NF-κB signaling pathway in the hepatocytes of NAFLD rats. Medicines. 2018;5(3):106.
Article CAS PubMed PubMed Central Google Scholar
Imarisio C, et al. Oxidative and ER stress-dependent ASK1 activation in steatotic hepatocytes and Kupffer cells sensitizes mice fatty liver to ischemia/reperfusion injury. Free Radical Biol Med. 2017;112:141–8.
Scott MJ, Billiar TR. β2-Integrin-induced p38 MAPK Activation Is a Key Mediator in the CD14/TLR4/MD2-dependent Uptake of Lipopolysaccharide by Hepatocytes∗. J Biol Chem. 2008;283(43):29433–46.
Article CAS PubMed PubMed Central Google Scholar
Stojsavljević S, et al. Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol. 2014;20(48):18070.
Article PubMed PubMed Central Google Scholar
Niederreiter L, Tilg H. Cytokines and fatty liver diseases. Liver Research. 2018;2(1):14–20.
Thirunavukkarasu C, Watkins SC, Gandhi CR. Mechanisms of endotoxin-induced NO, IL-6, and TNF-α production in activated rat hepatic stellate cells: Role of p38 MAPK. Hepatology. 2006;44(2):389–98.
Article CAS PubMed Google Scholar
Fanaei H, et al. Gallic acid protects the liver against NAFLD induced by dust exposure and high-fat diet through inhibiting oxidative stress and repressing the inflammatory signaling pathways NF-kβ/TNF-α/IL-6 in Wistar rats. Avicenna J Phytomed. 2021;11(5):527.
CAS PubMed PubMed Central Google Scholar
Zhang X, et al. Macrophage p38α promotes nutritional steatohepatitis through M1 polarization. J Hepatol. 2019;71(1):163–74.
Article CAS PubMed Google Scholar
Ghafouri-Fard S, et al. Highly upregulated in liver cancer (HULC): An update on its role in carcinogenesis. J Cell Physiol. 2020;235(12):9071–9.
Article CAS PubMed Google Scholar
Xin X, et al. Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a. Mol Cancer. 2018;17(1):1–16.
Yu X, et al. HULC: an oncogenic long non-coding RNA in human cancer. J Cell Mol Med. 2017;21(2):410–7.
Article CAS PubMed Google Scholar
Shen X, et al. Inhibition of lncRNA HULC improves hepatic fibrosis and hepatocyte apoptosis by inhibiting the MAPK signaling pathway in rats with nonalcoholic fatty liver disease. J Cell Physiol. 2019;234(10):18169–79.
Article CAS PubMed Google Scholar
Cui M, et al. Long noncoding RNA HULC modulates abnormal lipid metabolism in Hepatoma cells through an miR-9–mediated RXRA signaling pathway. Can Res. 2015;75(5):846–57.
Moradzad M, et al. Possible correlation between high circulatory levels of trimethylamine-N-oxide and 2177G> C polymorphisms of hepatic flavin containing monooxygenase 3 in Kurdish Population with non-alcoholic fatty liver disease. Mol Biol Rep. 2022;49(7):5927–37.
Article CAS PubMed Google Scholar
Theofilis P, Vordoni A, Kalaitzidis RG. Trimethylamine N-Oxide levels in non-alcoholic fatty liver disease: A systematic review and meta-analysis. Metabolites. 2022;12(12):1243.
Article CAS PubMed PubMed Central Google Scholar
Abdolahi A et al., 2022 Vaspin attenuates steatosis-induced fibrosis via GRP78 receptor by targeting AMPK signaling pathway. J Physiol Biochem. 1 13.
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2− ΔΔCT method. Methods. 2001;25(4):402–8.
Article CAS PubMed Google Scholar
Chen Y-M, et al. Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults. Sci Rep. 2016;6(1):19076.
Article CAS PubMed PubMed Central Google Scholar
Ye M, et al. Scoparone inhibits the development of hepatocellular carcinoma by modulating the p38 MAPK/Akt/NF-κB signaling in nonalcoholic fatty liver disease mice. Environ Toxicol. 2024;39(2):551–61.
Article CAS PubMed Google Scholar
Zhu M, et al. Amorphous selenium nanodots alleviate non-alcoholic fatty liver disease via activating VEGF receptor 1 to further inhibit phosphorylation of JNK/p38 MAPK pathways. Eur J Pharmacol. 2022;932:175235.
Article CAS PubMed Google Scholar
Alshehade S, et al. The role of protein kinases as key drivers of metabolic dysfunction-associated fatty liver disease progression: New insights and future directions. Life Sci. 2022;305:120732.
Article CAS PubMed Google Scholar
Stefania K, et al. TMAO enhances TNF-α mediated fibrosis and release of inflammatory mediators from renal fibroblasts. Sci Rep. 2024;14(1):9070.
Article CAS PubMed PubMed Central Google Scholar
Trépo E, et al. PNPLA3 gene in liver diseases. J Hepatol. 2016;65(2):399–412.
Li T, et al. Activated NK cells kill hepatic stellate cells via p38/PI3K signaling in a TRAIL-involved degranulation manner. J Leukoc Biol. 2019;105(4):695–704.
Article CAS PubMed Google Scholar
Singal AG, et al. The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis. Am J Gastroenterol. 2014;109(3):325.
Article CAS PubMed PubMed Central Google Scholar
Hatori K, Iwasaki T, Wada R. Effect of urea and trimethylamine N-oxide on the binding between actin molecules. Biophys Chem. 2014;193:20–6.
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