MLKL–Mediated Necroptosis Predominantly Contributes to Immune-Associated Myocardial Damage

Frangogiannis, N.G. 2014. The inflammatory response in myocardial injury, repair, and remodelling. Nature Reviews Cardiology 11: 255–265. https://doi.org/10.1038/nrcardio.2014.28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rose, M.L., and M.H. Yacoub. 1989. Heart transplantation: Cellular and humoral immunity. Springer Seminars in Immunopathology 11: 423–438. https://doi.org/10.1007/BF00201880.

Article  CAS  PubMed  Google Scholar 

Kyaw, T., G. Drummond, A. Bobik, and K. Peter. 2023. Myocarditis: Causes, mechanisms, and evolving therapies. Expert Opinion on Therapeutic Targets 27: 225–238. https://doi.org/10.1080/14728222.2023.2193330.

Article  CAS  PubMed  Google Scholar 

Swirski, F.K., and M. Nahrendorf. 2018. Cardioimmunology: The immune system in cardiac homeostasis and disease. Nature Reviews Immunology 18: 733–744. https://doi.org/10.1038/s41577-018-0065-8.

Article  CAS  PubMed  Google Scholar 

Kociol, R.D., Cooper, L.T., Fang, J.C., Moslehi, J.J., Pang, P.S., Sabe, M.A., Shah, R.V., Sims, D.B., Thiene, G., Vardeny, O. 2020. Recognition and Initial Management of Fulminant Myocarditis. Circulation 141. https://doi.org/10.1161/cir.0000000000000745

Caforio, A.L.P., S. Pankuweit, E. Arbustini, C. Basso, J. Gimeno-Blanes, S.B. Felix, M. Fu, T. Helio, S. Heymans, R. Jahns, K. Klingel, A. Linhart, B. Maisch, W. McKenna, J. Mogensen, Y.M. Pinto, A. Ristic, H.P. Schultheiss, H. Seggewiss, L. Tavazzi, G. Thiene, A. Yilmaz, P. Charron, and P.M. Elliott. 2013. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: A position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. European Heart Journal 34: 2636–2648. https://doi.org/10.1093/eurheartj/eht210.

Article  PubMed  Google Scholar 

Schadendorf, D., A.C.J. van Akkooi, C. Berking, K.G. Griewank, R. Gutzmer, A. Hauschild, A. Stang, A. Roesch, and S. Ugurel. 2018. Melanoma. Lancet 392: 971–984. https://doi.org/10.1016/S0140-6736(18)31559-9.

Article  PubMed  Google Scholar 

Borghaei, H., L. Paz-Ares, L. Horn, D.R. Spigel, M. Steins, N.E. Ready, L.Q. Chow, E.E. Vokes, E. Felip, E. Holgado, F. Barlesi, M. Kohlhaufl, O. Arrieta, M.A. Burgio, J. Fayette, H. Lena, E. Poddubskaya, D.E. Gerber, S.N. Gettinger, C.M. Rudin, N. Rizvi, L. Crino, G.R. Blumenschein Jr., S.J. Antonia, C. Dorange, C.T. Harbison, F. Graf Finckenstein, and J.R. Brahmer. 2015. Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer. The New England journal of medicine 373: 1627–1639. https://doi.org/10.1056/NEJMoa1507643.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Quhal, F., K. Mori, A. Bruchbacher, I. Resch, H. Mostafaei, B. Pradere, V.M. Schuettfort, E. Laukhtina, S. Egawa, H. Fajkovic, M. Remzi, S.F. Shariat, and M. Schmidinger. 2021. First-line Immunotherapy-based Combinations for Metastatic Renal Cell Carcinoma: A Systematic Review and Network Meta-analysis. European Urology Oncology 4: 755–765. https://doi.org/10.1016/j.euo.2021.03.001.

Article  PubMed  Google Scholar 

Kraehenbuehl, L., C.H. Weng, S. Eghbali, J.D. Wolchok, and T. Merghoub. 2022. Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways. Nature Reviews Clinical Oncology 19: 37–50. https://doi.org/10.1038/s41571-021-00552-7.

Article  CAS  PubMed  Google Scholar 

Marei, H.E., Hasan, A., Pozzoli, G., Cenciarelli, C. 2023. Cancer immunotherapy with immune checkpoint inhibitors (ICIs): potential, mechanisms of resistance, and strategies for reinvigorating T cell responsiveness when resistance is acquired. Cancer Cell International 23. https://doi.org/10.1186/s12935-023-02902-0

Salem, J.-E., A. Manouchehri, M. Moey, B. Lebrun-Vignes, L. Bastarache, A. Pariente, A. Gobert, J.-P. Spano, J.M. Balko, M.P. Bonaca, D.M. Roden, D.B. Johnson, and J.J. Moslehi. 2018. Cardiovascular toxicities associated with immune checkpoint inhibitors: An observational, retrospective, pharmacovigilance study. The Lancet Oncology 19: 1579–1589. https://doi.org/10.1016/s1470-2045(18)30608-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johnson, D.B., J.M. Balko, M.L. Compton, S. Chalkias, J. Gorham, Y. Xu, M. Hicks, I. Puzanov, M.R. Alexander, T.L. Bloomer, J.R. Becker, D.A. Slosky, E.J. Phillips, M.A. Pilkinton, L. Craig-Owens, N. Kola, G. Plautz, D.S. Reshef, J.S. Deutsch, R.P. Deering, B.A. Olenchock, A.H. Lichtman, D.M. Roden, C.E. Seidman, I.J. Koralnik, J.G. Seidman, R.D. Hoffman, J.M. Taube, L.A. Diaz Jr., R.A. Anders, J.A. Sosman, and J.J. Moslehi. 2016. Fulminant Myocarditis with Combination Immune Checkpoint Blockade. The New England journal of medicine 375: 1749–1755. https://doi.org/10.1056/NEJMoa1609214.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bracamonte-Baran, W., Čiháková, D. 2017. Cardiac Autoimmunity: Myocarditis. 1003:187-221. https://doi.org/10.1007/978-3-319-57613-8_10

Matzen, E., Bartel,s L.E, Løgstrup, B., Horskær, S., Stilling, C., Donskov, F. 2021. Immune checkpoint inhibitor-induced myocarditis in cancer patients: a case report and review of reported cases. Cardio-Oncology 7. https://doi.org/10.1186/s40959-021-00114-x

Duarte, T., C. Costa, S. Gonçalves, L. Raposo, A. Ferreira, C. Albuquerque, N. Vau, and R. Caria. 2022. A case of lymphocytic myocarditis in a patient treated with an immune checkpoint inhibitor, a recent class of chemotherapy agents. Revista Portuguesa de Cardiologia 41: 1047–1051. https://doi.org/10.1016/j.repc.2019.03.013.

Article  PubMed  Google Scholar 

Lehmann, L.H., J. Cautela, N. Palaskas, A.H. Baik, W.C. Meijers, Y. Allenbach, J. Alexandre, T. Rassaf, O.J. Muller, M. Aras, A.H. Asnani, A. Deswal, M. Laufer-Perl, F. Thuny, M. Kerneis, S.S. Hayek, S. Ederhy, J.E. Salem, and J.J. Moslehi. 2021. Clinical Strategy for the Diagnosis and Treatment of Immune Checkpoint Inhibitor-Associated Myocarditis: A Narrative Review. JAMA Cardiology 6: 1329–1337. https://doi.org/10.1001/jamacardio.2021.2241.

Article  PubMed  Google Scholar 

Laubli, H., C. Balmelli, M. Bossard, O. Pfister, K. Glatz, and A. Zippelius. 2015. Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma. Journal for ImmunoTherapy of Cancer 3: 11. https://doi.org/10.1186/s40425-015-0057-1.

Article  PubMed  PubMed Central  Google Scholar 

Axelrod, M.L., W.C. Meijers, E.M. Screever, J. Qin, M.G. Carroll, X. Sun, E. Tannous, Y. Zhang, A. Sugiura, B.C. Taylor, A. Hanna, S. Zhang, K. Amancherla, W. Tai, J.J. Wright, S.C. Wei, S.R. Opalenik, A.L. Toren, J.C. Rathmell, P.B. Ferrell, E.J. Phillips, S. Mallal, D.B. Johnson, J.P. Allison, J.J. Moslehi, and J.M. Balko. 2022. T cells specific for alpha-myosin drive immunotherapy-related myocarditis. Nature 611: 818–826. https://doi.org/10.1038/s41586-022-05432-3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Won, T., H.M. Kalinoski, M.K. Wood, D.M. Hughes, C.M. Jaime, P. Delgado, M.V. Talor, N. Lasrado, J. Reddy, and D. Cihakova. 2022. Cardiac myosin-specific autoimmune T cells contribute to immune-checkpoint-inhibitor-associated myocarditis. Cell Reports 41: 111611. https://doi.org/10.1016/j.celrep.2022.111611.

Article  CAS  PubMed  Google Scholar 

Shi, C., P. Cao, Y. Wang, Q. Zhang, D. Zhang, Y. Wang, L. Wang, and Z. Gong. 2023. PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis. Journal of Inflammation Research 16: 1523–1532. https://doi.org/10.2147/jir.s403819.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Newton, K., A. Strasser, N. Kayagaki, and V.M. Dixit. 2024. Cell death. Cell 187: 235–256. https://doi.org/10.1016/j.cell.2023.11.044.

Article  CAS  PubMed  Google Scholar 

Quagliariello, V., Passariello, M, Rea, D., Barbieri, A., Iovine, M., Bonelli, A., Caronna, A., Botti, G., De Lorenzo, C., Maurea, N. 2020. Evidences of CTLA-4 and PD-1 Blocking Agents-Induced Cardiotoxicity in Cellular and Preclinical Models. Journal of Personalized Medicine 10. https://doi.org/10.3390/jpm10040179

Sun, S-J., Jiao, X-D., Chen, Z-G., Cao, Q., Zhu, J-H., Shen, Q-R., Liu, Y., Zhang, Z., Xu, F-F., Shi, Y., Tong, J., Ouyang, S-X., Fu, J-T., Zhao, Y., Ren, J., Li, D-J., Shen, F-M., Wang, P. 2024. Gasdermin-E-mediated pyroptosis drives immune checkpoint inhibitor-associated myocarditis via cGAS-STING activation. Nature Communications 15. https://doi.org/10.1038/s41467-024-50996-5

Wu, Y., Zheng, Z., Cao, X., Yang, Q., Norton, V., Adini, A., Maiti, A.K., Adini, I., Wu, H. 2021. RIP1/RIP3/MLKL Mediates Myocardial Function Through Necroptosis in Experimental Autoimmune Myocarditis. Frontiers in Cardiovascular Medicine 8. https://doi.org/10.3389/fcvm.2021.696362

Piccini, I., J. Rao, G. Seebohm, and B. Greber. 2015. Human pluripotent stem cell-derived cardiomyocytes: Genome-wide expression profiling of long-term in vitro maturation in comparison to human heart tissue. Genomics Data 4: 69–72. https://doi.org/10.1016/j.gdata.2015.03.008.

Article  PubMed  PubMed Central  Google Scholar 

Smith, A.S.T., J. Macadangdang, W. Leung, M.A. Laflamme, and D.-H. Kim. 2017. Human iPSC-derived cardiomyocytes and tissue engineering strategies for disease modeling and drug screening. Biotechnology Advances 35: 77–94. https://doi.org/10.1016/j.biotechadv.2016.12.002.

Article  CAS  PubMed  Google Scholar 

Thompson, C.B., T. Lindsten, J.A. Ledbetter, S.L. Kunkel, H.A. Young, S.G. Emerson, J.M. Leiden, and C.H. June. 1989. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proceedings of the National Academy of Sciences of the United States of America 86: 1333–1337. https://doi.org/10.1073/pnas.86.4.1333.

Article  CAS  PubMed  PubMed Central  Google Scholar 

An, F., Wang, H., Liu, Z., Wu, F., Zhang, J., Tao, Q., Li, Y., Shen, Y., Ruan, Y., Zhang, Q., Pan, Y., Zhu, W., Qin, H., Wang, Y., Fu, Y., Feng, Z., Zhai, Z. 2020. Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia. Nature Communications 11. https://doi.org/10.1038/s41467-020-19774-x

Ji, C., M.D. Roy, J. Golas, A. Vitsky, S. Ram, S.W. Kumpf, M. Martin, F. Barletta, W.A. Meier, A.T. Hooper, P. Sapra, N.K. Khan, M. Finkelstein, M. Guffroy, and B.S. Buetow. 2019. Myocarditis in Cynomolgus Monkeys Following Treatment with Immune Checkpoint Inhibitors. Clinical Cancer Research 25: 4735–4748. https://doi.org/10.1158/1078-0432.CCR-18-4083.

Article  CAS  PubMed  Google Scholar 

Zhang, Y., Sun, C., Li, Y., Qin, J., Amancherla, K., Jing,Y., Hu, Q., Liang, K., Zhang, Z., Ye, Y., Huang, L.A., Nguyen, T.K., Egranov, S.D., Zhao, Z., Wu, A., Xi, Y., Yao, J., Hung, M-C., Calin, G.A., Cheng, J., Lim, B., Lehmann, L.H., Salem, J-E., Johnson, D.B., Curran, M.A., Yu, D., Han, L., Darabi, R., Yang, L., Moslehi, J

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