Dellinger, R. Phillip., Mitchell M. Levy, Andrew Rhodes, Djillali Annane, Herwig Gerlach, Steven M. Opal, Jonathan E. Sevransky, et al. 2013. Surviving Sepsis Campaign. Critical Care Medicine 41: 580–637. https://doi.org/10.1097/CCM.0b013e31827e83af.

Article  PubMed  Google Scholar 

Backer, De., Clifford S. Daniel, Judith Hellman Deutschman, Sheila Nainan Myatra, Marlies Ostermann, Hallie C. Prescott, Daniel Talmor, et al. 2024. Surviving Sepsis Campaign Research Priorities 2023. Critical Care Medicine 52: 268–296. https://doi.org/10.1097/CCM.0000000000006135.

Article  PubMed  Google Scholar 

Lu, Hong. 2024. Inflammatory liver diseases and susceptibility to sepsis. Clinical Science 138: 435–487. https://doi.org/10.1042/CS20230522.

Article  CAS  PubMed  Google Scholar 

Maiwall, Rakhi, Anand V. Kulkarni, Juan Pablo Arab, and Salvatore Piano. 2024. Acute liver failure. The Lancet 404: 789–802. https://doi.org/10.1016/S0140-6736(24)00693-7.

Article  CAS  Google Scholar 

Kobashi, Haruhiko, Junichi Toshimori, and Kazuhide Yamamoto. 2013. Sepsis-associated liver injury: Incidence, classification and the clinical significance. Hepatology Research 43: 255–266. https://doi.org/10.1111/j.1872-034X.2012.01069.x.

Article  PubMed  Google Scholar 

Guilliams, Martin, and Charlotte L. Scott. 2022. Liver macrophages in health and disease. Immunity 55: 1515–1529. https://doi.org/10.1016/j.immuni.2022.08.002.

Article  CAS  PubMed  Google Scholar 

MacParland, Sonya A., Jeff C. Liu, Xue-Zhong. Ma, Brendan T. Innes, Agata M. Bartczak, Blair K. Gage, Justin Manuel, et al. 2018. Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations. Nature Communications 9: 4383. https://doi.org/10.1038/s41467-018-06318-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng, Weng Chuan, Catriona Y. Logan, Matt Fish, Teni Anbarchian, Francis Aguisanda, Adrián Álvarez-Varela, Wu. Peng, et al. 2018. Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture. Cell 175: 1607-1619.e15. https://doi.org/10.1016/j.cell.2018.11.012.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Poisson, Johanne, Sara Lemoinne, Chantal Boulanger, François Durand, Richard Moreau, Dominique Valla, and Pierre-Emmanuel. Rautou. 2017. Liver sinusoidal endothelial cells: Physiology and role in liver diseases. Journal of Hepatology 66: 212–227. https://doi.org/10.1016/j.jhep.2016.07.009.

Article  CAS  PubMed  Google Scholar 

Sun, Xuejing, Wu. Junru, Lun Liu, Yuanyuan Chen, Yan Tang, Suzhen Liu, Hang Chen, et al. 2022. Transcriptional switch of hepatocytes initiates macrophage recruitment and T-cell suppression in endotoxemia. Journal of Hepatology 77: 436–452. https://doi.org/10.1016/j.jhep.2022.02.028.

Article  CAS  PubMed  Google Scholar 

Yao, Yongming, Dawei Wang, and Yimei Yin. 2014. Advances in sepsis-associated liver dysfunction. Burns & Trauma 2: 97. https://doi.org/10.4103/2321-3868.132689.

Article  Google Scholar 

Xu, Wanling, Hailong Hou, Weiying Yang, Wenjing Tang, and Lichao Sun. 2024. Immunologic role of macrophages in sepsis-induced acute liver injury. International Immunopharmacology 143: 113492. https://doi.org/10.1016/j.intimp.2024.113492.

Article  CAS  PubMed  Google Scholar 

Strnad, Pavel, Frank Tacke, Alexander Koch, and Christian Trautwein. 2017. Liver - guardian, modifier and target of sepsis. Nature reviews. Gastroenterology & hepatology 14: 55–66. https://doi.org/10.1038/nrgastro.2016.168.

Article  CAS  Google Scholar 

Kang, Rui, Ling Zeng, Shan Zhu, Yangchun Xie, Jiao Liu, Qirong Wen, Lizhi Cao, et al. 2018. Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis. Cell Host & Microbe 24: 97-108.e4. https://doi.org/10.1016/j.chom.2018.05.009.

Article  CAS  Google Scholar 

Fu, Jianing, and Wu. Hao. 2023. Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation. Annual Review of Immunology 41: 301–316. https://doi.org/10.1146/annurev-immunol-081022-021207.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmidt, Florian I., Lu. Alvin, Jeff W. Chen, Jianbin Ruan, Catherine Tang, Wu. Hao, and Hidde L. Ploegh. 2016. A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. Journal of Experimental Medicine 213: 771–790. https://doi.org/10.1084/jem.20151790.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi, Jianjin, Yue Zhao, Kun Wang, Xuyan Shi, Yue Wang, Huanwei Huang, Yinghua Zhuang, Tao Cai, Fengchao Wang, and Feng Shao. 2015. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526: 660–665. https://doi.org/10.1038/nature15514.

Article  CAS  PubMed  Google Scholar 

Peng, Fanglin, Yi Wu, Xianping Dong, and Peng Huang. "Proton-Activated Chloride Channel: Physiology and Disease. Frontiers in Bioscience-Landmark 28, no. 1 (2023): 11. https://doi.org/10.31083/j.fbl2801011.

Novarino, Gaia. 2004. Involvement of the Intracellular Ion Channel CLIC1 in Microglia-Mediated -Amyloid-Induced Neurotoxicity. Journal of Neuroscience 24: 5322–5330. https://doi.org/10.1523/JNEUROSCI.1170-04.2004.

Article  CAS  PubMed  Google Scholar 

Landry, D.W., M. Reitman, E.J. Cragoe, and Q. Al-Awqati. 1987. Epithelial chloride channel. Development of inhibitory ligands. The Journal of general physiology 90: 779–798. https://doi.org/10.1085/jgp.90.6.779.

Article  CAS  PubMed  Google Scholar 

Huang, Wenjie, Meiling Tan, Yue Wang, Lei Liu, Yan Pan, Jingjing Li, Mingxing Ouyang, et al. 2020. Increased intracellular Cl - concentration improves airway epithelial migration by activating the RhoA/ROCK Pathway. Theranostics 10: 8528–8540. https://doi.org/10.7150/thno.46002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Loyo-Celis, Veronica, Devendra Patel, Shridhar Sanghvi, Kamalpreet Kaur, Devasena Ponnalagu, Yang Zheng, Sahej Bindra, et al. 2023. Biophysical characterization of chloride intracellular channel 6 (CLIC6). Journal of Biological Chemistry 299: 105349. https://doi.org/10.1016/j.jbc.2023.105349.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Astill, D. St J., G. Rychkov, J. D. Clarke, B. P. Hughes, M. L. Roberts, and A. H. Bretag. Characteristics of skeletal muscle chloride channel CIC-1 and point mutant R304E expressed in Sf-9 insect cells. Biochimica et Biophysica Acta (BBA)-Biomembranes 1280, 2 (1996): 178-186. https://doi.org/10.1016/0005-2736(95)00281-2.

Lelubre, Christophe, and Jean-Louis. Vincent. 2018. Mechanisms and treatment of organ failure in sepsis. Nature Reviews Nephrology 14: 417–427. https://doi.org/10.1038/s41581-018-0005-7.

Article  PubMed  Google Scholar 

Ruart, Maria, Laia Chavarria, Genís Campreciós, Nuria Suárez-Herrera, Carla Montironi, Sergi Guixé-Muntet, Jaume Bosch, Scott L. Friedman, Juan Carlos Garcia-Pagán, and Virginia Hernández-Gea. 2019. Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury. Journal of Hepatology 70: 458–469. https://doi.org/10.1016/j.jhep.2018.10.015.

Article  CAS  PubMed  Google Scholar 

Puche, Juan E., Yedidya Saiman, and Scott L. Friedman. 2013. Hepatic Stellate Cells and Liver Fibrosis. In Comprehensive Physiology, 1473–1492. Wiley. https://doi.org/10.1002/cphy.c120035.

de Andrade, Joao A., and Victor J. Thannickal. 2009. Innovative approaches to the therapy of fibrosis. Current Opinion in Rheumatology 21: 649–655. https://doi.org/10.1097/BOR.0b013e328330da9b.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng, Yujia, Xiaolu Zhang, Ziyu Wang, Ruifeng Zhang, Huayuan Wei, Xu Yan, Xijuan Jiang, and Lin Yang. 2024. MCC950 as a promising candidate for blocking NLRP3 inflammasome activation: A review of preclinical research and future directions. Archiv der Pharmazie 357. https://doi.org/10.1002/ardp.202400459.

Liu, Jiali, Du. Shuya, Qiuyue Kong, Xiaojin Zhang, Surong Jiang, Xiaofei Cao, Yuehua Li, et al. 2020. HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1α-dependent acyloxyacyl hydrolase expression. Cell Death & Differentiation 27: 2651–2667. https://doi.org/10.1038/s41418-020-0536-x.

Article  CAS  Google Scholar 

He, Yuan, Melody Y. Zeng, Dahai Yang, Benny Motro, and Gabriel Núñez. 2016. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature 530: 354–357. https://doi.org/10.1038/nature16959.

Article  CAS  PubMed  PubMed Central