Fiore, N.T., S.R. Debs, J.P. Hayes, S.S. Duffy, and G. Moalem-Taylor. 2023. Pain-resolving immune mechanisms in neuropathic pain. Nature Reviews Neurology 19 (4): 199–220.
Alles, S.R.A., and P.A. Smith. 2018. Etiology and pharmacology of neuropathic pain. Pharmacological Reviews 70 (2): 315–347.
Article CAS PubMed Google Scholar
Cohen, S.P., L. Vase, and W.M. Hooten. 2021. Chronic pain: an update on burden, best practices, and new advances. Lancet 397 (10289): 2082–2097.
Bannister, K., J. Sachau, R. Baron, and A.H. Dickenson. 2020. Neuropathic pain: mechanism-based therapeutics. Annual Review of Pharmacology and Toxicology 60: 257–274.
Article CAS PubMed Google Scholar
Di, Z., C. Zhenni, Z. Zifeng, J. Bei, C. Yong, L. Yixuan, P. Yuwei, G. Li, C. Jiaxu, and Z. Guoping. 2024. Danggui sini decoction normalizes the intestinal microbiota and serum metabolite levels to treat sciatica. Phytomedicine 132: 155740.
Article CAS PubMed Google Scholar
Huang, Y.K., Y.G. Lu, X. Zhao, J.B. Zhang, F.M. Zhang, Y. Chen, L.B. Bi, J.H. Gu, Z.J. Jiang, X.M. Wu, Q.Y. Li, Y. Liu, J.X. Shen, and X.J. Liu. 2020. Cytokine activin C ameliorates chronic neuropathic pain in peripheral nerve injury rodents by modulating the TRPV1 channel. British Journal of Pharmacology 177 (24): 5642–5657.
Article CAS PubMed PubMed Central Google Scholar
Grace, P.M., M.R. Hutchinson, S.F. Maier, and L.R. Watkins. 2014. Pathological pain and the neuroimmune interface. Nature Reviews Immunology 14 (4): 217–231.
Article CAS PubMed PubMed Central Google Scholar
Chen, O., C.R. Donnelly, and R.R. Ji. 2020. Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons. Current Opinion in Neurobiology 62: 17–25.
Article CAS PubMed Google Scholar
Ji, R.R., A. Chamessian, and Y.Q. Zhang. 2016. Pain regulation by non-neuronal cells and inflammation. Science 354 (6312): 572–577.
Article CAS PubMed PubMed Central Google Scholar
Tsuda, M., T. Masuda, and K. Kohno. 2023. Microglial diversity in neuropathic pain. Trends in Neurosciences 46 (7): 597–610.
Article CAS PubMed Google Scholar
Chen, G., Y.Q. Zhang, Y.J. Qadri, C.N. Serhan, and R.R. Ji. 2018. Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain. Neuron 100 (6): 1292–1311.
Article CAS PubMed PubMed Central Google Scholar
Peng, J., G. Nan, L. Zhou, U.B. Eyo, M. Murugan, W.B. Gan, and W. Long-Jun. 2016. Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury. Nature Communications 7: 12029.
Article CAS PubMed PubMed Central Google Scholar
Wang, Q., Y. Xie, S. Ma, H. Luo, and Y. Qiu. 2024. Role of microglia in diabetic neuropathic pain. Front Cell Dev Biol. 12: 1421191.
Article PubMed PubMed Central Google Scholar
Burke, N.N., D.M. Kerr, O. Moriarty, D.P. Finn, and M. Roche. 2014. Minocycline modulates neuropathic pain behaviour and cortical M1–M2 microglial gene expression in a rat model of depression. Brain, Behavior, and Immunity 42: 147–156.
Article CAS PubMed Google Scholar
Jin, J., J. Guo, H. Cai, C. Zhao, H. Wang, Z. Liu, and Z.M. Ge. 2020. M2-like microglia polarization attenuates neuropathic pain associated with Alzheimer’s disease. Journal of Alzheimer’s Disease 76 (4): 1255–1265.
Article CAS PubMed Google Scholar
Wofford, K.L., R.B. Shultz, J.C. Burrell, and D.K. Cullen. 2022. Neuroimmune interactions and immunoengineering strategies in peripheral nerve repair. Progress in Neurobiology 208: 102172.
Article CAS PubMed Google Scholar
Zigmond, R.E., and F.D. Echevarria. 2019. Macrophage biology in the peripheral nervous system after injury. Progress in Neurobiology 173: 102–121.
Article CAS PubMed Google Scholar
Silva, C.E.A., R.M. Guimaraes, and T.M. Cunha. 2021. Sensory neuron-associated macrophages as novel modulators of neuropathic pain. Pain Rep. 6 (1): e873.
Article PubMed PubMed Central Google Scholar
Jiang, B.C., T. Liu, and Y.J. Gao. 2020. Chemokines in chronic pain: Cellular and molecular mechanisms and therapeutic potential. Pharmacology & Therapeutics 212: 107581.
Wang, Q., H.Y. Li, Z.M. Ling, G. Chen, and Z.Y. Wei. 2022. Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses. Journal of Neuroinflammation 19 (1): 244.
Article CAS PubMed PubMed Central Google Scholar
Bruck, W., I. Huitinga, and C.D. Dijkstra. 1996. Liposome-mediated monocyte depletion during wallerian degeneration defines the role of hematogenous phagocytes in myelin removal. Journal of Neuroscience Research 46 (4): 477–484.
Article CAS PubMed Google Scholar
Van Rooijen, N., and A. Sanders. 1994. Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. Journal of Immunological Methods 174 (1–2): 83–93.
Mika, J., E. Rojewska, W. Makuch, and B. Przewlocka. 2010. Minocycline reduces the injury-induced expression of prodynorphin and pronociceptin in the dorsal root ganglion in a rat model of neuropathic pain. Neuroscience 165 (4): 1420–1428.
Article CAS PubMed Google Scholar
Li, Z., H. Wei, S. Piirainen, Z. Chen, E. Kalso, A. Pertovaara, and L. Tian. 2016. Spinal versus brain microglial and macrophage activation traits determine the differential neuroinflammatory responses and analgesic effect of minocycline in chronic neuropathic pain. Brain, Behavior, and Immunity 58: 107–117.
Article CAS PubMed Google Scholar
Santa-Cecília, F.V., D.W. Ferreira, R.M. Guimaraes, N.T. Cecilio, M.M. Fonseca, A.H. Lopes, M. Davoli-Ferreira, R. Kusuda, G.R. Souza, U. Nachbur, J.C. Alves-Filho, M.M. Teixeira, D.S. Zamboni, F.Q. Cunha, and T.M. Cunha. 2019. The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development. Pain 160 (1): 102–116.
Mosser DM, Zhang X (2008) Activation of murine macrophages. Current Protocols Immunology.Chapter 14:14 2 1- 2 8.
Matsuda, M., Y. Huh, and R.R. Ji. 2019. Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain. Journal of Anesthesia 33 (1): 131–139.
Liu, T., N. Van Rooijen, and D.J. Tracey. 2000. Depletion of macrophages reduces axonal degeneration and hyperalgesia following nerve injury. Pain 86 (1–2): 25–32.
Article CAS PubMed Google Scholar
Pan, D., J. Sayanagi, J.A. Acevedo-Cintrón, L. Schellhardt, A.K. Snyder-Warwick, S.E. Mackinnon, and M.D. Wood. 2021. Liposomes embedded within fibrin gels facilitate localized macrophage manipulations within nerve. Journal of neuroscience methods. 348: 108981.
Article CAS PubMed Google Scholar
Jung, S., I. Huitinga, B. Schmidt, J. Zielasek, C.D. Dijkstra, K.V. Toyka, and H.P. Hartung. 1993. Selective elimination of macrophages by dichlormethylene diphosphonate-containing liposomes suppresses experimental autoimmune neuritis. Journal of the Neurological Sciences 1198277335 (2): 195–202.
Miura, T., S. Mitsunaga, M. Ikeda, I. Ohno, H. Takahashi, T. Kuwata, and A. Ochiai. 2018. Neural invasion spreads macrophage-related allodynia via neural root in pancreatic cancer. Anesthesia and Analgesia 126 (5): 1729–1738.
Sekiguchi, F., R. Domoto, K. Nakashima, D. Yamasoba, H. Yamanishi, M. Tsubota, H. Wake, M. Nishibori, and A. Kawabata. 2018.
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