Multi-parametric [18F]PI-2620 tau PET/MRI for the phenotyping of different Alzheimer’s disease variants

Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, et al. NIA-AA research framework: Toward a biological definition of Alzheimer’s disease. Alzheimers Dement. 2018;14:535–62. https://doi.org/10.1016/j.jalz.2018.02.018.

Article  PubMed  Google Scholar 

McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology. 1984;34:939–44. https://doi.org/10.1212/wnl.34.7.939.

Article  PubMed  CAS  Google Scholar 

Villain N, Dubois B. Alzheimer’s disease including focal presentations. Semin Neurol. 2019;39:213–26. https://doi.org/10.1055/s-0039-1681041.

Article  PubMed  Google Scholar 

Cummings JL. Alzheimer’s disease. N Engl J Med. 2004;351:56–67. https://doi.org/10.1056/NEJMra040223.

Article  PubMed  CAS  Google Scholar 

Querfurth HW, LaFerla FM. Alzheimer’s disease. N Engl J Med. 2010;362:329–44. https://doi.org/10.1056/NEJMra0909142.

Article  PubMed  CAS  Google Scholar 

Montembeault M, Migliaccio R. Atypical forms of Alzheimer’s disease: patients not to forget. Curr Opin Neurol. 2023;36:245–52. https://doi.org/10.1097/WCO.0000000000001182.

Article  PubMed  Google Scholar 

Crutch SJ, Schott JM, Rabinovici GD, Murray M, Snowden JS, van der Flier WM, et al. Consensus classification of posterior cortical atrophy. Alzheimers Dement. 2017;13:870–84. https://doi.org/10.1016/j.jalz.2017.01.014.

Article  PubMed  Google Scholar 

Galton CJ, Patterson K, Xuereb JH, Hodges JR. Atypical and typical presentations of Alzheimer’s disease: a clinical, neuropsychological, neuroimaging and pathological study of 13 cases. Brain. 2000;123(Pt 3):484–98. https://doi.org/10.1093/brain/123.3.484.

Article  PubMed  Google Scholar 

Ross SJ, Graham N, Stuart-Green L, Prins M, Xuereb J, Patterson K, Hodges JR. Progressive biparietal atrophy: an atypical presentation of Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 1996;61:388–95. https://doi.org/10.1136/jnnp.61.4.388.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz A, Mendez M, Cappa SF, et al. Classification of primary progressive aphasia and its variants. Neurology. 2011;76:1006–14. https://doi.org/10.1212/WNL.0b013e31821103e6.

Article  PubMed  PubMed Central  Google Scholar 

Clark CM, Xie S, Chittams J, Ewbank D, Peskind E, Galasko D, et al. Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses? Arch Neurol. 2003;60:1696–702. https://doi.org/10.1001/archneur.60.12.1696.

Article  PubMed  Google Scholar 

Santangelo R, Coppi E, Ferrari L, Bernasconi MP, Pinto P, Passerini G, et al. Cerebrospinal fluid biomarkers can play a pivotal role in the diagnostic work up of primary progressive aphasia. J Alzheimers Dis. 2015;43:1429–40. https://doi.org/10.3233/JAD-141122.

Article  PubMed  CAS  Google Scholar 

Teichmann M, Kas A, Boutet C, Ferrieux S, Nogues M, Samri D, et al. Deciphering logopenic primary progressive aphasia: a clinical, imaging and biomarker investigation. Brain. 2013;136:3474–88. https://doi.org/10.1093/brain/awt266.

Article  PubMed  Google Scholar 

Leyton CE, Villemagne VL, Savage S, Pike KE, Ballard KJ, Piguet O, et al. Subtypes of progressive aphasia: application of the International Consensus Criteria and validation using beta-amyloid imaging. Brain. 2011;134:3030–43. https://doi.org/10.1093/brain/awr216.

Article  PubMed  Google Scholar 

Rabinovici GD, Jagust WJ, Furst AJ, Ogar JM, Racine CA, Mormino EC, et al. Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia. Ann Neurol. 2008;64:388–401. https://doi.org/10.1002/ana.21451.

Article  PubMed  PubMed Central  Google Scholar 

Formaglio M, Costes N, Seguin J, Tholance Y, Le Bars D, Roullet-Solignac I, et al. In vivo demonstration of amyloid burden in posterior cortical atrophy: a case series with PET and CSF findings. J Neurol. 2011;258:1841–51. https://doi.org/10.1007/s00415-011-6030-0.

Article  PubMed  Google Scholar 

Ng SY, Villemagne VL, Masters CL, Rowe CC. Evaluating atypical dementia syndromes using positron emission tomography with carbon 11 labeled Pittsburgh Compound B. Arch Neurol. 2007;64:1140–4. https://doi.org/10.1001/archneur.64.8.1140.

Article  PubMed  Google Scholar 

Ossenkoppele R, Cohn-Sheehy BI, La Joie R, Vogel JW, Moller C, Lehmann M, et al. Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer’s disease. Hum Brain Mapp. 2015;36:4421–37. https://doi.org/10.1002/hbm.22927.

Article  PubMed  PubMed Central  Google Scholar 

Ossenkoppele R, Schonhaut DR, Baker SL, O’Neil JP, Janabi M, Ghosh PM, et al. Tau, amyloid, and hypometabolism in a patient with posterior cortical atrophy. Ann Neurol. 2015;77:338–42. https://doi.org/10.1002/ana.24321.

Article  PubMed  CAS  Google Scholar 

Macedo AC, Tissot C, Therriault J, Servaes S, Wang YT, Fernandez-Arias J, et al. The use of Tau PET to stage alzheimer disease according to the Braak staging framework. J Nucl Med. 2023;64:1171–8. https://doi.org/10.2967/jnumed.122.265200.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Brown RK, Bohnen NI, Wong KK, Minoshima S, Frey KA. Brain PET in suspected dementia: patterns of altered FDG metabolism. Radiographics. 2014;34:684–701. https://doi.org/10.1148/rg.343135065.

Article  PubMed  Google Scholar 

Fasnacht JS, Wueest AS, Berres M, Thomann AE, Krumm S, Gutbrod K, et al. Conversion between the montreal cognitive assessment and the mini-mental status examination. J Am Geriatr Soc. 2023;71:869–79. https://doi.org/10.1111/jgs.18124.

Article  PubMed  Google Scholar 

Brendel M, Barthel H, van Eimeren T, Marek K, Beyer L, Song M, et al. Assessment of 18F-PI-2620 as a biomarker in progressive Supranuclear palsy. JAMA Neurol. 2020;77:1408–19. https://doi.org/10.1001/jamaneurol.2020.2526.

Article  PubMed  Google Scholar 

Beyer L, Nitschmann A, Barthel H, van Eimeren T, Unterrainer M, Sauerbeck J, et al. Early-phase [(18)F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury. Eur J Nucl Med Mol Imaging. 2020;47:2911–22. https://doi.org/10.1007/s00259-020-04788-w.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Marques JP, Kober T, Krueger G, van der Zwaag W, Van de Moortele PF, Gruetter R. MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field. Neuroimage. 2010;49:1271–81. https://doi.org/10.1016/j.neuroimage.2009.10.002.

Article  PubMed  Google Scholar 

Ichise M, Liow JS, Lu JQ, Takano A, Model K, Toyama H, et al. Linearized reference tissue parametric imaging methods: application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain. J Cereb Blood Flow Metab. 2003;23:1096–112. https://doi.org/10.1097/01.WCB.0000085441.37552.CA.

Article  PubMed  Google Scholar 

Jenkinson M, Beckmann CF, Behrens TE, Woolrich MW, Smith SM. Fsl Neuroimage. 2012;62:782–90. https://doi.org/10.1016/j.neuroimage.2011.09.015.

Article  PubMed  Google Scholar 

Shirer WR, Ryali S, Rykhlevskaia E, Menon V, Greicius MD. Decoding subject-driven cognitive states with whole-brain connectivity patterns. Cereb Cortex. 2012;22:158–65. https://doi.org/10.1093/cercor/bhr099.

Article  PubMed  CAS  Google Scholar 

Rullmann M, Brendel M, Schroeter ML, Saur D, Levin J, Perneczky RG, et al. Multicenter (18)F-PI-2620 PET for in vivo Braak staging of tau pathology in Alzheimer's disease. Biomolecules. 2022;12. https://doi.org/10.3390/biom12030458.

Schwarz AJ, Yu P, Miller BB, Shcherbinin S, Dickson J, Navitsky M, et al. Regional profiles of the candidate tau PET ligand 18F-AV-1451 recapitulate key features of Braak histopathological stages. Brain. 2016;139:1539–50. https://doi.org/10.1093/brain/aww023.

Article  PubMed 

Comments (0)

No login
gif