Aarsland D, Batzu L, Halliday GM, Geurtsen GJ, Ballard C, Ray Chaudhuri K, et al. Parkinson disease-associated cognitive impairment. Nat Reviews Disease Primers. 2021;7:1–21.
Poewe W, Seppi K, Tanner CM, Halliday GM, Brundin P, Volkmann J, et al. Parkinson disease. Nat Reviews Disease Primers. 2017;3:1–21.
Mitchell T, Lehéricy S, Chiu SY, Strafella AP, Stoessl AJ, Vaillancourt DE. Emerging neuroimaging biomarkers across disease stage in Parkinson disease: a review. JAMA Neurol. 2021;78:1262–72.
Article PubMed PubMed Central Google Scholar
Meles SK, Teune LK, de Jong BM, Dierckx RA, Leenders KL. Metabolic imaging in Parkinson disease. J Nucl Med. 2017;58:23–8.
Article CAS PubMed Google Scholar
Mattis PJ, Niethammer M, Sako W, Tang CC, Nazem A, Gordon ML, et al. Distinct brain networks underlie cognitive dysfunction in Parkinson and Alzheimer diseases. Neurology. 2016;87:1925–33.
Article CAS PubMed PubMed Central Google Scholar
Huang C, Tang C, Feigin A, Lesser M, Ma Y, Pourfar M, et al. Changes in network activity with the progression of Parkinson’s disease. Brain. 2007;130:1834–46.
Lu J, Ge J, Chen K, Sun Y, Liu F, Yu H, et al. Consistent abnormalities in metabolic patterns of Lewy body dementias. Mov Disord. 2022;37:1861–71.
Article CAS PubMed Google Scholar
Sasikumar S, Strafella AP. Imaging mild cognitive impairment and dementia in Parkinson’s disease. Front Neurol. 2020;11:47.
Article PubMed PubMed Central Google Scholar
Schrag A, Siddiqui UF, Anastasiou Z, Weintraub D, Schott JM. Clinical variables and biomarkers in prediction of cognitive impairment in patients with newly diagnosed Parkinson’s disease: a cohort study. Lancet Neurol. 2017;16:66–75.
Article CAS PubMed Google Scholar
Niethammer M, Tang CC, Ma Y, Mattis PJ, Ko JH, Dhawan V, et al. Parkinson’s disease cognitive network correlates with caudate dopamine. NeuroImage. 2013;78:204–9.
Article CAS PubMed Google Scholar
Sung C, Oh SJ, Kim JS. Imaging Procedure and clinical studies of [18F] FP-CIT PET. Nuclear Med Mol Imaging. 2024:1–18.
Booth S, Ko JH. Radionuclide Imaging of the neuroanatomical and neurochemical substrate of cognitive decline in Parkinson’s Disease. Nuclear Med Mol Imaging. 2024:1–14.
Nagano-Saito A, Kato T, Arahata Y, Washimi Y, Nakamura A, Abe Y, et al. Cognitive- and motor-related regions in Parkinson’s disease: FDOPA and FDG PET studies. NeuroImage. 2004;22:553–61. https://doi.org/10.1016/j.neuroimage.2004.01.030.
Pasquini J, Durcan R, Wiblin L, Stokholm MG, Rochester L, Brooks DJ, et al. Clinical implications of early caudate dysfunction in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2019;90:1098–104.
Chung SJ, Yoo HS, Oh JS, Kim JS, Ye BS, Sohn YH, et al. Effect of striatal dopamine depletion on cognition in de novo Parkinson’s disease. Parkinsonism Relat Disord. 2018;51:43–8. https://doi.org/10.1016/j.parkreldis.2018.02.048.
Fox PT, Mintun MA, Reiman EM, Raichle ME. Enhanced detection of focal brain responses using intersubject averaging and change-distribution analysis of subtracted PET images. J Cereb Blood Flow Metab. 1988;8:642–53. https://doi.org/10.1038/jcbfm.1988.111.
Article CAS PubMed Google Scholar
Huber M, Beyer L, Prix C, Schönecker S, Palleis C, Rauchmann BS, et al. Metabolic correlates of dopaminergic loss in dementia with Lewy Bodies. Mov Disord. 2020;35:595–605. https://doi.org/10.1002/mds.27945.
Article CAS PubMed Google Scholar
Chung SJ, Kim YJ, Kim YJ, Lee HS, Jeong SH, Hong J-M, et al. Association between White Matter Networks and the pattern of Striatal dopamine depletion in patients with Parkinson Disease. Neurology. 2022;99:e2672–82. https://doi.org/10.1212/wnl.0000000000201269.
Article CAS PubMed Google Scholar
Jeong SH, Kim SH, Park CW, Lee HS, Lee PH, Kim YJ, et al. Differential implications of cerebral hypoperfusion and hyperperfusion in Parkinson’s disease. Mov Disord. 2023;38:1881–90.
Article CAS PubMed Google Scholar
Jeong SH, Lee E-C, Chung SJ, Lee HS, Jung JH, Sohn YH, et al. Local striatal volume and motor reserve in drug-naïve Parkinson’s disease. Npj Parkinson’s Disease. 2022;8:168. https://doi.org/10.1038/s41531-022-00429-1.
Article CAS PubMed PubMed Central Google Scholar
Lee Yg, Jeon S, Park M, Kang SW, Yoon SH, Baik K, et al. Effects of Alzheimer and Lewy body disease pathologies on brain metabolism. Ann Neurol. 2022;91:853–63.
Ryu HJ, Yang DW. The Seoul neuropsychological screening battery (SNSB) for comprehensive neuropsychological assessment. Dement Neurocognitive Disorders. 2023;22:1.
Firth NC, Primativo S, Brotherhood E, Young AL, Yong KX, Crutch SJ, et al. Sequences of cognitive decline in typical Alzheimer’s disease and posterior cortical atrophy estimated using a novel event-based model of disease progression. Alzheimer’s Dement. 2020;16:965–73.
Young AL, Oxtoby NP, Garbarino S, Fox NC, Barkhof F, Schott JM, et al. Data-driven modelling of neurodegenerative disease progression: thinking outside the black box. Nat Rev Neurosci. 2024;25:111–30.
Article CAS PubMed Google Scholar
Berron D, Vogel JW, Insel PS, Pereira JB, Xie L, Wisse LE, et al. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain. 2021;144:2771–83.
Article PubMed PubMed Central Google Scholar
Young AL, Oxtoby NP, Daga P, Cash DM, Fox NC, Ourselin S, et al. A data-driven model of biomarker changes in sporadic Alzheimer’s disease. Brain. 2014;137:2564–77.
Article PubMed PubMed Central Google Scholar
Oxtoby NP, Leyland L-A, Aksman LM, Thomas GE, Bunting EL, Wijeratne PA, et al. Sequence of clinical and neurodegeneration events in Parkinson’s disease progression. Brain. 2021;144:975–88.
Article PubMed PubMed Central Google Scholar
Fonteijn HM, Modat M, Clarkson MJ, Barnes J, Lehmann M, Hobbs NZ, et al. An event-based model for disease progression and its application in familial Alzheimer’s disease and Huntington’s disease. NeuroImage. 2012;60:1880–9.
Pedregosa F, Varoquaux G, Gramfort A, Michel V, Thirion B, Grisel O, et al. Scikit-learn: machine learning in Python. J Mach Learn Res. 2011;12:2825–30.
Muller ML, Bohnen NI. Cholinergic dysfunction in Parkinson’s disease. Curr Neurol Neurosci Rep. 2013;13:377. https://doi.org/10.1007/s11910-013-0377-9.
Article CAS PubMed PubMed Central Google Scholar
Hilker R, Thomas AV, Klein JC, Weisenbach S, Kalbe E, Burghaus L, et al. Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways. Neurology. 2005;65:1716–22. https://doi.org/10.1212/01.wnl.0000191154.78131.f6.
Article CAS PubMed Google Scholar
Meles SK, Renken RJ, Pagani M, Teune LK, Arnaldi D, Morbelli S, et al. Abnormal pattern of brain glucose metabolism in Parkinson’s disease: replication in three European cohorts. Eur J Nucl Med Mol Imaging. 2020;47:437–50.
Article CAS PubMed Google Scholar
Baba T, Hosokai Y, Nishio Y, Kikuchi A, Hirayama K, Suzuki K, et al. Longitudinal study of cognitive and cerebral metabolic changes in Parkinson’s disease. J Neurol Sci. 2017;372:288–93. https://doi.org/10.1016/j.jns.2016.11.068.
Article CAS PubMed Google Scholar
Bohnen NI, Koeppe RA, Minoshima S, Giordani B, Albin RL, Frey KA, et al. Cerebral glucose metabolic features of Parkinson disease and incident dementia: longitudinal study. J Nucl Med. 2011;52:848–55. https://doi.org/10.2967/jnumed.111.089946.
Comments (0)