Cofano F, Boido M, Monticelli M et al (2019) Mesenchymal stem cells for spinal cord injury: current options, limitations, and future of cell therapy. Int J Mol Sci 20(11):2698
Article CAS PubMed PubMed Central Google Scholar
Anjum A, Yazid MD, Daud MF et al (2020) Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms. Int J Mol Sci 21(20):7533
Article CAS PubMed PubMed Central Google Scholar
Wang H, Liu X, Zhao Y et al (2016) Incidence and pattern of traumatic spinal fractures and associated spinal cord injury resulting from motor vehicle collisions in China over 11 years: an observational study. Medicine 95(43):e5220
Article PubMed PubMed Central Google Scholar
Chen J, Chen Z, Zhang K et al (2021) Epidemiological features of traumatic spinal cord injury in Guangdong Province, China. J Spinal Cord Med 44(2):276–281
Khorasanizadeh M, Yousefifard M, Eskian M, Lu Y, Chalangari M, Harrop JS, Jazayeri SB, Seyedpour S, Khodaei B, Hosseini M, Rahimi-Movaghar V (2019) Neurological recovery following traumatic spinal cord injury: a systematic review and meta-analysis. J Neurosurg Spine. 30(5):683–699. https://doi.org/10.3171/2018.10.SPINE18802
O’Shea TM, Burda JE, Sofroniew MV (2017) Cell biology of spinal cord injury and repair. J Clin Invest 127(9):3259–3270
Article PubMed PubMed Central Google Scholar
Alonso-Calviño E, Martínez-Camero I, Fernández-López E et al (2016) Increased responses in the somatosensory thalamus immediately after spinal cord injury. Neurobiol Dis 87:39–49
Lukovic D, Stojkovic M, Moreno-Manzano V et al (2015) Concise review: reactive astrocytes and stem cells in spinal cord injury: good guys or bad guys? Stem Cells (Dayton, Ohio) 33(4):1036–1041
Kim YH, Ha KY, Kim SI (2017) Spinal cord injury and related clinical trials. Clin Orthop Surg 9(1):1–9
Article PubMed PubMed Central Google Scholar
Kwon BK, Tetzlaff W, Grauer JN et al (2004) Pathophysiology and pharmacologic treatment of acute spinal cord injury. Spine J 4(4):451–464
Al Mamun A, Wu Y, Monalisa I et al (2021) Role of pyroptosis in spinal cord injury and its therapeutic implications. J Adv Res 28:97–109
Article CAS PubMed Google Scholar
Liu Y, Pan L, Jiang A et al (2018) Hydrogen sulfide upregulated lncRNA CasC7 to reduce neuronal cell apoptosis in spinal cord ischemia-reperfusion injury rat. Biomed Pharmacother 98:856–862
Article CAS PubMed Google Scholar
Zhao J, Cheng W, He X et al (2018) Chronic obstructive pulmonary disease molecular subtyping and pathway deviation-based candidate gene identification. Cell J 20(3):326–332
PubMed PubMed Central Google Scholar
Lemaire SA, Price MD, Green SY et al (2012) Results of open thoracoabdominal aortic aneurysm repair. Ann Cardiothorac Surg 1(3):286–292
PubMed PubMed Central Google Scholar
Zhao W, Gasterich N, Clarner T et al (2022) Astrocytic Nrf2 expression protects spinal cord from oxidative stress following spinal cord injury in a male mouse model. J Neuroinflammation 19(1):134
Article CAS PubMed PubMed Central Google Scholar
Yu M, Wang Z, Wang D et al (2023) Oxidative stress following spinal cord injury: from molecular mechanisms to therapeutic targets. J Neurosci Res 101(10):1538–1554
Article CAS PubMed Google Scholar
Xu T, Gao P, Huang Y et al (2023) Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling. Redox Biol 62:102682
Article CAS PubMed PubMed Central Google Scholar
Yao X, Carlson D, Sun Y et al (2015) Mitochondrial ROS induces cardiac inflammation via a pathway through mtDNA damage in a pneumonia-related sepsis model. PLoS ONE 10(10):e0139416
Article PubMed PubMed Central Google Scholar
Yu Q, Huang J, Hu J et al (2016) Advance in spinal cord ischemia reperfusion injury: blood-spinal cord barrier and remote ischemic preconditioning. Life Sci 154:34–38
Article CAS PubMed Google Scholar
He J, Ritzel RM, Wu J (2021) Functions and mechanisms of the voltage-gated proton channel Hv1 in brain and spinal cord injury. Front Cell Neurosci 15:662971
Article CAS PubMed PubMed Central Google Scholar
Smith JA, Park S, Krause JS et al (2013) Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration. Neurochem Int 62(5):764–775
Article CAS PubMed PubMed Central Google Scholar
Sun F, Zhang H, Shi J et al (2021) Astragalin protects against spinal cord ischemia reperfusion injury through attenuating oxidative stress-induced necroptosis. Biomed Res Int 2021:7254708
Article PubMed PubMed Central Google Scholar
Ma Q (2013) Role of Nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol 53:401–426
Article CAS PubMed PubMed Central Google Scholar
He F, Ru X, Wen T (2020) NRF2, a transcription factor for stress response and beyond. Int J Mol Sci 21(13):4777
Article CAS PubMed PubMed Central Google Scholar
Schmidlin CJ, Shakya A, Dodson M et al (2021) The intricacies of NRF2 regulation in cancer. Semin Cancer Biol 76:110–119
Article CAS PubMed PubMed Central Google Scholar
Kang TC (2020) Nuclear factor-erythroid 2-related factor 2 (Nrf2) and mitochondrial dynamics/mitophagy in neurological diseases. Antioxidants (Basel, Switzerland) 9(7):617
Zeng XP, Li XJ, Zhang QY et al (2017) Tert-butylhydroquinone protects liver against ischemia/reperfusion injury in rats through Nrf2-activating anti-oxidative activity. Transpl Proc 49(2):366–372
Kerr F, Sofola-Adesakin O, Ivanov DK et al (2017) Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease. PLoS Genet 13(3):e1006593
Article PubMed PubMed Central Google Scholar
Mazzuferi M, Kumar G, van Eyll J et al (2013) Nrf2 defense pathway: experimental evidence for its protective role in epilepsy. Ann Neurol 74(4):560–568
Article CAS PubMed Google Scholar
Zhai X, Chen X, Shi J et al (2013) Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression. Free Radical Biol Med 65:731–741
Dwivedi S, Rajasekar N, Hanif K et al (2016) Sulforaphane ameliorates okadaic acid-induced memory impairment in rats by activating the Nrf2/HO-1 antioxidant pathway. Mol Neurobiol 53(8):5310–5323
Article CAS PubMed Google Scholar
Hall ED (2011) Antioxidant therapies for acute spinal cord injury. Neurotherapeutics 8(2):152–67
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