Nrf2 Signaling Pathway: Focus on Oxidative Stress in Spinal Cord Injury

Cofano F, Boido M, Monticelli M et al (2019) Mesenchymal stem cells for spinal cord injury: current options, limitations, and future of cell therapy. Int J Mol Sci 20(11):2698

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anjum A, Yazid MD, Daud MF et al (2020) Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms. Int J Mol Sci 21(20):7533

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang H, Liu X, Zhao Y et al (2016) Incidence and pattern of traumatic spinal fractures and associated spinal cord injury resulting from motor vehicle collisions in China over 11 years: an observational study. Medicine 95(43):e5220

Article  PubMed  PubMed Central  Google Scholar 

Chen J, Chen Z, Zhang K et al (2021) Epidemiological features of traumatic spinal cord injury in Guangdong Province, China. J Spinal Cord Med 44(2):276–281

Article  PubMed  Google Scholar 

Khorasanizadeh M, Yousefifard M, Eskian M, Lu Y, Chalangari M, Harrop JS, Jazayeri SB, Seyedpour S, Khodaei B, Hosseini M, Rahimi-Movaghar V (2019) Neurological recovery following traumatic spinal cord injury: a systematic review and meta-analysis. J Neurosurg Spine. 30(5):683–699. https://doi.org/10.3171/2018.10.SPINE18802

O’Shea TM, Burda JE, Sofroniew MV (2017) Cell biology of spinal cord injury and repair. J Clin Invest 127(9):3259–3270

Article  PubMed  PubMed Central  Google Scholar 

Alonso-Calviño E, Martínez-Camero I, Fernández-López E et al (2016) Increased responses in the somatosensory thalamus immediately after spinal cord injury. Neurobiol Dis 87:39–49

Article  PubMed  Google Scholar 

Lukovic D, Stojkovic M, Moreno-Manzano V et al (2015) Concise review: reactive astrocytes and stem cells in spinal cord injury: good guys or bad guys? Stem Cells (Dayton, Ohio) 33(4):1036–1041

Article  PubMed  Google Scholar 

Kim YH, Ha KY, Kim SI (2017) Spinal cord injury and related clinical trials. Clin Orthop Surg 9(1):1–9

Article  PubMed  PubMed Central  Google Scholar 

Kwon BK, Tetzlaff W, Grauer JN et al (2004) Pathophysiology and pharmacologic treatment of acute spinal cord injury. Spine J 4(4):451–464

Article  PubMed  Google Scholar 

Al Mamun A, Wu Y, Monalisa I et al (2021) Role of pyroptosis in spinal cord injury and its therapeutic implications. J Adv Res 28:97–109

Article  CAS  PubMed  Google Scholar 

Liu Y, Pan L, Jiang A et al (2018) Hydrogen sulfide upregulated lncRNA CasC7 to reduce neuronal cell apoptosis in spinal cord ischemia-reperfusion injury rat. Biomed Pharmacother 98:856–862

Article  CAS  PubMed  Google Scholar 

Zhao J, Cheng W, He X et al (2018) Chronic obstructive pulmonary disease molecular subtyping and pathway deviation-based candidate gene identification. Cell J 20(3):326–332

PubMed  PubMed Central  Google Scholar 

Lemaire SA, Price MD, Green SY et al (2012) Results of open thoracoabdominal aortic aneurysm repair. Ann Cardiothorac Surg 1(3):286–292

PubMed  PubMed Central  Google Scholar 

Zhao W, Gasterich N, Clarner T et al (2022) Astrocytic Nrf2 expression protects spinal cord from oxidative stress following spinal cord injury in a male mouse model. J Neuroinflammation 19(1):134

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu M, Wang Z, Wang D et al (2023) Oxidative stress following spinal cord injury: from molecular mechanisms to therapeutic targets. J Neurosci Res 101(10):1538–1554

Article  CAS  PubMed  Google Scholar 

Xu T, Gao P, Huang Y et al (2023) Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling. Redox Biol 62:102682

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yao X, Carlson D, Sun Y et al (2015) Mitochondrial ROS induces cardiac inflammation via a pathway through mtDNA damage in a pneumonia-related sepsis model. PLoS ONE 10(10):e0139416

Article  PubMed  PubMed Central  Google Scholar 

Yu Q, Huang J, Hu J et al (2016) Advance in spinal cord ischemia reperfusion injury: blood-spinal cord barrier and remote ischemic preconditioning. Life Sci 154:34–38

Article  CAS  PubMed  Google Scholar 

He J, Ritzel RM, Wu J (2021) Functions and mechanisms of the voltage-gated proton channel Hv1 in brain and spinal cord injury. Front Cell Neurosci 15:662971

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smith JA, Park S, Krause JS et al (2013) Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration. Neurochem Int 62(5):764–775

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun F, Zhang H, Shi J et al (2021) Astragalin protects against spinal cord ischemia reperfusion injury through attenuating oxidative stress-induced necroptosis. Biomed Res Int 2021:7254708

Article  PubMed  PubMed Central  Google Scholar 

Ma Q (2013) Role of Nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol 53:401–426

Article  CAS  PubMed  PubMed Central  Google Scholar 

He F, Ru X, Wen T (2020) NRF2, a transcription factor for stress response and beyond. Int J Mol Sci 21(13):4777

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmidlin CJ, Shakya A, Dodson M et al (2021) The intricacies of NRF2 regulation in cancer. Semin Cancer Biol 76:110–119

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kang TC (2020) Nuclear factor-erythroid 2-related factor 2 (Nrf2) and mitochondrial dynamics/mitophagy in neurological diseases. Antioxidants (Basel, Switzerland) 9(7):617

CAS  PubMed  Google Scholar 

Zeng XP, Li XJ, Zhang QY et al (2017) Tert-butylhydroquinone protects liver against ischemia/reperfusion injury in rats through Nrf2-activating anti-oxidative activity. Transpl Proc 49(2):366–372

Article  CAS  Google Scholar 

Kerr F, Sofola-Adesakin O, Ivanov DK et al (2017) Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease. PLoS Genet 13(3):e1006593

Article  PubMed  PubMed Central  Google Scholar 

Mazzuferi M, Kumar G, van Eyll J et al (2013) Nrf2 defense pathway: experimental evidence for its protective role in epilepsy. Ann Neurol 74(4):560–568

Article  CAS  PubMed  Google Scholar 

Zhai X, Chen X, Shi J et al (2013) Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression. Free Radical Biol Med 65:731–741

Article  CAS  Google Scholar 

Dwivedi S, Rajasekar N, Hanif K et al (2016) Sulforaphane ameliorates okadaic acid-induced memory impairment in rats by activating the Nrf2/HO-1 antioxidant pathway. Mol Neurobiol 53(8):5310–5323

Article  CAS  PubMed  Google Scholar 

Hall ED (2011) Antioxidant therapies for acute spinal cord injury. Neurotherapeutics 8(2):152–67

Article  CAS 

Comments (0)

No login
gif