Ferroptosis in Cognitive Impairment Associated with Diabetes and Alzheimer’s Disease: Mechanistic Insights and New Therapeutic Opportunities

(2023) 2023 Alzheimer’s disease facts and figures. Alzheimers Dement 19:1598–1695. https://doi.org/10.1002/alz.13016

Scheltens P, De Strooper B, Kivipelto M et al (2021) Alzheimer’s disease. Lancet 397:1577–1590. https://doi.org/10.1016/S0140-6736(20)32205-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dove A, Shang Y, Xu W et al (2021) The impact of diabetes on cognitive impairment and its progression to dementia. Alzheimers Dement 17:1769–1778. https://doi.org/10.1002/alz.12482

Article  PubMed  Google Scholar 

Chatterjee S, Peters SAE, Woodward M et al (2016) Type 2 Diabetes as a risk factor for dementia in women compared with men: a pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia. Diabetes Care 39:300–307. https://doi.org/10.2337/dc15-1588

Article  CAS  PubMed  Google Scholar 

Rawlings AM, Sharrett AR, Albert MS et al (2019) The association of late-life diabetes status and hyperglycemia with incident mild cognitive impairment and dementia: the ARIC study. Diabetes Care 42:1248–1254. https://doi.org/10.2337/dc19-0120

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bellia C, Lombardo M, Meloni M et al (2022) Diabetes and cognitive decline. Adv Clin Chem 108:37–71. https://doi.org/10.1016/bs.acc.2021.07.006

Article  CAS  PubMed  Google Scholar 

Verhagen C, Janssen J, Biessels GJ et al (2022) Females with type 2 diabetes are at higher risk for accelerated cognitive decline than males: CAROLINA-COGNITION study. Nutr Metab Cardiovasc Dis 32:355–364. https://doi.org/10.1016/j.numecd.2021.10.013

Article  CAS  PubMed  Google Scholar 

González A, Calfío C, Churruca M, Maccioni RB (2022) Glucose metabolism and AD: evidence for a potential diabetes type 3. Alzheimers Res Ther 14:56. https://doi.org/10.1186/s13195-022-00996-8

Article  PubMed  PubMed Central  Google Scholar 

Wang L, Yin Y-L, Liu X-Z et al (2020) Current understanding of metal ions in the pathogenesis of Alzheimer’s disease. Transl Neurodegener 9:10. https://doi.org/10.1186/s40035-020-00189-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Talbot K, Wang H-Y, Kazi H et al (2012) Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest 122:1316–1338. https://doi.org/10.1172/JCI59903

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sajan M, Hansen B, Ivey R et al (2016) Brain insulin signaling is increased in insulin-resistant states and decreases in FOXOs and PGC-1α and increases in Aβ1-40/42 and phospho-tau may abet Alzheimer development. Diabetes 65:1892–1903. https://doi.org/10.2337/db15-1428

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nguyen TT, Ta QTH, Nguyen TKO et al (2020) Type 3 diabetes and its role implications in Alzheimer’s disease. Int J Mol Sci 21:3165. https://doi.org/10.3390/ijms21093165

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rad SK, Arya A, Karimian H et al (2018) Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer’s disease. Drug Des Devel Ther 12:3999–4021. https://doi.org/10.2147/DDDT.S173970

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dixon SJ, Lemberg KM, Lamprecht MR et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060–1072. https://doi.org/10.1016/j.cell.2012.03.042

Article  CAS  PubMed  PubMed Central  Google Scholar 

Newton K, Strasser A, Kayagaki N, Dixit VM (2024) Cell death. Cell 187:235–256. https://doi.org/10.1016/j.cell.2023.11.044

Article  CAS  PubMed  Google Scholar 

Feng L, Sun J, Xia L et al (2024) Ferroptosis mechanism and Alzheimer’s disease. Neural Regen Res 19:1741. https://doi.org/10.4103/1673-5374.389362

Article  PubMed  Google Scholar 

Guo T, Yu Y, Yan W et al (2023) Erythropoietin ameliorates cognitive dysfunction in mice with type 2 diabetes mellitus via inhibiting iron overload and ferroptosis. Exp Neurol 365:114414. https://doi.org/10.1016/j.expneurol.2023.114414

Article  CAS  PubMed  Google Scholar 

David S, Ryan F, Jhelum P, Kroner A (2023) Ferroptosis in neurological disease. Neuroscientist 29:591–615. https://doi.org/10.1177/10738584221100183

Article  PubMed  Google Scholar 

Andrews NC (1999) Disorders of iron metabolism. N Engl J Med 341:1986–1995. https://doi.org/10.1056/NEJM199912233412607

Article  CAS  PubMed  Google Scholar 

Ward RJ, Zucca FA, Duyn JH et al (2014) The role of iron in brain ageing and neurodegenerative disorders. Lancet Neurol 13:1045–1060. https://doi.org/10.1016/S1474-4422(14)70117-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun S, Shen J, Jiang J et al (2023) Targeting ferroptosis opens new avenues for the development of novel therapeutics. Signal Transduct Target Ther 8:372. https://doi.org/10.1038/s41392-023-01606-1

Article  PubMed  PubMed Central  Google Scholar 

Gao M, Monian P, Quadri N et al (2015) Glutaminolysis and transferrin regulate ferroptosis. Mol Cell 59:298–308. https://doi.org/10.1016/j.molcel.2015.06.011

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Yu C, Kang R, Tang D (2020) Iron metabolism in ferroptosis. Front Cell Dev Biol 8:590226. https://doi.org/10.3389/fcell.2020.590226

Article  PubMed  PubMed Central  Google Scholar 

Xie Y, Hou W, Song X et al (2016) Ferroptosis: process and function. Cell Death Differ 23:369–379. https://doi.org/10.1038/cdd.2015.158

Article  CAS  PubMed  PubMed Central  Google Scholar 

Forcina GC, Dixon SJ (2019) GPX4 at the crossroads of lipid homeostasis and ferroptosis. Proteomics 19:e1800311. https://doi.org/10.1002/pmic.201800311

Article  CAS  PubMed  Google Scholar 

Kagan VE, Mao G, Qu F et al (2017) Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol 13:81–90. https://doi.org/10.1038/nchembio.2238

Article  CAS  PubMed  Google Scholar 

Yang WS, SriRamaratnam R, Welsch ME et al (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell 156:317–331. https://doi.org/10.1016/j.cell.2013.12.010

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao JY, Dixon SJ (2016) Mechanisms of ferroptosis. Cell Mol Life Sci 73:2195–2209. https://doi.org/10.1007/s00018-016-2194-1

Article  CAS  PubMed 

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