The potential role of ANXA11/ANXA3 protein level ratio in predicting antidepressant treatment outcomes

Monroe SM, Harkness KL (2022) Major depression and its recurrences: life course matters[J]. Ann Rev Clin Psychol 18(1):329–357

Article  Google Scholar 

Yin J, Song X, Wang C et al (2023) Escitalopram versus other antidepressive agents for major depressive disorder: a systematic review and meta-analysis[J]. BMC Psychiatry 23(1):876

Article  PubMed  PubMed Central  Google Scholar 

Ferkingstad E, Sulem P, Atlason BA et al (2021) Large-scale integration of the plasma proteome with genetics and disease[J]. Nat Genet 53(12):1712–1721

Article  PubMed  CAS  Google Scholar 

Pietzner M, Wheeler E, Carrasco-Zanini J et al (2021) Mapping the proteo-genomic convergence of human diseases[J]. Science 374(6569):eabj1541

Article  PubMed  PubMed Central  Google Scholar 

Park B, Choi GE (2025) Changes in astrocyte function induced by stress-induced glucocorticoid exacerbate major depressive disorder[J]. Prog Neurobiol, : 102786

Luan D, Li Y, Zhang A et al (2025) The regulatory variant rs1950834 confers the risk of depressive disorder by reducing LRFN5 expression[J]. BMC Med 23(1):316

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dong WT, Long LH, Deng Q et al (2023) Mitochondrial fission drives neuronal metabolic burden to promote stress susceptibility in male mice[J]. Nat Metabolism 5(12):2220–2236

Article  CAS  Google Scholar 

Dang X, Song M, Lv L et al (2023) Proteome-wide Mendelian randomization reveals the causal effects of immune-related plasma proteins on psychiatric disorders[J]. Hum Genet 142(6):809–818

Article  PubMed  CAS  Google Scholar 

Osimo EF, Pillinger T, Rodriguez IM et al (2020) Inflammatory markers in depression: a meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls[J]. Brain, behavior, and immunity. 87:901–909

Schneider E, Doll JPK, Schweinfurth N et al (2023) Effect of short-term, high-dose probiotic supplementation on cognition, related brain functions and BDNF in patients with depression: a secondary analysis of a randomized controlled trial[J]. J Psychiatry Neurosci 48(1):E23–E33

Article  PubMed  PubMed Central  Google Scholar 

Kendall KM, Van Assche E, Andlauer TFM et al (2021) The genetic basis of major depression[J]. Psychol Med 51(13):2217–2230

Article  PubMed  CAS  Google Scholar 

Levey DF, Stein MB, Wendt FR et al (2021) Bi-ancestral depression GWAS in the million veteran program and meta-analysis in > 1.2 million individuals highlight new therapeutic directions[J]. Nat Neurosci 24(7):954–963

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen Z, Wang X, Teng Z et al (2024) Modifiable lifestyle factors influencing psychiatric disorders mediated by plasma proteins: a systemic Mendelian randomization study[J]. J Affect Disord 350:582–589

Article  PubMed  CAS  Google Scholar 

Birney E (2022) Mendelian randomization[J]. Cold Spring Harbor Perspect Med 12(4):a041302

Google Scholar 

Chen L, Zhang YH, Zheng M et al (2016) Identification of compound–protein interactions through the analysis of gene ontology, KEGG enrichment for proteins and molecular fragments of compounds[J]. Mol Genet Genomics 291(6):2065–2079

Article  PubMed  CAS  Google Scholar 

Suhre K (2024) Genetic associations with ratios between protein levels detect new pQTLs and reveal protein-protein interactions[J]. Cell Genomics, 4(3)

Pain O, Hodgson K, Trubetskoy V et al (2022) Identifying the common genetic basis of antidepressant response[J]. Biol Psychiatry Global Open Sci 2(2):115–126

Article  Google Scholar 

Maj M, Stein DJ, Parker G et al (2020) The clinical characterization of the adult patient with depression aimed at personalization of management[J]. World Psychiatry 19(3):269–293

Article  PubMed  PubMed Central  Google Scholar 

Pu J, Yu Y, Liu Y et al (2024) ProMENDA: an updated resource for proteomic and metabolomic characterization in depression[J]. Translational Psychiatry 14(1):229

Article  PubMed  PubMed Central  CAS  Google Scholar 

Carboni L, Becchi S, Piubelli C et al (2010) Early-life stress and antidepressants modulate peripheral biomarkers in a gene–environment rat model of depression[J]. Prog Neuropsychopharmacol Biol Psychiatry 34(6):1037–1048

Article  PubMed  CAS  Google Scholar 

Almeida OP, Norman PE, Allcock R et al (2009) Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: the health in men Study[J]. Int J Epidemiol 38(4):1049–1059

Article  PubMed  PubMed Central  Google Scholar 

Haroon E, Daguanno AW, Woolwine BJ et al (2018) Antidepressant treatment resistance is associated with increased inflammatory markers in patients with major depressive disorder[J]. Psychoneuroendocrinology 95:43–49

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhou Q, Lv X, Zhou S et al (2021) Inflammatory cytokines, cognition, and response to antidepressant treatment in patients with major depressive disorder[J]. Psychiatry Res 305:114202

Article  PubMed  CAS  Google Scholar 

Liao Y, Xie B, Zhang H et al (2019) Efficacy of omega-3 PUFAs in depression: a meta-analysis[J]. Translational Psychiatry 9(1):190

Article  PubMed  PubMed Central  Google Scholar 

Boye TL, Jeppesen JC, Maeda K et al (2018) Annexins induce curvature on free-edge membranes displaying distinct morphologies[J]. Sci Rep 8(1):10309

Article  PubMed  PubMed Central  Google Scholar 

Gerke V, Creutz CE, Moss SE (2005) Annexins: linking Ca2 + signalling to membrane dynamics[J]. Nat Rev Mol Cell Biol 6(6):449–461

Article  PubMed  CAS  Google Scholar 

Bouter A, Gounou C, Bérat R et al (2011) Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair[J]. Nat Commun 2(1):270

Article  PubMed  Google Scholar 

Mellgren RL, Miyake K, Kramerova I et al (2009) Calcium-dependent plasma membrane repair requires m-or µ-calpain, but not calpain-3, the proteasome, or caspases[J]. Biochim Et Biophys Acta (BBA)-Molecular Cell Res 1793(12):1886–1893

Article  CAS  Google Scholar 

Sadleir KR, Gomez KP, Edwards AE et al (2025) Annexin A6 membrane repair protein protects against amyloid-induced dystrophic neurites and Tau phosphorylation in alzheimer’s disease model mice[J]. Acta Neuropathol 149(1):51

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nahm M, Lim SM, Kim YE et al (2020) ANXA11 mutations in ALS cause dysregulation of calcium homeostasis and stress granule dynamics[J]. Sci Transl Med 12(566):eaax3993

Article  PubMed  CAS  Google Scholar 

Lizarbe MA, Barrasa JI, Olmo N et al (2013) Annexin-phospholipid interactions. Functional implications[J]. Int J Mol Sci 14(2):2652–2683

Article  PubMed  PubMed Central  CAS  Google Scholar 

Xing M, Liang S, Cao W et al (2025) Annexin A3 represses endothelial permeability and inflammation during sepsis via actin cytoskeleton Modulation[J]. Adv Sci, : 2416904

Pepinsky RB, Tizard R, Mattaliano RJ et al (1988) Five distinct calcium and phospholipid binding proteins share homology with Lipocortin I[J]. J Biol Chem 263(22):10799–10811

Article  PubMed  CAS  Google Scholar 

Liao YC, Fernandopulle MS, Wang G et al (2019) RNA granules hitchhike on lysosomes for long-distance transport, using Annexin A11 as a molecular tether[J]. Cell 179(1):147–164e20

Article  PubMed  PubMed Central  CAS  Google Scholar 

Comments (0)

No login
gif