Brown P, Pratt AG, Hyrich KL. Therapeutic advances in rheumatoid arthritis. BMJ. 2024;384:e070856.
Article PubMed CAS Google Scholar
Yang X, Zhang W, Wang L, Zhao Y, Wei W. Metabolite-sensing GPCRs in rheumatoid arthritis. Trends Pharmacol Sci. 2024;45:118–33.
Article PubMed CAS Google Scholar
Souto-Carneiro M, Tóth L, Behnisch R, Urbach K, Klika KD, Carvalho RA, et al. Differences in the serum metabolome and lipidome identify potential biomarkers for seronegative rheumatoid arthritis versus psoriatic arthritis. Ann Rheum Dis. 2020;79:499–506.
Article PubMed CAS Google Scholar
Wu B, Qiu J, Zhao TV, Wang Y, Maeda T, Goronzy IN, et al. Succinyl-CoA ligase deficiency in oro-inflammatory and tissue-invasive T cells. Cell Metab. 2020;32:967–80.
Article PubMed PubMed Central CAS Google Scholar
Meyer A, Zack SR, Nijim W, Burgos A, Patel V, Zanotti B, et al. Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis. Cell Mol Immunol. 2024;21:33–46.
Article PubMed CAS Google Scholar
You DG, Lim GT, Kwon S, Um W, Oh BH, Song SH, et al. Metabolically engineered stem cell-derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis. Sci Adv. 2021;7:eabe0083.
Article PubMed PubMed Central CAS Google Scholar
Evans HG, Gullick NJ, Kelly S, Pitzalis C, Lord GM, Kirkham BW, et al. In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses. Proc Natl Acad Sci USA. 2009;106:6232–7.
Article PubMed PubMed Central CAS Google Scholar
Yang X, Zhao Y, Wei Q, Zhu X, Wang L, Zhang W, et al. GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis. Acta Pharm Sin B. 2024;14:241–55.
Article PubMed CAS Google Scholar
Grayson PC, Eddy S, Taroni JN, Lightfoot YL, Mariani L, Parikh H, et al. Metabolic pathways and immunometabolism in rare kidney diseases. Ann Rheum Dis. 2018;77:1226–33.
Liu Z, Xu J, Ma Q, Zhang X, Yang Q, Wang L, et al. Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche. Sci Transl Med. 2020;12:eaay1371.
Article PubMed PubMed Central CAS Google Scholar
Jia N, Gao Y, Li M, Liang Y, Li Y, Lin Y, et al. Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms. Signal Transduct Target Ther. 2023;8:280.
Article PubMed PubMed Central CAS Google Scholar
Van Raemdonck K, Umar S, Palasiewicz K, Volin MV, Elshabrawy HA, Romay B, et al. Interleukin-34 reprograms glycolytic and osteoclastic rheumatoid arthritis macrophages via syndecan 1 and macrophage colony-stimulating factor receptor. Arthritis Rheumatol. 2021;73:2003–14.
Article PubMed PubMed Central Google Scholar
Jing C, Castro-Dopico T, Richoz N, Tuong ZK, Ferdinand JR, Lok LSC, et al. Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis. Proc Natl Acad Sci USA. 2020;117:15160–71.
Article PubMed PubMed Central CAS Google Scholar
Hanlon MM, McGarry T, Marzaioli V, Amaechi S, Song Q, Nagpal S, et al. Rheumatoid arthritis macrophages are primed for inflammation and display bioenergetic and functional alterations. Rheumatology. 2023;62:2611–20.
Article PubMed CAS Google Scholar
Murdoch C, Giannoudis A, Lewis CE. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood. 2004;104:2224–34.
Article PubMed CAS Google Scholar
Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, et al. HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity. Nat Commun. 2016;7:11635.
Article PubMed PubMed Central CAS Google Scholar
Leach RM, Treacher DF. Oxygen transport-2. Tissue hypoxia. BMJ. 1998;317:1370–3.
Article PubMed PubMed Central CAS Google Scholar
Radoux-Mergault A, Oberhauser L, Aureli S, Gervasio FL, Stoeber M. Subcellular location defines GPCR signal transduction. Sci Adv. 2023;9:eadf6059.
Article PubMed PubMed Central CAS Google Scholar
Cheng J, Klei LR, Hubel NE, Zhang M, Schairer R, Maurer LM, et al. GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein. J Clin Invest. 2020;130:1036–51.
Article PubMed PubMed Central CAS Google Scholar
Evron T, Daigle TL, Caron MG. GRK2: multiple roles beyond G protein-coupled receptor desensitization. Trends Pharmacol Sci. 2012;33:154–64.
Article PubMed PubMed Central CAS Google Scholar
Tu J, Chen W, Fang Y, Han D, Chen Y, Jiang H, et al. PU.1 promotes development of rheumatoid arthritis via repressing FLT3 in macrophages and fibroblast-like synoviocytes. Ann Rheum Dis. 2023;82:198–211.
Article PubMed CAS Google Scholar
Habtemichael EN, Li DT, Camporez JP, Westergaard XO, Sales CI, Liu X, et al. Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake. Nat Metab. 2021;3:378–93.
Article PubMed PubMed Central CAS Google Scholar
Wang S, Zhou L, Ji N, Sun C, Sun L, Sun J, et al. Targeting ACYP1-mediated glycolysis reverses lenvatinib resistance and restricts hepatocellular carcinoma progression. Drug Resist Updat. 2023;69:100976.
Article PubMed CAS Google Scholar
Jia H, Li M, Li W, Liu L, Jian Y, Yang Z, et al. A serine/threonine protein kinase encoding gene KERNEL NUMBER PER ROW6 regulates maize grain yield. Nat Commun. 2020;11:988.
Article PubMed PubMed Central CAS Google Scholar
Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, et al. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem. 2009;55:611–22.
Article PubMed CAS Google Scholar
Han C, Jiang L, Wang W, Zuo S, Gu J, Chen L, et al. GRK2 activates TRAF2–NF-κB signaling to promote hyperproliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Acta Pharm Sin B. 2025. https://doi.org/10.1016/j.apsb.2025.02.031.
Yang Y, Ren P, Liu X, Sun X, Zhang C, Du X, et al. PPP1R26 drives hepatocellular carcinoma progression by controlling glycolysis and epithelial-mesenchymal transition. J Exp Clin Cancer Res. 2022;41:101.
Article PubMed PubMed Central CAS Google Scholar
Theret M, Gsaier L, Schaffer B, Juban G, Ben Larbi S, Weiss-Gayet M, et al. AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis. EMBO J. 2017;36:1946–62.
Article PubMed PubMed Central CAS Google Scholar
Xu J, Jiang C, Wang X, Geng M, Peng Y, Guo Y, et al. Upregulated PKM2 in macrophages exacerbates experimental arthritis via STAT1 signaling. J Immunol. 2020;205:181–92.
Article PubMed CAS Google Scholar
Li X, Tian BM, Deng DK, Liu F, Zhou H,
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