Kv1.3 knockdown attenuates alcohol-related liver injury in mice through induction of tryptamine

Åberg F, Jiang ZG, Cortez-Pinto H, Männistö V. Alcohol-associated liver disease-Global epidemiology. Hepatology. 2024;80:1307–22.

Leggio L, Lee MR. Treatment of alcohol use disorder in patients with alcoholic liver disease. Am J Med. 2017;130:124–34.

Article  PubMed  Google Scholar 

Mackowiak B, Fu Y, Maccioni L, Gao B. Alcohol-associated liver disease. J Clin Invest. 2024;134:e176345.

Louvet A, Mathurin P. Alcoholic liver disease: mechanisms of injury and targeted treatment. Nat Rev Gastroenterol Hepatol. 2015;12:231–42.

Article  PubMed  Google Scholar 

Gao H, Jiang Y, Zeng G, Huda N, Thoudam T, Yang Z, et al. Cell-to-cell and organ-to-organ crosstalk in the pathogenesis of alcohol-associated liver disease. eGastroenterology. 2024;2:e100104.

Ambade A, Lowe P, Kodys K, Catalano D, Gyongyosi B, Cho Y, et al. Pharmacological inhibition of CCR2/5 signaling prevents and reverses alcohol-induced liver damage, steatosis, and inflammation in mice. Hepatology. 2019;69:1105–21.

Article  CAS  PubMed  Google Scholar 

Marin V, Poulsen K, Odena G, McMullen MR, Altamirano J, Sancho-Bru P, et al. Hepatocyte-derived macrophage migration inhibitory factor mediates alcohol-induced liver injury in mice and patients. J Hepatol. 2017;67:1018–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang M, Shen G, Xu L, Liu X, Brown JM, Feng D, et al. IL-1 receptor-like 1 protects against alcoholic liver injury by limiting NF-κB activation in hepatic macrophages. J Hepatol. 2017;S0168-8278:32263–8.

Wu X, Fan X, McMullen MR, Miyata T, Kim A, Pathak V, et al. Macrophage-derived MLKL in alcohol-associated liver disease: regulation of phagocytosis. Hepatology. 2023;77:902–19.

Article  PubMed  Google Scholar 

Van den Bossche J, O’Neill LA, Menon D. Macrophage immunometabolism: where are we (going)? Trends Immunol. 2017;38:395–406.

Article  PubMed  Google Scholar 

Liu J, Lv XW, Zhang L, Wang H, Li J, Wu B. Review on biological characteristics of Kv1.3 and its role in liver diseases. Front Pharmacol. 2021;12:652508.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Selvakumar P, Fernández-Mariño AI, Khanra N, He C, Paquette AJ, Wang B, et al. Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators. Nat Commun. 2022;13:3854.

Article  CAS  PubMed  PubMed Central  Google Scholar 

DeCoursey TE, Chandy KG, Gupta S, Cahalan MD. Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis? Nature. 1984;307:465–8.

Article  CAS  PubMed  Google Scholar 

Upadhyay SK, Eckel-Mahan KL, Mirbolooki MR, Tjong I, Griffey SM, Schmunk G, et al. Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance. Proc Natl Acad Sci USA. 2013;110:E2239–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee WH, Najjar SM, Kahn CR, Hinds TD Jr. Hepatic insulin receptor: new views on the mechanisms of liver disease. Metabolism. 2023;145:155607.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Man S, Deng Y, Ma Y, Fu J, Bao H, Yu C, et al. Prevalence of liver steatosis and fibrosis in the general population and various high-risk populations: a nationwide study with 5.7 million adults in China. Gastroenterology. 2023;165:1025–40.

Article  PubMed  Google Scholar 

Gao B, Xu MJ, Bertola A, Wang H, Zhou Z, Liangpunsakul S. Animal models of alcoholic liver disease: pathogenesis and clinical relevance. Gene Expr. 2017;17:173–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sougioultzis S, Dalakas E, Hayes PC, Plevris JN. Alcoholic hepatitis: from pathogenesis to treatment. Curr Med Res Opin. 2005;21:1337–46.

Article  CAS  PubMed  Google Scholar 

Dhanda AD, Collins PL, McCune CA. Is liver biopsy necessary in the management of alcoholic hepatitis? World J Gastroenterol. 2013;19:7825–9.

Article  PubMed  PubMed Central  Google Scholar 

Navarro-Pérez M, Capera J, Benavente-Garcia A, Cassinelli S, Colomer-Molera M, Felipe A. Kv1.3 in the spotlight for treating immune diseases. Expert Opin Ther Targets. 2024;28:67–82.

Article  PubMed  Google Scholar 

Cheng S, Jiang D, Lan X, Liu K, Fan C. Voltage-gated potassium channel 1.3: a promising molecular target in multiple disease therapy. Biomed Pharmacother. 2024;175:116651.

Article  CAS  PubMed  Google Scholar 

Wu B, Liu JD, Bian E, Hu W, Huang C, Meng X, et al. Blockage of Kv1.3 regulates macrophage migration in acute liver injury by targeting δ-catenin through RhoA signaling. Int J Biol Sci. 2020;16:671–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu BM, Liu JD, Li YH, Li J. Margatoxin mitigates CCl4‑induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion, and STAT signaling. Int J Mol Med. 2020;45:103–14.

CAS  PubMed  Google Scholar 

O’Neill LA, Kishton RJ, Rathmell J. A guide to immunometabolism for immunologists. Nat Rev Immunol. 2016;16:553–65.

Article  PubMed  PubMed Central  Google Scholar 

Ayres JS. Immunometabolism of infections. Nat Rev Immunol. 2020;20:79–80.

Article  CAS  PubMed  Google Scholar 

Makowski L, Chaib M, Rathmell JC. Immunometabolism: from basic mechanisms to translation. Immunol Rev. 2020;295:5–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buck MD, Sowell RT, Kaech SM, Pearce EL. Metabolic instruction of immunity. Cell. 2017;169:570–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ravishankar B, Liu H, Shinde R, Chandler P, Baban B, Tanaka M, et al. Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase. Proc Natl Acad Sci USA. 2012;109:3909–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krishnan S, Ding Y, Saedi N, Choi M, Sridharan GV, Sherr DH, et al. Gut microbiota-derived tryptophan metabolites modulate inflammatory response in hepatocytes and macrophages. Cell Rep. 2018;23:1099–111.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Agista AZ, Tanuseputero SA, Koseki T, Ardiansyah, Budijanto S, Sultana H, et al. Tryptamine, a microbial metabolite in fermented rice bran suppressed lipopolysaccharide-induced inflammation in a murine macrophage model. Int J Mol Sci. 2022;23:11209.

Williams BB, Van Benschoten AH, Cimermancic P, Donia MS, Zimmermann M, Taketani M, et al. Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host Microbe. 2014;16:495–503.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhai L, Xiao H, Lin C, Wong HLX, Lam YY, Gong M, et al. Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome. Nat Commun. 2023;14:4986.

Article  CAS  PubMed  PubMed Central  Google Scholar 

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