Drug-related falls: proportion and impact of hospitalizations in geriatric departments on the prescription of fall-risk increasing drugs (FRIDs)

Step safely: strategies for preventing and managing falls across the life-course. https://www.who.int/publications/i/item/978924002191-4. Accessed 16 Aug 2024

Montero-Odasso M, van der Velde N, Martin FC, et al (2022) World guidelines for falls prevention and management for older adults: a global initiative. Age Ageing 51:afac205. https://doi.org/10.1093/ageing/afac205

Seppala LJ, Wermelink AMAT, de Vries M et al (2018) Fall-risk-increasing drugs: a systematic review and meta-analysis: II. Psychotropics J Am Med Dir Assoc 19:371.e11-371.e17. https://doi.org/10.1016/j.jamda.2017.12.098

Article  PubMed  Google Scholar 

de Vries M, Seppala LJ, Daams JG et al (2018) Fall-risk-increasing drugs: a systematic review and meta-analysis: I. Cardiovascular drugs. J Am Med Dir Assoc 19:371.e1-371.e9. https://doi.org/10.1016/j.jamda.2017.12.013

Article  PubMed  Google Scholar 

Seppala LJ, van de Glind EMM, Daams JG et al (2018) Fall-risk-increasing drugs: a systematic review and meta-analysis: III. Others J Am Med Dir Assoc 19:372.e1-372.e8. https://doi.org/10.1016/j.jamda.2017.12.099

Article  PubMed  Google Scholar 

Ambrose AF, Paul G, Hausdorff JM (2013) Risk factors for falls among older adults: a review of the literature. Maturitas 75:51–61. https://doi.org/10.1016/j.maturitas.2013.02.009

Article  PubMed  Google Scholar 

Laroche M-L, Gautier S, Polard E et al (2023) Incidence and preventability of hospital admissions for adverse drug reactions in France: a prospective observational study (IATROSTAT). Br J Clin Pharmacol 89:390–400. https://doi.org/10.1111/bcp.15510

Article  CAS  PubMed  Google Scholar 

Beijer HJM, de Blaey CJ (2002) Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies. Pharm World Sci 24:46–54. https://doi.org/10.1023/a:1015570104121

Article  CAS  PubMed  Google Scholar 

Hohl CM, Zed PJ, Brubacher JR et al (2010) Do emergency physicians attribute drug-related emergency department visits to medication-related problems? Ann Emerg Med 55:493-502.e4. https://doi.org/10.1016/j.annemergmed.2009.10.008

Article  PubMed  Google Scholar 

Zerah L, Henrard S, Thevelin S, et al (2022) Performance of a trigger tool for detecting drug-related hospital admissions in older people: analysis from the OPERAM trial. Age Ageing 51:afab196. https://doi.org/10.1093/ageing/afab196

Thevelin S, Spinewine A, Beuscart J-B et al (2018) Development of a standardized chart review method to identify drug-related hospital admissions in older people. Br J Clin Pharmacol 84:2600–2614. https://doi.org/10.1111/bcp.13716

Article  PubMed  PubMed Central  Google Scholar 

Vaesken C, Boulouard VL, Fedrizzi S et al (2023) Validation of a method for detecting hospitalizations for falls related to adverse drug reactions in geriatric departments. Geriatr Psychol Neuropsychiatr Vieil 21:437–446. https://doi.org/10.1684/pnv.2023.1132

Article  PubMed  Google Scholar 

Zidrou C, Vasiliadis AV, Tsatlidou M et al (2022) The prevalence of polypharmacy and fall-risk-increasing drugs after hospital discharge for hip fracture: a retrospective study. J Frailty Sarcopenia Falls 7:81–87. https://doi.org/10.22540/JFSF-07-081

Article  PubMed  PubMed Central  Google Scholar 

Hart LA, Phelan EA, Yi JY et al (2020) Use of fall risk–increasing drugs around a fall-related injury in older adults: a systematic review. J Am Geriatr Soc 68:1334–1343. https://doi.org/10.1111/jgs.16369

Article  PubMed  PubMed Central  Google Scholar 

Osman A, Kamkar N, Speechley M et al (2022) Fall risk-increasing drugs and gait performance in community-dwelling older adults: a systematic review. Ageing Res Rev 77:101599. https://doi.org/10.1016/j.arr.2022.101599

Article  CAS  PubMed  Google Scholar 

Shaver AL, Clark CM, Hejna M et al (2021) Trends in fall-related mortality and fall risk increasing drugs among older individuals in the United States, 1999–2017. Pharmacoepidemiol Drug Saf 30:1049–1056. https://doi.org/10.1002/pds.5201

Article  PubMed  PubMed Central  Google Scholar 

Fixen DR (2019) American Geriatrics Society 2019 updated AGS Beers Criteria® for potentially inappropriate medication use in older adults-PubMed. J Am Geriatr Soc 67:674–694

Article  Google Scholar 

O’Mahony D, O’Sullivan D, Byrne S et al (2015) STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing 44:213–218. https://doi.org/10.1093/ageing/afu145

Article  PubMed  Google Scholar 

Seppala LJ, Petrovic M, Ryg J et al (2020) STOPPFall (screening tool of older persons prescriptions in older adults with high fall risk): a Delphi study by the EuGMS task and finish group on fall-risk-increasing drugs. Age Ageing 50:1189–1199. https://doi.org/10.1093/ageing/afaa249

Article  PubMed Central  Google Scholar 

Chen Y, Zhu L-L, Zhou Q (2014) Effects of drug pharmacokinetic/pharmacodynamic properties, characteristics of medication use, and relevant pharmacological interventions on fall risk in elderly patients. Ther Clin Risk Manag 10:437–448. https://doi.org/10.2147/TCRM.S63756

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cameron ID, Dyer SM, Panagoda CE, et al (2018) Interventions for preventing falls in older people in care facilities and hospitals. Cochrane Database Syst Rev 9:CD005465. https://doi.org/10.1002/14651858.CD005465.pub4

Frankenthal D, Lerman Y, Kalendaryev E, Lerman Y (2014) Intervention with the screening tool of older persons potentially inappropriate prescriptions/screening tool to alert doctors to right treatment criteria in elderly residents of a chronic geriatric facility: a randomized clinical trial. J Am Geriatr Soc 62:1658–1665. https://doi.org/10.1111/jgs.12993

Article  PubMed  Google Scholar 

Gillespie LD, Robertson MC, Gillespie WJ, et al (2012) Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev. CD007146. https://doi.org/10.1002/14651858.CD007146.pub3

Schwenk M, Lauenroth A, Stock C et al (2012) Definitions and methods of measuring and reporting on injurious falls in randomised controlled fall prevention trials: a systematic review. BMC Med Res Methodol 12:50. https://doi.org/10.1186/1471-2288-12-50

Article  PubMed  PubMed Central  Google Scholar 

Penm J, Vaillancourt R, Pouliot A (2019) Defining and identifying concepts of medication reconciliation: an international pharmacy perspective. Res Social Adm Pharm 15:632–640. https://doi.org/10.1016/j.sapharm.2018.07.020

Article  PubMed  Google Scholar 

Carnahan RM, Lund BC, Perry PJ et al (2006) The anticholinergic drug scale as a measure of drug-related anticholinergic burden: associations with serum anticholinergic activity. J Clin Pharmacol 46:1481–1486. https://doi.org/10.1177/0091270006292126

Article  CAS  PubMed  Google Scholar 

Hallas J, Harvald B, Gram LF et al (1990) Drug related hospital admissions: the role of definitions and intensity of data collection, and the possibility of prevention. J Intern Med 228:83–90. https://doi.org/10.1111/j.1365-2796.1990.tb00199.x

Article  CAS  PubMed  Google Scholar 

Ministère chargé de l’autonomie (2022) Plan antichute des personnes agées. https://sante.gouv.fr/IMG/pdf/dp_plan-antichute-accessible28-02-2022.pdf. Accessed 8 April 2025

Kongkaew C, Noyce PR, Ashcroft DM (2008) Hospital admissions associated with adverse drug reactions: a systematic review of prospective observational studies. Ann Pharmacother 42:1017–1025. https://doi.org/10.1345/aph.1L037

Article  PubMed  Google Scholar 

Munson JC, Bynum JPW, Bell J-E et al (2016) Patterns of prescription drug use before and after fragility fracture. JAMA Intern Med 176:1531–1538. https://doi.org/10.1001/jamainternmed.2016.4814

Article  PubMed  PubMed Central  Google Scholar 

Marvin V, Ward E, Poots AJ et al (2017) Deprescribing medicines in the acute setting to reduce the risk of falls. Eur J Hosp Pharm 24:10–15. https://doi.org/10.1136/ejhpharm-2016-001003

Article  PubMed  Google Scholar 

Francis E, Dyks D, Kanji S (2014) Influence of admission to a tertiary care hospital after a fall on use of potentially inappropriate medications among older patients. Can J Hosp Pharm 67:429–435

Article  PubMed  PubMed Central  Google Scholar 

Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC et al (2004) Effect of vitamin D on falls: a meta-analysis. JAMA 291:1999–2006. https://doi.org/10.1001/jama.291.16.1999

Article  CAS  PubMed  Google Scholar 

Joseph A, Wanono R, Flamant M, Vidal-Petiot E (2017) Orthostatic hypotension: a review. Nephrol Ther 13:S55–S67. https://doi.org/10.1016/j.nephro.2017.01.003

Article  PubMed 

Comments (0)

No login
gif