The Role of Lactate and Lactylation in the Dysregulation of Immune Responses in Psoriasis

Chen C, Yi X, Liu P et al (2023) CD147 facilitates the pathogenesis of psoriasis through glycolysis and H3K9me3 modification in keratinocytes. Research (Washington, DC) 6:0167

CAS  Google Scholar 

Griffiths CEM, Armstrong AW, Gudjonsson JE, Barker J (2021) Psoriasis. Lancet 397(10281):1301–1315

Article  CAS  PubMed  Google Scholar 

Armstrong AW, Read C (2020) Pathophysiology, clinical presentation, and treatment of psoriasis: a review. JAMA 323(19):1945–1960

Article  CAS  PubMed  Google Scholar 

Guo J, Zhang H, Lin W, Lu L, Su J, Chen X (2023) Signaling pathways and targeted therapies for psoriasis. Signal Transduct Target Ther 8(1):437

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lowes MA, Suárez-Fariñas M, Krueger JG (2014) Immunology of psoriasis. Annu Rev Immunol 32:227–255

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Qi C, Feng F et al (2023) Resveratrol ameliorates imiquimod-induced psoriasis-like mouse model via reducing macrophage infiltration and inhibiting glycolysis. J Inflamm Res 16:3823–3836

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qian J, Li X, Yin Z et al (2024) Yogurt alleviates imiquimod-induced psoriasis by activating the lactate/GPR81 signaling axis in mice. J Agric Food Chem 72(2):1055–1066

Article  CAS  PubMed  Google Scholar 

Zhao S, Wu T, Fu M, Zhang Z (2024) Histone lactylation participates in psoriasis progression by regulating the adiponectin expression. Clin Cosmet Investig Dermatol 17:219–227

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Yang Y, Zhang B et al (2022) Lactate metabolism in human health and disease. Signal Transduct Target Ther 7(1):305

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun W, Jia M, Feng Y, Cheng X (2023) Lactate is a bridge linking glycolysis and autophagy through lactylation. Autophagy 19(12):3240–3241

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brooks GA (2020) Lactate as a fulcrum of metabolism. Redox Biol 35:101454

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang Y, Li Z, Yang L et al (2024) Emerging roles of lactate in acute and chronic inflammation. Cell Commun Signal 22(1):276

Article  PubMed  PubMed Central  Google Scholar 

Koguchi-Yoshioka H, Watanabe R, Matsumura Y et al (2021) Serum lactate dehydrogenase level as a possible predictor of treatment preference in psoriasis. J Dermatol Sci 103(2):109–115

Article  CAS  PubMed  Google Scholar 

Subudhi I, Konieczny P, Prystupa A et al (2024) Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation. Immunity 57(7):1665–80.e7

Article  CAS  PubMed  Google Scholar 

Yang Z, Yan C, Ma J et al (2023) Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma. Nat Metab 5(1):61–79

Article  CAS  PubMed  Google Scholar 

Zhang D, Tang Z, Huang H et al (2019) Metabolic regulation of gene expression by histone lactylation. Nature 574(7779):575–580

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Z, Hao D, Zhao S, Zhang Z, Zeng Z, Wang X (2023) Lactate and lactylation: clinical applications of routine carbon source and novel modification in human diseases. Mol Cel Proteom: MCP 22(10):100641

Article  CAS  Google Scholar 

Izzo LT, Wellen KE (2019) Histone lactylation links metabolism and gene regulation. Nature 574(7779):492–493

Article  CAS  PubMed  Google Scholar 

Liberti MV, Locasale JW (2020) Histone lactylation: a new role for glucose metabolism. Trends Biochem Sci 45(3):179–182

Article  CAS  PubMed  Google Scholar 

Li Y, Cao Q, Hu Y et al (2024) Advances in the interaction of glycolytic reprogramming with lactylation. Biomed Pharmacother = Biomed Pharmacother 177:116982

Article  CAS  PubMed  Google Scholar 

Ye L, Jiang Y, Zhang M (2022) Crosstalk between glucose metabolism, lactate production and immune response modulation. Cytokine Growth Factor Rev 68:81–92

Article  CAS  PubMed  Google Scholar 

Jiang X, Yang Y, Li X, Li T, Yu T, Fu X (2024) Lactylation: an innovative approach to disease control. Aging Dis. Advance online publication

Robert M, Miossec P (2024) Structural cell heterogeneity underlies the differential contribution of IL-17A, IL-17F and IL-23 to joint versus skin chronic inflammation. Autoimmun Rev 23(4):103529

Article  CAS  PubMed  Google Scholar 

Neuwirth T, Stary G (2024) Expanding strategies to resolve psoriasis-like inflammation: Non-canonical NF-κB signaling controls IL-23 production in dendritic cells. Mol Ther 32(5):1195–1196

Article  CAS  PubMed  Google Scholar 

Nair RP, Duffin KC, Helms C et al (2009) Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet 41(2):199–204

Article  CAS  PubMed  PubMed Central  Google Scholar 

McGeachy MJ, Cua DJ, Gaffen SL (2019) The IL-17 family of cytokines in health and disease. Immunity 50(4):892–906

Article  CAS  PubMed  PubMed Central  Google Scholar 

Foerster J (2017) Rare diseases and costly treatments: the role of IL-1β in pustular psoriasis. Br J Dermatol 176(1):17–18

Blauvelt A (2017) IL-6 differs from TNF-α: unpredicted clinical effects caused by IL-6 blockade in psoriasis. J Invest Dermatol 137(3):541–542

Article  CAS  PubMed  Google Scholar 

Villanova F, Flutter B, Tosi I et al (2014) Characterization of innate lymphoid cells in human skin and blood demonstrates increase of NKp44+ ILC3 in psoriasis. J Invest Dermatol 134(4):984–991

Article  CAS  PubMed  Google Scholar 

Jiang B, Zhang H, Wu Y, Shen Y (2022) Single-cell immune ecosystem and metabolism reprogramming imprinted by psoriasis niche. Ann Transl Med 10(15):837

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu H, Huang H, Zhao Y (2023) Interplay between metabolic reprogramming and post-translational modifications: from glycolysis to lactylation. Front Immunol 14:1211221

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin Y, Xue K, Li Q et al (2021) Cyclin-dependent kinase 7 promotes Th17/Th1 cell differentiation in psoriasis by modulating glycolytic metabolism. J Invest Dermatol 141(11):2656–2667

Article  CAS  PubMed  Google Scholar 

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