The Role of MA Modification in Autoimmunity: Emerging Mechanisms and Therapeutic Implications

Xiao ZX, Miller JS, Zheng SG (2021) An updated advance of autoantibodies in autoimmune diseases. Autoimmun Rev 20(2):102743. https://doi.org/10.1016/j.autrev.2020.102743

Article  CAS  PubMed  Google Scholar 

Pisetsky DS (2023) Pathogenesis of autoimmune disease. Nat Rev Nephrol 19(8):509–524. https://doi.org/10.1038/s41581-023-00720-1

Article  CAS  PubMed  Google Scholar 

Cao F, Liu YC, Ni QY, Chen Y, Wan CH, Liu SY et al (2023) Temporal trends in the prevalence of autoimmune diseases from 1990 to 2019. Autoimmun Rev 22(8):103359. https://doi.org/10.1016/j.autrev.2023.103359

Article  PubMed  Google Scholar 

Scherlinger M, Mertz P, Sagez F, Meyer A, Felten R, Chatelus E et al (2020) Worldwide trends in all-cause mortality of auto-immune systemic diseases between 2001 and 2014. Autoimmun Rev 19(6):102531. https://doi.org/10.1016/j.autrev.2020.102531

Article  CAS  PubMed  Google Scholar 

Conrad N, Misra S, Verbakel JY, Verbeke G, Molenberghs G, Taylor PN et al (2023) Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK. Lancet 401(10391):1878–1890. https://doi.org/10.1016/s0140-6736(23)00457-9

Article  PubMed  Google Scholar 

Esteller M (2008) Epigenetics in cancer. N Engl J Med 358(11):1148–1159. https://doi.org/10.1056/NEJMra072067

Article  CAS  PubMed  Google Scholar 

Humpherys D, Eggan K, Akutsu H, Hochedlinger K, Rideout WM 3rd, Biniszkiewicz D et al (2001) Epigenetic instability in ES cells and cloned mice. Science 293(5527):95–97. https://doi.org/10.1126/science.1061402

Article  CAS  PubMed  Google Scholar 

Saini A, Ghoneim HE, Lio CJ, Collins PL, Oltz EM (2022) Gene regulatory circuits in innate and adaptive immune cells. Annu Rev Immunol 40:387–411. https://doi.org/10.1146/annurev-immunol-101320-025949

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Q, Zhu F, Liu X, Lu Y, Yao K, Tian N et al (2022) Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics. Nat Metab 4(5):559–574. https://doi.org/10.1038/s42255-022-00575-z

Article  CAS  PubMed  Google Scholar 

Desrosiers R, Friderici K, Rottman F (1974) Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc Natl Acad Sci U S A 71(10):3971–3975. https://doi.org/10.1073/pnas.71.10.3971

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang C, Liu N (2022) N6-methyladenosine (m6A) modification in gynecological malignancies. J Cell Physiol 237(9):3465–3479. https://doi.org/10.1002/jcp.30828

Article  CAS  PubMed  Google Scholar 

Zhang C, Chen L, Peng D, Jiang A, He Y, Zeng Y et al (2020) METTL3 and N6-methyladenosine promote homologous recombination-mediated repair of DSBs by modulating DNA-RNA hybrid accumulation. Mol Cell 79(3):425–42.e7. https://doi.org/10.1016/j.molcel.2020.06.017

Article  CAS  PubMed  Google Scholar 

Li Y, Xia L, Tan K, Ye X, Zuo Z, Li M et al (2020) N(6)-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2. Nat Genet 52(9):870–877. https://doi.org/10.1038/s41588-020-0677-3

Article  CAS  PubMed  Google Scholar 

Liu J, Dou X, Chen C, Chen C, Liu C, Xu MM et al (2020) N (6)-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription. Science 367(6477):580–586. https://doi.org/10.1126/science.aay6018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haussmann IU, Bodi Z, Sanchez-Moran E, Mongan NP, Archer N, Fray RG et al (2016) m(6)A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination. Nature 540(7632):301–304. https://doi.org/10.1038/nature20577

Article  CAS  PubMed  Google Scholar 

Lesbirel S, Wilson SA (2019) The m(6)A-methylase complex and mRNA export. Biochim Biophys Acta Gene Regul Mech 1862(3):319–328. https://doi.org/10.1016/j.bbagrm.2018.09.008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee Y, Choe J, Park OH, Kim YK (2020) Molecular mechanisms driving mRNA degradation by m(6)A modification. Trends Genet 36(3):177–188. https://doi.org/10.1016/j.tig.2019.12.007

Article  CAS  PubMed  Google Scholar 

Meyer KD (2019) m(6)A-mediated translation regulation. Biochim Biophys Acta Gene Regul Mech 1862(3):301–309. https://doi.org/10.1016/j.bbagrm.2018.10.006

Article  CAS  PubMed  Google Scholar 

Roignant JY, Soller M (2017) m(6)A in mRNA: an ancient mechanism for fine-tuning gene expression. Trends Genet 33(6):380–390. https://doi.org/10.1016/j.tig.2017.04.003

Article  CAS  PubMed  Google Scholar 

Boo SH, Kim YK (2020) The emerging role of RNA modifications in the regulation of mRNA stability. Exp Mol Med 52(3):400–408. https://doi.org/10.1038/s12276-020-0407-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Tran N, Ernst FGM, Hawley BR, Zorbas C, Ulryck N, Hackert P et al (2019) The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. Nucleic Acids Res 47(15):7719–7733. https://doi.org/10.1093/nar/gkz619

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen YG, Chen R, Ahmad S, Verma R, Kasturi SP, Amaya L et al (2019) N6-methyladenosine modification controls circular RNA immunity. Mol Cell 76(1):96-109.e9. https://doi.org/10.1016/j.molcel.2019.07.016

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang X, Liu B, Nie Z, Duan L, Xiong Q, Jin Z et al (2021) The role of m6A modification in the biological functions and diseases. Signal Transduct Target Ther 6(1):74. https://doi.org/10.1038/s41392-020-00450-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geula S, Moshitch-Moshkovitz S, Dominissini D, Mansour AA, Kol N, Salmon-Divon M et al (2015) Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation. Science 347(6225):1002–6. https://doi.org/10.1126/science.1261417

Article  CAS  PubMed  Google Scholar 

Frye M, Harada BT, Behm M, He C (2018) RNA modifications modulate gene expression during development. Science 361(6409):1346–1349. https://doi.org/10.1126/science.aau1646

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li W, Hao Y, Zhang X, Xu S, Pang D (2022) Targeting RNA N(6)-methyladenosine modification: a precise weapon in overcoming tumor immune escape. Mol Cancer 21(1):176. https://doi.org/10.1186/s12943-022-01652-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu L, Li H, Hu D, Wang Y, Shao W, Zhong J et al (2022) Insights into N6-methyladenosine and programmed cell death in cancer. Mol Cancer 21(1):32. https://doi.org/10.1186/s12943-022-01508-w

Article  CAS  PubMed 

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