Abu-Hayyeh S, Williamson C (2014) Estradiol, farnesoid X receptor, and altered metabolism in pregnancy. Hepatology 60(6):1815–1817

Article  CAS  PubMed  Google Scholar 

Bacq Y, Sentilhes L, Reyes HB et al (2012) Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis. Gastroenterology 143(6):1492–1501

Article  CAS  PubMed  Google Scholar 

Boaglio AC, Zucchetti AE, Sánchez Pozzi EJ et al (2010) Phosphoinositide 3-kinase/protein kinase B signaling pathway is involved in estradiol 17β-D-glucuronide-induced cholestasis: complementarity with classical protein kinase C. Hepatology 52(4):1465–1476. https://doi.org/10.1002/hep.23846

Article  CAS  PubMed  Google Scholar 

Boyer JL, Soroka CJ (2021) Bile formation and secretion: an update. J Hepatol 75(1):190–201

Article  PubMed  Google Scholar 

Elferink MG, Olinga P, Draaisma AL et al (2004) LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process. Am J Physiol Gastrointest Liver Physiol 287(5):G1008–G1016

Article  CAS  PubMed  Google Scholar 

Geenes V, Williamson C (2009) Intrahepatic cholestasis of pregnancy. World J Gastroenterol 15(17):2049–2066

Article  PubMed  PubMed Central  Google Scholar 

Han F, Xu L, Huang Y et al (2018) Magnesium sulphate can alleviate oxidative stress and reduce inflammatory cytokines in rat placenta of intrahepatic cholestasis of pregnancy model. Arch Gynecol Obstet 298:631–638. https://doi.org/10.1007/s00404-018-4850-1

Article  CAS  PubMed  Google Scholar 

Hayashi H, Sugiyama Y (2007) 4-phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps. Hepatology 45(6):1506–1516

Article  CAS  PubMed  Google Scholar 

Hsu HS, Liu CC, Lin JH et al (2017) Involvement of ER stress, PI3K/AKT activation, and lung fibroblast proliferation in bleomycin-induced pulmonary fibrosis. Sci Rep 7(1):14272

Article  PubMed  PubMed Central  Google Scholar 

Jelski W, Piechota J, Orywal K, Mroczko B (2020) The alterations in of alcohol dehydrogenase activity in the sera of women with intrahepatic cholestasis of pregnancy. Anticancer Res 40:1997–2001

Article  CAS  PubMed  Google Scholar 

Lee HY, Lee GH, Kim HR et al (2020) Phosphatidylinositol 3-kinase-δ controls endoplasmic reticulum membrane fluidity and permeability in fungus-induced allergic inflammation in mice. Br J Pharmacol 177(7):1556–1567

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liao E, Li Z, Shao Y (2018) Resveratrol regulates the silent information regulator 1-nuclear factor-κB signaling pathway in intrahepatic cholestasis of pregnancy. Hepatol Res 48(12):1031–1044

Article  CAS  PubMed  Google Scholar 

Miszczuk GS, Barosso IR, Larocca MC et al (2018) Mechanisms of canalicular transporter endocytosis in the cholestatic rat liver. Biochim Biophys Acta Mol Basis Dis 1864(4 Pt A):1072–85

Article  CAS  PubMed  Google Scholar 

Ovadia C, Seed PT, Sklavounos A et al (2019) Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. Lancet 393(10174):899–909

Article  PubMed  PubMed Central  Google Scholar 

Ovadia C, Sajous J, Seed PT et al (2021) Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis. Lancet Gastroenterol Hepatol 6(7):547–558

Article  PubMed  PubMed Central  Google Scholar 

Papacleovoulou G, Abu-Hayyeh S, Nikolopoulou E et al (2013) Maternal cholestasis during pregnancy programs metabolic disease in offspring. J Clin Invest 123(7):3172–3181

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qin L, Wang Z, Tao L et al (2010) ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy. Autophagy 6(2):239–247

Article  CAS  PubMed  Google Scholar 

Song X, Vasilenko A, Chen Y et al (2014) Transcriptional dynamics of bile salt export pump during pregnancy: mechanisms and implications in intrahepatic cholestasis of pregnancy. Hepatology (Baltimore, MD) 60(6):1993–2007

Article  CAS  PubMed  Google Scholar 

Yu Y, Zhou CL, Yu TT et al (2017) Effect of endoplasmic reticulum stress in trophocytes on the pathogenesis of intrahepatic cholestasis of pregnancy. Zhonghua fu Chan ke za zhi 52(6):392–397

CAS  PubMed  Google Scholar 

Zou S, Zou P, Wang Y et al (2019) ERp29 inhibition attenuates TCA toxicity via affecting p38/p53-dependent pathway in human trophoblast HTR-8/SVeno cells. Arch Biochem Biophys 676:108125

Article  CAS  PubMed  Google Scholar 

Zu Y, Yang J, Zhang C et al (2021) The pathological mechanisms of Estrogen-induced cholestasis: current perspectives. Front Pharmacol 12:761255

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zucchetti AE, Barosso IR, Boaglio AC et al (2014) G-protein-coupled receptor 30/adenylyl cyclase/protein kinase A pathway is involved in estradiol 17ß-D-glucuronide-induced cholestasis. Hepatology 59(3):1016–1029

Article  CAS  PubMed  Google Scholar