Ciliary neurotrophic factor (CNTF) contributes to pelvic organ prolapse by modulating collagen expression via the JAK2–STAT3 pathway

Åkervall S, Al-Mukhtar Othman J, Molin M, Gyhagen M (2020) Symptomatic pelvic organ prolapse in middle-aged women: a national matched cohort study on the influence of childbirth. Am J Obstet Gynecol 222(4):356.e1-356.e14. https://doi.org/10.1016/j.ajog.2019.10.007

Article  PubMed  Google Scholar 

Allen RE, Hosker GL, Smith AR, Warrell DW (1990) Pelvic floor damage and childbirth: a neurophysiological study. Br J Obstet Gynaecol 97(9):770–779. https://doi.org/10.1111/j.1471-0528.1990.tb02570.x

Article  PubMed  CAS  Google Scholar 

Barca JA, Bravo C, Pintado-Recarte MP, Asúnsolo Á, Cueto-Hernández I, Ruiz-Labarta J, Buján J, Ortega MA, De León-Luis JA (2021) Pelvic floor morbidity following vaginal delivery versus cesarean delivery: systematic review and meta-analysis. J Clin Med 10(8):1652. https://doi.org/10.3390/jcm10081652

Article  PubMed  PubMed Central  Google Scholar 

Blomquist JL, Carroll M, Muñoz A, Handa VL (2020) Pelvic floor muscle strength and the incidence of pelvic floor disorders after vaginal and cesarean delivery. Am J Obstet Gynecol 222(1):62.e1-62.e8. https://doi.org/10.1016/j.ajog.2019.08.003

Article  PubMed  Google Scholar 

Bray R, Derpapas A, Fernando R, Khullar V, Panayi DC (2017) Does the vaginal wall become thinner as prolapse grade increases? Int Urogynecol J 28(3):397–402. https://doi.org/10.1007/s00192-016-3150-1

Article  PubMed  Google Scholar 

Catlett-Falcone R et al (1999) Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 10:105–115. https://doi.org/10.1016/s1074-7613(00)80011-4

Article  PubMed  CAS  Google Scholar 

Chi N, Lozo S, Rathnayake RAC, Botros-Brey S, Ma Y, Damaser M, Wang RR (2022) Distinctive structure, composition and biomechanics of collagen fibrils in vaginal wall connective tissues associated with pelvic organ prolapse. Acta Biomater 15(152):335–344. https://doi.org/10.1016/j.actbio.2022.08.059

Article  CAS  Google Scholar 

Connell KA, Guess MK, Chen H, Andikyan V, Bercik R, Taylor HS (2008) HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse. J Clin Invest 118(3):1050–1055. https://doi.org/10.1172/JCI34193

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cui W, Liu CX, Wang J, Zhang YC, Shen Q, Feng ZH, Wu J, Li JX (2019) An oleanolic acid derivative reduces denervation-induced muscle atrophy via activation of CNTF-mediated JAK2/STAT3 signaling pathway. Eur J Pharmacol 15(861):172612. https://doi.org/10.1016/j.ejphar.2019.172612

Article  CAS  Google Scholar 

DeLancey JOL, Masteling M, Pipitone F, LaCross J, Mastrovito S, Ashton-Miller JA (2024) Pelvic floor injury during vaginal birth is life-altering and preventable: what can we do about it? Am J Obstet Gynecol 230(3):279-294.e2. https://doi.org/10.1016/j.ajog.2023.11.1253. (Epub 2024 Jan 2)

Article  PubMed  PubMed Central  Google Scholar 

Duan Y, Chen Y, He Y, Gong R, Xia Z (2024) Expression of insulin-like growth factor binding protein 5 in the vaginal wall tissues of older women with pelvic organ prolapse. Sci Rep 14(1):18353. https://doi.org/10.1038/s41598-024-69098-9

Article  PubMed  PubMed Central  Google Scholar 

Gregory WT, Lou JS, Stuyvesant A, Clark AL (2004) Quantitative electromyography of the anal sphincter after uncomplicated vaginal delivery. Obstet Gynecol 104(2):327–335. https://doi.org/10.1097/01.AOG.0000134527.07034.81

Article  PubMed  Google Scholar 

Guler Z, Roovers JP (2022) Role of fibroblasts and myofibroblasts on the pathogenesis and treatment of pelvic organ prolapse. Biomolecules 12(1):94. https://doi.org/10.3390/biom12010094

Article  PubMed  PubMed Central  CAS  Google Scholar 

Guo T, Du Z, Wang XQ, Lang JH, Sun ZJ (2023) Ovariectomy with simulated vaginal delivery to establish a rat model for pelvic organ prolapse. Connect Tissue Res 64(4):376–388. https://doi.org/10.1080/03008207.2023.2199091

Article  PubMed  Google Scholar 

Hu Z, Deng N, Liu K, Zhou N, Sun Y, Zeng W (2020) CNTF-STAT3-IL-6 axis mediates neuroinflammatory cascade across Schwann cell-neuron-microglia. Cell Rep 31(7):107657. https://doi.org/10.1016/j.celrep.2020.107657

Article  PubMed  CAS  Google Scholar 

Hu Y, Wu R, Li H, Gu Y, Wei W (2017) Expression and significance of metalloproteinase and collagen in vaginal wall tissues of patients with pelvic organ prolapse. Ann Clin Lab Sci 47(6):698–705

PubMed  CAS  Google Scholar 

Jelovsek JE, Maher C, Barber MD (2007) Pelvic organ prolapse. Lancet 369(9566):1027–1038. https://doi.org/10.1016/S0140-6736(07)60462-0

Article  PubMed  Google Scholar 

Kenne KA, Wendt L, Brooks JJ (2022) Prevalence of pelvic floor disorders in adult women being seen in a primary care setting and associated risk factors. Sci Rep 12(1):9878. https://doi.org/10.1038/s41598-022-13501-w

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kerkhof MH, Ruiz-Zapata AM, Bril H, Bleeker MC, Belien JA, Stoop R, Helder MN (2014) Changes in tissue composition of the vaginal wall of premenopausal women with prolapse. Am J Obstet Gynecol 210(2):168.e1–9. https://doi.org/10.1016/j.ajog.2013.10.881

Article  PubMed  CAS  Google Scholar 

Liu X, Hao F, Hao P, Zhang J, Wang L, You SW, Wang N, Yang Z, So KF, Li X (2023) Regeneration and functional recovery of the completely transected optic nerve in adult rats by CNTF-chitosan. Signal Transduct Target Ther 8(1):81. https://doi.org/10.1038/s41392-022-01289-0

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu T, Hou X, Xie B, Wu J, Yang X, Sun X, Wang J (2020) Pelvic incidence: a study of a spinopelvic parameter in MRI evaluation of pelvic organ prolapse. Eur J Radiol 132:109286. https://doi.org/10.1016/j.ejrad.2020.109286

Article  PubMed  Google Scholar 

Mukwege A, Harlow SD, Hood MM, Reed BD, Dugan SA, Miller JM (2024) Race/ethnicity and incidence of pelvic organ prolapse in midlife women: the study of women’s health across the nation. J Womens Health (Larchmt). https://doi.org/10.1089/jwh.2023.0804

Article  PubMed  Google Scholar 

Palacios JL, Juárez M, Morán C, Xelhuantzi N, Damaser MS, Cruz Y (2016) Neuroanatomic and behavioral correlates of urinary dysfunction induced by vaginal distension in rats. Am J Physiol Renal Physiol 310(10):F1065–F1073. https://doi.org/10.1152/ajprenal.00417.2015

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pelvic Organ Prolapse (2019) ACOG Practice Bulletin, Number 214. Obstet Gynecol 134(5):e126–e142. https://doi.org/10.1097/AOG.0000000000003519

Article  Google Scholar 

Schulten SFM, Claas-Quax MJ, Weemhoff M, van Eijndhoven HW, van Leijsen SA, Vergeldt TF, IntHout J, Kluivers KB (2022) Risk factors for primary pelvic organ prolapse and prolapse recurrence: an updated systematic review and meta-analysis. Am J Obstet Gynecol 227(2):192–208. https://doi.org/10.1016/j.ajog.2022.04.046

Article  PubMed  Google Scholar 

Sferra R, Pompili S, D’Alfonso A, Sabetta G, Gaudio E, Carta G, Festuccia C, Colapietro A, Vetuschi A (2019) Neurovascular alterations of muscularis propria in the human anterior vaginal wall in pelvic organ prolapse. J Anat 235(2):281–288. https://doi.org/10.1111/joa.13014

Article  PubMed  PubMed Central  CAS  Google Scholar 

Thanos S, Böhm MR, Schallenberg M, Oellers P (2012) Traumatology of the optic nerve and contribution of crystallins to axonal regeneration. Cell Tissue Res 349(1):49–69. https://doi.org/10.1007/s00441-012-1442-4

Article  PubMed  CAS  Google Scholar 

Tian Z, Li Q, Wang X, Sun Z (2024) The difference in extracellular matrix metabolism in women with and without pelvic organ prolapse: a systematic review and meta-analysis. BJOG 131(8):1029–1041. https://doi.org/10.1111/1471-0528.17768

Article  PubMed  CAS  Google Scholar 

Vergeldt TF, Weemhoff M, IntHout J, Kluivers KB (2015) Risk factors for pelvic organ prolapse and its recurrence: a systematic review. Int Urogynecol J 26(11):1559–1573.

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