Abyad A (2015) Alzheimer’s in the middle East. Population 6:12

Google Scholar 

Aggarwal BB, Harikumar KB (2009) Potential therapeutic effects of Curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 41(1):40–59

CAS  PubMed  Google Scholar 

Al Kahtani MA (2020) Effect of both selenium and biosynthesized nanoselenium particles on cadmium-induced neurotoxicity in albino rats. Hum Exp Toxicol 39(2):159–172

CAS  PubMed  Google Scholar 

Algharib SA (2016) Antioxidant effect of selenium and its nano form on oxidative stress induced by iron overload. Benha Vet Med J 31(1):96–102

Google Scholar 

Ali HF, El-Sayed NM, Ahmed AA, Hanna PA, Moustafa YM (2020) Nano selenium ameliorates oxidative stress and inflammatory response associated with cypermethrin-induced neurotoxicity in rats. Ecotoxicol Environ Saf 195:110479

CAS  PubMed  Google Scholar 

Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB (2007) Bioavailability of curcumin: problems and promises. Mol Pharm 4(6):807–818

CAS  PubMed  Google Scholar 

Bancroft JD, Stevens A (2016) Theory and practice of histological techniques. Churchill Livingstone, London. Edition: 7th. P: 120:131

Bancroft J, Stevens A, Turner D (1996) Theory and practice of histological techniques, fourth ed. churchill living stone, new york edinburgh, Madrid, Sanfrancisco 20

Beltagy DM, Nawar NF, Mohamed TM, Tousson E, El-Keey MM (2024) The synergistic effect of Nanocurcumin and donepezil on Alzheimer’s via PI3K/AKT/GSK-3β pathway modulating. Prostaglandins Other Lipid Mediat 170:106791

CAS  PubMed  Google Scholar 

Chen J, Berry MJ (2003) Selenium and selenoproteins in the brain and brain diseases. J Neurochem 86(1):1–12

CAS  PubMed  Google Scholar 

Danzon PM, Furukawa MF (2006) Prices and availability of biopharmaceuticals: an international comparison. Health Aff 25(5):1353–1362

Google Scholar 

De Plano LM, Calabrese G, Rizzo MG, Oddo S, Caccamo A (2023) The role of the transcription factor Nrf2 in Alzheimer’s disease: therapeutic opportunities. Biomolecules 13(3):549

PubMed  PubMed Central  Google Scholar 

Ebokaiwe AP, Okori S, Nwankwo JO, Ejike CE, Osawe SO (2021) Selenium nanoparticles and Metformin ameliorate streptozotocin-instigated brain oxidative-inflammatory stress and neurobehavioral alterations in rats. Naunyn Schmiedebergs Arch Pharmacol 394(4):591–602

CAS  PubMed  Google Scholar 

El-Gizawy MM, Hosny EN, Mourad HH, Abd-El Razik AN (2020) Curcumin nanoparticles ameliorate hepatotoxicity and nephrotoxicity induced by cisplatin in rats. Naunyn Schmiedebergs Arch Pharmacol 393(10):1941–1953. https://doi.org/10.1007/s00210-020-01888-0

Article  CAS  PubMed  Google Scholar 

ELBini-Dhouib I, Doghri R, Ellefi A, Degrach I, Srairi-Abid N, Gati A (2021) Curcumin attenuated neurotoxicity in sporadic animal model of Alzheimer’s disease. Molecules 26(10):3011. https://doi.org/10.3390/molecules26103011

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elfakharany SA, Eskaros SS, Azhary NME, Abdelmonsif DA, Zeitoun TM, Ammar GA, Hatem YA (2024) Neuroprotective role of selenium nanoparticles against behavioral, neurobiochemical and histological alterations in rats subjected to chronic restraint stress. Mol Neurobiol 1–23

Elizabeth MA, Samson P, Itohan OR (2020) Histomorphological evaluations on the frontal cortex extrapyramidal cell layer following administration of N-Acetyl cysteine in aluminum induced neurodegeneration rat model. Metab Brain Dis 35:829–839

CAS  PubMed  PubMed Central  Google Scholar 

Feng L, Wang H, Xue X (2020) Recent progress of nanomedicine in the treatment of central nervous system diseases. Adv Ther 3(5):1900159

Google Scholar 

Genchi G, Lauria G, Catalano A, Carocci A, Sinicropi MS (2024) Neuroprotective effects of curcumin in neurodegenerative diseases. Foods 13(11):1774. https://doi.org/10.3390/foods13111774

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghosh S, Banerjee S, Sil PC (2015) The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: a recent update. Food Chem Toxicol 83:111–124

CAS  PubMed  Google Scholar 

Hamdan DI, Tawfeek N, El-Shiekh RA, Khalil HMA, Mahmoud MY, Bakr AF, Zaafar D, Farrag N, Wink M, El-Shazly AM (2022) Salix subserrata bark extract-loaded chitosan nanoparticles attenuate neurotoxicity induced by sodium arsenate in rats in relation with HPLC–PDA-ESI–MS/MS profile. AAPS PharmSciTech 24:15. https://doi.org/10.1208/s12249-022-02478-4

Article  CAS  PubMed  Google Scholar 

He F, Ru X, Wen T (2020) NRF2, a transcription factor for stress response and beyond. Int J Mol Sci 21(13):4777

CAS  PubMed  PubMed Central  Google Scholar 

Irnidayanti Y, Herlina N (2022) Nanocurcumin, promising potential protective agent against histopathological damage in the cerebral cortex of mice induced by aluminum chloride. Pak J Biol Sci PJBS 25(6):560–568

CAS  Google Scholar 

Jembrek MJ, Slade N, Hof PR, Šimić G (2018) The interactions of p53 with Tau and Aß as potential therapeutic targets for Alzheimer’s disease. Prog Neurobiol 168:104–127

Google Scholar 

Jembrek MJ, Newberg K, Šimić G (2019) The role of p53 in Alzheimer’s disease: impact on Tau pathology. Pathol Prev Ther Neurodegen Disease 39–48

Joseph TM, Kar Mahapatra D, Esmaeili A, Piszczyk Ł, Hasanin MS, Kattali M, Haponiuk J, Thomas S (2023) Nanoparticles: taking a unique position in medicine. Nanomaterials 13(3):574

CAS  PubMed  PubMed Central  Google Scholar 

Kamel B, Elnabtity SM, AbdelHafeez MM, Mehanna E, Abo-El-Matty D (2022) A brief review on nanomedicine and the therapeutic applications of gold nanoparticles. Records Pharm Biomedical Sci 6(1):101–102

Google Scholar 

Kandelshein H, Bloemer J (2022) Side effects of drugs used in the treatment of Alzheimer’s disease. Side Eff Drugs Annual 44:69–75

Google Scholar 

Karas RA, Alexeree S, Elsayed H, Attia YA (2024a) Assessment of wound healing activity in diabetic mice treated with a novel therapeutic combination of selenium nanoparticles and platelets rich plasma. Sci Rep 14(1):5346

CAS  PubMed  PubMed Central  Google Scholar 

Karas RA, Alexeree S, Elzohery N, Abdel-Hafez SH, Attia YA (2024b) Antidiabetic potential of selenium nanoparticles and plasma-rich platelets in diabetic mice. Appl Biol Chem 67(1):62

CAS  Google Scholar 

Karthikeyan A, Senthil N, Min T (2020) Nanocurcumin: a promising candidate for therapeutic applications. Front Pharmacol 11:487

CAS  PubMed  PubMed Central  Google Scholar 

Kawahara M, Kato-Negishi M (2011) Link between aluminum and the pathogenesis of Alzheimer’s disease: the integration of the aluminum and amyloid cascade hypotheses. Int J Alzheimer’s Dis 2011:276393

Google Scholar 

Khalil HMA, Salama HH, Al-Mokaddem AK, Aljuaydi SH, Edris AE (2020) Edible dairy formula fortified with coconut oil for neuroprotection against aluminium chloride-induced Alzheimer’s disease in rats. J Funct Foods 75:104296

CAS  Google Scholar 

Khalil HMA, Khalil IA, Al-Mokaddem AK, Hassan M, El-Shiekh RA, Eliwa HA, Tawfek AM, El-Maadawy WH (2023) Ashwagandha-loaded nanocapsules improved the behavioral alterations, and blocked MAPK and induced Nrf2 signaling pathways in a hepatic encephalopathy rat model. Drug Deliv Transl Res 13(1):252–274. https://doi.org/10.1007/s13346-022-01181-y

Article  CAS  PubMed  Google Scholar 

Khan NH, Mir M, Ngowi EE, Zafar U, Khakwani MMAK, Khattak S, Zhai YK, Jiang ES, Zheng M, Duan SF, Wei JS, Wu DD, Ji XY (2021) Nanomedicine: a promising way to manage Alzheimer’s disease. Front Bioeng Biotechnol 9:630055

PubMed  PubMed Central  Google Scholar 

Liu L, He Y, Xiao Z, Tao W, Zhu J, Wang B, Liu Z, Wang M (2017) Effects of selenium nanoparticles on reproductive performance of male Sprague-Dawley rats at supranutritional and nonlethal levels. Biol Trace Elem Res 180(1):81–89. https://doi.org/10.1007/s12011-017-0980-8

Article  CAS  PubMed  Google Scholar 

Makuch S, Więcek K, Wo´ zniak M (2021) The Immunomodulatory and anti-inflammatory effect of Curcumin on immune cell populations, cytokines, and in vivo models of rheumatoid arthritis. Pharmaceuticals 14:309

CAS  PubMed  PubMed Central  Google Scholar 

McClements DJ (2012) Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft Matter 8(6):1719–1729

CAS  Google Scholar 

Menon VP, Sudheer AR (2007) Antioxidant and anti-inflammatory properties of Curcumin. Adv Exp Med Biol 595:105–125

PubMed  Google Scholar 

Mirza A, King A, Troakes C, Exley C (2017) Aluminium in brain tissue in familial Alzheimer’s disease. J Trace Elem Med Biol 40:30–36

CAS  PubMed  Google Scholar 

Mohamed AB, Mohamed AZ, Aly S (2020) Effect of thymoquinone against aluminum chloride-induced Alzheimer-like model in rats: a neurophysiological and behavioral study. Med J Cairo Univ 88(March):355–365

Google Scholar 

Mohammed ET, Safwat GM (2013) Assessment of the ameliorative role of selenium nanoparticles on the oxidative stress of acetaminophen in some tissues of male albino rats. Beni-Suef Univ J Basic Appl Sci 2(2):80–85

Google Scholar