Global Cardiovascular Risk C, Magnussen C, Ojeda FM, Leong DP, Alegre-Diaz J, Amouyel P, et al. Global effect of modifiable risk factors on cardiovascular disease and mortality. N Engl J Med. 2023;389:1273–85.

Article  Google Scholar 

Kim CJ, Park MW, Kim MC, Choo EH, Hwang BH, Lee KY, et al. Unguided de-escalation from ticagrelor to clopidogrel in stabilised patients with acute myocardial infarction undergoing percutaneous coronary intervention (TALOS-AMI): an investigator-initiated, open-label, multicentre, non-inferiority, randomised trial. Lancet. 2021;398:1305–16.

Article  CAS  PubMed  Google Scholar 

Yusuf S, Joseph P, Dans A, Gao P, Teo K, Xavier D, et al. Polypill with or without aspirin in persons without cardiovascular disease. N Engl J Med. 2021;384:216–28.

Article  CAS  PubMed  Google Scholar 

Gabisonia K, Prosdocimo G, Aquaro GD, Carlucci L, Zentilin L, Secco I, et al. MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs. Nature. 2019;569:418–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Gao Y, Li G. Preclinical multi-target strategies for myocardial ischemia-reperfusion injury. Front Cardiovasc Med. 2022;9:967115.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prabhu SD, Frangogiannis NG. The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis. Circ Res. 2016;119:91–112.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang H, Kim H, Park BW, Noh M, Kim Y, Park J, et al. CU06-1004 enhances vascular integrity and improves cardiac remodeling by suppressing edema and inflammation in myocardial ischemia-reperfusion injury. Exp Mol Med 2022;54:23–34.

Kuruvilla L, Kartha CC. Molecular mechanisms in endothelial regulation of cardiac function. Mol Cell Biochem. 2003;253:113–23.

Article  CAS  PubMed  Google Scholar 

Gan L, Liu D, Liu J, Chen E, Chen C, Liu L, et al. CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice. Signal Transduct Target Ther. 2021;6:223.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barallobre-Barreiro J, Radovits T, Fava M, Mayr U, Lin WY, Ermolaeva E, et al. Extracellular matrix in heart failure: role of ADAMTS5 in proteoglycan remodeling. Circulation. 2021;144:2021–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim S, Iwao H. Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases. Pharmacol Rev. 2000;52:11–34.

CAS  PubMed  Google Scholar 

Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, et al. Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med. 2002;8:856–63.

Article  CAS  PubMed  Google Scholar 

Li Y, Yao Y, Li J, Chen Q, Zhang L, Wang QK. Losartan protects against myocardial ischemia and reperfusion injury via vascular integrity preservation. FASEB J. 2019;33:8555–64.

Article  CAS  PubMed  Google Scholar 

Ye B, Zhou H, Chen Y, Luo W, Lin W, Zhao Y, et al. USP25 ameliorates pathological cardiac hypertrophy by stabilizing SERCA2a in cardiomyocytes. Circ Res. 2023;132:465–80.

Article  CAS  PubMed  Google Scholar 

Oyamada S, Bianchi C, Takai S, Robich MP, Clements RT, Chu L, et al. Impact of acute myocardial ischemia reperfusion on the tissue and blood-borne renin-angiotensin system. Basic Res Cardiol. 2010;105:513–22.

Article  CAS  PubMed  Google Scholar 

Kang JS, Lee SJ, Lee JH, Kim JH, Son SS, Cha SK, et al. Angiotensin II-mediated MYH9 downregulation causes structural and functional podocyte injury in diabetic kidney disease. Sci Rep. 2019;9:7679.

Article  PubMed  PubMed Central  Google Scholar 

Morrison AR, Yarovinsky TO, Young BD, Moraes F, Ross TD, Ceneri N, et al. Chemokine-coupled beta2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. J Exp Med. 2014;211:1957–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu ST, Sun BH, Ge JN, Shi JL, Zhu MS, Wei ZG, et al. CRLF1-MYH9 interaction regulates proliferation and metastasis of papillary thyroid carcinoma through the ERK/ETV4 axis. Front Endocrinol. 2020;11:535.

Article  Google Scholar 

Figueiredo AM, Barbacena P, Russo A, Vaccaro S, Ramalho D, Pena A, et al. Endothelial cell invasion is controlled by dactylopodia. Proc Natl Acad Sci USA. 2021;118:e2023829118.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heuze ML, Sankara Narayana GHN, D’Alessandro J, Cellerin V, Dang T, Williams DS, et al. Myosin II isoforms play distinct roles in adherens junction biogenesis. Elife. 2019;8:e46599.

Article  PubMed  PubMed Central  Google Scholar 

Vicente-Manzanares M, Ma X, Adelstein RS, Horwitz AR. Non-muscle myosin II takes centre stage in cell adhesion and migration. Nat Rev Mol Cell Biol. 2009;10:778–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gong S, Cao G, Li F, Chen Z, Pan X, Ma H, et al. Endothelial conditional knockdown of NMMHC IIA (nonmuscle myosin heavy Chain IIA) attenuates blood-brain barrier damage during ischemia-reperfusion injury. Stroke. 2021;52:1053–64.

Article  CAS  PubMed  Google Scholar 

Huang CK, Dai D, Xie H, Zhu Z, Hu J, Su M, et al. Lgr4 governs a pro-inflammatory program in macrophages to antagonize post-infarction cardiac repair. Circ Res. 2020;127:953–73.

Article  CAS  PubMed  Google Scholar 

Beisaw A, Kuenne C, Guenther S, Dallmann J, Wu CC, Bentsen M, et al. AP-1 contributes to chromatin accessibility to promote sarcomere disassembly and cardiomyocyte protrusion during zebrafish heart regeneration. Circ Res. 2020;126:1760–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Galvagni F, Orlandini M, Oliviero S. Role of the AP-1 transcription factor FOSL1 in endothelial cells adhesion and migration. Cell Adh Migr. 2013;7:408–11.

Article  PubMed  PubMed Central  Google Scholar 

Evellin S, Galvagni F, Zippo A, Neri F, Orlandini M, Incarnato D, et al. FOSL1 controls the assembly of endothelial cells into capillary tubes by direct repression of alphav and beta3 integrin transcription. Mol Cell Biol. 2013;33:1198–209.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo B, Cao J, Liu Y, Wang Y, Qian Y, Chen G, et al. Cardiac protection of a Novel lupane-type triterpenoid from injuries induced by hypoxia-reperfusion. Int J Mol Sci. 2022;23:9473.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao W, Yang L, Chen X, Qian H, Zhang S, Chen Y, et al. Phenotypic and functional characterization of tumor-derived endothelial cells isolated from primary human hepatocellular carcinoma. Hepatol Res. 2018;48:1149–62.

Article  CAS  PubMed  Google Scholar 

Lymperopoulos A, Borges JI, Stoicovy RA. RGS proteins and cardiovascular angiotensin II signaling: novel opportunities for therapeutic targeting. Biochem Pharmacol. 2023;218:115904.

Article  CAS  PubMed  Google Scholar 

Zhang C, Hein TW, Wang W, Kuo L. Divergent roles of angiotensin II AT1 and AT2 receptors in modulating coronary microvascular function. Circ Res. 2003;92:322–9.

Article  CAS  PubMed  Google Scholar 

Forrester SJ, Booz GW, Sigmund CD, Coffman TM, Kawai T, Rizzo V, et al. Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology. Physiol Rev. 2018;98:1627–738.