Fu Y, Mackowiak B, Lin YH, Maccioni L, Lehner T, Pan H, et al. Coordinated action of a gut-liver pathway drives alcohol detoxification and consumption. Nat Metab. 2024;6:1380–96.

Article  CAS  PubMed  Google Scholar 

Avila MA, Dufour JF, Gerbes AL, Zoulim F, Bataller R, Burra P, et al. Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting. Gut. 2020;69:764–80.

Article  PubMed  Google Scholar 

GBD 2017 Cirrhosis Collaborators. The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol. 2020;5:245–66.

Article  Google Scholar 

Xia H, Green DR, Zou W. Autophagy in tumour immunity and therapy. Nat Rev Cancer. 2021;21:281–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Malhi H, Kaufman RJ. Endoplasmic reticulum stress in liver disease. J Hepatol. 2011;54:795–809.

Article  CAS  PubMed  Google Scholar 

Ferro-Novick S, Reggiori F, Brodsky JL. ER-phagy, ER homeostasis, and ER quality control: implications for disease. Trends Biochem Sci. 2021;46:630–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hübner CA, Dikic I. ER-phagy and human diseases. Cell Death Differ. 2020;27:833–42.

Article  PubMed  Google Scholar 

Mochida K, Oikawa Y, Kimura Y, Kirisako H, Hirano H, Ohsumi Y, et al. Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus. Nature. 2015;522:359–62.

Article  CAS  PubMed  Google Scholar 

Chino H, Mizushima N. ER-phagy: quality control and turnover of endoplasmic reticulum. Trends Cell Biol. 2020;30:384–98.

Article  CAS  PubMed  Google Scholar 

Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, et al. Regulation of endoplasmic reticulum turnover by selective autophagy. Nature. 2015;522:354–8.

Article  CAS  PubMed  Google Scholar 

Fumagalli F, Noack J, Bergmann TJ, Cebollero E, Pisoni GB, Fasana E, et al. Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery. Nat Cell Biol. 2016;18:1173–84.

Article  CAS  PubMed  Google Scholar 

Grumati P, Morozzi G, Hölper S, Mari M, Harwardt MI, Yan R, et al. Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy. Elife. 2017;6:e25555.

Article  PubMed  PubMed Central  Google Scholar 

Smith MD, Harley ME, Kemp AJ, Wills J, Lee M, Arends M, et al. CCPG1 is a non-canonical autophagy cargo receptor essential for ER-phagy and pancreatic ER proteostasis. Dev Cell. 2018;44:217–32.e11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen QZ, Xiao Y, Chai PY, Zheng PL, Teng JL, Chen JG. ATL3 is a tubular ER-Phagy receptor for GABARAP-mediated selective autophagy. Curr Biol. 2019;29:846–55.e6.

Article  CAS  PubMed  Google Scholar 

Chino H, Hatta T, Natsume T, Mizushima N. Intrinsically disordered protein TEX264 mediates ER-phagy. Mol Cell. 2019;74:909–21.e6.

Article  CAS  PubMed  Google Scholar 

An H, Ordureau A, Paulo JA, Shoemaker CJ, Denic V, Harper JW. TEX264 is an endoplasmic reticulum-resident ATG8-interacting protein critical for ER remodeling during nutrient stress. Mol Cell. 2019;74:891–908.e10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pang LJ, Liu K, Liu DJ, Lv FD, Zang YJ, Xie F, et al. Differential effects of reticulophagy and mitophagy on nonalcoholic fatty liver disease. Cell Death Dis. 2018;9:90.

Article  PubMed  PubMed Central  Google Scholar 

Zielke S, Kardo S, Zein L, Mari M, Covarrubias-Pinto A, Kinzler MN, et al. ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy. 2021;17:2432–48.

Article  CAS  PubMed  Google Scholar 

Lingueglia E. Acid-sensing ion channels in sensory perception. J Biol Chem. 2007;282:17325–9.

Article  CAS  PubMed  Google Scholar 

Wemmie JA, Price MP, Welsh MJ. Acid-sensing ion channels: advances, questions and therapeutic opportunities. Trends Neurosci. 2006;29:578–86.

Article  CAS  PubMed  Google Scholar 

Immke DC, McCleskey EW. Protons open acid-sensing ion channels by catalyzing relief of Ca2+ blockade. Neuron. 2003;37:75–84.

Article  CAS  PubMed  Google Scholar 

Hey JG, Chu XP, Seeds J, Simon RP, Xiong ZG. Extracellular zinc protects against acidosis-induced injury of cells expressing Ca2+-permeable acid-sensing ion channels. Stroke. 2007;38:670–3.

Article  CAS  PubMed  Google Scholar 

Sun AW, Wu MH, Vijayalingam M, Wacker MJ, Chu XP. The role of zinc in modulating acid-sensing ion channel function. Biomolecules. 2023;13:229.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Immke DC, McCleskey EW. Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons. Nat Neurosci. 2001;4:869–70.

Article  CAS  PubMed  Google Scholar 

Poirot O, Vukicevic M, Boesch A, Kellenberger S. Selective regulation of acid-sensing ion channel 1 by serine proteases. J Biol Chem. 2004;279:38448–57.

Article  CAS  PubMed  Google Scholar 

Allen NJ, Attwell D. Modulation of ASIC channels in rat cerebellar Purkinje neurons by ischaemia-related signals. J Physiol. 2002;543:521–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chu XP, Close N, Saugstad JA, Xiong ZG. ASIC1a-specific modulation of acid-sensing ion channels in mouse cortical neurons by redox reagents. J Neurosci. 2006;26:5329–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou RP, Leng TD, Yang T, Chen FH, Xiong ZG. Acute ethanol exposure promotes autophagy-lysosome pathway-dependent ASIC1a protein degradation and protects against acidosis-induced neurotoxicity. Mol Neurobiol. 2019;56:3326–40.

Article  CAS  PubMed  Google Scholar 

Wang YH, Sun YC, Zuo LQ, Wang YN, Huang Y. ASIC1a promotes high glucose and PDGF-induced hepatic stellate cell activation by inducing autophagy through CaMKKβ/ERK signaling pathway. Toxicol Lett. 2019;300:1–9.

Article  CAS  PubMed  Google Scholar 

Zuo LQ, Zhu YQ, Hu LL, Liu YY, Wang YH, Hu YM, et al. PI3-kinase/Akt pathway-regulated membrane transportation of acid-sensing ion channel 1a/Calcium ion influx/endoplasmic reticulum stress activation on PDGF-induced HSC Activation. J Cell Mol Med. 2019;23:3940–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu YQ, Pan XS, Du N, Li KY, Hu YM, Wang LL, et al. ASIC1a regulates miR-350/SPRY2 by N6 -methyladenosine to promote liver fibrosis. FASEB J. 2020;34:14371–88.

Article  CAS