Calise SJ, Abboud G, Kasahara H, Morel L, Chan EKL. Immune response-dependent assembly of IMP dehydrogenase filaments. Front Immunol. 2018;9:2789.
Article PubMed PubMed Central Google Scholar
Chen J, Yang S, Li Y, Ziwen X, Zhang P, Song Q, et al. De novo nucleotide biosynthetic pathway and cancer. Genes Dis. 2023;10:2331–8.
Article CAS PubMed Google Scholar
Rodriguez-Pascual J, Sha P, Garcia-Garcia E, Rajeshkumar NV, De Vicente E, Quijano Y, et al. A preclinical and clinical study of mycophenolate mofetil in pancreatic cancer. Invest N Drugs. 2013;31:14–9.
He X, Cui J, Ma H, Abuduaini N, Huang Y, Tang L, et al. Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer. Biochem Pharmacol. 2023;218:115868.
Article CAS PubMed Google Scholar
Floryk D, Thompson TC. Antiproliferative effects of AVN944, a novel inosine 5-monophosphate dehydrogenase inhibitor, in prostate cancer cells. Int J Cancer. 2008;123:2294–302.
Article CAS PubMed PubMed Central Google Scholar
Hood KA, Zarembski DG. Mycophenolate mofetil: a unique immunosuppressive agent. Am J Health Syst Pharmacol. 1997;54:285–94.
Blaheta RA, Leckel K, Wittig B, Zenker D, Oppermann E, Harder S, et al. Inhibition of endothelial receptor expression and of T-cell ligand activity by mycophenolate mofetil. Transpl Immunol. 1998;6:251–9.
Article CAS PubMed Google Scholar
Staatz CE, Tett SE. Pharmacology and toxicology of mycophenolate in organ transplant recipients: an update. Arch Toxicol. 2014;88:1351–89.
Article CAS PubMed Google Scholar
Beigel JH, Bao Y, Beeler J, Manosuthi W, Slandzicki A, Dar SM, et al. Oseltamivir, amantadine, and ribavirin combination antiviral therapy versus oseltamivir monotherapy for the treatment of influenza: a multicentre, double-blind, randomised phase 2 trial. Lancet Infect Dis. 2017;17:1255–65.
Article CAS PubMed PubMed Central Google Scholar
Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012;12:252–64.
Article CAS PubMed PubMed Central Google Scholar
Prestipino A, Zeiser R. Clinical implications of tumor-intrinsic mechanisms regulating PD-L1. Sci Transl Med. 2019;11:eaav4810.
Article CAS PubMed Google Scholar
Cha JH, Chan LC, Li CW, Hsu JL, Hung MC. Mechanisms controlling PD-L1 expression in cancer. Mol Cell. 2019;76:359–70.
Article CAS PubMed PubMed Central Google Scholar
Huang F, Huffman KE, Wang Z, Wang X, Li K, Cai F, et al. Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer. J Clin Invest. 2021;131:e139929.
Article CAS PubMed PubMed Central Google Scholar
Chen B, Hu J, Hu X, Chen H, Bao R, Zhou Y, et al. DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion. Nat Commun. 2022;13:2059.
Article CAS PubMed PubMed Central Google Scholar
Fan Z, Wu C, Chen M, Jiang Y, Wu Y, Mao R, et al. The generation of PD-L1 and PD-L2 in cancer cells: from nuclear chromatin reorganization to extracellular presentation. Acta Pharm Sin B. 2022;12:1041–53.
Article CAS PubMed Google Scholar
Schoenberg DR, Maquat LE. Regulation of cytoplasmic mRNA decay. Nat Rev Genet. 2012;13:246–59.
Article CAS PubMed PubMed Central Google Scholar
Vlasova-St Louis I, Bohjanen PR. Post-transcriptional regulation of cytokine and growth factor signaling in cancer. Cytokine Growth Factor Rev. 2017;33:83–93.
Article CAS PubMed Google Scholar
Yang K, Zhou J, Chen Y, Chen Y, Chen L, Zhang P, et al. Angiotensin II contributes to intratumoral immunosuppressionvia induction of PD-L1 expression in non-small cell lung carcinoma. Int Immunopharmacol. 2020;84:106507.
Article CAS PubMed Google Scholar
Zhang W, Pan X, Xu Y, Guo H, Zheng M, Chen X, et al. Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA. Acta Pharm Sin B. 2023;13:2585–600.
Article CAS PubMed PubMed Central Google Scholar
Coelho MA, de Carne Trecesson S, Rana S, Zecchin D, Moore C, Molina-Arcas M, et al. Oncogenic RAS signaling promotes tumor immunoresistance by stabilizing PD-L1 mRNA. Immunity. 2017;47:1083–99. e6
Article CAS PubMed PubMed Central Google Scholar
Zhang J, Bu X, Wang H, Zhu Y, Geng Y, Nihira NT, et al. Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Nature. 2018;553:91–5.
Article CAS PubMed Google Scholar
Armstrong VW, Tenderich G, Shipkova M, Parsa A, Koerfer R, Schroder H, et al. Pharmacokinetics and bioavailability of mycophenolic acid after intravenous administration and oral administration of mycophenolate mofetil to heart transplant recipients. Ther Drug Monit. 2005;27:315–21.
Article CAS PubMed Google Scholar
Xu H, Ma H, Zha L, Li Q, Yang G, Pan H, et al. IMPDH2 promotes cell proliferation and epithelial-mesenchymal transition of non-small cell lung cancer by activating the Wnt/beta-catenin signaling pathway. Oncol Lett. 2020;20:219.
Article CAS PubMed PubMed Central Google Scholar
Sagiv-Barfi I, Kohrt HE, Czerwinski DK, Ng PP, Chang BY, Levy R. Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK. Proc Natl Acad Sci USA. 2015;112:E966–72.
Article CAS PubMed PubMed Central Google Scholar
Idos GE, Kwok J, Bonthala N, Kysh L, Gruber SB, Qu C. The prognostic implications of tumor infiltrating lymphocytes in colorectal cancer: a systematic review and meta-analysis. Sci Rep. 2020;10:3360.
Article CAS PubMed PubMed Central Google Scholar
Youn JC, Stehlik J, Wilk AR, Cherikh W, Kim IC, Park GH, et al. Temporal trends of de novo malignancy development after heart transplantation. J Am Coll Cardiol. 2018;71:40–9.
Zeier M, Hartschuh W, Wiesel M, Lehnert T, Ritz E. Malignancy after renal transplantation. Am J Kidney Dis. 2002;39:E5.
Al-Adra D, Al-Qaoud T, Fowler K, Wong G. De novo malignancies after kidney transplantation. Clin J Am Soc Nephrol. 2022;17:434–43.
Article CAS PubMed PubMed Central Google Scholar
Marcen R. Immunosuppressive drugs in kidney transplantation: impact on patient survival, and incidence of cardiovascular disease, malignancy and infection. Drugs. 2009;69:2227–43.
Article CAS PubMed Google Scholar
Lin JY, Wang J, Mishra K, Osmani S, Rumsey K, Singh PP, et al. Non-melanoma skin cancer in solid organ transplant recipients with skin of color. J Am Acad Dermatol. 2024;90:159–60.
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