Chronic renal impairment predicts oncological outcomes in UTUC patients undergoing RNU

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7–30.

Article  PubMed  Google Scholar 

Roupret M, Seisen T, Birtle AJ, Capoun O, Comperat EM, Dominguez-Escrig JL, et al. European Association of Urology Guidelines on Upper urinary tract Urothelial Carcinoma: 2023 update. Eur Urol. 2023;84(1):49–64.

Article  PubMed  Google Scholar 

Teoh JY, Ng CF, Eto M, Chiruvella M, Capitanio U, Esen T, et al. Radical nephroureterectomy for UTUC conferred survival benefits irrespective of age and comorbidities. World J Urol. 2022;40(11):2657–65.

Article  PubMed  Google Scholar 

Rink M, Sjoberg D, Comploj E, Margulis V, Xylinas E, Lee RK, et al. Risk of cancer-specific mortality following recurrence after radical nephroureterectomy. Ann Surg Oncol. 2012;19(13):4337–44.

Article  PubMed  PubMed Central  Google Scholar 

Zhao H, Liu K, Giannakopoulos S, Yuruk E, De Naeyer G, Alvarez-Maestro M, et al. Impact of previous malignancy at diagnosis on oncological outcomes of upper tract urothelial carcinoma. BMC Urol. 2023;23(1):49.

Article  PubMed  PubMed Central  Google Scholar 

Lughezzani G, Burger M, Margulis V, Matin SF, Novara G, Roupret M, et al. Prognostic factors in upper urinary tract urothelial carcinomas: a comprehensive review of the current literature. Eur Urol. 2012;62(1):100–14.

Article  PubMed  Google Scholar 

Liu K, Zhao H, Ng CF, Teoh JY, Laguna P, Gontero P et al. The prognostic role of body Mass Index on Oncological outcomes of Upper Tract Urothelial Carcinoma. Cancers (Basel). 2023;15(22).

Rausch S, Hennenlotter J, Todenhofer T, Aufderklamm S, Schwentner C, Sievert KD, et al. Impaired estimated glomerular filtration rate is a significant predictor for non-muscle-invasive bladder cancer recurrence and progression–introducing a novel prognostic model for bladder cancer recurrence. Urol Oncol. 2014;32(8):1178–83.

Article  PubMed  Google Scholar 

Merseburger AS, Connelly RR, Sun L, Richter E, Moul JW. Use of serum creatinine to predict pathologic stage and recurrence among radical prostatectomy patients. Urology. 2001;58(5):729–34.

Article  CAS  PubMed  Google Scholar 

Woldu SL, Weinberg AC, RoyChoudhury A, Chase H, Kalloo SD, McKiernan JM, et al. Renal insufficiency is associated with an increased risk of papillary renal cell carcinoma histology. Int Urol Nephrol. 2014;46(11):2127–32.

Article  CAS  PubMed  Google Scholar 

Gaber AO, Moore LW, Aloia TA, Suki WN, Jones SL, Graviss EA, et al. Cross-sectional and case-control analyses of the association of kidney function staging with adverse postoperative outcomes in general and vascular surgery. Ann Surg. 2013;258(1):169–77.

Article  PubMed  Google Scholar 

Schmid M, Ravi P, Abd-El-Barr AE, Klap J, Sammon JD, Chang SL, et al. Chronic kidney disease and perioperative outcomes in urological oncological surgery. Int J Urol. 2014;21(12):1245–52.

Article  PubMed  Google Scholar 

Xylinas E, Rink M, Margulis V, Clozel T, Lee RK, Comploj E, et al. Impact of renal function on eligibility for chemotherapy and survival in patients who have undergone radical nephro-ureterectomy. BJU Int. 2013;112(4):453–61.

Article  CAS  PubMed  Google Scholar 

O’Brien T, Ray E, Singh R, Coker B, Beard R. British Association of Urological Surgeons Section of O. Prevention of bladder tumours after nephroureterectomy for primary upper urinary tract urothelial carcinoma: a prospective, multicentre, randomised clinical trial of a single postoperative intravesical dose of mitomycin C (the ODMIT-C trial). Eur Urol. 2011;60(4):703–10.

Article  PubMed  Google Scholar 

Levy A, Canes D. Perioperative complications and adverse sequelae of radical nephroureterectomy. Transl Androl Urol. 2020;9(4):1853–9.

Article  PubMed  PubMed Central  Google Scholar 

Lee IW, Wang HJ, Liu HY, Chang YL, Wu YT, Chen YT et al. Prevalence and oncologic impact of chronic kidney disease for upper tract urothelial carcinoma in endemic area. J Formos Med Assoc. 2023.

Luo HL, Ohyama C, Hatakeyama S, Wang HJ, Yoneyama T, Yang WC, et al. Unusual presentation of upper urinary tract urothelial carcinoma in Taiwan: direct comparison from Taiwan-Japan UTUC collaboration cohort. Int J Urol. 2020;27(4):327–32.

Article  PubMed  Google Scholar 

Registry for Treatment of Upper Urinary Tract Tumours. NIH U.S. National Library of Medicine ClinicalTrials.gov.

Baard J, Celebi M, de la Rosette J, Alcaraz A, Shariat S, Cormio L, et al. Evaluation of patterns of presentation, practice, and outcomes of Upper Tract Urothelial Cancer: protocol for an Observational, International, Multicenter, Cohort Study by the Clinical Research Office of the Endourology Society. JMIR Res Protoc. 2020;9(1):e15363.

Article  PubMed  PubMed Central  Google Scholar 

Gliklich RE, Dreyer NA, Leavy MB, editors. Registries for Evaluating Patient Outcomes: A User’s Guide. AHRQ Methods for Effective Health Care. 3rd ed. Rockville (MD)2014.

Stevens PE, Levin A, Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group M. Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med. 2013;158(11):825–30.

Article  PubMed  Google Scholar 

Stevens LA, Coresh J, Feldman HI, Greene T, Lash JP, Nelson RG, et al. Evaluation of the modification of diet in renal disease study equation in a large diverse population. J Am Soc Nephrol. 2007;18(10):2749–57.

Article  PubMed  Google Scholar 

Cao J, Zhao X, Zhong Z, Zhang L, Zhu X, Xu R. Prognostic value of pre-operative renal insufficiency in Urothelial Carcinoma: a systematic review and Meta-analysis. Sci Rep. 2016;6:35214.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen JS, Lu CL, Huang LC, Shen CH, Chen SC. Chronic kidney disease is Associated with Upper Tract Urothelial Carcinoma: a Nationwide Population-based Cohort Study in Taiwan. Med (Baltim). 2016;95(14):e3255.

Article  Google Scholar 

Yu HS, Hwang JE, Chung HS, Cho YH, Kim MS, Hwang EC, et al. Is preoperative chronic kidney disease status associated with oncologic outcomes in upper urinary tract urothelial carcinoma? A multicenter propensity score-matched analysis. Oncotarget. 2017;8(39):66540–9.

Article  PubMed  PubMed Central  Google Scholar 

Birtle AJ, Jones R, Chester J, Lewis R, Biscombe K, Johnson M et al. Improved Disease-Free Survival with Adjuvant Chemotherapy after Nephroureterectomy for Upper Tract Urothelial Cancer: final results of the POUT Trial. J Clin Oncol. 2024:JCO2301659.

Lane BR, Smith AK, Larson BT, Gong MC, Campbell SC, Raghavan D, et al. Chronic kidney disease after nephroureterectomy for upper tract urothelial carcinoma and implications for the administration of perioperative chemotherapy. Cancer. 2010;116(12):2967–73.

Article  PubMed  Google Scholar 

Margulis V, Puligandla M, Trabulsi EJ, Plimack ER, Kessler ER, Matin SF, et al. Phase II trial of Neoadjuvant systemic chemotherapy followed by extirpative surgery in patients with high Grade Upper Tract Urothelial Carcinoma. J Urol. 2020;203(4):690–8.

Article  PubMed  Google Scholar 

Coleman JA, Yip W, Wong NC, Sjoberg DD, Bochner BH, Dalbagni G, et al. Multicenter Phase II Clinical Trial of Gemcitabine and Cisplatin as Neoadjuvant Chemotherapy for patients with high-Grade Upper Tract Urothelial Carcinoma. J Clin Oncol. 2023;41(8):1618–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim DK, Lee JY, Kim JW, Hah YS, Cho KS. Effect of neoadjuvant chemotherapy on locally advanced upper tract urothelial carcinoma: a systematic review and meta-analysis. Crit Rev Oncol Hematol. 2019;135:59–65.

Article  PubMed  Google Scholar 

Leow JJ, Chong YL, Chang SL, Valderrama BP, Powles T, Bellmunt J. Neoadjuvant and Adjuvant Chemotherapy for Upper Tract Urothelial Carcinoma: a 2020 systematic review and Meta-analysis, and future perspectives on systemic therapy. Eur Urol. 2021;79(5):635–54.

Article  CAS  PubMed  Google Scholar 

Jadot I, Decleves AE, Nortier J, Caron N. An Integrated View of Aristolochic Acid Nephropathy: update of the literature. Int J Mol Sci. 2017;18(2).

Oberg BP, McMenamin E, Lucas FL, McMonagle E, Morrow J, Ikizler TA, et al. Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease. Kidney Int. 2004;65(3):1009–16.

Article  PubMed  Google Scholar 

Tafuri A, Marchioni M, Cerrato C, Mari A, Tellini R, Odorizzi K, et al. Changes in renal function after nephroureterectomy for upper urinary tract carcinoma: analysis of a large multicenter cohort (radical nephroureterectomy outcomes (RaNeO) Research Consortium). World J Urol. 2022;40(11):2771–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaag M, Trost L, Thompson RH, Favaretto R, Elliott V, Shariat SF, et al. Preoperative predictors of renal function decline after radical nephroureterectomy for upper tract urothelial carcinoma. BJU Int. 2014;114(5):674–9.

Article  CAS  PubMed  Google Scholar 

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