Birnbaum AK, Meador KJ, Karanam A, Brown C, May RC, Gerard EE, et al. Antiepileptic drug exposure in infants of breastfeeding mothers with epilepsy. JAMA Neurol. 2020;77(4):441.
Soussan C, Gouraud A, Portolan G, Jean-Pastor M-J, Pecriaux C, Montastruc J-L, et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70(11):1361–6.
Article CAS PubMed Google Scholar
Verstegen RHJ, Anderson PO, Ito S. Infant drug exposure via breast milk. Br J Clin Pharmacol. 2020;88(10): 4311–27.
FDA. Content and format of labeling for human prescription drug and biological products; requirements for pregnancy and lactation labeling. Final rule; 2014.
European Medicines Agency. Risk assessment of medicinal products on human reproduction and lactation: from data to labelling—European Medicines Agency. 2009. https://www.ema.europa.eu/en/risk-assessment-medicinal-products-human-reproduction-lactation-data-labelling-scientific-guideline#current-effective-version-section. Accessed 1 June 2024.
Food and Drug Administration. Pregnancy, lactation, and reproductive potential: labeling for human prescription drug and biological products-content and format. 2020. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/pregnancy-lactation-and-reproductive-potential-labeling-human-prescription-drug-and-biological. Accessed 29 July 2020.
Hotham N, Hotham E. Drugs in breastfeeding. Aust Prescr. 2015;38(5):156–9.
Article PubMed PubMed Central Google Scholar
Lönnerdal B, Erdmann P, Thakkar SK, Sauser J, Destaillats F. Longitudinal evolution of true protein, amino acids and bioactive proteins in breast milk: a developmental perspective. J Nutr Biochem. 2017;41:1–11.
Dror DK, Allen LH. Overview of nutrients in human milk. Adv Nutr. 2018;9(suppl_1):278S–94S.
Caldeo V, Downey E, O’Shea CA, Affolter M, Volger S, Courtet-Compondu MC, et al. Protein levels and protease activity in milk from mothers of pre-term infants: a prospective longitudinal study of human milk macronutrient composition. Clin Nutr. 2021;40(5):3567–77.
Article CAS PubMed Google Scholar
Czosnykowska-Łukacka M, Królak-Olejnik B, Orczyk-Pawiłowicz M. Breast milk macronutrient components in prolonged lactation. Nutrients. 2018;10(12):1893.
Begg EJ, Atkinson HC. Modelling of the passage of drugs into milk. Pharmacol Ther. 1993;59(3):301–10.
Ansell C, Moore A, Barrie H. Electrolyte and pH changes in human milk. Pediatr Res. 1977;11(12):1177–9.
Article CAS PubMed Google Scholar
Morriss FH Jr, Brewer ED, Spedale SB, Riddle L, Temple DM, Caprioli RM, et al. Relationship of human milk pH during course of lactation to concentrations of citrate and fatty acids. Pediatrics. 1986;78(3):458–64.
Article CAS PubMed Google Scholar
Harrison VC, Peat G. Significance of milk pH in newborn infants. Br Med J. 1972;4(5839):515–8.
Article CAS PubMed PubMed Central Google Scholar
Ferris AM, Jensen RG. Lipids in human milk: a review. 1: sampling, determination, and content. J Pediatr Gastroenterol Nutr. 1984;3(1):108–22.
Lönnerdal B, Forsum E, Hambraeus L. A longitudinal study of the protein, nitrogen, and lactose contents of human milk from Swedish well-nourished mothers. Am J Clin Nutr. 1976;29(10):1127–33.
Beardmore KS, Morris JM, Gallery EDM. Excretion of antihypertensive medication into human breast milk: a systematic review. Hypertens Pregn. 2002;21(1):85–95.
Begg EJ. 3—Determinants of drug transfer into human milk. In: Bennett PN, editor. Drugs and human lactation. 2nd ed. Amsterdam: Elsevier Science B.V; 1996. p. 47–58.
Larsen LA, Ito S, Koren G. Prediction of milk/plasma concentration ratio of drugs. Ann Pharmacother. 2003;37(9):1299–306.
Article CAS PubMed Google Scholar
Stebler T, Guentert TW. Binding of drugs in milk: the role of casein in milk protein binding. Pharm Res. 1990;07(6):633–7.
Horn A. Maternal medication and breastfeeding: current recommendations. S Afr Fam Pract. 2005;47(9):42–7.
Wilson JT, Brown RD, Cherek DR, Dailey JW, Hilman B, Jobe PC, et al. Drug excretion in human breast milk: principles, pharmacokinetics and projected consequences. Clin Pharmacokinet. 1980;5(1):1–66.
Meskin MS, Lien EJ. QSAR analysis of drug excretion into human breast milk. J Clin Hosp Pharm. 1985;10(3):269–78.
Fleishaker JC, Desai N, McNamara PJ. Factors affecting the milk-to-plasma drug concentration ratio in lactating women: physical interactions with protein and fat. J Pharm Sci. 1987;76(3):189–93.
Article CAS PubMed Google Scholar
Atkinson HC, Begg EJ. Prediction of drug distribution into human milk from physicochemical characteristics. Clin Pharmacokinet. 1990;18(2):151–67.
Article CAS PubMed Google Scholar
Weisskopf E, Guidi M, Fischer CJ, Bickle Graz M, Beaufils E, Nguyen KA, et al. A population pharmacokinetic model for escitalopram and its major metabolite in depressive patients during the perinatal period: prediction of infant drug exposure through breast milk. Br J Clin Pharmacol. 2020;86(8):1642–53.
Article CAS PubMed PubMed Central Google Scholar
Stowe ZN, Cohen LS, Hostetter A, Ritchie JC, Owens MJ, Nemeroff CB. Paroxetine in human breast milk and nursing infants. Am J Psychiatry. 2000;157(2):185–9.
Article CAS PubMed Google Scholar
Yoshida K, Smith B, Craggs M, Kumar RC. Investigation of pharmacokinetics and of possible adverse effects in infants exposed to tricyclic antidepressants in breast-milk. J Affect Disord. 1997;43(3):225–37.
Article CAS PubMed Google Scholar
Saarela T, Kokkonen J, Koivisto M. Macronutrient and energy contents of human milk fractions during the first six months of lactation. Acta Paediatr. 2005;94(9):1176–81.
Atkinson HC, Begg EJ, Darlow BA. Drugs in human milk. Clinical pharmacokinetic considerations. Clin Pharmacokinet. 1988;14(4):217–40.
Article CAS PubMed Google Scholar
Pansari A, Faisal M, Jamei M, Abduljalil K. Prediction of basic drug exposure in milk using a lactation model algorithm integrated within a physiologically based pharmacokinetic model. Biopharm Drug Dispos. 2022;43(5):201–12.
Article CAS PubMed Google Scholar
Chai T, Draxler RR. Root mean square error (RMSE) or mean absolute error (MAE)?—arguments against avoiding RMSE in the literature. Geosci Model Dev. 2014;7(3):1247–50.
Hale T, Abbey J. 23—drug transfer during breast-feeding. In: Polin RA, Abman SH, Rowitch DH, Benitz WE, Fox WW, editors. Fetal and neonatal physiology (fifth edition). Elsevier; 2017. pp. 239–48.e5.
Mathew JL. Effect of maternal antibiotics on breast feeding infants. Postgrad Med J. 2004;80(942):196–200.
Article CAS PubMed PubMed Central Google Scholar
Fleishaker JC, Desai N, McNamara PJ. Possible effect of lactational period on the milk-to-plasma drug concentration ratio in lactating women: results of an in vitro evaluation. J Pharm Sci. 1989;78(2):137–41.
Article CAS PubMed Google Scholar
Macheras PE, Koupparis MA, Antimisiaris SG. Effect of temperature and fat content on the binding of hydrochlorothiazide and chlorothiazide to milk. J Pharm Sci. 1988;77(4):334–6.
Article CAS PubMed Google Scholar
Atkinson HC, Begg EJ. Relationship between human milk lipid-ultrafiltrate and octanol-water partition coefficients. J Pharm Sci. 1988;77(9):796–8.
Article CAS PubMed Google Scholar
Rampono J, Kristensen JH, Hackett LP, Paech M, Kohan R, Ilett KF. Citalopram and demethylcitalopram in human milk; distribution, excretion and effects in breast fed infants. Br J Clin Pharmacol. 2000;50(3):263–8.
Article CAS PubMed PubMed Central Google Scholar
Zhao S, Gockenbach M, Grimstein M, Sachs HC, Mirochnick M, Struble K, et al. Characterization of plasma protein alterations in pregnant and postpartum individuals living with HIV to support physiologically-based pharmacokinetic model development. Front Pediatr. 2021;9: 721059.
Article PubMed PubMed Central Google Scholar
Kuvibidila SR, Warrier RP. Ceruloplasmin and alpha-1-acid glycoprotein, but not C-reactive protein, correlate with serum ferritin during various postpartum/lactation periods in congolese females. Ochsner J. 2022;22(1):26–34.
Stebler T, Guentert TW. Binding of drugs in milk: the role of casein in milk protein binding. Pharm Res. 1990Jun;7(6):633–7.
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