Valles-Colomer M, Falony G, Darzi Y, Tigchelaar EF, Wang J, Tito RY, et al. The neuroactive potential of the human gut microbiota in quality of life and depression. Nat Microbiol. 2019;4:623–32.

Article  CAS  PubMed  Google Scholar 

Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, et al. Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson’s disease. Cell. 2016;167:1469–80.e12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim MS, Kim Y, Choi H, Kim W, Park S, Lee D, et al. Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model. Gut. 2020;69:283–94.

Article  CAS  PubMed  Google Scholar 

Wang XY, Sun GQ, Feng T, Zhang J, Huang X, Wang T, et al. Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression. Cell Res. 2019;29:787–803.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Q, Xi YJ, Wang QX, Liu JH, Li PR, Meng X, et al. Mannan oligosaccharide attenuates cognitive and behavioral disorders in the 5×FAD Alzheimer’s disease mouse model via regulating the gut microbiota-brain axis. Brain Behav Immun. 2021;95:330–43.

Article  CAS  PubMed  Google Scholar 

Chen C, Zhou Y, Wang H, Alam A, Kang SS, Ahn EH, et al. Gut inflammation triggers C/EBPβ/δ-secretase-dependent gut-to-brain propagation of Aβ and Tau fibrils in Alzheimer’s disease. EMBO J. 2021;40:e106320.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fülling C, Dinan TG, Cryan JF. Gut microbe to brain signaling: what happens in vagus. Neuron. 2019;101:998–1002.

Article  PubMed  Google Scholar 

Williams EK, Chang RB, Strochlic DE, Umans BD, Lowell BB, Liberles SD. Sensory neurons that detect stretch and nutrients in the digestive system. Cell. 2016;166:209–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Osadchiy V, Martin CR, Mayer EA. Gut microbiome and modulation of CNS function. Compr Physiol. 2019;10:57–72.

Article  PubMed  Google Scholar 

Bohórquez DV, Shahid RA, Erdmann A, Kreger AM, Wang Y, Calakos N, et al. Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells. J Clin Invest. 2015;125:782–6.

Article  PubMed  PubMed Central  Google Scholar 

Martin AM, Young RL, Leong L, Rogers GB, Spencer NJ, Jessup CF, et al. The diverse metabolic roles of peripheral serotonin. Endocrinology. 2017;158:1049–63.

Article  CAS  PubMed  Google Scholar 

Latorre R, Sternini C, De Giorgio R, Greenwood-Van Meerveld B. Enteroendocrine cells: a review of their role in brain-gut communication. Neurogastroenterol Motil. 2016;28:620–30.

Article  CAS  PubMed  Google Scholar 

Kaelberer MM, Buchanan KL, Klein ME, Barth BB, Montoya MM, Shen X, et al. A gut-brain neural circuit for nutrient sensory transduction. Science. 2018;361:eaat5236.

Article  PubMed  PubMed Central  Google Scholar 

Alcaino C, Knutson KR, Treichel AJ, Yildiz G, Strege PR, Linden DR, et al. A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release. Proc Natl Acad Sci USA. 2018;115:E7632–E7641.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bellono NW, Bayrer JR, Leitch DB, Castro J, Zhang C, O’Donnell TA, et al. Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways. Cell. 2017;170:185–98.e16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martin AM, Lumsden AL, Young RL, Jessup CF, Spencer NJ, Keating DJ. The nutrient-sensing repertoires of mouse enterochromaffin cells differ between duodenum and colon. Neurogastroenterol Motil. 2017;29:e13046.

Furness JB, Rivera LR, Cho H-J, Bravo DM, Callaghan B. The gut as a sensory organ. Nat Rev Gastroenterol Hepatol. 2013;10:729–40.

Article  CAS  PubMed  Google Scholar 

Berthoud HR. Vagal and hormonal gut-brain communication: from satiation to satisfaction. Neurogastroenterol Motil. 2008;20:64–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Suarez AN, Hsu TM, Liu CM, Noble EE, Cortella AM, Nakamoto EM, et al. Gut vagal sensory signaling regulates hippocampus function through multi-order pathways. Nat Commun. 2018;9:2181.

Article  PubMed  PubMed Central  Google Scholar 

Klarer M, Krieger J-P, Richetto J, Weber-Stadlbauer U, Günther L, Winter C, et al. Abdominal vagal afferents modulate the brain transcriptome and behaviors relevant to schizophrenia. J Neurosci. 2018;38:1634–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Klarer M, Arnold M, Günther L, Winter C, Langhans W, Meyer U. Gut vagal afferents differentially modulate innate anxiety and learned fear. J Neurosci. 2014;34:7067–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ronchi G, Ryu V, Fornaro M, Czaja K. Hippocampal plasticity after a vagus nerve injury in the rat. Neural Regen Res. 2012;7:1055–63.

PubMed  PubMed Central  Google Scholar 

O’Leary OF, Ogbonnaya ES, Felice D, Levone BR, C Conroy L, Fitzgerald P, et al. The vagus nerve modulates BDNF expression and neurogenesis in the hippocampus. Eur Neuropsychopharmacol. 2018;28:307–16.

Article  PubMed  Google Scholar 

Clark KB, Smith DC, Hassert DL, Browning RA, Naritoku DK, Jensen RA. Posttraining electrical stimulation of vagal afferents with concomitant vagal efferent inactivation enhances memory storage processes in the rat. Neurobiol Learn Mem. 1998;70:364–73.

Article  CAS  PubMed  Google Scholar 

Biggio F, Gorini G, Utzeri C, Olla P, Marrosu F, Mocchetti I, et al. Chronic vagus nerve stimulation induces neuronal plasticity in the rat hippocampus. Int J Neuropsychopharmacol. 2009;12:1209–21.

Article  PubMed  Google Scholar 

Zuo Y, Smith DC, Jensen RA. Vagus nerve stimulation potentiates hippocampal LTP in freely-moving rats. Physiol Behav. 2007;90:583–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clark KB, Naritoku DK, Smith DC, Browning RA, Jensen RA. Enhanced recognition memory following vagus nerve stimulation in human subjects. Nat Neurosci. 1999;2:94–98.

Article  CAS  PubMed  Google Scholar 

Sjögren MJ, Hellström PT, Jonsson MA, Runnerstam M, Silander HC, Ben-Menachem E. Cognition-enhancing effect of vagus nerve stimulation in patients with Alzheimer’s disease: a pilot study. J Clin Psychiatry. 2002;63:972–80.

Article  PubMed  Google Scholar 

Merrill CA, Jonsson MAG, Minthon L, Ejnell H, C-son Silander H, Blennow K, et al. Vagus nerve stimulation in patients with Alzheimer’s disease: Additional follow-up results of a pilot study through 1 year. J Clin Psychiatry. 2006;67:1171–8.

Article  CAS  PubMed  Google Scholar 

Rush AJ, George MS, Sackeim HA, Marangell LB, Husain MM, Giller C, et al. Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multicenter study. Biol Psychiatry. 2000;47:276–86.

Article  CAS  PubMed  Google Scholar 

Nozawa K, Kawabata-Shoda E, Doihara H, Kojima R, Okada H, Mochizuki S, et al. TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells. Proc Natl Acad Sci USA. 2009;106:3408–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han LH, Gong HS, Zhu CH, Zhang GH, Rong WF. Role of NaV1.3 in control of excitability of RIN-14B cells. J Shanghai Jiaotong Univ (Med Sci). 2019;39:142–6.

Google Scholar 

Rong W, Hillsley K, Davis JB, Hicks G, Winchester WJ, Grundy D. Jejunal afferent nerve sensitivity in wild-type and TRPV1 knockout mice. J Physiol. 2004;560:867–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rong W, Winchester WJ, Grundy D. Spontaneous hypersensitivity in mesenteric afferent nerves of mice deficient in the sst2 subtype of somatostatin receptor. J Physiol. 2007;581:779–86.

Article  PubMed  PubMed Central  Google Scholar 

Lund ML, Egerod KL, Engelstoft MS, Dmytriyeva O, Theodorsson E, Patel BA, et al. Enterochromaffin 5-HT cells - a major target for GLP-1 and gut microbial metabolites. Mol Metab. 2018;11:70–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cho HJ, Callaghan B, Bron R, Bravo DM, Furness JB. Identification of enteroendocrine cells that express TRPA1 channels in the mouse intestine. Cell Tissue Res. 2014;356:77–82.

Article  CAS  PubMed  Google Scholar