Blomqvist A, Engblom D. Neural mechanisms of inflammation-induced fever. Neuroscientist. 2018;24:381–99.
Article CAS PubMed PubMed Central Google Scholar
Evans SS, Repasky EA, Fisher DT. Fever and the thermal regulation of immunity: the immune system feels the heat. Nat Rev Immunol. 2015;15:335–49.
Article CAS PubMed PubMed Central Google Scholar
Machado NLS, Bandaru SS, Abbott SBG, Saper CB. EP3R-expressing glutamatergic preoptic neurons mediate inflammatory fever. J Neurosci. 2020;40:2573–88.
Article CAS PubMed PubMed Central Google Scholar
Song K, Wang H, Kamm GB, Pohle J, Reis FC, Heppenstall P, et al. The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia. Science. 2016;353:1393–8.
Article CAS PubMed PubMed Central Google Scholar
Nakamura K, Morrison SF. A thermosensory pathway that controls body temperature. Nat Neurosci. 2008;11:62–71.
Article CAS PubMed Google Scholar
Nakamura K, Morrison SF. A thermosensory pathway mediating heat-defense responses. Proc Natl Acad Sci USA. 2010;107:8848–53.
Article CAS PubMed PubMed Central Google Scholar
Nakamura K, Nakamura Y, Kataoka N. A hypothalamomedullary network for physiological responses to environmental stresses. Nat Rev Neurosci. 2022;23:35–52.
Article CAS PubMed Google Scholar
Geerling JC, Kim M, Mahoney CE, Abbott SB, Agostinelli LJ, Garfield AS, et al. Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus. Am J Physiol Regul Integr Comp Physiol. 2016;310:R41–54.
Engblom D, Ek M, Ericsson-Dahlstrand A, Blomqvist A. Activation of prostanoid EP3 and EP4 receptor mRNA-expressing neurons in the rat parabrachial nucleus by intravenous injection of bacterial wall lipopolysaccharide. J Comp Neurol. 2001;440:378–86.
Article CAS PubMed Google Scholar
Buller KM, Allen T, Wilson LD, Munro F, Day TA. A critical role for the parabrachial nucleus in generating central nervous system responses elicited by a systemic immune challenge. J Neuroimmunol. 2004;152:20–32.
Article CAS PubMed Google Scholar
Skibicka KP, Alhadeff AL, Leichner TM, Grill HJ. Neural controls of prostaglandin 2 pyrogenic, tachycardic, and anorexic actions are anatomically distributed. Endocrinology. 2011;152:2400–8.
Article CAS PubMed PubMed Central Google Scholar
Cheng YJ, Xu JH, Zeng RX, Zhao X, Gao WM, Quan JR, et al. The role of prostaglandin E2 synthesized in rat lateral parabrachial nucleus in LPS-iduced fever. Neuroendocrinology. 2022;112:399–416.
Article CAS PubMed Google Scholar
Tkacs NC, Li J. Immune stimulation induces Fos expression in brainstem amygdala afferents. Brain Res Bull. 1999;48:223–31.
Article CAS PubMed Google Scholar
Zhang YH, Lu J, Elmquist JK, Saper CB. Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain. J Comp Neurol. 2003;463:3–12.
Article CAS PubMed Google Scholar
Jagot F, Gaston-Breton R, Choi AJ, Pascal M, Lena Bourhy L, Dorado-Doncel R, et al. The parabrachial nucleus elicits a vigorous corticosterone feedback response to the pro-inflammatory cytokine IL-1β. Neuron. 2023;111:2367–82.
Article CAS PubMed Google Scholar
Kohler C, Schwarcz R. Comparison of ibotenate and kainate neurotoxicity in rat brain: a histological study. Neuroscience. 1983;8:819–35.
Article CAS PubMed Google Scholar
Mu D, Deng J, Liu KF, Wu ZY, Shi YF, Guo WM, et al. A central neural circuit for itch sensation. Science. 2017;357:695–9.
Article CAS PubMed Google Scholar
Xue YW, Yang YL, Tang Y, Ye MP, Xu JH, Zeng YZ, et al. In vitro thermosensitivity of rat lateral parabrachial neurons. Neurosci Lett. 2016;619:15–20.
Article CAS PubMed Google Scholar
Xu JH, Tang Y, Qi HP, Yu XY, Liu MX, Wang N, et al. Electrophysiological properties of thermosensitive neurons in slices of rat lateral parabrachial nucleus. J Therm Biol. 2019;83:87–94.
Ren S, Wang Y, Yue F, Cheng X, Dang R, Qiao Q, et al. The paraventricular thalamus is a critical thalamic area for wakefulness. Science. 2018;362:429–34.
Article CAS PubMed Google Scholar
Li XY, Han Y, Zhang W, Wang SR, Wei YC, Li SS, et al. AGRP neurons project to the medial preoptic area and modulate maternal nest-building. J Neurosci. 2019;39:456–71.
Article CAS PubMed PubMed Central Google Scholar
Zhao Y, Boulant JA. Temperature effects on neuronal membrane potentials and inward currents in rat hypothalamic tissue slices. J Physiol. 2005;564:245–57.
Article CAS PubMed PubMed Central Google Scholar
Wrobel LJ, Reymond-Marron I, Dupré A, Raggenbass M. Oxytocin and vasopressin enhance synaptic transmission in the hypoglossal motor nucleus of young rats by acting on distinct receptor types. Neuroscience. 2010;165:723–35.
Article CAS PubMed Google Scholar
Xu JH, Gao WM, He TH, Yao L, Wu HH, Chen ZW, et al. The hyperthermic response to intra-preoptic area administration of agmatine in male rats. J Therm Biol. 2023;113:103529.
Article CAS PubMed Google Scholar
Kataoka N, Shima Y, Nakajima K, Nakamura K. A central master driver of psychosocial stress responses in the rat. Science. 2020;367:1105–12.
Article CAS PubMed Google Scholar
Zhang J, Rivest S. Distribution, regulation and colocalization of the genes encoding the EP2- and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic inflammation. Eur J Neurosci. 1999;11:2651–68.
Article CAS PubMed Google Scholar
Simm B, Ott D, Pollatzek E, Murgott J, Gerstberger R, Rummel C, et al. Effects of prostaglandin E2 on cells cultured from the rat organum vasculosum laminae terminalis and median preoptic nucleus. Neuroscience. 2016;313:23–35.
Article CAS PubMed Google Scholar
Chen C, Bazan NG. Endogenous PGE2 regulates membrane excitability and synaptic transmission in hippocampal CA1 pyramidal neurons. J Neurophysiol. 2005;93:929–41.
Article CAS PubMed Google Scholar
Mizutani Y, Ohi Y, Kimura S, Miyazawa K, Goto S, Haji A. Effects of prostaglandin E2 on synaptic transmission in the rat spinal trigeminal subnucleus caudalis. Brain Res. 2015;1625:29–38.
Article CAS PubMed Google Scholar
Li GY, Wu QZ, Song TJ, Zhen XC, Yu X. Dynamic regulation of excitatory and inhibitory synaptic transmission by growth hormone in the developing mouse brain. Acta Pharmacol Sin. 2023;44:1109–21.
Article CAS PubMed Google Scholar
Redman S. Quantal analysis of synaptic potentials in neurons of the central nervous system. Physiol Rev. 1990;70:165–98.
Article CAS PubMed Google Scholar
Hayward LF, Felder RB. Electrophysiological properties of rat lateral parabrachial neurons in vitro. Am J Physiol. 1999;276:R696–706.
Siwiec M, Kusek M, Sowa JE, Tokarski K, Hess G. 5-HT7 receptors increase the excitability of hippocampal CA1 pyramidal neurons by inhibiting the A-type potassium current. Neuropharmacology. 2020;177:108248.
Article CAS PubMed Google Scholar
Nakamura Y, Yahiro T, Fukushima A, Kataoka N, Hioki H, Nakamura K. Prostaglandin EP3 receptor-expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling. Sci Adv. 2022;8:eadd5463.
Article CAS PubMed PubMed Central Google Scholar
Machado NLS, Saper CB. Genetic identification of preoptic neurons that regulate body temperature in mice. Temperature. 2022;9:14–22.
Yang WZ, Du X, Zhang W, Gao C, Xie H, Xiao Y, et al. Parabrachial neuron types categorically encode thermoregulation variables during heat defense. Sci Adv. 2020;6:eabb9414.
Comments (0)