Trachtman H, Komers R, Inrig J (2024) Sparsentan: the first and only non-immunosuppressive therapy for the reduction of proteinuria in IgA nephropathy. Expert Rev Clin Immunol 20:571–576. https://doi.org/10.1080/1744666X.2024.2319132
Article CAS PubMed Google Scholar
Kohan DE, Bedard PW, Jenkinson C et al (2024) Mechanism of protective actions of sparsentan in the kidney: lessons from studies in models of chronic kidney disease. Clin Sci (Lond) 138:645–662. https://doi.org/10.1042/CS20240249
Article CAS PubMed Google Scholar
Nagasawa H, Suzuki H, Ueda S, Suzuki Y (2024) Dual blockade of endothelin A and angiotensin II type 1 receptors with sparsentan as a novel treatment strategy to alleviate IgA nephropathy. Expert Opin Investig Drugs 33:1143–1152. https://doi.org/10.1080/13543784.2024.2414902
Article CAS PubMed Google Scholar
Heerspink HJL, Radhakrishnan J, Alpers CE et al (2023) Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial. Lancet 401:1584–1594. https://doi.org/10.1016/S0140-6736(23)00569-X
Article CAS PubMed Google Scholar
Komers R, Diva U, Inrig JK et al (2020) Study design of the phase 3 sparsentan versus irbesartan (DUPLEX) study in patients with focal segmental glomerulosclerosis. Kidney Int Rep 5:494–502. https://doi.org/10.1016/j.ekir.2019.12.017
Article PubMed PubMed Central Google Scholar
Rovin BH, Barratt J, Heerspink HJL et al (2023) Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial. Lancet 402:2077–2090. https://doi.org/10.1016/S0140-6736(23)02302-4
Article CAS PubMed Google Scholar
Wang M (2024) Renoprotective effects of sparsentan: clinical trial evidence in IgA nephropathy and FSGS. Nat Rev Nephrol 20:6. https://doi.org/10.1038/s41581-023-00795-w
Article CAS PubMed Google Scholar
Zhang Y, Zhang H (2024) Current understanding and new insights in the treatment of IgA nephropathy. Nephrology (Carlton) 29(Suppl 2):75–79. https://doi.org/10.1111/nep.14340
Article CAS PubMed Google Scholar
Campbell KN, Griffin S, Trachtman H et al (2023) Practical considerations for the use of sparsentan in the treatment of patients with IgAN in clinical practice. Int J Nephrol Renovasc Dis 16:281–291. https://doi.org/10.2147/IJNRD.S430377
Article CAS PubMed PubMed Central Google Scholar
Kant S, Kronbichler A, Sharma P, Geetha D (2022) Advances in understanding of pathogenesis and treatment of immune-mediated kidney disease: a review. Am J Kidney Dis 79:582–600. https://doi.org/10.1053/j.ajkd.2021.07.019
Article CAS PubMed Google Scholar
Tang SCW, Wei C, Aldworth C et al (2024) Clinical and humanistic burden of IgAN in adult patients: a global real-world survey. Kidney360. https://doi.org/10.34067/KID.0000000613
Article PubMed PubMed Central Google Scholar
van De Ven NS, Pozniak AL, Levi JA et al (2020) Analysis of pharmacovigilance databases for dolutegravir safety in pregnancy. Clin Infect Dis 70:2599–2606. https://doi.org/10.1093/cid/ciz684
Article CAS PubMed Google Scholar
Huang Y, Xu M, Ma X et al (2024) Characterizing ADRs of Enfortumab vedotin and Erdafitinib in bladder cancer treatment: a descriptive analysis from WHO-VigiAccess. Front Pharmacol 15:1503154. https://doi.org/10.3389/fphar.2024.1503154
Article CAS PubMed PubMed Central Google Scholar
Keshishi D, Makunts T, Abagyan R (2021) Common osteoporosis drug associated with increased rates of depression and anxiety. Sci Rep 11:23956. https://doi.org/10.1038/s41598-021-03214-x
Article CAS PubMed PubMed Central Google Scholar
He M, Yang T, Zhou J et al (2024) A real-world study of antifibrotic drugs-related adverse events based on the United States food and drug administration adverse event reporting system and VigiAccess databases. Front Pharmacol 15:1310286. https://doi.org/10.3389/fphar.2024.1310286
Article CAS PubMed PubMed Central Google Scholar
Rothman KJ, Lanes S, Sacks ST (2004) The reporting odds ratio and its advantages over the proportional reporting ratio. Pharmacoepidemiol Drug Saf 13:519–523. https://doi.org/10.1002/pds.1001
Chen S, Fang W, Zhao L, Xu H (2024) Safety assessment of cenobamate: real-world adverse event analysis from the FAERS database. Front Pharmacol 15:1369384. https://doi.org/10.3389/fphar.2024.1369384
Article CAS PubMed PubMed Central Google Scholar
Jiang Y, Zhou L, Shen Y et al (2024) Safety assessment of Brexpiprazole: real-world adverse event analysis from the FAERS database. J Affect Disord 346:223–229. https://doi.org/10.1016/j.jad.2023.11.025
Article CAS PubMed Google Scholar
Selvaskandan H, Barratt J, Cheung CK (2024) Novel treatment paradigms: primary IgA nephropathy. Kidney Int Rep 9:203–213. https://doi.org/10.1016/j.ekir.2023.11.026
Rheault MN, Alpers CE, Barratt J et al (2023) Sparsentan versus irbesartan in focal segmental glomerulosclerosis. N Engl J Med 389:2436–2445. https://doi.org/10.1056/NEJMoa2308550
Article CAS PubMed Google Scholar
Liu ID, Willis NS, Craig JC, Hodson EM (2019) Interventions for idiopathic steroid-resistant nephrotic syndrome in children. Cochrane Database Syst Rev 2019:CD003594. https://doi.org/10.1002/14651858.CD003594.pub6
Article PubMed PubMed Central Google Scholar
Chavez E, Rodriguez J, Drexler Y, Fornoni A (2022) Novel therapies for Alport syndrome. Front Med (Lausanne) 9:848389. https://doi.org/10.3389/fmed.2022.848389
El Karoui K, Fervenza FC, De Vriese AS (2024) Treatment of IgA nephropathy: a rapidly evolving field. J Am Soc Nephrol 35:103–116. https://doi.org/10.1681/ASN.0000000000000242
Barr B, Barbour S (2024) New therapies for immunoglobulin A nephropathy: what’s the standard of care in 2023? Curr Opin Nephrol Hypertens 33:311–317. https://doi.org/10.1097/MNH.0000000000000979
Liang Q, Liao X, Huang Y et al (2024) Safety study on adverse events of zanubrutinib based on WHO-VigiAccess and FAERS databases. Expert Opin Drug Saf. https://doi.org/10.1080/14740338.2024.2416917
Huang Y, Gao H, Lin Y et al (2024) Real-world pharmacovigilance study of FDA adverse event reporting system events for finerenone. Expert Opin Drug Saf. https://doi.org/10.1080/14740338.2024.2412218
Chiu AW, Bredenkamp N (2024) Sparsentan: a first-in-class dual endothelin and angiotensin II receptor antagonist. Ann Pharmacother 58:645–656. https://doi.org/10.1177/10600280231198925
Groothof D, Gans ROB, Bakker SJL (2024) Sparsentan and kidney protection: improved medullary oxygenation? Lancet 404:1808. https://doi.org/10.1016/S0140-6736(24)01168-1
Chung EYM, Badve SV, Heerspink HJL, Wong MG (2023) Endothelin receptor antagonists in kidney protection for diabetic kidney disease and beyond? Nephrology (Carlton) 28:97–108. https://doi.org/10.1111/nep.14130
Comments (0)