Wood IS, Trayhurn P (2003) Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Brit J Nutr 89:3–9. https://doi.org/10.1079/BJN2002763

Article  CAS  PubMed  Google Scholar 

Thorens B, Mueckler M (2010) Glucose transporters in the 21st century. Amer J Physiol Endocrinol Metab 298:E141–E145. https://doi.org/10.1152/ajpendo.00712.2009

Article  CAS  Google Scholar 

Mueckler M, Thorens B (2013) The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med 34:121–138. https://doi.org/10.1016/j.mam.2012.07.001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holman GD (2020) Structure, function, and regulation of mammalian glucose transporters of the SLC2 family. Pflügers Archiv – Eur J Physiol 472:1155–1175. https://doi.org/10.1007/s00424-020-02411-3

Article  CAS  Google Scholar 

Koespell H (2020) Glucose transporters in brain in health and disease. Pflugers Arch 472:1299–1343. https://doi.org/10.1007/s00424-020-02441-x

Article  CAS  Google Scholar 

Matschinsky FM (1996) Banting lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 45:223–241. https://doi.org/10.2337/diab.45.2.223

Article  CAS  PubMed  Google Scholar 

Pénicaud L, Leloup C, Lorsignol A, Alquier T, Guillod E (2002) Brain glucose sensing mechanism and glucose homeostasis. Curr Opin Clin Nutr Metab Care 5:539–543. https://doi.org/10.1097/00075197-200209000-00013

Article  PubMed  Google Scholar 

Blázquez Fernández E (2003) Molecular aspects of a hypothalamic glucose sensor system and their implications in the control of food intake. R Acad Nac Med (Madr) 120:513–522

Google Scholar 

Lenzen S (2014) A fresh view of Glycolysis and glucokinase regulation: history and current status. J Biol Chem 289:12189–12194. https://doi.org/10.1074/jbc.R114.557314

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Backer I, Hussain SS, Bloom SR, Gardiner JV (2016) Insights into the role of neuronal glucokinase. Am J Physiol Endocrinol Metab 311:E42–E55. https://doi.org/10.1152/ajpendo.00034.2016

Article  PubMed  PubMed Central  Google Scholar 

Matschinsky FM, Wilson DF (2019) The central role of glucokinase in glucose homeostasis; a perspective 50 years after demonstrating the presence of the enzyme in Islets of Langerhans. Front Physiol 10:148. https://doi.org/10.3389/fphys.2019.00148

Article  PubMed  PubMed Central  Google Scholar 

Thorens B (2001) GLUT2 in pancreatic and extra-pancreatic gluco-detection (review). Mol Membr Biol 18(4):265–273. https://doi.org/10.1080/09687680110100995

Article  CAS  PubMed  Google Scholar 

Medeiros N, Dai L, Ferguson AV (2012) Glucose-responsive neurons in the subfornical organ of the rat–a novel site for direct CNS monitoring of Circulating glucose. Neuroscience 201:157–165. https://doi.org/10.1016/j.neuroscience.2011.11.028

Article  CAS  PubMed  Google Scholar 

Shen KZ, Yakhnitsa V, Munhall AC, Johnson SW (2014) AMP kinase regulates K-ATP currents evoked by NMDA receptor stimulation in rat subthalamic nucleus neurons. Neuroscience 274:138–152. https://doi.org/10.1016/j.neuroscience.2014.05.03

Article  CAS  PubMed  Google Scholar 

Kim MS, Lee KU (2005) Role of hypothalamic 5’-AMP-activated protein kinase in the regulation of food intake and energy homeostasis. J Mol Med (Berl) 83(7):514–520. https://doi.org/10.1007/s00109-005-0659-z

Article  CAS  PubMed  Google Scholar 

Xue B, Kahn BB (2006) AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J Physiol 574(Pt 1):73–83. https://doi.org/10.1113/jphysiol.2006.113217

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mountjoy PD, Rutter GA (2007) Glucose sensing by hypothalamic neurones and pancreatic islet cells: ample evidence for common mechanisms? Exp Physiol 92(2):311–319. https://doi.org/10.1113/expphysiol.2006.036004

Article  CAS  PubMed  Google Scholar 

Hardie DG, Ross FA, Hawley SA (2012) AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 13:251–262. https://doi.org/10.1038/nrm3311

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hardie DG, Schaffer BE, Brunet A (2016) AMPK: an Energy-Sensing pathway with multiple inputs and outputs. Trends Cell Biol 26:190–201. https://doi.org/10.1016/j.tcb.2015.10.013

Article  CAS  PubMed  Google Scholar 

Langlet F (2019) Tanycyte gene expression dynamics in the regulation of energy homeostasis. Front Endocrinol 10:286. https://doi.org/10.3389/fendo.2019.00286

Article  Google Scholar 

Rodríguez E, Guerra M, Peruzzo B, Blázquez JL (2019) Tanycytes: a rich morphological history to underpin future molecular and physiological investigations. J Neuroendocrinol 31:e12690. https://doi.org/10.1111/jne.12690

Article  CAS  PubMed  Google Scholar 

Rodríguez E, Blázquez JL, Pastor FE, Peláez B, Peña P, Peruzzo B, Amat P (2005) Hypothalamic tanycytes: a key component of brain-endocrine interaction. Int Rev Cytol 247:89–164

Article  PubMed  Google Scholar 

Lhomme T, Clasadonte J, Imbernon M, Fernandois ED, Sauve F, Caron E, Lima N, Heras V, Martinez-Corral I, Muller-Pielitz H, Rasika S, Schwaninger M, Norgueiras R, Prevot V (2021) Tanycytic networks mediate energy balance by feeding lactate to glucose-insensitive POMC neurons. J Clin Invest 140521. https://doi.org/10.1172/JCI140521

Namipoothiri S, Nogueiras R, Schwaninger M, Prevot V (2022) Glial cels as integrators of peripheral and central signals in the regulation of energy homeostasis. Nat Metab 4:813–825. https://doi.org/10.1038/s42255-022-00610z

Article  Google Scholar 

Millán C, Martínez F, Cortés-Campos C, Lizama I, Yañez MJ, Llanos P, Reinicke K, Rodríguez F, Peruzzo B, Nualart F, García MA (2010) Glial glucokinase expression in adult and post-natal development of the hypothalamic region. ASN Neuro 2(3):e00035. https://doi.org/10.1042/AN20090059

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dali R, Estrada-Meza J, Langlet F (2023) Tanycyte, the neuron whisperer. Physiol Behav 263:114108. https://doi.org/10.1016/j.physbeh.2023.114108

Article  CAS  PubMed  Google Scholar 

Nilaweera K, Herwig A, Bolborea M, Campbell G, Mayer CD, Morgan PJ, Ebling FJ, Barrett P (2011) Photoperiodic regulation of glycogen metabolism, glycolysis, and glutamine synthesis in tanycytes of the Siberian hamster suggests novel roles of tanycytes in hypothalamic function. Glia 59(11):1695–1705. https://doi.org/10.1002/glia.21216

Article  PubMed  Google Scholar 

Elizondo-Vega R, Cortes-Campos C, Barahona MJ, Oyarce KA, Carril CA, García-Robles MA (2015) The role of tanycytes in hypothalamic glucosensing. J Cell Mol Med 19(7):1471–1482. https://doi.org/10.1111/jcmm.12590

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elizondo-Vega R, Cortés-Campos C, Barahona MJ, Carril C, Ordenes P, Salgado M, Oyarce K, García-Robles ML (2016) Inhibition of hypothalamic MCT1 expression increases food intake and alters orexigenic and anorexigenic neuropeptide expression. Sci Rep 6:33606. https://doi.org/10.1038/srep33606

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salgado M, Elizondo-Vega R, Villar PS, Konar M, Gallegos S, Tarifeño-Saldivia E, Luz-Crawford P, Aguayo LG, Araneda RC, Uribe E, García-Robles MÁ (2022) GKRP-dependent modulation of feeding behavior by tanycyte-released monocarboxylates. Theranostics 12(4):1518–1536. https://doi.org/10.7150/thno.66634

Article  CAS